CN104892774A - HPMCP (hydroxypropyl methylcellulose phthalate) and preparation method - Google Patents
HPMCP (hydroxypropyl methylcellulose phthalate) and preparation method Download PDFInfo
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- CN104892774A CN104892774A CN201510334326.2A CN201510334326A CN104892774A CN 104892774 A CN104892774 A CN 104892774A CN 201510334326 A CN201510334326 A CN 201510334326A CN 104892774 A CN104892774 A CN 104892774A
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Abstract
The invention discloses HPMCP (hydroxypropyl methylcellulose phthalate) and a preparation method. The HPMCP is mainly prepared from components in parts by weight as follows: 1 parts of lignocellulose, 0.4-0.6 parts of phthalic anhydride, 0.4-0.6 parts of sodium acetate, 0.1-0.5 parts of a catalyst and 20-30 parts of a solvent through reactions, wherein the solvent is one of acetic acid, acetone and ethanol. The preparation method comprises steps as follows: the lignocellulose, the solvent and the sodium acetate are placed in a one-step reaction kettle in proportion to be dissolved for 1.5-2.5 h, then the phthalic anhydride and the catalyst are added to the one-step reaction kettle, and the mixture reacts at the temperature of 60-120 DEG C for 6-8 h. The HPMCP and the preparation method have the characteristics that the raw material source is wide, the cost is low, the preparation process is simple and reliable, and the like.
Description
Technical field
That the present invention relates to is a kind of medicinal hypromellose o-2 potassium acid ester and preparation method, belongs to pharmaceutical purpose enteric solubility sugar coating material and preparing technical field.
Background technology
Phthalic ester is a kind of conventional plastic plasticizer, and this softening agent is the industrial chemicals of technical grade, cannot be used for food grade product; Continually developing and using along with pharmaceutical prod, the application of the sugar-coat raw material of enteric solubility was more and more wider in recent years, but the enteric sugar-coat material due to this food grade must meet the edible standard of human-body safety, therefore require that raw material is relative with manufacture craft strict, thus cost is high, manufacture craft relative complex, is therefore badly in need of a kind of raw material sources at present wide, cost is low, simple, the reliable enteric sugar panned product of manufacture craft.
Summary of the invention
The object of the invention is to the deficiency overcoming prior art existence, and provide a kind of raw material sources wide, cost is low, simple, the reliable hypromellose phthalate of manufacture craft and preparation method.
The object of the invention is to have come by following technical solution, a kind of hypromellose phthalate, it forms according to following ratio reaction primarily of following component: the solvent of the lignocellulose of 1 weight part, the stupid acid anhydride of 0.4-0.6 weight part, the sodium acetate of 0.4-0.6 weight part, 0.1-0.5 part of catalyzer and 20-30 weight parts.
The present invention is preferably: it forms according to following ratio reaction primarily of following component: the solvent of the sodium acetate of the lignocellulose of 1 weight part, the stupid acid anhydride of 0.5 weight part, 0.5 weight part, 0.3 part of catalyzer and 25 weight parts.
Solvent of the present invention is the one in acetic acid, acetone, ethanol.
A kind of preparation method of hypromellose phthalate described above, described preparation method comprises: in proportion lignocellulose, solvent and sodium acetate are put into single step reaction still and dissolve 1.5-2.5 hours, and then phthalic anhydride is added in single step reaction still together with catalyzer, react 6-8 hours at the temperature of 60-120 DEG C.
The present invention is preferably: described dissolution time is 2 hours, and temperature of reaction is at 90-100 DEG C, and reaction 7 hours, and make finished product after being incubated 2 hours.
The present invention is a kind of enteric solubility sugar coating material of excellence, there is specific viscosity and excellent anti-hydrochloric acid in gastric juice performance, can not dissolve under the condition of Ph=5.0-5.5, mainly can be used as tablet, granule frame material, tackiness agent, implant, and the aspects such as aquaculture, industry, biotechnology can be widely used in, there are raw material sources wide, the features such as cost is low, and manufacture craft is simple, reliable.
Embodiment
Below in conjunction with specific embodiment, the present invention will be described in detail: a kind of hypromellose phthalate of the present invention, and it forms according to following ratio reaction primarily of following component: the solvent of the lignocellulose of 1 weight part, the stupid acid anhydride of 0.4-0.6 weight part, the sodium acetate of 0.4-0.6 weight part, 0.1-0.5 part of catalyzer and 20-30 weight parts.
The preferred embodiment of the invention is: it forms according to following ratio reaction primarily of following component: the solvent of the sodium acetate of the lignocellulose of 1 weight part, the stupid acid anhydride of 0.5 weight part, 0.5 weight part, 0.3 part of catalyzer and 25 weight parts.
Solvent of the present invention is the one in acetic acid, acetone, ethanol; Described catalyzer is existing common catalyzer, especially the catalyzer usually selected in medicine making processes is selected, because catalyzer is existing can conveniently selection, and can by experiment to obtain best catalizer variety, therefore, the catalyzer above and described in following examples is and existingly can be used in catalyzer common in medicine making processes.
A kind of preparation method of hypromellose phthalate described above, described preparation method comprises: in proportion lignocellulose, solvent and sodium acetate are put into single step reaction still and dissolve 1.5-2.5 hours, and then phthalic anhydride is added in single step reaction still together with catalyzer, react 6-8 hours at the temperature of 60-120 DEG C.
The preferred embodiment of the invention is: described dissolution time is 2 hours, and temperature of reaction at 90-100 DEG C, and is reacted 7 hours, and makes finished product after being incubated 2 hours.
Embodiment 1: a kind of hypromellose phthalate, it forms according to following ratio reaction primarily of following component: the solvent of the sodium acetate of the lignocellulose of 1 weight part, the stupid acid anhydride of 0.5 weight part, 0.5 weight part, 0.3 part of catalyzer and 25 weight parts; Described solvent is acetic acid;
A kind of preparation method of hypromellose phthalate, described preparation method comprises: in proportion lignocellulose, solvent and sodium acetate are put into single step reaction still and dissolve 2 hours, and then phthalic anhydride is added in single step reaction still together with catalyzer, react 7 hours at the temperature of 90-100 DEG C; And make finished product after being incubated 2 hours.
Embodiment 2: a kind of hypromellose phthalate, it forms according to following ratio reaction primarily of following component: the solvent of the sodium acetate of the lignocellulose of 1 weight part, the stupid acid anhydride of 0.4 weight part, 0.4 weight part, 0.1 part of catalyzer and 20 weight parts; Described solvent is acetone;
A kind of preparation method of described hypromellose phthalate, described preparation method comprises: in proportion lignocellulose, solvent and sodium acetate are put into single step reaction still and dissolve 1.5 hours, and then phthalic anhydride is added in single step reaction still together with catalyzer, react 6 hours at the temperature of 60 DEG C.
Embodiment 3: a kind of hypromellose phthalate, it forms according to following ratio reaction primarily of following component: the solvent of the sodium acetate of the lignocellulose of 1 weight part, the stupid acid anhydride of 0.6 weight part, 0.6 weight part, 0.5 part of catalyzer and 30 weight parts; Described solvent is ethanol;
A kind of preparation method of described hypromellose phthalate, described preparation method comprises: in proportion lignocellulose, solvent and sodium acetate are put into single step reaction still and dissolve 2.5 hours, and then phthalic anhydride is added in single step reaction still together with catalyzer, react 8 hours at the temperature of 120 DEG C.
Claims (5)
1. a hypromellose phthalate, is characterized in that: it forms according to following ratio reaction primarily of following component: the solvent of the lignocellulose of 1 weight part, the stupid acid anhydride of 0.4-0.6 weight part, the sodium acetate of 0.4-0.6 weight part, 0.1-0.5 part of catalyzer and 20-30 weight parts.
2. hypromellose phthalate according to claim 1, is characterized in that: it forms according to following ratio reaction primarily of following component: the solvent of the sodium acetate of the lignocellulose of 1 weight part, the stupid acid anhydride of 0.5 weight part, 0.5 weight part, 0.3 part of catalyzer and 25 weight parts.
3. hypromellose phthalate according to claim 1 and 2, is characterized in that: described solvent is the one in acetic acid, acetone, ethanol.
4. the preparation method of a hypromellose phthalate as described in claim 1 or 2 or 3, it is characterized in that described preparation method comprises: in proportion lignocellulose, solvent and sodium acetate are put into single step reaction still and dissolve 1.5-2.5 hours, and then phthalic anhydride is added in single step reaction still together with catalyzer, react 6-8 hours at the temperature of 60-120 DEG C.
5. the preparation method of hypromellose phthalate according to claim 4, is characterized in that described dissolution time is 2 hours, and temperature of reaction at 90-100 DEG C, and is reacted 7 hours, and makes finished product after being incubated 2 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510334326.2A CN104892774A (en) | 2015-06-17 | 2015-06-17 | HPMCP (hydroxypropyl methylcellulose phthalate) and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510334326.2A CN104892774A (en) | 2015-06-17 | 2015-06-17 | HPMCP (hydroxypropyl methylcellulose phthalate) and preparation method |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1503808A (en) * | 2001-04-19 | 2004-06-09 | ���Ǿ��ܻ�ѧ��ʽ���� | Purification method of hydroxypropylmethyl cellulose phthalate |
| US20050244365A1 (en) * | 2004-05-03 | 2005-11-03 | Novaflux Biosciences, Inc. | Methods, compositions, formulations, and uses of cellulose and acrylic-based polymers |
| CN104231091A (en) * | 2014-09-29 | 2014-12-24 | 泸州北方化学工业有限公司 | Preparation method of hydroxypropyl methyl cellulose phthalate |
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2015
- 2015-06-17 CN CN201510334326.2A patent/CN104892774A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1503808A (en) * | 2001-04-19 | 2004-06-09 | ���Ǿ��ܻ�ѧ��ʽ���� | Purification method of hydroxypropylmethyl cellulose phthalate |
| US20050244365A1 (en) * | 2004-05-03 | 2005-11-03 | Novaflux Biosciences, Inc. | Methods, compositions, formulations, and uses of cellulose and acrylic-based polymers |
| CN104231091A (en) * | 2014-09-29 | 2014-12-24 | 泸州北方化学工业有限公司 | Preparation method of hydroxypropyl methyl cellulose phthalate |
Non-Patent Citations (4)
| Title |
|---|
| 周伟等: ""羟丙甲纤维素邻苯二甲酸酯的合成新方法及工艺优化"", 《武汉理工大学学报》 * |
| 张宪康等: ""肠溶性药用辅料HPMCP的合成研究"", 《中国医药工业杂志》 * |
| 祁荣: ""肠溶包衣材料羟丙甲纤维素邻苯二甲酸酯的研究"", 《中国优秀博硕士学位论文全文数据库（硕士） 医药卫生科技辑》 * |
| 邵自强等: ""羟丙基甲基纤维素酞酸酯的制备与性能测定"", 《华西药学杂志》 * |
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