CN104888227A - Hydroxypropyl starch copolymer for hollow capsules and preparation method of capsules taking hydroxypropyl starch copolymer as raw material - Google Patents
Hydroxypropyl starch copolymer for hollow capsules and preparation method of capsules taking hydroxypropyl starch copolymer as raw material Download PDFInfo
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Abstract
The invention discloses hydroxypropyl starch copolymer hollow capsules and a preparation method thereof, and belongs to the technical field of medicinal auxiliary materials. A preparation method of a hydroxypropyl starch copolymer sequentially comprises the following steps: adding hydroxypropyl starch, an esterification agent and a catalyst into a reaction container, adjusting a pH value, and stirring and heating for performing polymerization reaction; adding cellulose ether, a condensation agent and a reaction medium into the reaction container, and stirring and heating for performing polymerization reaction; and after reaction ends, cooling to room temperature, concentrating reaction liquid, then adding a precipitating agent, and filtering, washing and drying precipitates to obtain the hydroxypropyl starch copolymer. By adopting a preparation method of plant capsules which adopts a dipping process and takes the hydroxypropyl starch copolymer as a main raw material, the problems of too high production cost, complicated operation, unstable quality standards and uncontrollable quality generally existing in a current plant hollow capsule production process can be solved.
Description
Technical field:
The present invention relates to the preparation method of hydroxypropyl emthylcellulose copolymer and plant capsule thereof, belong to chemosynthesis and medical auxiliary materials technical field.
Background technology:
Capsule (Capsules) has plurality of advantages such as covering flavour of a drug, high-drug-effect, control slow release and is widely used in medicine, health product and functional food.At present, the Capsules product on market substantially with gelatin (Gelatin) for material is prepared from.Gelatin is obtained through being hydrolyzed by the bone of animal, skin, the architectural feature of its molecule uniqueness makes it have the shortcoming being difficult to overcome in the application, such as, be easy to be cross-linked with containing medicines such as aldehyde, reducing sugar base class compound and vitamin Cs, gelatin shell water solublity is deteriorated, causes the delay of capsule shells disintegrate and capsule 's content stripping; Gelatin can produce build-up of electrostatic charges in dry conditions, has impact to following process; Long storage periods, at the environment of low humidity, easily becomes fragile and causes capsule broken.In addition, due to faith and the factor of religion aspect, animal sources capsule is not accepted at Islam and minority name race of China area.In recent years, because pharmagel short supply agent holds at high price, and then cause the toxic capsule event that domestic illegal enterprise abuse industrial gelatine causes, cause society greatly panic, allow the development and production of traditional gelatine capsule make the matter worse especially.Therefore, the new capsule material of replacing gelatin is used in the urgent need to research and development.
In capsule pharmaceutic adjuvant market, plant capsule is one of fastest-rising product, and industry generally believes to only have and is only with plant-based capsule replacing gelatin capsule the fundamental way solving capsule persistent ailment.Some hydrophilic macromolecule foodstuff glues, as gellan gum, carrageenan, xanthan gum, cellulose ether etc. have been used to study the succedaneum preparing gelatine capsule.Wherein starch is as a kind of renewable natural resources, and having the advantages such as abundance, cheap, easily biological-degradable, is most potential capsule raw material substitution thing.But also there is a lot of defect in starch: do not dissolve in cold water, gelatinized corn starch viscosity is unstable, make it apply and be extremely restricted.For making full use of the economic worth of starch resource and raising starch, need to carry out modification to improve its performance to starch.Hydroxypropyl starch is the important etherificate modified starch of a class, have gelatinizing stablize low, stick with paste the advantages such as the transparency is high, filming performance is good, included as Capsules adjuvant catalogue by version Chinese Pharmacopoeia in 2015.But it is easily crisp that single hydroxypropyl starch Capsules exists film, the shortcomings such as breakage rate is high, limit its large-scale application in preparing Capsules.Hypromellose, the cellulose ethers such as hydroxyethyl-cellulose are the water soluble polyhydroxy macromolecular compounds commonly used at food and field of pharmaceutical excipients, there is good film property and pliability, also Capsules manufacture is used to, as " phyteral glue and Capsules thereof for the preparation of Capsules " (CN103933011), the invention such as " a kind of production method of starch hollow capsule " (CN103830736) all employ cellulose ether and starch blending system, but cellulose ether and hydroxypropyl starch solution belong to thermodynamics Immiscible Polymer Blends, simple blend very easily causes the wild effects such as glue layering, have a strong impact on product quality.
Summary of the invention:
The object of this invention is to provide a kind of hydroxypropyl starch copolymer of replacing gelatin and utilize the preparation method of plant capsule that this hydroxypropyl starch copolymer is primary raw material.
For achieving the above object, technical scheme provided by the invention is as follows.
A preparation method for Capsules hydroxypropyl starch copolymer, is characterized in that: the raw material reaction that it comprises following parts by weight forms, hydroxypropyl starch 100 parts, esterifying agent 1-30 part, cellulose ether 1-50 part, condensing agent 0.1-1 part; Its preparation method comprises the steps:
(1) esterification: join in reaction vessel by hydroxypropyl starch, esterifying agent and catalyst, agitating heating is reacted;
(2) be polymerized: join in reaction vessel by cellulose ether, condensing agent and reaction medium, agitating heating carries out polyreaction;
(3) product extracts: after reaction terminates, be chilled to room temperature, adds precipitant, filters, washs and obtain hydroxypropyl starch copolymer after dry sediment after reactant liquor is concentrated.
Further, a kind of preparation method of Capsules hydroxypropyl starch copolymer, the raw material reaction that it comprises following parts by weight forms, hydroxypropyl starch 100 parts, esterifying agent 5-30 part, cellulose ether 15-30 part, condensing agent 0.1-1 part.
Esterifying agent described in above-mentioned steps (1) be sodium hydrogen phosphate, sodium dihydrogen phosphate, sodium trimetaphosphate, sodium tripolyphosphate, chlorethoxyfos, acetic anhydride, vinylacetate, glacial acetic acid, ketenes, octenyl succinic acid anhydride, the last of the ten Heavenly stems enetutanedioic acid anhydride, dodecenylsuccinic anhydride, one or several in octadecylene base succinic anhydride, preferred esterifying agent is sodium hydrogen phosphate, sodium dihydrogen phosphate, acetic anhydride and octenyl succinic acid anhydride, and its charged material weight is the 1-30% of hydroxypropyl starch dry weight.
Catalyst described in above-mentioned steps (1) is one or several in sodium hydroxide, sodium carbonate, tertiary sodium phosphate, magnesium hydroxide, sulphuric acid, ammonium acetate, and preferred catalyst is sodium hydroxide, sodium carbonate.
Esterifying agent charged material weight described in above-mentioned steps (1) is the 1-30% of hydroxypropyl starch dry weight.Preferred charged material weight 5-10%
Cellulose ether described in above-mentioned steps (2) is one or several in hypromellose, hydroxypropyl cellulose, hydroxyethyl-cellulose, carboxymethyl cellulose.Preferred cellulose ether is hypromellose, hydroxypropyl cellulose.
Cellulose ether charged material weight described in above-mentioned steps (2) is the 0.1-50% of hydroxypropyl starch dry weight.Preferred charged material weight is 15-30%
Condensing agent described in above-mentioned steps (2) is one or several in sodium trimetaphosphate, sodium hexametaphosphate, phosphorus oxychloride, epoxychloropropane.Preferred condensing agent sodium trimetaphosphate, sodium hexametaphosphate.
Reaction medium described in above-mentioned steps (2) is deionized water or pH value is the buffer solution of 3-12.The buffer solution of preferred reaction medium to be pH value be 5.5-9.
Reaction temperature described in above-mentioned steps (2) be room temperature to 30-80 DEG C, the response time is 0.5-24 h.Preferred reaction temperature is 40-70 DEG C, and the response time is 2-12 h.
Precipitant described in above-mentioned steps (3) is one or several in ether, methanol, ethanol, isopropyl alcohol, acetone, dioxane.Preferred precipitant is ethanol, acetone, and its deal is 2-3 times of the concentrated rear liquid weight of step (3).
Catalyst action mentioned in above-mentioned steps is the pH value regulating reaction environment.
More than one state the preparation method that hydroxypropyl starch copolymer is the Capsules of primary raw material, comprise the steps:
(1) be the hydroxypropyl starch copolymer of 10-35% by percentage by weight, the flocculation aid of 0.05-5%, the plasticizer of 0.1-20% be added to the water, and is heated with stirring to 35-90 DEG C and makes system dissolve clarification completely to obtain glue;
(2) by solvent under reduced pressure or evacuation and centrifugal degassing, remain in 35-60 DEG C, the template preparing capsule immerses feed liquid, dips in film molding obtain capsule with dipping in embrane method;
(3) capsule cut after 25-45 DEG C of dry 0.5-5 h, pull out shell and obtain capsule finished product.
Further, above-mentioned with in the preparation method step (1) of the hydroxypropyl starch copolymer Capsules that is primary raw material, percentage by weight is the hydroxypropyl starch copolymer of 15-30%, the flocculation aid of 0.8-1%, the plasticizer of 2-6% are added to the water, and is heated with stirring to 45-50 DEG C and makes system dissolve clarification completely to obtain glue.
Above-mentioned is one or several in pectin, xanthan gum, locust bean gum, carrageenan, agar with the flocculation aid described in the preparation method step (1) of the hydroxypropyl starch copolymer Capsules that is primary raw material, and preferred flocculation aid is xanthan gum, carrageenan.
Above-mentioned is one or several in glycerol, Polyethylene Glycol, ethylene glycol, Glycerine 1,3-diacetate, monoacetin, polypropylene glycol with the plasticizer described in the preparation method step (1) of the hydroxypropyl starch copolymer Capsules that is primary raw material.Preferred plasticizer is glycerol, Polyethylene Glycol, Glycerine 1,3-diacetate.
Beneficial effect of the present invention is: existing capsule, cellulose ether and hydroxypropyl starch solution belong to thermodynamics Immiscible Polymer Blends, simple blend very easily causes the wild effects such as glue layering, have a strong impact on product quality, by lot of experiments, patent formula of the present invention finds that hydroxypropyl starch has excellent compatibility with cellulose ether after suitable esterification modification, and react the copolymer of generation for the preparation of plant hollow capsule by the activity hydroxy on strand, can the premium properties of these two kinds of natural materials of effective integration, significantly improve the quality of hydroxypropyl starch copolymer capsule and become Capsule technologies (dipping method) operability, and significantly reduce plant capsule preparation cost, this invention is applicable to hydroxypropyl starch plant capsule and produces, ubiquitous production cost in the manufacture of current plant capsule can be solved too high, complicated operation, the problems such as the unstable and quality of matter mark is uncontrollable.
Detailed description of the invention:
Example below will illustrate content of the present invention, but content of the present invention is not only confined to the following examples.
Embodiment 1
A kind of hydroxypropyl starch copolymer Capsules and preparation method thereof, its preparation process is as follows: first 50kg hydroxypropyl starch is added adjust pH 5.5 in the 120kg water containing 5kg sodium hydrogen phosphate and 20kg sodium dihydrogen phosphate, 55 DEG C are stirred and heated to reaction 1 hour, add 10kg hypromellose, 0.1kg sodium hexametaphosphate, adjust pH to 9,55 DEG C of stirring reactions 3 hours.After reaction terminates, be chilled to room temperature, be concentrated into 90kg, add 180kg ethanol, fully stir, copolymer is precipitated, filter, wash and obtain hydroxypropyl starch copolymer 58kg after dry sediment.Be the hydroxypropyl starch copolymer of 15% by percentage by weight, the xanthan gum of 1%, the glycerol of 5% is added to the water, 50 DEG C of agitating heating 2 hours, make system dissolve clarification completely and obtain glue; Solvent under reduced pressure or evacuation and centrifugal degassing, remain in 45 DEG C, and the template preparing capsule immerses feed liquid, dips in film molding obtain capsule with dipping in embrane method; Capsule is cut after 40 DEG C of drying 1 h, fit obtains capsule finished product.Adopting official method to detect Capsules disintegration is 6-13 minute, and get 50 test friabilities, none is damaged.
Embodiment 2
A kind of hydroxypropyl starch copolymer Capsules and preparation method thereof, its preparation process is as follows: first by 10kg hydroxypropyl starch, add in 40kg water, slowly add containing 0.8kg acetic anhydride, maintain pH value 8,35 DEG C and be stirred and heated to reaction 2 hours, add 3kg hypromellose, 0.1kg epoxychloropropane, adjust pH to 10,50 DEG C of stirring reactions 2 hours.After reaction terminates, be chilled to room temperature, be concentrated into 30kg, add 60kg ethanol, fully stir, copolymer is precipitated, filter, wash and obtain hydroxypropyl starch copolymer 1 2.5kg after dry sediment.Be the hydroxypropyl starch copolymer of 15% by percentage by weight, the carrageenan of 1%, the glycerol of 4% is added to the water, 50 DEG C of agitating heating 2 hours, make system dissolve clarification completely and obtain glue; Solvent under reduced pressure or evacuation and centrifugal degassing, remain in 50 DEG C, and the template preparing capsule immerses feed liquid, dips in film molding obtain capsule with dipping in embrane method; Capsule is cut after 50 DEG C of drying 1 h, fit obtains capsule finished product.Adopting official method to detect Capsules disintegration is 7-15 minute, and get 50 test friabilities, none is damaged.
Embodiment 3
A kind of hydroxypropyl starch copolymer Capsules and preparation method thereof, its preparation process is as follows: first added by 30kg hydroxypropyl starch in the 90kg water containing 3kg octenyl succinic acid anhydride, 35 DEG C are stirred and heated to reaction 10 hours, add 6kg hydroxyethyl-cellulose, 0.1kg sodium hexametaphosphate, adjust pH to 9,55 DEG C of stirring reactions 3 hours.After reaction terminates, be chilled to room temperature, filter, concentrated supernatant, to 90kg, adds 200kg methanol, fully stirs, and copolymer is precipitated, and filters, washs and obtain hydroxypropyl starch copolymer 35kg after dry sediment.Be the hydroxypropyl starch copolymer of 25% by percentage by weight, the carrageenan of 1%, the ethylene glycol of 5% is added to the water, 55 DEG C of agitating heating 2 hours, make system dissolve clarification completely and obtain glue; Solvent under reduced pressure or evacuation and centrifugal degassing, remain in 45 DEG C, and the template preparing capsule immerses feed liquid, dips in film molding obtain capsule with dipping in embrane method; Capsule is cut after 40 DEG C of drying 2 h, fit obtains capsule finished product.Adopting official method to detect Capsules disintegration is 5-10 minute, and get 50 test friabilities, none is damaged.
Embodiment 4
A kind of hydroxypropyl starch copolymer Capsules and preparation method thereof, its preparation process is as follows: first 50kg hydroxypropyl starch is added adjust pH 5.5 in the 120kg water containing 5kg octadecylene base succinic anhydride, 35 DEG C are stirred and heated to reaction 8 hours, add 10kg hypromellose, 0.1kg sodium hexametaphosphate, adjust pH to 9,55 DEG C of stirring reactions 3 hours.After reaction terminates, be chilled to room temperature, filter, concentrated supernatant, to 90kg, adds 180kg methanol, fully stirs, and copolymer is precipitated, and filters, washs and obtain hydroxypropyl starch copolymer 58kg after dry sediment.Be the hydroxypropyl starch copolymer of 25% by percentage by weight, the carrageenan of 0.8%, the Polyethylene Glycol of 6% be added to the water, 50 DEG C of agitating heating 2 hours, make system dissolve clarification completely and obtain glue; Solvent under reduced pressure or evacuation and centrifugal degassing, remain in 50 DEG C, and the template preparing capsule immerses feed liquid, dips in film molding obtain capsule with dipping in embrane method; Capsule is cut after 40 DEG C of dry 3h, fit obtains capsule finished product.Adopting official method to detect Capsules disintegration is 6-11 minute, and get 50 test friabilities, none is damaged.
Embodiment 5
A kind of hydroxypropyl starch copolymer Capsules and preparation method thereof, its preparation process is as follows: first 20kg hydroxypropyl starch is added adjust pH 8 in the 60kg water containing 1kg phosphorus oxychloride, 55 DEG C are stirred and heated to reaction 1 hour, add 3kg hypromellose, 0.2kg sodium hexametaphosphate, adjust pH to 9,55 DEG C of stirring reactions 5 hours.After reaction terminates, be chilled to room temperature, filter, concentrated supernatant, to 50kg, adds 100kg acetone, fully stirs, and copolymer is precipitated, and filters, washs and obtain hydroxypropyl starch copolymer 21kg after dry sediment.Be the hydroxypropyl starch copolymer of 18% by percentage by weight, the carrageenan of 1%, the glycerol of 4% is added to the water, 50 DEG C of agitating heating 2 hours, make system dissolve clarification completely and obtain glue; Solvent under reduced pressure or evacuation and centrifugal degassing, remain in 50 DEG C, and the template preparing capsule immerses feed liquid, dips in film molding obtain capsule with dipping in embrane method; Capsule is cut after 45 DEG C of drying 1 h, fit obtains capsule finished product.Adopting official method to detect Capsules disintegration is 9-18 minute, and get 50 test friabilities, none is damaged.
Embodiment 6
A kind of hydroxypropyl starch copolymer Capsules and preparation method thereof, its preparation process is as follows: first add in 60kg glacial acetic acid by 100kg hydroxypropyl starch, 80 DEG C of stirring reactions 10 hours, reclaim removing penitent ice acetic acid, add 100kg water, 20kg hydroxypropyl cellulose, 0.1kg sodium hexametaphosphate, adjust pH to 9,55 DEG C of stirring reactions 4 hours.After reaction terminates, be chilled to room temperature, filter, concentrated supernatant, to 150kg, adds 300kg ethanol, fully stirs, and copolymer is precipitated, and filters, washs and obtain hydroxypropyl starch copolymer 1 15kg after dry sediment.Be the hydroxypropyl starch copolymer of 15% by percentage by weight, the carrageenan of 1%, the glycerol of 4% is added to the water, 50 DEG C of agitating heating 2 hours, make system dissolve clarification completely and obtain glue; Solvent under reduced pressure or evacuation and centrifugal degassing, remain in 50 DEG C, and the template preparing capsule immerses feed liquid, dips in film molding obtain capsule with dipping in embrane method; Capsule is cut after 45 DEG C of dry 1.5h, fit obtains capsule finished product.Adopting official method to detect Capsules disintegration is 5-13 minute, and get 50 test friabilities, none is damaged.
Embodiment 7
A kind of hydroxypropyl starch copolymer Capsules and preparation method thereof, its preparation process is as follows: first added by 50kg hydroxypropyl starch in the 120kg water containing 5kg enetutanedioic acid anhydride in the last of the ten Heavenly stems, 25 DEG C of stirring reactions 18 hours, add 15kg hypromellose, 0.2kg sodium hexametaphosphate, adjust pH to 9,55 DEG C of stirring reactions 5 hours.After reaction terminates, be chilled to room temperature, filter, concentrated supernatant, to 90kg, adds 200kg ethanol, fully stirs, and copolymer is precipitated, and filters, washs and obtain hydroxypropyl starch copolymer 58kg after dry sediment.Be the hydroxypropyl starch copolymer of 30% by percentage by weight, the carrageenan of 1%, the Glycerine 1,3-diacetate of 2% be added to the water, 50 DEG C of agitating heating 2 hours, make system dissolve clarification completely and obtain glue; Solvent under reduced pressure or evacuation and centrifugal degassing, remain in 50 DEG C, and the template preparing capsule immerses feed liquid, dips in film molding obtain capsule with dipping in embrane method; Capsule is cut after 35 DEG C of drying 1 h, fit obtains capsule finished product.Adopting official method to detect Capsules disintegration is 4-9 minute, and get 50 test friabilities, none is damaged.
Embodiment 8
A kind of hydroxypropyl starch copolymer Capsules and preparation method thereof, its preparation process is as follows: first added by 25kg hydroxypropyl starch in the 60kg water containing 2kg sodium hydrogen phosphate and 3kg sodium dihydrogen phosphate, adjust pH 5,45 DEG C are stirred and heated to reaction 3 hours, add 4kg carboxymethyl cellulose, 0.1kg Sodium metaphosphate, adjust pH to 9,55 DEG C of stirring reactions 5 hours.After reaction terminates, be chilled to room temperature, filter, concentrated supernatant, to 60kg, adds 180kg ethanol, fully stirs, and copolymer is precipitated, and filters, washs and obtain hydroxypropyl starch copolymer 27kg after dry sediment.By percentage by weight be the hydroxypropyl starch copolymer of 15%, 1% locust bean gum, the potassium citrate of 0.1%, the polypropylene glycol of 4% be added to the water, 50 DEG C of agitating heating 2 hours, make system dissolve clarification completely and obtain glue; Solvent under reduced pressure or evacuation and centrifugal degassing, remain in 50 DEG C, and the template preparing capsule immerses feed liquid, dips in film molding obtain capsule with dipping in embrane method; Capsule is cut after 35 DEG C of drying 1 h, fit obtains capsule finished product.Adopting official method to detect Capsules disintegration is 5-12 minute, and get 50 test friabilities, none is damaged.
Claims (10)
1. the Capsules preparation method of hydroxypropyl starch copolymer, is characterized in that: the raw material reaction that it comprises following parts by weight forms, hydroxypropyl starch 100 parts, esterifying agent 1-30 part, cellulose ether 1-50 part, condensing agent 0.1-1 part; Its preparation method comprises the steps:
(1) esterification: join in reaction vessel by hydroxypropyl starch, esterifying agent and catalyst, agitating heating is reacted;
(2) be polymerized: join in reaction vessel by cellulose ether, condensing agent and reaction medium, agitating heating carries out polyreaction;
(3) product extracts: after reaction terminates, be chilled to room temperature, adds precipitant, filters, washs and obtain hydroxypropyl starch copolymer after dry sediment after reactant liquor is concentrated.
2. the preparation method of Capsules hydroxypropyl starch copolymer according to claim 1, it is characterized in that: the esterifying agent described in step (1) be sodium hydrogen phosphate, sodium dihydrogen phosphate, sodium trimetaphosphate, sodium tripolyphosphate, phosphorus oxychloride, acetic anhydride, vinylacetate, glacial acetic acid, ketenes, octenyl succinic acid anhydride, the last of the ten Heavenly stems enetutanedioic acid anhydride, dodecenylsuccinic anhydride, one or several in octadecylene base succinic anhydride, its charged material weight is the 1-30% of hydroxypropyl starch dry weight.
3. the preparation method of Capsules hydroxypropyl starch copolymer according to claim 1, is characterized in that: the catalyst described in step (1) is one or several in sodium hydroxide, sodium carbonate, tertiary sodium phosphate, magnesium hydroxide, sulphuric acid, ammonium acetate.
4. the preparation method of Capsules hydroxypropyl starch copolymer according to claim 1, is characterized in that: step (1), reaction temperature described in (2) be room temperature to 30-80 DEG C, the response time is 0.5-24 h.
5. the preparation method of Capsules hydroxypropyl starch copolymer according to claim 1, it is characterized in that: the cellulose ether described in step (2) is one or several in hypromellose, hydroxypropyl cellulose, hydroxyethyl-cellulose, carboxymethyl cellulose, and cellulose ether charged material weight is the 1-50% of hydroxypropyl starch dry weight.
6. the preparation method of Capsules hydroxypropyl starch copolymer according to claim 1, is characterized in that: the condensing agent described in step (2) is one or several in sodium trimetaphosphate, sodium hexametaphosphate, phosphorus oxychloride, epoxychloropropane; Precipitant described in step (3) is one or several in ether, methanol, ethanol, isopropyl alcohol, acetone, dioxane.
7. the preparation method of Capsules hydroxypropyl starch copolymer according to claim 1, is characterized in that: the reaction medium described in step (2) is deionized water or pH value is the buffer solution of 3-12.
8., with a preparation method for the hydroxypropyl starch copolymer Capsules that is raw material, it is characterized in that: comprise the steps:
Be the hydroxypropyl starch copolymer of 10-35% by percentage by weight, the flocculation aid of 0.05-5%, the plasticizer of 0.1-20% be added to the water, be heated with stirring to 35-90 DEG C and make system dissolve clarification completely to obtain glue;
By solvent under reduced pressure or evacuation and centrifugal degassing, remain in 35-60 DEG C, the template preparing capsule immerses feed liquid, dips in film molding obtain capsule with dipping in embrane method;
Capsule is cut after 25-45 DEG C of dry 0.5-5 h, pulls out shell and obtain capsule finished product.
9. according to claim 8 with the preparation method of the hydroxypropyl starch copolymer Capsules that is raw material, it is characterized in that: the flocculation aid described in preparation method step (1) of Capsules is one or several in pectin, xanthan gum, locust bean gum, carrageenan, agar.
10. according to claim 8 with the preparation method of the hydroxypropyl starch copolymer Capsules that is raw material, it is characterized in that: the plasticizer described in preparation method step (1) of Capsules is one or several in glycerol, Polyethylene Glycol, ethylene glycol, Glycerine 1,3-diacetate, monoacetin, polypropylene glycol.
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| CN201510273754.9A CN104888227B (en) | 2015-05-26 | 2015-05-26 | Capsules hydroxypropul starch copolymer and using the hydroxypropul starch copolymer as the preparation method of the capsule of raw material |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112704671A (en) * | 2020-12-28 | 2021-04-27 | 普洛药业股份有限公司 | Amoxicillin and clavulanate potassium capsule and preparation method thereof |
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| CN102952280A (en) * | 2012-08-23 | 2013-03-06 | 安徽大学 | Hydroxypropyl methylcellulose copolymer for preparing plant capsules and preparation method thereof |
| CN103087264A (en) * | 2013-01-27 | 2013-05-08 | 桂林理工大学 | Preparation method of amphipathic acrylic acid/maleic anhydride (AA/MA) grafted esterified hydroxypropyl cassava starch |
| CN103638001A (en) * | 2013-12-10 | 2014-03-19 | 中国科学院长春应用化学研究所 | Vegetable hard capsules and preparation method thereof |
| CN103830736A (en) * | 2014-03-05 | 2014-06-04 | 中国科学院青岛生物能源与过程研究所 | Production method of starch empty capsule |
| CN104530491A (en) * | 2014-12-15 | 2015-04-22 | 浙江中同科技有限公司 | Preparation method of amylocellulose composite material |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102952280A (en) * | 2012-08-23 | 2013-03-06 | 安徽大学 | Hydroxypropyl methylcellulose copolymer for preparing plant capsules and preparation method thereof |
| CN103087264A (en) * | 2013-01-27 | 2013-05-08 | 桂林理工大学 | Preparation method of amphipathic acrylic acid/maleic anhydride (AA/MA) grafted esterified hydroxypropyl cassava starch |
| CN103638001A (en) * | 2013-12-10 | 2014-03-19 | 中国科学院长春应用化学研究所 | Vegetable hard capsules and preparation method thereof |
| CN103830736A (en) * | 2014-03-05 | 2014-06-04 | 中国科学院青岛生物能源与过程研究所 | Production method of starch empty capsule |
| CN104530491A (en) * | 2014-12-15 | 2015-04-22 | 浙江中同科技有限公司 | Preparation method of amylocellulose composite material |
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| CN112704671A (en) * | 2020-12-28 | 2021-04-27 | 普洛药业股份有限公司 | Amoxicillin and clavulanate potassium capsule and preparation method thereof |
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