CN104890950A - Injection cefoxitin sodium preparation technology for automatically examining products - Google Patents
Injection cefoxitin sodium preparation technology for automatically examining products Download PDFInfo
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- CN104890950A CN104890950A CN201510200610.0A CN201510200610A CN104890950A CN 104890950 A CN104890950 A CN 104890950A CN 201510200610 A CN201510200610 A CN 201510200610A CN 104890950 A CN104890950 A CN 104890950A
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- cefoxitin sodium
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- preparation technology
- sodium
- cefoxitin
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B57/00—Automatic control, checking, warning, or safety devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/02—Sterilising, e.g. of complete packages
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/02—Sterilising, e.g. of complete packages
- B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B57/00—Automatic control, checking, warning, or safety devices
- B65B57/02—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of binding or wrapping material, containers, or packages
- B65B57/06—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of binding or wrapping material, containers, or packages and operating to control, or to stop, the feed of articles or material to be packaged
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B65/00—Details peculiar to packaging machines and not otherwise provided for; Arrangements of such details
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65C—LABELLING OR TAGGING MACHINES, APPARATUS, OR PROCESSES
- B65C9/00—Details of labelling machines or apparatus
- B65C9/40—Controls; Safety devices
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Dispersion Chemistry (AREA)
- Fodder In General (AREA)
Abstract
The invention relates to an injection cefoxitin sodium preparation technology for automatically examining products. The preparation technology comprises following steps of synthesis of cefoxitin sodium, making the cefoxitin sodium into powder; and then manufacturing the injection cefoxitin sodium. The preparation technology comprises steps of firstly cleaning reagent bottles used for containing the cefoxitin sodium powder; then quantitively adding the cefoxitin sodium powder into cleaned reagent bottles according to specification; filling the reagent bottles containing the cefoxitin sodium powder with nitrogen; covering the reagent bottles by preprocessed rubber plugs; performing cover bundling processing with aluminum covers so as to seal the products; performing successively interior labels pasting, packing and light detection for bundled reagent bottles; and then pasting exterior labels on, detecting and packaging packing boxes. According to the invention, a weighing device, a full load channel switch and a no-load channel switch are arranged on the outer end of a conveyor belt, so a problem of no-load of reagent bottles is avoided; and an automatic shooting camera, an untagged channel switch and a qualified product channel switch are arranged on a full load channel, so a problem of untagged reagent bottles is avoided.
Description
Technical field
The present invention relates to medical drugs preparation method field, particularly, relate to a kind of preparation technology of cefoxitin sodium for injection of automatic checking product.
Background technology
Cefoxitin sodium is semi-synthetic second generation cephalosporin, it is a kind of cephamycin, developed by Merck & Co., Inc., and in Britain, many countries such as Canadian, Italian listing, cefoxitin sodium is head moldin antibiotics, acts on similar to second generation cephalosporin, and its anaerobe resistant effect is better than second generation cephalosporin.Cefoxitin sodium is a safety and all confirmed medicine with bright market prospects of curative effect, has height broad-spectrum antibacterial action to Major Clinical pathogenic bacteria.
Cefoxitin sodium be suitable for symptom: for the pneumonia caused by sensitive bacterial and other ALRI, urinary tract infections, meningitis, blood poisoning, abdominal cavity infection, pelvic infection, skin soft-tissue infection, RTI, bone and the infection of joint etc.
The effect and the safety that how to improve injecting drug use always are that pharmaceutical producing enterprise wishes the problem solved, the effect of injecting drug use solves from two aspects with safety is main, one is effect and the safety that Formulation guarantees medication, and two is effect and the safety that the process for producing of medicine guarantees medicine.Cefoxitin sodium for injection is a most existing injection agent, and its prescription is single, guarantees that the effect of its medicine and safe main path are exactly by controlling its preparation technology.
The nonconformity of the cefoxitin sodium for injection finished product that the preparation technology of existing injection cefoxitin sodium easily causes.
Summary of the invention
Technical matters to be solved by this invention is to provide a kind of preparation technology of cefoxitin sodium for injection of automatic checking product, the inferior-quality problem of the cefoxitin sodium for injection finished product easily caused with the preparation technology overcoming existing injection cefoxitin sodium.
The present invention's adopted technical scheme that solves the problem is: the preparation technology of the cefoxitin sodium for injection of automatic checking product, comprises the following steps:
(1), the experiment synthesis of cefoxitin sodium: taking 35g acetyl group cephalothin acid, to add temperature be in the tetrahydrofuran solution 380mL of 50 DEG C, stir 30min, keep temperature, slowly add CSI27g, add rear maintenance said temperature and continue reaction 60min, liquid phase test sample reactant purity is less than 2%, add water 150mL, temperature is raised 10 DEG C, keep thermotonus 90min, add ethyl acetate 750mL, 10% sodium-chloride water solution 750mL layering, ethyl acetate layer 20% sodium chloride solution 2000mL washes twice, add purified water 200mL, regulate pH to 7.2 with sodium bicarbonate, isolate water layer, be 1.8 with hcl acidifying to pH, leach crystallization, obtain cefoxitin acid wet product, wet product is dissolved in 230mL methyl alcohol, temperature is kept to be 25 DEG C, the acetone soln 100mL containing sodium iso-octoate 20g that slow dropping is solvent in advance, add after rear maintenance temperature stirs 1h and filter, vacuum drying white solid is cefoxitin sodium, the ratio row that commercial production is empirically synthesized are multiplied,
(2), the cefoxitin sodium of synthesis dried and be prepared into Powdered;
(3), the preparation technology of cefoxitin sodium: first cleaning is used for the reagent bottle of splendid attire cefoxitin sodium powder, then cefoxitin sodium powder is quantitatively loaded the above-mentioned reagent bottle cleaned by specification, again the reagent bottle that cefoxitin sodium powder is housed is filled with nitrogen, then pretreated plug is covered, Zha Gai process is carried out again with aluminium lid, product is sealed, successively interior label is pasted to the reagent bottle after Zha Gai, packaging, lamp is examined, then label outer on packing box, test again, packing, in above-mentioned preparation process, adopt control system to control, described control system comprises monitoring and control centre, monitoring and control centre is connected with controller, controller is connected with setting weight sensor on the belt, belt conveyor start stop switch, controller is connected with the weighing machine being arranged on belt conveyor mouth, fully loaded channel switch, unloaded channel switch, controller is connected with the automatic camera camera be arranged on fully loaded passage, unlabelled channel switch, certified products channel switch, described monitoring and control centre is connected with network service by network interface, and described controller is connected with counting machine, and monitoring and control centre is connected with data center.The nonconformity of the cefoxitin sodium for injection finished product that the preparation technology of existing injection cefoxitin sodium easily causes is due to the speed of pipelining, manual operation does not catch up with the speed of belt conveyor sometimes, reagent bottle usually can be caused to occur unloaded, the appearance of the off-grades such as reagent bottle unlabelled, monitoring and control centre of the present invention specifically refers to Control Room, for the whole production procedure of same monitoring management, controller specifically refers to PLC, zero load refers in reagent bottle have splendid attire powder reagent, be fully loaded with the powder reagent referring in reagent bottle and be loaded with specification and arrange, weight sensor can be real-time the weight sensing the product on belt conveyor, when product have little time flow into next process cause blocking up on a moving belt time, driving band is overweight, weight sensor by the weight transmitting that senses to controller, judged whether overweight by controller, and judge whether that sending instruction stops belt conveyor, when product flow into the mouth of driving band, weighed not obtaining reagent bottle by weighing machine, the numerical value of weighing is passed to controller, according to numerical value, controller judges that whether this reagent bottle is unloaded, if unloaded controller sends instruction and opens unloaded channel switch, make product introduction arrive unloaded passage, otherwise open fully loaded channel switch, avoid unloaded off gauge to flow into next process, the reagent bottle flowing into fully loaded passage is taken pictures through automatic licence plate camera, license plate information is passed to controller, judge whether reagent bottle labels by controller, if unlabelled, controller sends instruction and opens unlabelled channel switch, make product introduction to unlabelled passage, otherwise opening certified products channel switch makes product introduction to certified products passage, the present invention, by arranging weighing machine, fully loaded channel switch, unloaded channel switch at the mouth of belt conveyor, avoids the problem of reagent bottle zero load, by being provided with automatic camera camera, unlabelled channel switch, certified products channel switch on fully loaded passage, avoid the problem of reagent bottle unlabelled, so, the inferior-quality problem of the cefoxitin sodium for injection finished product that the preparation technology that instant invention overcomes existing injection cefoxitin sodium easily causes.
Further, controller is connected to temperature sensor, and the temperature signal sensed is passed to controller by temperature sensor, and controller analysis temperature signal judges whether the heating arrangement that unlatching is connected with controller or heat abstractor.Report and submit to controller by temperature sensor acquisition environment temperature, controller carries out the calculating of temperature data and compares, when temperature is lower than setting value time, start electro-heat equipment, and can the power of regulation heating device, thus keep whole controller not affected by too low temperature, and when ambient temperature is higher than certain setting value, start heat abstractor, and environmentally the height of temperature carrys out the power of adjusting heat dissipation device, electronic component is made to be unlikely to be burned, thus make each electronic devices and components keep more rational operating temperature, add the service life of equipment.
Further, controller is connected with camera, the picture via controller of camera shooting passes to the computing machine be connected with monitoring and control centre.So, the production procedure observing product that just can be real-time.
Further, the cleaning process of reagent bottle is followed successively by supersound washing, Shui Chong, air oven dry, oven for drying, sterilizing.Guarantee the thoroughly clean of reagent bottle and gnotobasis, avoid reagent bottle to have influence on the quality of cefoxitin sodium.
Further, aluminium lid need pass through and process, and pretreated concrete steps are: poured into by aluminium lid in clean porose stainless steel framework, add in electrically heated drying cabinet, be incubated PTO Power Take Off after a hour.
To sum up, the invention has the beneficial effects as follows:
1, the present invention is by arranging weighing machine, fully loaded channel switch, unloaded channel switch at the mouth of belt conveyor, avoids the problem of reagent bottle zero load; By being provided with automatic camera camera, unlabelled channel switch, certified products channel switch on fully loaded passage, avoid the problem of reagent bottle unlabelled.
2, the present invention strictly carries out handle control to each operation in the preparation technology of cefoxitin sodium, from wash bottle, packing, Zha Gai to external packing, all sterilization treatment is carried out to working environment, the problem that its result of use avoiding the performance impairment of the cefoxitin sodium caused in preparation process to cause reduces from use equipment.
Accompanying drawing explanation
Fig. 1 is functional block diagram of the present invention.
Detailed description of the invention
Below in conjunction with embodiment and accompanying drawing, to the detailed description further of invention do, but embodiments of the present invention are not limited thereto.
Embodiment:
As shown in Figure 1, the preparation technology of the cefoxitin sodium for injection of automatic checking product, comprises the following steps:
(1), the experiment synthesis of cefoxitin sodium: taking 35g acetyl group cephalothin acid, to add temperature be in the tetrahydrofuran solution 380mL of 50 DEG C, stir 30min, keep temperature, slowly add CSI27g, add rear maintenance said temperature and continue reaction 60min, liquid phase test sample reactant purity is less than 2%, add water 150mL, temperature is raised 10 DEG C, keep thermotonus 90min, add ethyl acetate 750mL, 10% sodium-chloride water solution 750mL layering, ethyl acetate layer 20% sodium chloride solution 2000mL washes twice, add purified water 200mL, regulate pH to 7.2 with sodium bicarbonate, isolate water layer, be 1.8 with hcl acidifying to pH, leach crystallization, obtain cefoxitin acid wet product, wet product is dissolved in 230mL methyl alcohol, temperature is kept to be 25 DEG C, the acetone soln 100mL containing sodium iso-octoate 20g that slow dropping is solvent in advance, add after rear maintenance temperature stirs 1h and filter, vacuum drying white solid is cefoxitin sodium, the ratio row that commercial production is empirically synthesized are multiplied,
(2), the cefoxitin sodium of synthesis dried and be prepared into Powdered;
(3), the preparation technology of cefoxitin sodium: first cleaning is used for the reagent bottle of splendid attire cefoxitin sodium powder, the cleaning process of reagent bottle is followed successively by supersound washing, water rushes, air is dried, oven for drying, sterilizing, then cefoxitin sodium powder is quantitatively loaded the above-mentioned reagent bottle cleaned by specification, again the reagent bottle that cefoxitin sodium powder is housed is filled with nitrogen, then pretreated plug is covered, Zha Gai process is carried out again with aluminium lid, aluminium lid need pass through and process, pretreated concrete steps are: poured into by aluminium lid in clean porose stainless steel framework, add in electrically heated drying cabinet, being incubated PTO Power Take Off after a hour makes product seal, successively interior label is pasted to the reagent bottle after Zha Gai, packaging, lamp is examined, then label outer on packing box, test again, packing, in above-mentioned preparation process, adopt control system to control, described control system comprises monitoring and control centre, monitoring and control centre is connected with controller, controller is connected with setting weight sensor on the belt, belt conveyor start stop switch, controller is connected with the weighing machine being arranged on belt conveyor mouth, fully loaded channel switch, unloaded channel switch, controller is connected with the automatic camera camera be arranged on fully loaded passage, unlabelled channel switch, certified products channel switch, described monitoring and control centre is connected with network service by network interface, and described controller is connected with counting machine, and monitoring and control centre is connected with data center, described controller is connected to temperature sensor, the temperature signal sensed is passed to controller by temperature sensor, controller analysis temperature signal judges whether the heating arrangement that unlatching is connected with controller or heat abstractor, described controller is connected with camera, and the picture via controller of camera shooting passes to the computing machine be connected with monitoring and control centre.
As mentioned above, the present invention can be realized preferably.
Claims (5)
1. the preparation technology of the cefoxitin sodium for injection of automatic checking product, is characterized in that, comprises the following steps: comprise the following steps:
(1), the experiment synthesis of cefoxitin sodium: taking 35g acetyl group cephalothin acid, to add temperature be in the tetrahydrofuran solution 380mL of 50 DEG C, stir 30min, keep temperature, slowly add CSI27g, add rear maintenance said temperature and continue reaction 60min, liquid phase test sample reactant purity is less than 2%, add water 150mL, temperature is raised 10 DEG C, keep thermotonus 90min, add ethyl acetate 750mL, 10% sodium-chloride water solution 750mL layering, ethyl acetate layer 20% sodium chloride solution 2000mL washes twice, add purified water 200mL, regulate pH to 7.2 with sodium bicarbonate, isolate water layer, be 1.8 with hcl acidifying to pH, leach crystallization, obtain cefoxitin acid wet product, wet product is dissolved in 230mL methyl alcohol, temperature is kept to be 25 DEG C, the acetone soln 100mL containing sodium iso-octoate 20g that slow dropping is solvent in advance, add after rear maintenance temperature stirs 1h and filter, vacuum drying white solid is cefoxitin sodium, the ratio row that commercial production is empirically synthesized are multiplied,
(2), the cefoxitin sodium of synthesis dried and be prepared into Powdered;
(3), the preparation technology of cefoxitin sodium: first cleaning is used for the reagent bottle of splendid attire cefoxitin sodium powder, then cefoxitin sodium powder is quantitatively loaded the above-mentioned reagent bottle cleaned by specification, again the reagent bottle that cefoxitin sodium powder is housed is filled with nitrogen, then pretreated plug is covered, Zha Gai process is carried out again with aluminium lid, product is sealed, successively interior label is pasted to the reagent bottle after Zha Gai, packaging, lamp is examined, then label outer on packing box, test again, packing, in above-mentioned preparation process, adopt control system to control, described control system comprises monitoring and control centre, monitoring and control centre is connected with controller, controller is connected with setting weight sensor on the belt, belt conveyor start stop switch, controller is connected with the weighing machine being arranged on belt conveyor mouth, fully loaded channel switch, unloaded channel switch, controller is connected with the automatic camera camera be arranged on fully loaded passage, unlabelled channel switch, certified products channel switch, described monitoring and control centre is connected with network service by network interface, and described controller is connected with counting machine, and monitoring and control centre is connected with data center.
2. the preparation technology of the cefoxitin sodium for injection of automatic checking product according to claim 1, it is characterized in that, described controller is connected to temperature sensor, the temperature signal sensed is passed to controller by temperature sensor, and controller analysis temperature signal judges whether the heating arrangement that unlatching is connected with controller or heat abstractor.
3. the preparation technology of the cefoxitin sodium for injection of automatic checking product according to claim 1 and 2, is characterized in that, described controller is connected with camera, and the picture via controller of camera shooting passes to the computing machine be connected with monitoring and control centre.
4. the preparation technology of the cefoxitin sodium for injection of automatic checking product according to claim 1, is characterized in that, the cleaning process of described reagent bottle is followed successively by supersound washing, Shui Chong, air oven dry, oven for drying, sterilizing.
5. the preparation technology of the cefoxitin sodium for injection of automatic checking product according to claim 4, it is characterized in that, described aluminium lid need pass through and process, pretreated concrete steps are: poured into by aluminium lid in clean porose stainless steel framework, add in electrically heated drying cabinet, be incubated PTO Power Take Off after a hour.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510200610.0A CN104890950A (en) | 2015-04-27 | 2015-04-27 | Injection cefoxitin sodium preparation technology for automatically examining products |
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| CN201510200610.0A CN104890950A (en) | 2015-04-27 | 2015-04-27 | Injection cefoxitin sodium preparation technology for automatically examining products |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117735462A (en) * | 2024-02-19 | 2024-03-22 | 四川丹璟琛科技有限公司 | Control system for cosmetic packaging quality detection equipment |
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| CN102895182A (en) * | 2012-10-22 | 2013-01-30 | 四川制药制剂有限公司 | Method for preparing cefoxitin sodium for injection |
| CN202863825U (en) * | 2012-11-12 | 2013-04-10 | 王艳 | Packaging production line combined control device |
| CN103450225A (en) * | 2013-08-22 | 2013-12-18 | 海南葫芦娃制药有限公司 | Preparation method of cefoxitin sodium |
-
2015
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| CN1903861A (en) * | 2005-07-27 | 2007-01-31 | 艾斯.多伯法股份公司 | Process for preparing sodium cefoxitin |
| CN201689317U (en) * | 2010-05-14 | 2010-12-29 | 山东大学 | Label detecting system |
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| CN202863825U (en) * | 2012-11-12 | 2013-04-10 | 王艳 | Packaging production line combined control device |
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| Title |
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| 赵振华等: "头孢西丁钠的合成", 《山东化工》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117735462A (en) * | 2024-02-19 | 2024-03-22 | 四川丹璟琛科技有限公司 | Control system for cosmetic packaging quality detection equipment |
| CN117735462B (en) * | 2024-02-19 | 2024-04-26 | 广东诗妃化妆品有限公司 | Control system for cosmetic packaging quality detection equipment |
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