CN104886581A - Biological agent for decreasing uric acid, treating gout and eliminating overnutrition and preparation method of biological agent - Google Patents
Biological agent for decreasing uric acid, treating gout and eliminating overnutrition and preparation method of biological agent Download PDFInfo
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- CN104886581A CN104886581A CN201510340998.4A CN201510340998A CN104886581A CN 104886581 A CN104886581 A CN 104886581A CN 201510340998 A CN201510340998 A CN 201510340998A CN 104886581 A CN104886581 A CN 104886581A
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- extract
- overnutrition
- trioxypurine
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- 201000005569 Gout Diseases 0.000 title claims abstract description 26
- 201000002451 Overnutrition Diseases 0.000 title claims abstract description 22
- 235000020823 overnutrition Nutrition 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 title abstract description 10
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 title abstract description 10
- 229940116269 uric acid Drugs 0.000 title abstract description 10
- 239000003124 biologic agent Substances 0.000 title abstract 6
- 230000003247 decreasing effect Effects 0.000 title abstract 3
- 239000000284 extract Substances 0.000 claims abstract description 90
- 238000000034 method Methods 0.000 claims abstract description 27
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 240000007087 Apium graveolens Species 0.000 claims abstract description 11
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 claims abstract description 11
- 235000010591 Appio Nutrition 0.000 claims abstract description 11
- 229940038487 grape extract Drugs 0.000 claims abstract description 11
- 241000512259 Ascophyllum nodosum Species 0.000 claims abstract description 6
- 240000000249 Morus alba Species 0.000 claims abstract description 6
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 6
- 238000001291 vacuum drying Methods 0.000 claims description 20
- 238000003809 water extraction Methods 0.000 claims description 20
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 5
- 235000012333 Vitis X labruscana Nutrition 0.000 claims description 5
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 5
- 240000006365 Vitis vinifera Species 0.000 claims 1
- 208000024891 symptom Diseases 0.000 abstract description 3
- 241000219095 Vitis Species 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 244000301850 Cupressus sempervirens Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229960002708 antigout preparations Drugs 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 235000014102 seafood Nutrition 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a biological agent for decreasing uric acid, treating gout and eliminating overnutrition and a preparation method of the biological agent. The biological agent is prepared from components and raw materials in percentage by weight as follows: 30%-40% of kelp extract, 15%-20% of dark grape extract, 15%-20% of morello extract, 10%-15% of celery extract and 10%-15% of mulberry leaf extract, the components are placed in a three-dimensional mixer to be mixed for 15-20 min and are screened by a 40-80-mesh sieve, the process is repeated for 2 times, and a finished product is obtained. Compared with the prior art, the clinic trial taking proves that after the biological agent is taken, the uric acid level is decreased within one hour, and the symptoms of gout are relieved within four hours.
Description
Technical field
The present invention relates to a kind of biologic product and preparation method thereof, especially relate to a kind of anti-trioxypurine, treat gout and remove overnutrition biologic product and preparation method thereof.
Background technology
Along with the raising of people's living standard, also there is larger change in the structure in people's daily life diet.Eating of a large amount of meat, seafood, internal organ, alcohol etc., causes the high heat of people's diet, high protein, high-fat feature.And these features result in people's overnutrition, thus the uric acid content that body metabolism is produced raises, and finally causes the generation of gout.
Chinese patent CN103735697A discloses Chinese medicine preparation with antigout effect and preparation method thereof, this Chinese medicine preparation comprises the raw material of following parts by weight: Mao Xu Cao 40 ~ 120 parts, folium cortex eucommiae 25 ~ 40 parts, the Radix Astragali 5 ~ 30 parts, golden cypress 10 ~ 50 parts, the bark of ash 5 ~ 50 parts, caulis trachelospermi 10 ~ 55 parts, but the raw material adopted in this patent is traditional Chinese medicine ingredients, still there is the problems such as the mechanism of action is indefinite, body absorption leaves a question open.
Summary of the invention
Object of the present invention be exactly in order to overcome above-mentioned prior art exist defect and a kind of anti-trioxypurine is provided, treats gout and removes overnutrition biologic product and preparation method thereof.
Object of the present invention can be achieved through the following technical solutions:
Anti-trioxypurine, treat gout and remove overnutrition biologic product, adopt the raw material of following composition and weight percent content to prepare:
Thallus Laminariae (Thallus Eckloniae) extract 30-40%, black grape extract 15-20%, morello extract 15-20%, Herba Apii graveolentis extract 10-15%, mulberry-leaf extract 10-15%.
Described Thallus Laminariae (Thallus Eckloniae) extract adopts following methods to obtain: pulverized by kelp, utilize the water extraction of 6-8 times of weight to get 2 times, and merge extract, 50-60 DEG C of Vacuum Concentration is to concentrated solution density 1.02-1.05g/cm
3, then obtain Thallus Laminariae (Thallus Eckloniae) extract 60-80 DEG C of vacuum drying.
Described black grape extract adopts following methods to obtain: pulled an oar by black grape, utilize the water extraction of 3-6 times of weight to get 2 times, and merge extract, 50-60 DEG C of Vacuum Concentration is to concentrated solution density 1.03-1.05g/cm
3, then obtain Thallus Laminariae (Thallus Eckloniae) extract 50-60 DEG C of vacuum drying.
Described morello extract adopts following methods to obtain: pulled an oar by morello, utilize the water extraction of 3-6 times of weight to get 2 times, and merge extract, 50-60 DEG C of Vacuum Concentration is to concentrated solution density 1.03-1.05g/cm
3, then obtain Thallus Laminariae (Thallus Eckloniae) extract 50-60 DEG C of vacuum drying.
Described Herba Apii graveolentis extract adopts following methods to obtain: pulverized by celery and squeeze the juice, by juice at least drying machine with centrifugal spray, with inlet temperature 180 DEG C, and outlet temperature 80 DEG C, rotating speed 8000-10000rpm, flow 1.5-2L/min, dry acquisition celery extract.
Described mulberry-leaf extract adopts following methods to obtain: after being pulverized by mulberry leaf, utilize the water extraction of 6-8 times of weight to get 2 times, merge extract, 50-60 DEG C of Vacuum Concentration is to concentrated solution density 1.02-1.05g/cm
3, 60-80 DEG C of vacuum drying obtains mulberry-leaf extract.
Anti-trioxypurine, treat gout and go the preparation method of overnutrition biologic product, adopt following steps:
(1) raw material is prepared according to above formula;
(2) above each component is inserted in three-dimensional mixer mix 15-20 minute, cross 40-80 mesh sieve, repeat 2 times, obtain final products.
Compared with prior art, the present invention, first by the alkalization body physique that raw extract obtains, suppresses uric acid to be formed, secondly, the activity of the relevant enzyme generated by suppressing uric acid, suppresses uric acid to be formed, finally, excreting by accelerating uric acid, reaching the object of anti-trioxypurine, treatment gout.Biologic product of the present invention is shown by clinical examination clothes: after taking this product, reduce uric acid level in one hour, alleviate gout symptom in four hours, daily 900mg, there is the effect of overnutrition, daily 1800mg, there is the effect of anti-trioxypurine, treatment gout.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail.
Embodiment 1
Anti-trioxypurine, treat gout and remove overnutrition biologic product, adopt the raw material of following composition and weight percent content to prepare:
Thallus Laminariae (Thallus Eckloniae) extract 40%, black grape extract 15%, morello extract 15%, Herba Apii graveolentis extract 15%, mulberry-leaf extract 15%.
Thallus Laminariae (Thallus Eckloniae) extract adopts following methods to obtain: pulverized by kelp, utilize the water extraction of 6 times of weight to get 2 times, and merge extract, 50 DEG C of Vacuum Concentrations are to concentrated solution density 1.02g/cm
3, then obtain Thallus Laminariae (Thallus Eckloniae) extract 60 DEG C of vacuum drying.
Black grape extract adopts following methods to obtain: pulled an oar by black grape, utilize the water extraction of 3 times of weight to get 2 times, and merge extract, 50 DEG C of Vacuum Concentrations are to concentrated solution density 1.03g/cm
3, then obtain Thallus Laminariae (Thallus Eckloniae) extract 50 DEG C of vacuum drying.
Morello extract adopts following methods to obtain: pulled an oar by morello, utilize the water extraction of 3 times of weight to get 2 times, and merge extract, 50 DEG C of Vacuum Concentrations are to concentrated solution density 1.03g/cm
3, then obtain Thallus Laminariae (Thallus Eckloniae) extract 50 DEG C of vacuum drying.
Herba Apii graveolentis extract adopts following methods to obtain: pulverized by celery and squeeze the juice, by juice at least drying machine with centrifugal spray, with inlet temperature 180 DEG C, and outlet temperature 80 DEG C, rotating speed 8000rpm, flow 1.5L/min, dry acquisition celery extract.
Mulberry-leaf extract adopts following methods to obtain: after being pulverized by mulberry leaf, utilize the water extraction of 6 times of weight to get 2 times, merge extract, 50 DEG C of Vacuum Concentrations are to concentrated solution density 1.02g/cm
3, 60 DEG C of vacuum drying obtain mulberry-leaf extract.
Anti-trioxypurine, treat gout and go the preparation method of overnutrition biologic product, adopt following steps:
(1) raw material is prepared according to above formula;
(2) above each component is inserted in three-dimensional mixer and mix 15 minutes, cross 40 mesh sieves, repeat 2 times, obtain final products.
Embodiment 2
Anti-trioxypurine, treat gout and remove overnutrition biologic product, its preparation method is identical with embodiment 1, and difference is, the present embodiment adopts the raw material of following composition and weight percent content to prepare:
Thallus Laminariae (Thallus Eckloniae) extract 30%, black grape extract 20%, morello extract 20%, Herba Apii graveolentis extract 15%, mulberry-leaf extract 15%.
Thallus Laminariae (Thallus Eckloniae) extract adopts following methods to obtain: pulverized by kelp, utilize the water extraction of 7 times of weight to get 2 times, and merge extract, 55 DEG C of Vacuum Concentrations are to concentrated solution density 1.03g/cm
3, then obtain Thallus Laminariae (Thallus Eckloniae) extract 70 DEG C of vacuum drying.
Black grape extract adopts following methods to obtain: pulled an oar by black grape, utilize the water extraction of 4 times of weight to get 2 times, and merge extract, 55 DEG C of Vacuum Concentrations are to concentrated solution density 1.04g/cm
3, then obtain Thallus Laminariae (Thallus Eckloniae) extract 55 DEG C of vacuum drying.
Morello extract adopts following methods to obtain: pulled an oar by morello, utilize the water extraction of 4 times of weight to get 2 times, and merge extract, 55 DEG C of Vacuum Concentrations are to concentrated solution density 1.04g/cm
3, then obtain Thallus Laminariae (Thallus Eckloniae) extract 55 DEG C of vacuum drying.
Herba Apii graveolentis extract adopts following methods to obtain: pulverized by celery and squeeze the juice, by juice at least drying machine with centrifugal spray, with inlet temperature 180 DEG C, and outlet temperature 80 DEG C, rotating speed 9000rpm, flow 1.8L/min, dry acquisition celery extract.
Mulberry-leaf extract adopts following methods to obtain: after being pulverized by mulberry leaf, utilize the water extraction of 7 times of weight to get 2 times, merge extract, 55 DEG C of Vacuum Concentrations are to concentrated solution density 1.03g/cm
3, 70 DEG C of vacuum drying obtain mulberry-leaf extract.
Anti-trioxypurine, treat gout and go the preparation method of overnutrition biologic product, adopt following steps:
(1) raw material is prepared according to above formula;
(2) above each component is inserted in three-dimensional mixer and mix 20 minutes, cross 60 mesh sieves, repeat 2 times, obtain final products.
Embodiment 3
Anti-trioxypurine, treat gout and remove overnutrition biologic product, its preparation method is identical with embodiment 1, and difference is, the present embodiment adopts the raw material of following composition and weight percent content to prepare:
Thallus Laminariae (Thallus Eckloniae) extract 40%, black grape extract 20%, morello extract 20%, Herba Apii graveolentis extract 10%, mulberry-leaf extract 10%.
Thallus Laminariae (Thallus Eckloniae) extract adopts following methods to obtain: pulverized by kelp, utilize the water extraction of 8 times of weight to get 2 times, and merge extract, 60 DEG C of Vacuum Concentrations are to concentrated solution density 1.05g/cm
3, then obtain Thallus Laminariae (Thallus Eckloniae) extract 80 DEG C of vacuum drying.
Black grape extract adopts following methods to obtain: pulled an oar by black grape, utilize the water extraction of 6 times of weight to get 2 times, and merge extract, 60 DEG C of Vacuum Concentrations are to concentrated solution density 1.05g/cm
3, then obtain Thallus Laminariae (Thallus Eckloniae) extract 60 DEG C of vacuum drying.
Morello extract adopts following methods to obtain: pulled an oar by morello, utilize the water extraction of 6 times of weight to get 2 times, and merge extract, 60 DEG C of Vacuum Concentrations are to concentrated solution density 1.05g/cm
3, then obtain Thallus Laminariae (Thallus Eckloniae) extract 60 DEG C of vacuum drying.
Herba Apii graveolentis extract adopts following methods to obtain: pulverized by celery and squeeze the juice, by juice at least drying machine with centrifugal spray, with inlet temperature 180 DEG C, and outlet temperature 80 DEG C, rotating speed 10000rpm, flow 2L/min, dry acquisition celery extract.
Mulberry-leaf extract adopts following methods to obtain: after being pulverized by mulberry leaf, utilize the water extraction of 8 times of weight to get 2 times, merge extract, 60 DEG C of Vacuum Concentrations are to concentrated solution density 1.05g/cm
3, 80 DEG C of vacuum drying obtain mulberry-leaf extract.
Anti-trioxypurine, treat gout and go the preparation method of overnutrition biologic product, adopt following steps:
(1) raw material is prepared according to above formula;
(2) above each component is inserted in three-dimensional mixer and mix 20 minutes, cross 80 mesh sieves, repeat 2 times, obtain final products.
This product obviously can reduce uric acid level after taking, and alleviates gout symptom, and in addition, its raw material is that pure natural is without any side effects, safer compared with Western medicine.
Claims (7)
1. anti-trioxypurine, treat gout and remove overnutrition biologic product, it is characterized in that, adopt the raw material of following composition and weight percent content to prepare:
Thallus Laminariae (Thallus Eckloniae) extract 30-40%, black grape extract 15-20%, morello extract 15-20%, Herba Apii graveolentis extract 10-15%, mulberry-leaf extract 10-15%.
2. a kind of anti-trioxypurine according to claim 1, treat gout and remove overnutrition biologic product, it is characterized in that, described Thallus Laminariae (Thallus Eckloniae) extract adopts following methods to obtain: pulverized by kelp, the water extraction of 6-8 times of weight is utilized to get 2 times, merge extract, 50-60 DEG C of Vacuum Concentration is to concentrated solution density 1.02-1.05g/cm
3, then obtain Thallus Laminariae (Thallus Eckloniae) extract 60-80 DEG C of vacuum drying.
3. a kind of anti-trioxypurine according to claim 1, treat gout and remove overnutrition biologic product, it is characterized in that, described black grape extract adopts following methods to obtain: pulled an oar by black grape, the water extraction of 3-6 times of weight is utilized to get 2 times, merge extract, 50-60 DEG C of Vacuum Concentration is to concentrated solution density 1.03-1.05g/cm
3, then obtain Thallus Laminariae (Thallus Eckloniae) extract 50-60 DEG C of vacuum drying.
4. a kind of anti-trioxypurine according to claim 1, treat gout and remove overnutrition biologic product, it is characterized in that, described morello extract adopts following methods to obtain: pulled an oar by morello, the water extraction of 3-6 times of weight is utilized to get 2 times, merge extract, 50-60 DEG C of Vacuum Concentration is to concentrated solution density 1.03-1.05g/cm
3, then obtain Thallus Laminariae (Thallus Eckloniae) extract 50-60 DEG C of vacuum drying.
5. a kind of anti-trioxypurine according to claim 1, treat gout and remove overnutrition biologic product, it is characterized in that, described Herba Apii graveolentis extract adopts following methods to obtain: pulverized by celery and squeeze the juice, by in juice at least drying machine with centrifugal spray, with inlet temperature 180 DEG C, outlet temperature 80 DEG C, rotating speed 8000-10000rpm, flow 1.5-2L/min, dry acquisition celery extract.
6. a kind of anti-trioxypurine according to claim 1, treat gout and remove overnutrition biologic product, it is characterized in that, described mulberry-leaf extract adopts following methods to obtain: after being pulverized by mulberry leaf, the water extraction of 6-8 times of weight is utilized to get 2 times, merge extract, 50-60 DEG C of Vacuum Concentration is to concentrated solution density 1.02-1.05g/cm
3, 60-80 DEG C of vacuum drying obtains mulberry-leaf extract.
7. the anti-trioxypurine according to any one of claim 1-6, treat gout and go the preparation method of overnutrition biologic product, it is characterized in that, the method adopts following steps:
(1) raw material is prepared according to above formula;
(2) above each component is inserted in three-dimensional mixer mix 15-20 minute, cross 40-80 mesh sieve, repeat 2 times, obtain final products.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510340998.4A CN104886581A (en) | 2015-06-18 | 2015-06-18 | Biological agent for decreasing uric acid, treating gout and eliminating overnutrition and preparation method of biological agent |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510340998.4A CN104886581A (en) | 2015-06-18 | 2015-06-18 | Biological agent for decreasing uric acid, treating gout and eliminating overnutrition and preparation method of biological agent |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105126067A (en) * | 2015-09-30 | 2015-12-09 | 北京知蜂堂蜂产品有限公司 | Composition for reducing uric acid and application thereof |
| CN105250817A (en) * | 2015-11-11 | 2016-01-20 | 广东明荃生物科技有限公司 | Herbaceous plant containing tea for treating gout and joint pain and reducing uric acid |
| CN105495258A (en) * | 2015-12-07 | 2016-04-20 | 广东盛元中天生物科技有限公司 | Fruit beverage facilitating reduction of uric acid |
| CN106107972A (en) * | 2016-06-27 | 2016-11-16 | 江西省蚕桑茶叶研究所 | A kind of Folium Mori green juice powder and the preparation method of Folium Mori green grass or young crops juice solid beverage thereof |
| CN106421427A (en) * | 2016-11-17 | 2017-02-22 | 兴义市东泰天然果蔬开发有限公司 | Tea for gout |
| CN106962551A (en) * | 2017-03-19 | 2017-07-21 | 贵阳中医学院第二附属医院 | A kind of tea-drinking for gout |
| CN109123307A (en) * | 2018-09-06 | 2019-01-04 | 沈阳大水兔科技有限公司 | It is a kind of suitable for high blood uric acid and the plant fruits and vegetables solid beverage of gout crowd |
| CN109430667A (en) * | 2018-10-19 | 2019-03-08 | 张东祥 | A kind of composition and solid beverage with anti-trioxypurine effect |
| CN114344328A (en) * | 2020-10-12 | 2022-04-15 | 深圳奥萨制药有限公司 | Composition for reducing risk of gout of hypertension patient |
| CN117882774A (en) * | 2024-03-13 | 2024-04-16 | 中国农业大学 | Composition with uric acid reducing effect and application thereof |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105126067A (en) * | 2015-09-30 | 2015-12-09 | 北京知蜂堂蜂产品有限公司 | Composition for reducing uric acid and application thereof |
| CN105126067B (en) * | 2015-09-30 | 2018-05-22 | 北京知蜂堂健康科技股份有限公司 | A kind of composition of anti-trioxypurine and application thereof |
| CN105250817A (en) * | 2015-11-11 | 2016-01-20 | 广东明荃生物科技有限公司 | Herbaceous plant containing tea for treating gout and joint pain and reducing uric acid |
| CN105495258B (en) * | 2015-12-07 | 2018-05-18 | 广东盛元中天生物科技有限公司 | A kind of fruit beverage for helping anti-trioxypurine |
| CN105495258A (en) * | 2015-12-07 | 2016-04-20 | 广东盛元中天生物科技有限公司 | Fruit beverage facilitating reduction of uric acid |
| CN106107972A (en) * | 2016-06-27 | 2016-11-16 | 江西省蚕桑茶叶研究所 | A kind of Folium Mori green juice powder and the preparation method of Folium Mori green grass or young crops juice solid beverage thereof |
| CN106421427A (en) * | 2016-11-17 | 2017-02-22 | 兴义市东泰天然果蔬开发有限公司 | Tea for gout |
| CN106962551A (en) * | 2017-03-19 | 2017-07-21 | 贵阳中医学院第二附属医院 | A kind of tea-drinking for gout |
| CN109123307A (en) * | 2018-09-06 | 2019-01-04 | 沈阳大水兔科技有限公司 | It is a kind of suitable for high blood uric acid and the plant fruits and vegetables solid beverage of gout crowd |
| CN109430667A (en) * | 2018-10-19 | 2019-03-08 | 张东祥 | A kind of composition and solid beverage with anti-trioxypurine effect |
| CN114344328A (en) * | 2020-10-12 | 2022-04-15 | 深圳奥萨制药有限公司 | Composition for reducing risk of gout of hypertension patient |
| CN114344328B (en) * | 2020-10-12 | 2024-01-16 | 深圳奥萨制药有限公司 | Composition for reducing gout occurrence risk of hypertensive patient |
| CN117882774A (en) * | 2024-03-13 | 2024-04-16 | 中国农业大学 | Composition with uric acid reducing effect and application thereof |
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Application publication date: 20150909 |