CN1048805A - Be used to cover the treatment material of wound and skin injury and their manufacture method - Google Patents
Be used to cover the treatment material of wound and skin injury and their manufacture method Download PDFInfo
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- CN1048805A CN1048805A CN 89104813 CN89104813A CN1048805A CN 1048805 A CN1048805 A CN 1048805A CN 89104813 CN89104813 CN 89104813 CN 89104813 A CN89104813 A CN 89104813A CN 1048805 A CN1048805 A CN 1048805A
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- oil
- emulsion
- treatment material
- wound
- carrier
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Abstract
The invention relates to treatment material and method for making thereof that covering wound and skin injury are used.
Treatment material of the present invention comprises the carrier that is impregnated with a kind of nonallergic Emulsion, can choose the active substance biologically that is mixed with effective dose in this Emulsion wantonly.
Cover this treatment material adhesion wound surface on the wound, secretions is easy to infiltrate wherein, and easy-to-use.
Description
The invention relates to and be used to cover the treatment material of wound and skin injury and their manufacture method.
Have the wound of exudate and the known method on compromised skin surface according to treatment, use the Gauze of gauze belt/sheet, local dipping usually or with the oil impregnated Gauze (Jelonet of paraffin
RSmith and Nephew company product) cover, under wound also must be with the situation that biologically effective substances is treated, can directly be applied in medicine on the gauze when treating so or be applied to the wound surface place, then the wound that covers is bandaged.
The shortcoming of this known method is as follows:
-when removing binder, newborn epithelial layer sustains damage, and epithelial layer is subjected to quite serious wound in many cases;
-secretions drying in common gauze layer, the result forms hard surface, makes not porous of secretions;
-because application mode, the amount of active substance is not only on the biology of using when needing;
-can not guarantee it all is aseptic in all cases.
In order to eliminate above-mentioned shortcoming, the purpose of this invention is to provide a kind of treatment material that is used to cover wound and skin injury, this treats material
-adhesion wound,
-after treatment, can easily remove and do not have any damage and wound from the surface;
-be permeable to secretions;
-can mix with arbitrary effective substances biologically, promptly if desired, it can with water soluble, the soluble or fatty soluble effective ingredient of oil mix, therefore can guarantee to have on the surface that needs are treated the effective ingredient of optimum dosage;
-can therefore can directly use at any time with the sterile form long term store.
We find, cover one deck Emulsion on the carrier that covers wound and skin injury or with Emulsion it are flooded being applicable to, can realize the target that will reach.Described Emulsion is to be made in the presence of oil-in-water emulsifiers by the mixture of various polyoxygenated ethylidene glycol (Polyoxyethylene glycols) and oil, this emulsifying agent has extra high HLB(hydrophile-lipophile balance) value (for example HLB＞10), and wherein can choose the effective substances biologically that is mixed with effective dose wantonly.In addition, but can also control the medication and the release of the effective ingredient of optional use by this solution.
Therefore, the present invention relates to be used to cover the treatment material of wound and skin injury, this treatment material comprises:
A) carrier of being made by textile or paper material or synthetic fibers is coated with one deck or is impregnated with on this carrier:
B) have the Emulsion of following composition:
Propylene glycol 0～20%(by weight)
Polyoxygenated ethylidene glycol 5～95%(by weight)
Oil 10～25%(by weight)
Emulsifying agent 5～20%(by weight)
Can choose wantonly in this Emulsion and be mixed with:
C) the effective composition biologically of effective dose, this effective ingredient system is selected from antibiotics, antiseptic, disinfectant, antimycotic agent, biologically effectively plant extract and dermatologic.
The treatment material that the present invention is used to cover wound and skin injury can be pressed method and make: from above-mentioned b) ingredients listed, prepare Emulsion according to known method own, and can choose wantonly resulting Emulsion and c) described in the effective substances biologically of effective dose mix mutually, then with a) the above-mentioned impregnation mixture of described carrier, with the resulting packing of product, can sterilize to it when needing.
A) carrier described in can adopt the textile material of different densities braiding, and they make (for example gauze or loose fabric) by plying or filamentary yarn; Perhaps also can adopt non-woven material (for example veil fabric (Veil fabrics)), paper, sticking paper, the two all can randomly be installed with eyelet, and/or net or the thin slice made by synthetic material.
Emulsion b) the polyoxygenated ethenylidene glycol in can adopt the mixture (for example n=300～6000) of polymeric in various degree polyoxygenated ethylidene glycol, wherein the ratio of low degree polymerization and highly polymeric polyoxygenated ethylidene glycol is (1: 40)～(40: 1), is preferably (1: 1)～(20: 1).
According to the present invention, above-mentioned Emulsion b) oil phase in can be any known oil that is generally used for injection, vegetable oil (as sunflower oil, olive oil, Oleum Arachidis hypogaeae semen, Semen Lini oil, Semen Ricini wet goods) for example, animal oil (as fish oil), mineral oil (as paraffin oil), synthetic oils (as silicone oil, the wet goods of Myritol Levitol type).
According to the present invention, above-mentioned Emulsion b) emulsifying agent in can adopt the have high HLB value ion-type or the nonionic emulsifier of (for example HLB＞10), the ester of fatty alcohol ethoxylate for example, the ester of making by polyhydroxy-alcohol and fatty acid, two anhydro sorbitol-the stearates of ethyoxyl, ethylene oxide adduct is as fatty acid-macrogol ester, aliphatic alcohol-ethylene oxide adduct etc.
The oil-in-water emulsion that is used for covering the treatment material of wound and skin injury of the present invention, effective substances (this material water soluble, oil or fat) is mixed with this Emulsion, active substance can be arrived the surface that needs treatment with predetermined only dose application like this, and above-mentioned treatment can also be undertaken by the layman.
Product of the present invention can be made size and shape arbitrarily as required, for example can make 13 * 18cm, the lamellar of 5 * 6cm and 8 * 15cm.The tablet of gained places on the cardboard or on the polymer flake, and packs with metal or polymer foil, can sterilize if desired.Resulting product for the sterilization, the sealing with unit product easy to use.
Product of the present invention is highly suitable for the surface injury for the treatment of burn, ulcus cruris, having suppurative secretions, and the skin loss that various exudates are arranged, after reduction operation with wound covering, product of the present invention can be used for patient's ambulatory treatment, there are part lastingly in first aid and any material of treatment wound that needs, and for example it can be used on army, the ship or the field of traumatology.
Describe the present invention in detail with following limiting examples, following biological example proves that treatment material of the present invention is applicable to skin.
Biological example
A) skin irritation test
Test is carried out on new zealand rabbit.Slough rabbit back 5cm
2The hair of area, the Gauze that floods with each 0.5g of following example 1-10 Emulsion covers, and wraps up with binder according to common clinical manipulation.
Handle the back and removed binder in 24 and 48 hours.In each processed group of each duration of test with 3 animals.
Test shows that Gauze is removed easily in all cases, and they are moist, and skin is not caused any stimulation yet.
B) microbiology test
1) sterile test
Before carrying out the skin irritation test, check the sterilization situation of applied dipping Gauze with following method: under aseptic condition, sterilization in the sterilization tank will be placed with the Gauze of polyethylene (PE) paper tinsel parcel, and be cut into about 1/2cm with sterile scissors and pliers then
2The small pieces sheet, these small gauze sheets are placed in aseptic liquid Semen sojae atricolor casein and Saab Luo Shi (Sabouraud) culture medium cultivate.The culture that obtains is in 32 ℃ and 26 ℃ of one weeks of insulation.Check with microscope then, find that all Gauzes all are aseptic.
2) microbiology stability test
In this test, use the different antibacterial (edge pus pseudomonas and aurococcus) of two strains.This test desire proves, 72 hours of hypothesis the longest wound covering is in the time, applied material can not become the culture medium of existing these two kinds of antibacterials.
Dipping is used above-mentioned bacterial infection with material (for example arbitrary Emulsion among the example 1-10), measures the number of antibacterial in 24,28 and 72 hours later in insulation.
The above-mentioned bacterial growth of any strain is not observed in this evidence, on the contrary, and initial number of bacteria (about 10
5～10
6/ g) reduce to 0～10/g gradually.The above results shows that the Emulsion that is used to flood also has bactericidal action.
The preparation of Emulsion
Example 1
Composition:
Propylene glycol 5%
Polyoxygenated ethylidene glycol 400
（Lutrol400） 59.5%
Polyoxygenated ethylidene glycol 4000
（Lutrol4000） 8.0%
Myritol 318 20.0%
Solutol HS 15 7.5%
Example 2
Composition:
Paraffin oil 1%
Propylene glycol 10%
Lutrol 400 75%
Lutrol 4000 10%
Cremophor RH60 4%
Example 3
Composition:
Semen Lini oil 2%
Propylene glycol 4%
Lutrol 300 80%
8%
Lutrol 6000 8%
Cremophor RH60 6%
Example 4
Composition:
Propylene glycol 5%
Lutrol 300 40%
Lutrol 1540 35%
Myritol 318 10%
Cremophor EL 10%
Example 5
Composition:
Luvitol EHO 13%
Lutrol 400 59.5%
Lutrol 4000 18%
Cremophor A6 9.6%
Example 6
Composition:
Silicone oil (300CP) 5%
Lutrol 400 70%
Lutrol 1540 10%
Cremophor S9 15%
Example 7
Composition:
Semen Maydis oil 15%
Lutrol 400 55%
Lutrol 4000 10%
Solutol HS 15 20%
Example 8
Composition:
Oleum sesami 8%
Propylene glycol 2%
Lutrol 400 70%
Lutrol 1540 5%
Solutol HS 15 15%
Example 9
Composition:
Oleum Arachidis hypogaeae semen 5%
Lutrol 300 70%
Lutrol 4000 20%
Polypropylene glycol 5%
Solutol HS 15 5%
Example 10
Composition:
Sunflower oil 6%
Lutrol 300 80%
Lutrol 6000 2%
Solutol HS 15 12%
The Emulsion of above-mentioned example 1-10 can for example by the various polyoxygenated ethylidene glycol of fusion, and under agitation mix fused mass and other compositions by known method preparation itself.
The chemical constituent of the above-mentioned material of representing with trade name is as follows:
Myritol 318: sad-certain herbaceous plants with big flowers acid-triglyceride
Solutol HS15: diethylene glycol-single ethylether
Cremophor RH60: polyethylene (660)-12-hydroxyl-stearate (60)
Cremophor EL: polyoxyethylene glycerol-triricinoleic acid ester (35)
CremophorA6: the mixture of fatty alcohol ethoxylate and free alkyl alcohol
CremophorS9: Polyethylene Glycol (400)-stearate
Be used to cover the method for making of the material of wound
Example 11
Be the Gauze of placing loose braiding on the polypropylene foil with holes of 6 * 6cm to specification, with the Emulsion dipping of Gauze, cover again subsequently, be cut into small pieces and through radiation sterilization with metal forming with example 1.
Example 12
According to the preparation of the method for example 11, before being to flood, difference will be suspended in the Emulsion as the gentamycin of the effective dose of effective ingredient.
Example 13
According to the method preparation of example 11, the porous thin slice that difference is to make with synthetic (as polypropylene alkene, polyamide, viscose rayon etc.) is as carrier.
Example 14
According to the method preparation of example 12, difference is one of following ingredients of using effective dose: erythromycin, neomycin, sisomicin, tetracycline, chloro hexedine gluconate, benzalkonium chloride, miconazole or metronidazole.
Claims (7)
1, is used to cover the treatment material of wound and skin injury, it is characterized in that it contains
A) carrier of making by textile or paper or synthetic fibers, the following b of this carrier) carry out bonding or dipping,
B) Emulsion of following composition;
Propylene glycol 0～2% (by weight)
Polyoxyethylene glycol 5～95% (by weight)
Oily 10～25% (by weight)
Emulsifying agent 5～20% (by weight)
This Emulsion can be chosen wantonly and following c) mix,
C) the effective material biologically of effective dose, this active substance system is selected from antibiotics, antiseptic, disinfectant, antimycotic agent, biologically effectively plant extract and dermatologic.
2, the described treatment material of claim 1 is characterized in that, carrier is the textile of different densities a), and it is to be made by plying or filamentary yarn, preferably gauze or loose cotton goods.
3, the described treatment material of claim 1 is characterized in that, carrier a) is foraminous viscose thin slice or the net made by synthetic fibers.
4, the described treatment material of claim 1, it is characterized in that, Emulsion b) oil that contains is vegetable oil (for example sunflower oil, olive oil, Semen Maydis oil, Oleum Arachidis hypogaeae semen, Semen Lini oil), animal oil (for example fish oil), synthetic oil (for example silicone oil (10～10000cp)) or mineral oil (for example paraffin oil).
5, the described treatment material of claim 1, it is characterized in that, Emulsion b) poly-ethoxyquin ethylidene glycol is the mixture of various polymeric in various degree polyoxygenated ethylidene glycols (n=300～6000) in, and the ratio of the polymeric polyoxygenated ethylidene glycol of low degree polymerization and high level is (1: 40)～(40: 1), is preferably (1: 1)～(20: 1).
6, the described treatment material of claim 1, it is characterized in that, wherein also can choose wantonly and contain effective substances c biologically), these active substance can be selected from gentamycin, erythromycin, neomycin, sisomicin, tetracycline, chloro hexedine gluconate, benzalkonium chloride, miconazole or metronidazole.
7, the described method that is used to cover the treatment material of wound and skin injury of preparation claim 1, the method is characterized in that, each composition is mixed, preparation Emulsion b), optional with the biologically effective substances c of resulting Emulsion with effective dose) mix, this Emulsion is bonded on the carrier or with this Emulsion floods, the product that obtains is packed, can sterilize if desired.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89104813 CN1048805A (en) | 1989-07-15 | 1989-07-15 | Be used to cover the treatment material of wound and skin injury and their manufacture method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89104813 CN1048805A (en) | 1989-07-15 | 1989-07-15 | Be used to cover the treatment material of wound and skin injury and their manufacture method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1048805A true CN1048805A (en) | 1991-01-30 |
Family
ID=4855706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 89104813 Pending CN1048805A (en) | 1989-07-15 | 1989-07-15 | Be used to cover the treatment material of wound and skin injury and their manufacture method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1048805A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1111072C (en) * | 1996-08-02 | 2003-06-11 | 高景星 | Body-compatible antiseptic and antiphlogitic bleeding-stopping dressing and its prepn |
| CN103974680A (en) * | 2011-12-09 | 2014-08-06 | 柯惠有限合伙公司 | Non-adherent wound dressings and related methods therefor |
| CN104906627A (en) * | 2011-03-15 | 2015-09-16 | 绍兴文理学院 | Hydrophilic petrolatum gauze |
-
1989
- 1989-07-15 CN CN 89104813 patent/CN1048805A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1111072C (en) * | 1996-08-02 | 2003-06-11 | 高景星 | Body-compatible antiseptic and antiphlogitic bleeding-stopping dressing and its prepn |
| CN104906627A (en) * | 2011-03-15 | 2015-09-16 | 绍兴文理学院 | Hydrophilic petrolatum gauze |
| CN103974680A (en) * | 2011-12-09 | 2014-08-06 | 柯惠有限合伙公司 | Non-adherent wound dressings and related methods therefor |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |