CN104874202B - Convenient-to-control chromatographic column frame - Google Patents

Convenient-to-control chromatographic column frame Download PDF

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Publication number
CN104874202B
CN104874202B CN201510312780.8A CN201510312780A CN104874202B CN 104874202 B CN104874202 B CN 104874202B CN 201510312780 A CN201510312780 A CN 201510312780A CN 104874202 B CN104874202 B CN 104874202B
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chromatographic column
slide block
control
panel
pipe joint
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CN104874202A (en
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王柯
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CHANGZHOU SANTAI TECHNOLOGY CO LTD
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CHANGZHOU SANTAI TECHNOLOGY CO LTD
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Abstract

The invention discloses a convenient-to-control chromatographic column frame, which comprises a base, a guide rail slide block pair, a power transmission device and a control panel, wherein a first pipeline joint assembly is arranged on the base, and is used for connecting a lower interface of a chromatographic column in a sealed way; the guide rail slide block pair comprises a slide block and a guide rail; the slide block is glidingly matched on the guide rail; the power transmission device is in transmission connection with the slide block, so that the power transmission device drives the slide block to slide on the guide rail; a second pipeline joint assembly is arranged on the slide block; the second pipeline joint assembly is used for connecting an upper interface of the chromatographic column in a sealed way; the control panel is in signal control connection with the power transmission device, so that the control panel controls the power transmission device to act. The convenient-to-control chromatographic column frame has the advantages that the use is convenient and fast, the automation degree is high, the joint part of the chromatographic column cannot be damaged, and the accurate degree of the butt joint position is improved; the flowing phase seepage cannot be generated at higher work pressure; the sealing performance is good.

Description

It is easy to the chromatographic column frame controlling
Technical field
The present invention relates to a kind of chromatographic column frame being easy to control, belong to liquid chromatography technology field.
Background technology
At present, on market, the conventional pylon structure of chromatograph of liquid device is: inlet pipe joint is fixed on slide block, goes out Liquid mouth pipe joint is fixed on understructure, and slide block is installed vertically on guide rail structure, and manually push-and-pull slide block is by chromatograph Post is fixed, and existing structure automaticity is not high, and operation is cumbersome, and position accuracy is difficult to be held, and is particularly susceptible and is damaged to chromatograph The luer lock portion of post, or sealing insecure leads to the phenomenon of leakage to take place frequently.
Content of the invention
The technical problem to be solved is the defect overcoming prior art, provides a kind of chromatographic column be easy to and control Frame, it is not only convenient to use, high degree of automation, and will not be damaged to the blank area of chromatographic column, improves its docking Position accuracy, also will not produce mobile phase seepage under larger operating pressure, and its sealing is excellent.
In order to solve above-mentioned technical problem, the technical scheme is that a kind of chromatographic column frame be easy to and control, it wraps Include:
Base, described base is provided with the first pipe joint assembly, and described first pipe joint assembly is for close Envelope connects the lower interface of chromatographic column;
Guide rail slide block pair, described guide rail slide block is secondary to include slide block and guide rail, and slide block slide fit is on guide rail;
Actuating unit, described actuating unit and slide block are in transmission connection, so that actuating unit drives slide block Guide rail slides, and the second pipe joint assembly is provided with described slide block, described second pipe joint assembly is used for close Envelope connects the upper interface of chromatographic column;
Panel, described panel is connected with the control of actuating unit signal, so that panel controls power transmission dress The action put.
Further, described slide block is provided with pylon head, the second described pipe joint assembly is arranged on pylon head.
Further, described second pipe joint assembly includes upper pipeline joint and down tube pipeline connector, described upper pipeline joint It is fixed on an end face of pylon head, described down tube pipeline connector is fixed on another end face of pylon head, described upper pipeline Joint and down tube pipeline connector pass through pipeline connection.
Further for ensureing that the first pipe joint assembly and/or the second pipe joint assembly are accurate with the interface of chromatographic column Connect, the first described pipe joint assembly and/or the second pipe joint assembly are provided with joint guide device.
Further for the position facilitating client to manually adjust slide block, to meet the chromatographic column connecting various height, institute It is provided with control device, described control device is connected with panel signal transmission, with convenient to operate control on the slide block stated or pylon head Device processed controls the action of actuating unit by panel.
Further, described control device is touch pad and/or controlling switch.
Further for the sliding position facilitating panel control slide block, to meet the chromatographic column connecting various height, The chromatographic column facilitating user installation to select, the chromatographic column frame being easy to control also includes position sensor, described position sensor Induction pieces are connected with slide block, and the signal output part of position sensor is connected with the signal input part of panel, so that Position sensor is by the sliding position signal transmission of the slide block collecting to panel.
Further for the sliding stroke facilitating panel control slide block, also include proximity switch, described proximity switch Proximity switch counterpart is connected with slide block, and the signal output part of proximity switch is connected with the signal input part of panel Connect, so that the sliding stroke of panel control slide block.
Further for induction pressure it is ensured that chromatographic column and each joint are in impaction state, described base is provided with Compression induction pieces, and compress the signal output part of induction pieces and be connected with panel, compress induction pieces will to collect Compression signal transmission is to panel.
Further, described compression induction pieces are pressure transducer.
Further for being easy to being used in series of chromatographic column or installing and using of large volume solid loading post, improve it flexible Property, the chromatographic column frame being easy to control also includes auxiliary stand, described auxiliary stand is provided with pipe joint and/or chromatograph Post, described pipe joint and/or chromatographic column carry out pipeline with the first pipe joint assembly and are connected, or described pipeline connects Head and/or chromatographic column carry out pipeline with the second pipe joint assembly and are connected.
After employing technique scheme, the chromatographic column frame of the present invention is automation equipment, by pylon reasonable in design Header structure, and control the slide block that actuating unit drives to control the second pipe joint assembly and chromatographic column by panel The docking of upper interface, realizes automatization, accurately control and the sealing of chromatographic column frame;In addition, joint guide device is used for protecting Demonstrate,prove the accurate correcting of the first pipe joint assembly and/or the second pipe joint assembly and the interface of chromatographic column and be tightly connected, its In, the pyramidal structure of joint guide device is mainly used in the interface of correcting chromatographic column, and the outer end in contact with the interface of chromatographic column; Rule (or other standards) bulge-structure within joint guide device is used for and generation sealing is agreed with interface the inner of chromatographic column; Touch pad and/or controlling switch for facilitating client to manually adjust the position of slide block, that is, adjust the position of pylon head, proximity switch By the position of the sensing of the proximity switch counterpart that is connected with slide block and control slide block, the i.e. position of pylon head;Position sensor, Can be specifically electronic ruler, by the position of the reflection of the electronic ruler slide block that is connected with slide block and control slide block, the i.e. position of pylon head Put;Pressure transducer is used for sensing the pressure of pylon head and chromatographic column it is ensured that it is in impaction state, and especially chromatographic column is multiple Even if still ensuring that compression sealing in the case of there is swelling set using rear chromatographic column inlet or liquid outlet, it can in addition contain Provided auxiliary support, is easy to being used in series of chromatographic column or installing and using of large volume solid loading post, improves its motility.
Brief description
Fig. 1 is the structural representation of the chromatographic column frame being easy to control of the present invention;
Fig. 2 is the down tube pipeline connector of the present invention and the connection diagram of joint guide device.
Specific embodiment
In order that present disclosure is easier to be clearly understood, below according to specific embodiment and combine accompanying drawing, right The present invention is described in further detail.
As shown in Figure 1, 2, a kind of chromatographic column frame being easy to control, it includes:
Base 1, base 1 is provided with the first pipe joint assembly 11, and the first pipe joint assembly 11 is used for sealing Connect the lower interface of chromatographic column 2;
Guide rail slide block pair, guide rail slide block is secondary to include slide block 3 and guide rail 4, and slide block 3 slide fit is on guide rail 4;
Actuating unit 5, actuating unit 5 is in transmission connection with slide block 3, so that actuating unit 5 drives slide block 3 Guide rail 4 slides, and the second pipe joint assembly is provided with slide block 3, described second pipe joint assembly is used for sealing Connect the upper interface of chromatographic column 2;Actuating unit 5 can be this structure, and it includes motor, leading screw and nut, and motor drives Dynamic leading screw rotation, nut and leading screw composition screw pair, nut is fixedly connected with slide block 3, thus driving slide block 3 in guide rail 4 Upper slip.
Panel, panel is connected with the control of actuating unit 5 signal, so that panel controls actuating unit 5 Action.
As shown in figure 1, being provided with pylon head 7 on slide block 3, the second pipe joint assembly is arranged on pylon head 7.
As shown in Fig. 2 the second pipe joint assembly includes upper pipeline joint 62 and down tube pipeline connector 61, upper pipeline joint 62 It is fixed on an end face of pylon head 7, down tube pipeline connector 61 is fixed on another end face of pylon head 7, upper pipeline joint 62 and down tube pipeline connector 61 pass through pipeline connection.
As shown in Fig. 2 being provided with joint guide device on the first pipe joint assembly 11 and/or the second pipe joint assembly 611, the docking port of joint guide device 611 is pyramidal structure.Joint guide device 611 is used for ensureing the first pipe joint assembly 11 and/or second pipe joint assembly and chromatographic column 2 interface accurate connection, wherein, the taper knot of joint guide device 611 Structure is mainly used in upper interface or the lower interface of correcting chromatographic column 2, and the outer end in contact with the interface of chromatographic column 2;Joint correcting fills Put the Rule within 611 (or other standards) bulge-structure for and chromatographic column 2 interface the inner agree with generation seal.
Control device is provided with slide block 3 or pylon head 7, control device is connected with panel signal transmission, with convenient to operate Control device controls the action of actuating unit 5 by panel, and control device can be touch pad and/or controlling switch, But not limited to this.Touch pad and/or controlling switch for facilitating client to manually adjust the position of slide block 3, that is, adjust pylon head 7 Position.
As shown in figure 1, the chromatographic column frame being easy to control also includes position sensor 8, the induction pieces of position sensor 8 and cunning Block 3 is connected, and the signal output part of position sensor 8 is connected with the signal input part of panel, so that position sensing Device 8 is by the sliding position signal transmission of the slide block collecting 3 to panel.Position sensor 8, can be specifically electronic ruler, lead to Cross the position of the electronic ruler slide block reflection being connected with slide block 3 and control slide block 3, the i.e. position of pylon head 7.
As shown in figure 1, the chromatographic column frame being easy to control also includes proximity switch 41, the proximity switch cooperation of proximity switch 41 Part 43 is connected with slide block 3, and the signal output part of proximity switch 41 is connected with the signal input part of panel, to control The sliding stroke of making sheet control slide block 3.Proximity switch 41 is sensed by the proximity switch counterpart 43 being connected with slide block 3 and controls The position of slide block 3, i.e. the position of pylon head 7.
Compression induction pieces are provided with base 1, and compress the signal output part of induction pieces and be connected with panel, so that Compression induction pieces are by the compression collecting signal transmission to panel.
Compression induction pieces are pressure transducer, but not limited to this or other induction apparatuss.Pressure transducer is used for The pressure of sensing pylon head 7 and chromatographic column 2 is it is ensured that it is in impaction state, even if chromatograph after especially chromatographic column 2 is used for multiple times Compression sealing is still ensured that in the case of post inlet or liquid outlet generation swelling set.
Be easy to control chromatographic column frame also include auxiliary stand, described auxiliary stand is provided with pipe joint and/or Chromatographic column, described pipe joint and/or chromatographic column carry out pipeline with the first pipe joint assembly and are connected, or described pipeline Union joint and/or chromatographic column carry out pipeline with the second pipe joint assembly and are connected.
Can also be moved to and selected chromatographic column 2 according to the size Control pylon head 7 of the chromatographic column 2 selected by panel The position of matched, facilitates the chromatographic column 2 that user installation is selected.The upper interface of chromatographic column 2 or lower interface enter joint correcting After device 611, can automatic impaction chromatographic column by panel.
The operation principle of the present invention is as follows:
The chromatographic column frame of the present invention is automation equipment, by pylon header structure reasonable in design, and passes through panel control The slide block 3 that braking force actuators 5 drive is controlling docking of the second pipe joint assembly and the upper interface of chromatographic column 2, realization Automatization, accurately control and the sealing of chromatographic column frame.
Particular embodiments described above, to present invention solves the technical problem that, technical scheme and beneficial effect carry out Further describe, be should be understood that the specific embodiment that the foregoing is only the present invention, be not limited to this Invention, all any modification, equivalent substitution and improvement within the spirit and principles in the present invention, done etc., should be included in this Within bright protection domain.

Claims (9)

1. a kind of chromatographic column frame being easy to control is it is characterised in that it includes:
Base (1), described base (1) is provided with the first pipe joint assembly (11), and described first pipe joint assembly (11) it is used for being tightly connected the lower interface of chromatographic column (2);
Guide rail slide block pair, described guide rail slide block is secondary to include slide block (3) and guide rail (4), and slide block (3) slide fit is on guide rail (4);
Actuating unit (5), described actuating unit (5) and slide block (3) are in transmission connection, so that actuating unit (5) Drive slide block (3) in the upper slip of guide rail (4), and the second pipe joint assembly, described second pipe are provided with described slide block (3) Pipeline connector assembly is used for being tightly connected the upper interface of chromatographic column (2);
Panel, described panel is connected with the control of actuating unit (5) signal, so that panel controls actuating unit (5) action;
Also include position sensor (8), the induction pieces of described position sensor (8) are connected with slide block (3), and position sensing The signal output part of device (8) is connected with the signal input part of panel, so that position sensor (8) is by the slide block collecting (3) sliding position signal transmission is to panel, thus controlling cunning by the action that panel controls actuating unit (5) The sliding position of block (3);
Also include proximity switch (41), the proximity switch counterpart (43) of described proximity switch (41) is connected with slide block (3), and And the signal output part of proximity switch (41) is connected with the signal input part of panel, so that panel control slide block (3) Sliding stroke.
2. according to claim 1 be easy to control chromatographic column frame it is characterised in that: be provided with described slide block (3) Pylon head (7), the second described pipe joint assembly is arranged on pylon head (7).
3. according to claim 2 be easy to control chromatographic column frame it is characterised in that: described second pipe joint assembly bag Include upper pipeline joint (62) and down tube pipeline connector (61), described upper pipeline joint (62) is fixed on an end face of pylon head (7) On, described down tube pipeline connector (61) is fixed on another end face of pylon head (7), described upper pipeline joint (62) and lower pipeline Joint (61) passes through pipeline connection.
4. according to claim 1 or 2 or 3 be easy to control chromatographic column frame it is characterised in that: the first described pipeline connects It is provided with joint guide device (611) in head assembly (11) and/or the second pipe joint assembly.
5. according to claim 1 or 2 or 3 be easy to control chromatographic column frame it is characterised in that: described slide block (3) or Pylon head is provided with control device on (7), and described control device is connected with panel signal transmission, so that operation control device leads to Cross the action that panel controls actuating unit (5).
6. according to claim 5 be easy to control chromatographic column frame it is characterised in that: described control device be touch pad And/or controlling switch.
7. according to claim 1 be easy to control chromatographic column frame it is characterised in that: be provided with described base (1) Compression induction pieces, and compress the signal output part of induction pieces and be connected with panel, compress induction pieces will to collect Compression signal transmission is to panel.
8. according to claim 7 be easy to control chromatographic column frame it is characterised in that: described compression induction pieces be pressure Sensor.
9. according to claim 1 be easy to control chromatographic column frame it is characterised in that: also include auxiliary stand, described auxiliary Help and pipe joint and/or chromatographic column are provided with support, described pipe joint and/or chromatographic column and the first pipe joint group Part (11) carries out pipeline connection, or described pipe joint and/or chromatographic column carry out pipeline with the second pipe joint assembly Connect.
CN201510312780.8A 2015-06-09 2015-06-09 Convenient-to-control chromatographic column frame Active CN104874202B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109239245A (en) * 2017-07-10 2019-01-18 中国科学院上海药物研究所 A kind of chromatography column holder
CN113339607A (en) * 2021-04-29 2021-09-03 北京明德正康医学研究有限公司 Combination device for connecting fluid passages

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451365A (en) * 1981-10-30 1984-05-29 Merck Patent Gesellschaft Mit Beschrankter Haftung Column clamping device for chromatography
CN103995073A (en) * 2013-02-18 2014-08-20 爱尔思泰科科技有限公司 Clamping device for clamping a plurality of columns for sample preparation
CN204709865U (en) * 2015-06-09 2015-10-21 常州三泰科技有限公司 Be convenient to the chromatographic column frame controlled

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451365A (en) * 1981-10-30 1984-05-29 Merck Patent Gesellschaft Mit Beschrankter Haftung Column clamping device for chromatography
CN103995073A (en) * 2013-02-18 2014-08-20 爱尔思泰科科技有限公司 Clamping device for clamping a plurality of columns for sample preparation
CN204709865U (en) * 2015-06-09 2015-10-21 常州三泰科技有限公司 Be convenient to the chromatographic column frame controlled

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