CN104855977A - 一种防治矽肺的营养保健食品及制备方法 - Google Patents
一种防治矽肺的营养保健食品及制备方法 Download PDFInfo
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Abstract
本发明公开了一种防治矽肺的营养保健食品及制备方法，该营养保健食品由枇杷叶、蛇胆、麦冬、冬虫夏草(冬虫夏草菌丝体)、川贝母、陈皮、五味子、鸡内金、黄精、丹参、山药、浙贝母、枳壳、牡丹皮、大黄、桃仁其中的8种以上或全部混合。以结合矽肺患者的体质特征，依据传统中医的精髓理论，因人而异，黄金配伍以8种以上药食两用的中药原料、短肽为主要原料，以益生元、多种维生素、氨基酸、多种矿物质为辅料制成的食品。本发明的营养保健食品具有预防和治疗矽肺患者功效、清热解毒、止咳平喘、扶正培本、增强免疫力、活血化瘀、养阴润肺、剂量成分稳定、服用方便、无毒副作用等优点，具有广大经济效益和社会效益。
Description
技术领域
本发明涉及矽肺的营养保健食品领域，尤其是提供一种防治矽肺的营养保健食品及制备方法。
背景技术
矽肺又称硅肺，是尘肺中最为常见的一种类型，是由于长期吸入大量游离二氧化硅粉尘所引起，以肺部广泛的结节性纤维化为主的疾病。矽肺是尘肺中最常见、进展最快、危害最严重的一种类型。我国每年有为2万例左右的尘肺新患者出现。因此，尘肺的防治是一项艰巨的工作。
临床表现为：有3种形式：慢性矽肺、急性矽肺和介于两者之间的加速性矽肺，这两种临床表现形式与接触粉尘浓度、矽肺含量与接尘年限有显著关系，临床以慢性矽肺最为常见。一般早期可无症状或症状不明显，随着病情的进展可出现多种症状。气促常较早出现，呈进行性加重。早期常感胸闷、胸痛，胸痛较轻微，为胀痛、隐痛或刺痛，与呼吸、体体位及劳动无关。胸闷和气促的程度与病变的范围及性质有关。早期由于吸入矽尘可出现刺激性咳嗽，并发感染或吸烟者可有咳痰。少数患者有血痰。合并肺结核、肺癌或支气管扩张时可反复或大量咯血。患者尚可有头昏、乏力、失眠、心悸、胃纳不佳等症状。III期矽肺由于大块纤维化使肺组织收缩，导致支气管移位和叩诊浊音。目前预防矽肺的营养保健品种甚少，不管病症什么时候发生，很多工作环境没办法避免，那么有预防矽肺营养保健食品问世，可以帮助潜在矽肺患者提前预防起来，降低和治疗患病发生。
发明内容
本发明的目的在于提供一种预防和治疗矽肺的营养保健食品，尤其是提供了一种防治矽肺的营养保健食品来解决上述背景技术提出的问题。
为了实现上述目的，本发明提供如下技术方案：
本发明的防治矽肺的营养保健食品，它是由下述药食两用的各原料重量配比制成：蒲 公英30g、枇杷叶10g、蛇胆10g、麦冬10g、冬虫夏草(冬虫夏草菌丝体)20g、川贝母12g、陈皮12g、五味子12g、鸡内金12g、黄精12g、丹参15g、山药15g、浙贝母15g、枳壳15g、牡丹皮15g、大黄15g、桃仁15g、短肽300g、益生元250g、氨基酸100g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g。
作为本发明的进一步方案：所述防治矽肺的营养保健食品，药食两用的中药原料是指蒲公英、枇杷叶、蛇胆、麦冬、冬虫夏草(冬虫夏草菌丝体)、川贝母、陈皮、五味子、鸡内金、黄精、丹参、山药、浙贝母、枳壳、牡丹皮、大黄、桃仁其中的8种以上或全部混合。短肽为主要原料，以益生元、多种维生素、氨基酸、多种矿物质为辅料制成的食品。
作为本发明的进一步方案：所述防治矽肺的营养保健食品，在于按照所述配方混合可制备成粉状、颗粒状、胶囊状、片剂状、饮料类食品。
作为本发明的进一步方案：所述防治矽肺的营养保健食品，包括以下关键技术：以微胶囊、生物酶解、预水解SBE及喷雾干燥集成创新，构成的产业化生产的关键技术，按以上微胶囊、生物酶解、预水解SBE及喷雾干燥集成创新工艺制成营养保健食品、固体饮料、颗粒剂或胶囊剂或压制成型的片剂、软胶囊。
作为本发明的进一步方案：所述的维生素为维生素A、维生素D、维生素E、维生素K、维生素K1、维生素C、维生素B1、维生素B2、维生素B6、维生素B12、维生素Be、维生素Bu、烟酸、叶酸、泛酸、胆碱、生物素其中的一种、几种或全部混合；所述的矿物质为钙、磷、钾、钠、镁、氯、铁、锌、硒、铜、锰、碘、氟、铬、钼其中的一种、几种或全部混合。
作为本发明的进一步方案：所述的短肽为海洋胶原肽、玉米低聚肽、小麦低聚肽、海 洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽其中一种、几种或全部混合。
作为本发明的再进一步方案：所述的氨基酸为L-谷氨酰胺、蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸其中的一种、几种或全部混合。
本发明还提供上述防治矽肺的营养保健食品的制备方法，本技术领域中通常采用人们熟知的方法包括如下步骤：
1)称取蒲公英30g、枇杷叶10g、蛇胆10g、麦冬10g、冬虫夏草(冬虫夏草菌丝体)20g、川贝母12g、陈皮12g、五味子12g、鸡内金12g、黄精12g、丹参15g、山药15g、浙贝母15g、枳壳15g、牡丹皮15g、大黄15g、桃仁15g；
2)将蒲公英、枇杷叶、蛇胆、麦冬、陈皮、五味子、鸡内金、黄精、丹参、山药、浙贝母、枳壳、牡丹皮、大黄浸泡后加入β-环状糊精，用预水解SBE技术提取后，经喷雾干燥而制备的粉状物质；
3)将上述步骤2)得到的粉状物质，加入到生物酶解提取的短肽、益生元、氨基酸、冬虫夏草(冬虫夏草菌丝体)、川贝母、桃仁、多种维生素及矿物质充分混合后进行巴氏灭菌1小时制成固体饮料；也可以加入适量附料制成胶囊、片剂或加入甜味剂和黑芝麻粉制成饼干等快速、方便食品便于外出携带食用，若做成饮料则省去经喷雾干燥，并不添加桃仁、黑芝麻粉，分装成10-65ml/瓶即可。
本发明所使用的药材具有如下特性：
蒲公英：性味-苦、甘，寒。归经-归肝、胃经。功能主治：清热解毒，消肿散结，利尿通淋。
枇杷叶：【性味】苦，微寒。【归经】归肺、胃经。【功能主治】清肺止咳，降逆止呕。用于肺热咳嗽，气逆喘急，胃热呕逆，烦热口渴。
蛇胆：【性味】甘、微苦，凉。【功能主治】清热解毒，化痰镇痉。
麦冬：【性味】甘，微苦，微寒。【归经】归心、肺、胃经。【功能主治】养阴 生津，润肺清心。用于肺燥干咳。
冬虫夏草(冬虫夏草菌丝体)：【性味】甘，平。【归经】归肺、肾经。【功能主治】补肺益肾，止血化痰。
川贝母：【性味】苦、甘，微寒。【归经】归肺、心经。【功能主治】清热润肺，化痰止咳。
陈皮：【性味】苦、辛，温。【归经】归肺、脾经。【功能主治】理气健脾，燥湿化痰。
五味子：【性味】酸、甘，温。【归经】归肺，心、肾经。【功能主治】收敛固涩，益气生津，补肾宁心。
鸡内金：【性味】甘，平。【归经】归脾、胃、小肠、膀胱经。【功能主治】健胃消食，涩精止遗。
黄精：【性味】甘，平。【归经】归脾、肺、肾经。【功能主治】补气养阴，健脾，润肺，益肾。
丹参：【性味】苦，微寒。【归经】归心、肝经。【功能主治】祛瘀止痛，活血通经，清心除烦。
山药：【性味】甘，平。【归经】归脾、肺、肾经。【功能主治】补脾养胃，生津益肺，补肾涩精。
浙贝母：【性味】苦，寒。【归经】归肺、心经。【功能主治】清热散结，化痰止咳，用于风热犯肺，痰火咳嗽，肺痈，乳痈，瘰疬，疮毒。
枳壳：【性味】苦、辛、酸，温。【归经】归脾、胃经。【功能主治】理气宽中，行滞消胀。
牡丹皮：【性味】苦、辛，微寒。【归经】归心、肝、肾经。【功能主治】清热凉血，活血化瘀。
大黄：【性味】苦，寒。【归经】归脾、胃、大肠、肝、心包经。【功能主治】泻 热通肠，凉血解毒，逐瘀通经。
桃仁：【性味】苦、甘，平。【归经】归心、肝、大肠经。【功能主治】活血祛瘀，润肠通便。
有益效果
本发明的防治矽肺的营养保健食品特性及其对机体的作用主要表现在以下几个方面：
1、本发明是防治矽肺的营养保健食品患者的体质特征，综合当今中西医的先进生理学、医药、营养学及临床应用等研究成果研制的，因人而异，黄金配伍。
2、本发明依据“消中寓补”、“均衡调养”的传统中医的精髓理论(肝、脾、肾三脏同调为主原则)，采用多种药食两用的中药提取物精华、短肽为主要原料，以益生元、氨基酸、多种维生素及矿物质为辅料，各种配料的有机组合，将各种功能进行融合，并通过有效成分之间的协同作用，增强作用效果。
3、具有高效吸收性，利用本发明配方，各种组分采用适宜的比例搭配制备的食品，经一定量水溶解后呈等渗状态，能快速通过胃到达小肠，吸收快速、完全，可以迅速补充矽肺患者所需营养。
4、本发明配方中采用各种药食两用中草药配比，含有多种功能活性成分，不仅提高了功能因子的浓度，减少各种杂质的摄入，有助于减轻肝肾负担，具有增强人体抵抗力的作用，还有起到行气散结、清热解毒、止咳平喘、清热润肺、化痰止咳、祛瘀止痛，活血通经、消肿散结、利尿通淋、调和肝脾、理气化浊以及增强免疫力的功效。
5.本发明的营养保健食品以多种来源的食源性生物活性短肽为氮源，因为短肽不需消化即可吸收，更有利于机体的利用，可以有效改善矽肺患者的负氮平衡，而且食源性短肽能够改善肺粘膜上皮细胞的结构和功能，提高肺粘膜的吸收能力。
6、本发明的营养保健食品所含的益生元，通过促进肠内益生菌的生长繁殖，抑制腐败菌的生长，同时在肺粘膜表面形成一道保护屏障，可以抵御肺腐败菌对肺粘膜的损伤，减少肺内有害物质的吸收，还可以促进肠道蠕动，加速肠内残留物质的排出，可以防止便秘， 而且通过促进肠道益生菌的生长繁殖也可以增强机体免疫力。
7、本发明的营养保健食品中所含的氨基酸，是构成蛋白质的基本单位，赋予蛋白质特定的分子结构形态，使其具有生化活性，有助于人体内各种含硫化合物的代谢并且其所含的甲基对有毒物或药物进行甲基化而起到解毒的作用，能够修复肌肉，控制血糖，并给身体组织提供能量，还可提高食物蛋白质的吸收和利用，达到均衡营养，促进生长发育。
8、本发明的营养保健食品含多种维生素和矿物质，可迅速补充矽肺患者所需的微量营养素，短肽通过与钙、铁、锌等的螯合后，更增加了矿物质元素的吸收率。
9、本发明的营养保健食品不含脂肪和胆固醇，能够在补充蛋白质、微量营养素的同时，不会增加脂肪、胆固醇的摄入，避免了肉、蛋等高蛋白食物的不利影响。
具体实施方式
实施例
原料：蒲公英30g、枇杷叶10g、蛇胆10g、麦冬10g、冬虫夏草(冬虫夏草菌丝体)20g、川贝母12g、陈皮12g、五味子12g、鸡内金12g、黄精12g、丹参15g、山药15g、浙贝母15g、枳壳15g、牡丹皮15g、大黄15g、桃仁15g。
制备：
1)称取上述各原料：蒲公英30g、枇杷叶10g、蛇胆10g、麦冬10g、冬虫夏草(冬虫夏草菌丝体)20g、川贝母12g、陈皮12g、五味子12g、鸡内金12g、黄精12g、丹参15g、山药15g、浙贝母15g、枳壳15g、牡丹皮15g、大黄15g、桃仁15g；
2)将蒲公英、枇杷叶、蛇胆、麦冬、陈皮、五味子、鸡内金、黄精、丹参、山药、浙贝母、枳壳、牡丹皮、大黄浸泡后加入β-环状糊精，用预水解SBE技术提取后，经喷雾干燥而制备的粉状物质；
3)将上述步骤2)得到的粉状物质，加入到生物酶解提取的短肽、益生元、氨基酸、冬虫夏草(冬虫夏草菌丝体)、川贝母、桃仁、多种维生素及矿物质充分混合后进行巴氏灭菌1小时制成固体饮料；也可以加入适量附料制成胶囊、片剂或加入甜味剂和黑芝麻粉 制成饼干等快速、方便食品便于外出携带食用，若做成饮料则省去经喷雾干燥，并不添加桃仁、黑芝麻粉，分装成10-65ml/瓶即可。
典型病例
病例1 严某，男性，45岁，安徽阜阳人，工作性质：矿井下工作。于2012年在一次体检时，检查出有轻微矽肺症状出现。之后患者听说有本发明的防治矽肺营养保健食品，患者选择之后，早中晚各服用1次，每次15ml，连续服用2个月，发现该保健食品的确具有生津润肺、软坚散结、标本兼治、行气散结、清热解毒、止咳平喘、清热润肺、化痰止咳、祛瘀止痛，活血通经、消肿散结、利尿通淋、调和肝脾、理气化浊以及增强免疫力的功效。半年后再去医院复查发现矽肺症状未出现，已完全康复。由于患者工作性质原因，患者仍坚持服用本发明的营养保健食品，且达到预防目的。
病例2 李师傅，男性，37岁，浙江镇海人，工作性质：化工车间。2013年7月经常出现咳嗽、心累、气紧、咳痰痰多症状，经医院检查为矽肺，中度混合性通气功能障碍(以阻塞性为主)，明显小气道阻塞，弥散功能正常，轻度RV/TLC比值班增高。两肺门影有扩大，密度增高；两肺出现多量不规则形小阴影、交错成网状、肺野内很快出现边缘清晰，密度增高的类圆形为主小阴影，数量由少到多，密度不断增高(从1级密集度～3级密集度)。患者喜欢选择中药治疗，之后选择本发明的防治矽肺的营养保健食品，连续服用3个月，早中晚各1次，每次15ml，目前已痊愈。
Claims (9)
1.一种防治矽肺的营养保健食品，其特征在于，它是由下述药食两用的各原料重量配比制成：蒲公英30g、枇杷叶10g、蛇胆10g、麦冬10g、冬虫夏草(冬虫夏草菌丝体)20g、川贝母12g、陈皮12g、五味子12g、鸡内金12g、黄精12g、丹参15g、山药15g、浙贝母15g、枳壳15g、牡丹皮15g、大黄15g、桃仁15g、短肽300g、益生元250g、氨基酸100g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g。
2.根据权利要求1所述的营养保健食品，其特征在于，以结合矽肺患者的体质特征，依据传统中医的精髓理论，因人而异，黄金配伍以8种以上药食两用的中药原料、短肽为主要原料，以益生元、多种维生素、氨基酸、多种矿物质为辅料制成的食品。
3.根据权利要求1所述的营养保健食品的制备方法，其特征在于该方法包括如下步骤：
1)称取蒲公英30g、枇杷叶10g、蛇胆10g、麦冬10g、冬虫夏草(冬虫夏草菌丝体)20g、川贝母12g、陈皮12g、五味子12g、鸡内金12g、黄精12g、丹参15g、山药15g、浙贝母15g、枳壳15g、牡丹皮15g、大黄15g、桃仁15g；
2)将蒲公英、枇杷叶、蛇胆、麦冬、陈皮、五味子、鸡内金、黄精、丹参、山药、浙贝母、枳壳、牡丹皮、大黄浸泡后加入β-环状糊精，用预水解SBE技术提取后，经喷雾干燥而制备的粉状物质；
3)将上述步骤2)得到的粉状物质，加入到生物酶解提取的短肽、益生元、氨基酸、冬虫夏草(冬虫夏草菌丝体)、川贝母、桃仁、多种维生素及矿物质充分混合后进行巴氏灭菌1小时制成固体饮料；也可以加入适量附料制成胶囊、片剂或加入甜味剂和黑芝麻粉制成饼干等快速、方便食品便于外出携带食用，若做成饮料则省去经喷雾干燥，并不添加桃仁、黑芝麻粉，分装成10-65ml/瓶即可。
4.根据权利要求1所述的营养保健食品，其特征在于，所述的药食两用的中药原料是指蒲公英、枇杷叶、蛇胆、麦冬、冬虫夏草(冬虫夏草菌丝体)、川贝母、陈皮、五味子、鸡内金、黄精、丹参、山药、浙贝母、枳壳、牡丹皮、大黄、桃仁其中的8种以上或全部混合。
5.根据权利要求1所述的营养保健食品，其特征在于按照所述配方混合可制备成粉状、颗粒状、胶囊状、片剂状、饮料类食品。
6.根据权利要求1所述的营养保健食品，其特征在于它包括以下关键技术：以微胶囊、生物酶解、预水解SBE及喷雾干燥集成创新，构成的产业化生产的关键技术，按以上微胶囊、生物酶解、预水解SBE及喷雾干燥集成创新工艺制成营养保健食品、固体饮料、颗粒剂或胶囊剂或压制成型的片剂、软胶囊。
7.根据权利要求1所述的营养保健食品，其特征是所述的维生素为维生素A、维生素D、维生素E、维生素K、维生素K1、维生素C、维生素B1、维生素B2、维生素B6、维生素B12、维生素Be、维生素Bu、烟酸、叶酸、泛酸、胆碱、生物素其中的一种、几种或全部混合；所述的矿物质为钙、磷、钾、钠、镁、氯、铁、锌、硒、铜、锰、碘、氟、铬、钼其中的一种、几种或全部混合。
8.根据权利要求1所述的营养保健食品，其特征是所述的短肽为海洋胶原肽、玉米低聚肽、小麦低聚肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽其中一种、几种或全部混合。
9.根据权利要求1所述的营养保健食品，其特征是所述的氨基酸为L-谷氨酰胺、蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸其中的一种、几种或全部混合。
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