CN104840800B - Bamboo-leaves flavones and the composition of γ-aminobutyric acid and its preparation method and application - Google Patents
Bamboo-leaves flavones and the composition of γ-aminobutyric acid and its preparation method and application Download PDFInfo
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- CN104840800B CN104840800B CN201510306041.8A CN201510306041A CN104840800B CN 104840800 B CN104840800 B CN 104840800B CN 201510306041 A CN201510306041 A CN 201510306041A CN 104840800 B CN104840800 B CN 104840800B
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- aminobutyric acid
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Abstract
The present invention provides the pharmaceutical composition containing bamboo-leaves flavones and gamma aminobutyric acid, and the dosage form of the drug is any pharmaceutical dosage form of acceptable in pharmacy, and the bamboo-leaves flavones are with gamma aminobutyric acid using weight ratio as (0.5~5):1 ratio combination; invention further provides the preparation methods of the composition; and the application in the drug for preparing lowering blood pressure and blood fat, protection cardiovascular and cerebrovascular or treatment cardiovascular and cerebrovascular disease is being prepared, reduce the application during the drug of risk caused by cardiovascular and cerebrovascular disease occurs in preparation.
Description
Technical field
The present invention relates to a kind of healthy product composition, and its preparation method and application, it is specifically bamboo-leaves flavones and gamma-amino
The composition of butyric acid, with and its preparation method and application.Health product composition of the present invention, including but not limited to drug,
Medical food, health food or functional food, ordinary food etc..
Background technology
Bamboo-leaves flavones are that the biology with physiological activity extracted from the leaf of bamboo of grass family Phyllostachys Ph. meyeri is yellow
Ketone, it is a kind of efficient biological anti-oxidant, is nutrient needed by human, has protection cardiovascular and cerebrovascular, improves cardiac muscle and lacks
Blood improves cerebral ischemia, adjusts blood fat, reduces the effect of blood viscosity, has prevention cardiovascular and cerebrovascular disease, anti-oxidant, anti-inflammatory
And adjust immune function, when human body lacks, be easy to cause heart and cerebral function not entirely, the production of the diseases such as vascular sclerosis
It is raw.
γ-aminobutyric acid (GABA) is a kind of active skull cap components, is distributed widely in the in vivo non-protein amino of animals and plants
Acid plays irreplaceable role to the adjusting of organism vital movement；It is a kind of more deep important suppression of current research
Nerve mediator processed, it participates in a variety of metabolic activities, has very high physiological activity, in terms of the cerebrovascular and cranial nerve, has
Promote the energetic supersession of brain, activate brain blood flow, increase oxygen supply amount, trophic nerve cell, promote brain vigor, recover brain cell
Function improves nervous function, delays brain aging etc., particularly significant for health.
However, disadvantageously, the mechanism of action of the γ-aminobutyric acid in terms of the cerebrovascular is relatively simple, for comprehensive guarantor
The function of the shield heart cerebrovascular or treatment cardiovascular and cerebrovascular disease etc. is weaker.
The content of the invention
The pleasantly surprised discovery of inventor combines bamboo-leaves flavones with γ-aminobutyric acid, has good synergistic effect, especially
In protection cardiovascular and cerebrovascular, protection heart and brain tissues, the synergistic effect for improving cardiac-cerebral ischemia etc. and reducing generation cardiac muscle stalk
Extremely, the effect of risk caused by cerebral apoplexy or angiocardiopathy.
The object of the present invention is to provide a kind of pharmaceutical composition containing bamboo-leaves flavones and γ-aminobutyric acid, the drugs
Dosage form be any pharmaceutical dosage form of acceptable in pharmacy.
It is a further object to provide the preparation methods of above-mentioned composition；
The invention further relates to application of the above-mentioned composition in drug, medical usages.
The present composition includes two kinds of combinations：
A kind of combination is that have bamboo-leaves flavones and γ-aminobutyric acid in the form of compound preparation, and the medicine
The dosage form of object is any pharmaceutical dosage form of acceptable in pharmacy.Using corresponding pharmaceutical carrier or auxiliary material, using different
Preparation process can be made into different compound medicinal formulations.It should be appreciated that compound preparation refers to bamboo-leaves flavones and gamma-amino fourth
Individual preparation is made as medicament active composition for acid, can be acceptable any pharmaceutical dosage form in pharmacy, preferably
Oral formulations, such as tablet (including dispersible tablet, enteric coatel tablets, chewable tablets, oral disnitegration tablet, effervescent tablet, etc.), hard capsule (bag
Include capsulae enterosolubilis), it is soft capsule, granule, pulvis, dry suspensoid agent, pill, micropill preparation (including enteric-coated micro-pill), pill, dry
Syrup, powder, oral solution, oral administration mixed suspension and oral quick-release or the dosage forms such as sustained release or controlled release or injection
Agent or cutaneous permeable agent, powder ampoule agent for injection (including the filling powder-injection of Injectable sterile, freeze drying powder injection), aqueous solution injection
Agent, injection can also be using glucose, sodium chloride, fructose, inverted sugar, xylitol or maltose etc. as osmotic pressure regulator
Intravenous injection use aqueous solution (including intravenous injection and intravenous drip)；Further include ointment, the gel of external preparation for skin
Agent, emulsion agent, emulsion agent, patch, etc.；Can also be the dosage forms such as quick-release, the slow-release controlled-release of any of the above dosage form, such as mouth
The dispersible tablet of clothes, sustained release tablets, spansule, enteric coatel tablets, effervescent tablet, oral disnitegration tablet, special-shaped tablets, born of the same parents rise particle, etc..Especially
Ground is prepared by means known in the art preferably for prepare pharmacy on use oral solution, tablet (including dispersible tablet,
Slow-release tablet, enteric coatel tablets, effervescent tablet, oral disnitegration tablet, special-shaped tablets), capsule (including soluble in the stomach, enteric, spansule), injection
Agent (including powder ampoule agent for injection and parenteral solution).Preferred combination dosage form is oral formulations, most preferably oral granule, powder
Agent, dry suspensoid agent, tablet (including dispersible tablet, enteric coatel tablets, chewable tablets, oral disnitegration tablet, effervescent tablet, etc.), hard capsule (including
Capsulae enterosolubilis), soft capsule, pill, micropill preparation (including enteric-coated micro-pill), pill, dry syrup, powder, oral solution,
Oral administration mixed suspension etc..
Another combination is that bamboo-leaves flavones and γ-aminobutyric acid are respectively prepared individual preparation, when in use, is suffered from
Person can successively medication successively, after can also the preparation of separated γ-aminobutyric acid be mixed with the preparation of bamboo-leaves flavones simultaneously
It uses, to be finally reached the purpose using composition of medicine of the present invention, it is necessary to, in order to facilitate patient medication and represent medicine
Two kinds of individual preparations, should be packaged in same pack arrangement by the feature of object combination；Further, bamboo-leaves flavones with
When γ-aminobutyric acid is independent preparation, the pharmaceutical dosage form of the two can be identical or different, such as γ-aminobutyric acid piece
With bamboo-leaves flavones tablet medicament composition, γ-aminobutyric acid capsule and bamboo-leaves flavones pharmaceutical capsules composition, γ-aminobutyric acid piece
With bamboo-leaves flavones pharmaceutical capsules composition, γ-aminobutyric acid capsule and bamboo-leaves flavones tablet medicament composition or more than it is each
The dosage forms such as quick-release, the slow-release controlled-release of kind of dosage form, for example, oral dispersible tablet, sustained release tablets, spansule, enteric coatel tablets, effervescent tablet,
Oral disnitegration tablet, special-shaped tablets, born of the same parents rise particle, etc..Particularly, prepared by means known in the art preferably for prepare medicament
Tablet (including dispersible tablet, slow-release tablet, enteric coatel tablets, effervescent tablet, oral disnitegration tablet, special-shaped tablets), the capsule (bag used on
Include soluble in the stomach, enteric, spansule), granule, pulvis, dry suspensoid agent, pill, micropill preparation (including enteric-coated micro-pill), pill,
Dry syrup, powder, oral solution, injection (including powder ampoule agent for injection and parenteral solution) etc..
It should be appreciated that the compound that the present invention combines can simultaneously or sequentially be given, these combination of compounds can be same
Or different pharmaceutical composition.If be sequentially administered, the delay administration of second of active component should not reduce the active ingredient group
The effect of the drug mechanism of synergistic therapeutic action or collaboration between conjunction.It is also understood that no matter simultaneously or sequentially give
Medicine, bamboo-leaves flavones and γ-aminobutyric acid can be administered in the form of either alone or in any combination, preferably by bamboo-leaves flavones and γ-ammonia
Base butyric acid is administered simultaneously or is sequentially administered with independent medicine type, is most preferably administered simultaneously.
It is preferred that give the pharmaceutical composition of the present invention in the form of compound preparation, such as tablet, in tablet it is special be double-layer tablets,
Chewable tablets, for another example capsule, granule, pulvis, dry suspensoid agent, oral solution, liquid preparation, medicinal tea, etc..
Particularly, the pharmaceutical composition provided by the invention containing bamboo-leaves flavones and γ-aminobutyric acid, when pharmaceutical dosage form is
When solid pharmaceutical preparations, wherein γ-aminobutyric acid or bamboo-leaves flavones are with micro- for tablet, capsule, granule, pulvis or dry suspensoid agent
Composition made of powder form, preferably bamboo-leaves flavones and γ-aminobutyric acid are crushed by low-temperature airflow crushing technology,
Powder size is more than 800 mesh, and preferably powder size is more than 1000 mesh in the granularity of 800~1000 mesh or even preferred powder.
Another aspect of the present invention provides bamboo-leaves flavones and γ-aminobutyric acid is deposited with the ratio of the drug dose to act synergistically
The present invention combination.
Another aspect of the present invention provides bamboo-leaves flavones with γ-aminobutyric acid with the combination of arbitrary proportion, preferably with collaboration
Present invention combination existing for the ratio of the dosage of effect, bamboo-leaves flavones are with γ-aminobutyric acid using weight ratio as (0.5~5):1
Ratio combines,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.4~4.9):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.5~4.8):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.6~4.7):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.7~4.6):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.8~4.5):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.9~4.4):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1~4.3):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1~4.2):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1~4.1):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1~4):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.1~3.9):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.2~3.8):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.3~3.7):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.4~3.6):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.5~3.5):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.6~3.4):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.7~3.3):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.8~3.2):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.9~3.1):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (2~3):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.5~3.5):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.6~3.4):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.7~3.3):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.8~3.2):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.9~3.1):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1~3):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.1~2.9):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.2~2.8):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.3~2.7):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.4~2.6):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.5~2.5):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1~5):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.1~4.9):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.2~4.8):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.3~4.7):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.4~4.6):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.5~4.5):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.6~4.4):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.7~4.3):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.8~4.2):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.9~4.1):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (2~4):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (2.1~3.9):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (2.2~3.8):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (2.3~3.7):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (2.4~3.6):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (2.5~3.5):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.5~2):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.6~1.9):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.7~1.8):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.8~1.7):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.9~1.6):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1~1.5):1 ratio combination；
Specifically, for example preferred bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as 0.5:1、0.6:1、0.7:1、0.8:
1、0.9:1、1:1、1.1:1、1.2:1、1.3:1、1.4:1、1.5:1、1.6:1、1.7:1、1.8:1、1.9:1、2:1、2.1:1、
2.2:1、2.3:1、2.4:1、2.5:1、2.6:1、2.7:1、2.8:1、2.9:1、3:1、3.1:1、3.2:1、3.3:1、3.4:1、
3.5:1、3.6:1、3.7:1、3.8:1、3.9:1、4:1、4.1:1、4.2:1、4.3:1、4.4:1、4.5:1、4.6:1、4.7:1、
4.8:1、4.9:1、5:1, etc..
Bamboo-leaves flavones, which take orally applicable dosage and are generally the amount of daily 50~2000mg of being grown up, to be given, such as is given daily
50mg、100mg、150mg、200mg、250mg、300mg、350mg、400mg、450mg、500mg、550mg、600mg、650mg、
700mg、750mg、800mg、850mg、900mg、950mg、1000mg、1100mg、1200mg、1300mg、1400mg、
The bamboo-leaves flavones of 1500mg, 1600mg, 1700mg, 1800mg, 1900mg or 2000mg；And give the γ of effective dose-
Aminobutyric acid, such as daily 50~1000mg levels give γ-aminobutyric acid, preferably daily 100~800mg singles or at twice
Give the compound, for example, 50mg, 100mg, 150mg, 200mg, 250mg, 300mg, 350mg, 400mg, 450mg, 500mg,
γ-aminobutyric acid of 550mg, 600mg, 650mg, 700mg, 750mg, 800mg, 900mg or 1000mg, etc..
It should be appreciated that the composition of the invention containing bamboo-leaves flavones and γ-aminobutyric acid, can also optionally contain it
Its efficacy of drugs or food function ingredient, for example, mannatide, lentinan, oligofructose, polyfructosan, xylo-oligosaccharide,
Oligomeric manna sugar, etc..
Preferably, the pharmaceutical composition of bamboo-leaves flavones and γ-aminobutyric acid, wherein it is preferred that in per unit preparation containing 50~
2000mg bamboo-leaves flavones and 50~1000mg γ-aminobutyric acids；
Specifically, contain 50mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 60mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 70mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 80mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 90mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 100mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 150mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 200mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 250mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 300mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 350mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 400mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 450mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 500mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 550mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 600mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 650mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 700mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 750mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 800mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 850mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 900mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 950mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 1000mg bamboo-leaves flavones and 50mg γ-aminobutyric acids in per unit preparation,
Or contain 50mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 60mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 70mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 80mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 90mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 100mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 150mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 160mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 200mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 250mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 300mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 350mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 400mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 450mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 500mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 550mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 600mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 650mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 700mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 750mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 800mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 850mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 900mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 950mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 1000mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 1200mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 1500mg bamboo-leaves flavones and 100mg γ-aminobutyric acids in per unit preparation,
Or contain 50mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 75mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 80mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 100mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 150mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 200mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 250mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 300mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 350mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 400mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 450mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 500mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 550mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 600mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 650mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 700mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 750mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 800mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 850mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 900mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 950mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 1000mg bamboo-leaves flavones and 150mg γ-aminobutyric acids in per unit preparation,
Or contain 50mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 80mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 100mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 150mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 200mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 250mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 300mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 350mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 400mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 450mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 500mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 550mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 600mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 650mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 700mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 750mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 800mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 850mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 900mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 950mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 1000mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 1100mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 1200mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 1300mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 1400mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 1500mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 1600mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 1700mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 1800mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 1900mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 2000mg bamboo-leaves flavones and 200mg γ-aminobutyric acids in per unit preparation,
Or contain 50mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 75mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 80mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 90mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 100mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 150mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 200mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 250mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 300mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 350mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 400mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 450mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 500mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 600mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 700mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 800mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 900mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 1000mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 1100mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 1200mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 1300mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 1400mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 1500mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 1600mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 1700mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 1800mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 1900mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 2000mg bamboo-leaves flavones and 250mg γ-aminobutyric acids in per unit preparation,
Or contain 50mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 80mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 100mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 150mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 200mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 250mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 300mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 350mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 400mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 450mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 500mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 600mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 700mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 800mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 900mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 1000mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 1100mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 1200mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 1300mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 1400mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 1500mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 1600mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 1700mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 1800mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 1900mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 2000mg bamboo-leaves flavones and 300mg γ-aminobutyric acids in per unit preparation,
Or contain 500mg bamboo-leaves flavones and 350mg γ-aminobutyric acids in per unit preparation,
Or contain 500mg bamboo-leaves flavones and 400mg γ-aminobutyric acids in per unit preparation,
Or contain 500mg bamboo-leaves flavones and 500mg γ-aminobutyric acids in per unit preparation,
Or contain 550mg bamboo-leaves flavones and 500mg γ-aminobutyric acids in per unit preparation,
Or contain 600mg bamboo-leaves flavones and 500mg γ-aminobutyric acids in per unit preparation,
Or contain 800mg bamboo-leaves flavones and 500mg γ-aminobutyric acids in per unit preparation,
Or contain 50mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 60mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 70mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 80mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 90mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 100mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 150mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 160mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 200mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 250mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 300mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 350mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 400mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 450mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 500mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 550mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 600mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 650mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 700mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 750mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 800mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 850mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 900mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 950mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 1000mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 1200mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation,
Or contain 1500mg bamboo-leaves flavones and 600mg γ-aminobutyric acids in per unit preparation；
" the per unit preparation " refers to the preparation unit of minimum package or minimum form of medication, including each capsule
It is agent, each tablet or pill, each bag of granule or pulvis, each bottle of oral administration solution, each injection or parenteral solution, every
One bottle of injection or parenteral solution, each piece of suppository, each bottle of eye drops, each pipe ointment, etc..
The active component of pharmaceutical composition can be usually given in the form of chemical raw material, but is preferably given in the form of Pharmaceutical composition
It gives.Pharmaceutical composition of the present invention includes bamboo-leaves flavones and γ-aminobutyric acid and one or more pharmaceutically acceptable carriers
Or the pharmaceutical composition of the present invention of excipient.These carriers must be acceptable, you can it is compatible with other components of formula, and
It is nontoxic to its recipient.When individually giving each component of said composition, they are generally individually Pharmaceutical composition form.It removes
It is otherwise noted, the signified composition of the present invention refers to the pharmaceutical composition containing bamboo-leaves flavones and γ-aminobutyric acid or the wherein leaf of bamboo
The composition of the pharmaceutical composition of flavones and each component of γ-aminobutyric acid.
Preferably, the combination of bamboo-leaves flavones and γ-aminobutyric acid is usually that having for unit dosage form is one or more
The Pharmaceutical composition of pharmaceutically acceptable carrier, the bamboo-leaves flavones contained in common unit formulation and γ-aminobutyric acid
Dosage is in the foregoing clearly.
Using corresponding, different pharmaceutical carrier and preparation process, pharmaceutical composition of the present invention can be made different
Pharmaceutical dosage form.Those skilled in the art are it will be appreciated that these pharmaceutical carriers are for the ease of producing and processing into each
Kind of dosage form, ensure drug safely, effectively with factors and the physics and chemistry according to different pharmaceutical dosage forms and drug itself such as stablizing
Property is selected.The selection of pharmaceutical carrier is using being that technical staff in field of the present invention is known and obvious.
It should be appreciated that for oral or injection, according to method well known in the art, selected generally according to different medicaments
With or the pharmaceutical carrier that is applied in combination, optionally including excipient or diluent, such as microcrystalline cellulose, mannitol, plant
Fat end, lactose, pregelatinized starch, starch, dextrin, cyclodextrin, maltodextrin, hydroxypropyl-β-cyclodextrin, calcium phosphate, phosphoric acid hydrogen
Calcium, hydroxypropyl methyl cellulose, sucrose, dextran, poloxamer, sodium chloride, sorbierite, glucose, oligofructose, poly
Fructose, xylo-oligosaccharide, polydextrose, Oligomeric manna sugar, solid polyethylene glycol（Such as polyethylene glycol-4000, polyethylene glycol-
12000th, polyethylene glycol-6000, Polyethylene glycol-2000 etc.）, resistant dextrin, fructose, water, propylene glycol, glycerine, coffee, milk powder,
Plant protein powder, etc.；For oral solid formulation, it is also an option that property includes adhesive, such as povidone (polyethylene
Pyrrolidones), methylcellulose, hydroxymethyl cellulose, hypromellose, pregelatinized starch, sodium carboxymethyl starch, hydroxypropyl
Base cellulose, hydroxyethyl cellulose, gelatin, guar gum, xanthans, etc.；Further include lubricant, such as magnesium stearate, tristearin
Acid, talcum powder, stearyl fumarate, lauryl sodium sulfate, etc.；Also optionally include disintegrant, such as carboxylic first
Base sodium starch, low-substituted hydroxypropyl cellulose, sodium carboxymethylcellulose, crosslinked polyvinylpyrrolidone, cross-linked carboxymethyl fiber
Plain sodium, crosslinked carboxymethyl fecula sodium, pregelatinized starch, etc.；Also optionally include surfactant or cosolvent, such as
Lauryl sodium sulfate, Tween-80, etc.；It may also include pH values conditioning agent or buffer or cosolvent, such as phosphoric acid
Salt buffer, citric acid, sodium citrate, acetate buffer, dilute hydrochloric acid, lactic acid, sodium carbonate, sodium hydroxide, alkalescence organise
Object is closed, such as arginine, lysine, meglumine, tromethamine, etc.；Also optionally include preservative, such as benzoic acid
Sodium, potassium sorbate, methyl p-hydroxybenzoate, propylparaben, etc.；Also optionally include stabilizer and resist
Oxygen agent, for example, metal chelating agent select ethylenediamine tetra-acetic acid and its salt (mosatil, natrium adetate) etc., sodium sulfite,
Sodium pyrosulfite, vitamin C, vitamin E, etc.；Also optionally include taste conditioning agent, such as maltitol, fructose,
Sucrose, saccharin sodium, flavoring orange essence, strawberry essence, etc.；It additionally can include other conventional, appropriate additives.Should also
Understand, can be film coating when agent type is tablet or capsule.For the material of film coating, including suitable coating agent,
Such as hypromellose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose phthalate (enteric
Coating material), etc.；Plasticizer, such as polyethylene glycol, triethyl citrate, etc. can also be included；Also optionally include
Suitable solubilizer, such as Polyoxyethylene Sorbitan Monooleate；Suitable pigment can be also included, such as titanium dioxide, various iron oxide, pink
Pigment, etc..It should be appreciated that above-mentioned " optionally including " refers to optionally select to use, can not also use.
Particularly, bamboo-leaves flavones of the present invention and the composition of γ-aminobutyric acid, bamboo-leaves flavones and γ-aminobutyric acid
Chemical composition can be different on medicament releasing pattern, such as γ-aminobutyric acid can be sustained or the form of controlled release occurs, and
Bamboo-leaves flavones can also be sustained or the form of controlled release occurs, to improve bamboo-leaves flavones with γ-aminobutyric acid in action or metabolism side
Blood concentration caused by the time difference in face does not act synergistically.
In the present patent application, " composition " refers to the γ-aminobutyric acid or/and bamboo-leaves flavones, with other chemistry into
Point, such as the mixture that physiologically/pharmaceutically acceptable carrier or excipient are formed, the purpose of pharmaceutical composition is to be conducive to
Application, carrying, the preservation of drug；" administration " mentioned here refers to prevent or treat disease and to organism（Including
Patient or healthy population）Deliver described compound, its pharmaceutically useful salt or its solvate；" the per unit preparation " refers to
The preparation unit of minimum package or minimum form of medication, such as each bottle of oral administration solution, each capsule, each tablet or ball
It is agent, each bag of granule or pulvis, each injection or parenteral solution, each bottle of injection or parenteral solution, each piece of suppository, every
One bottle of eye drops, each pipe ointment, etc..
Another aspect, it has been found that when bamboo-leaves flavones are applied in combination with γ-aminobutyric acid, show unexpectedly
The advantages of, especially the pharmaceutical composition shows outstanding, unexpected in blood pressure lowering, protection cardiovascular and cerebrovascular or treatment heart and brain
The synergistic effect of vascular diseases etc..Preferably, the pharmaceutical composition of bamboo-leaves flavones of the present invention and γ-aminobutyric acid, is used for
The application in the drug of lowering blood pressure and blood fat, protection cardiovascular and cerebrovascular or treatment cardiovascular and cerebrovascular disease is prepared, is preparing reduction
Application in the drug of risk caused by cardiovascular and cerebrovascular disease, etc..
Therefore, another aspect, the present invention provide a kind of blood pressure lowering, protection cardiovascular and cerebrovascular or treat cardiovascular and cerebrovascular disease
Pharmaceutical composition, it contains bamboo-leaves flavones and γ-aminobutyric acid.It will be appreciated by those skilled in the art that, pharmaceutical composition
In, before the combination of bamboo-leaves flavones and γ-aminobutyric acid, the dosage ratio in per unit preparation and content, with the present invention
The content stated is just the same.
Further, the present invention also provides bamboo-leaves flavones and the preparation method of the pharmaceutical composition of γ-aminobutyric acid, it
It is made acceptable in pharmacy including bamboo-leaves flavones and γ-aminobutyric acid are mixed with pharmaceutically acceptable pharmaceutical carrier
Any pharmaceutical preparation, such as bamboo-leaves flavones and γ-aminobutyric acid mix (dry method system with pharmaceutical carrier dry powder blend, dry granulation
Grain machine processing), wet granulation mixing (with water or ethanol solution wet granulation), liquid or semisolid mixing (such as soft capsule
Content, the mixing of dripping pill dropping liquid) etc., preferred pharmaceutical dosage form is that tablet (is collapsed including dispersible tablet, enteric coatel tablets, chewable tablets, oral cavity
Solve piece, effervescent tablet etc.), hard capsule (including capsulae enterosolubilis), granule, dry suspensoid agent, oral solution, dry syrup, dissipate
Agent, oral administration mixed suspension, soft capsule, pill, micropill preparation (including enteric-coated micro-pill), pill and oral quick-release or sustained release
Or the dosage forms such as controlled release, powder ampoule agent for injection (including the filling powder of Injectable sterile, freeze drying powder injection), aqueous solution injection, note
Agent is penetrated to can also be using glucose, sodium chloride, fructose, inverted sugar, xylitol or maltose etc. as the quiet of osmotic pressure regulator
Arteries and veins injection use the quick-release of aqueous solution (including intravenous injection and intravenous drip) or any of the above dosage form, sustained release,
The dosage forms such as controlled release, for example, oral dispersible tablet, sustained release tablets, spansule, enteric coatel tablets, effervescent tablet, oral disnitegration tablet, special-shaped tablets,
Born of the same parents rise particle, etc..Particularly, prepared by means known in the art preferably for prepare pharmacy on use tablet (including
Dispersible tablet, slow-release tablet, enteric coatel tablets, effervescent tablet, oral disnitegration tablet, special-shaped tablets), capsule (including soluble in the stomach, enteric, sustained release glue
Capsule), oral solution, injection (including powder ampoule agent for injection and parenteral solution) etc.；Or
The present invention also provides bamboo-leaves flavones and γ-aminobutyric acid pharmaceutical composition preparation method, it is included bamboo
Leaf flavones and γ-aminobutyric acid are mixed and made into individual pharmaceutical preparation with pharmaceutically acceptable pharmaceutical carrier respectively, and will
Two kinds of individual pharmaceutical preparation packages in same medicine box, preferred pharmaceutical dosage form be tablet (including dispersible tablet, enteric coatel tablets,
Chewable tablets, oral disnitegration tablet, effervescent tablet etc.), hard capsule (including capsulae enterosolubilis), granule, dry suspensoid agent, dry syrup,
Powder, soft capsule, oral solution, pill, micropill preparation (including enteric-coated micro-pill), pill, oral administration mixed suspension and oral
Quick-release or the dosage forms such as sustained release or controlled release, it is powder ampoule agent for injection (including the filling powder of Injectable sterile, freeze drying powder injection), water-soluble
Liquid injection, injection can also be using glucose, sodium chloride, fructose, inverted sugar, xylitol or maltose etc. as osmotic pressure
The intravenous injection of conditioning agent uses the aqueous solution (including intravenous injection and intravenous drip).It can also be any of the above dosage form
The dosage forms such as quick-release, slow-release controlled-release, such as oral dispersible tablet, sustained release tablets, spansule, enteric coatel tablets, effervescent tablet, Orally disintegrating
Piece, special-shaped tablets, effervescence granular, etc..Particularly, prepared by means known in the art preferably for prepare and used in pharmacy
Tablet (including dispersible tablet, slow-release tablet, enteric coatel tablets, effervescent tablet, oral disnitegration tablet, special-shaped tablets), capsule (including it is soluble in the stomach,
Enteric, spansule), oral solution, injection (including powder ampoule agent for injection and parenteral solution) etc..
Preferably, the present invention provides a kind of granule containing bamboo-leaves flavones and γ-aminobutyric acid, the bamboo-leaves flavones with
γ-aminobutyric acid is using weight ratio as (0.5~5):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.4~4.9):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.5~4.8):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.6~4.7):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.7~4.6):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.8~4.5):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.9~4.4):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1~4.3):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1~4.2):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1~4.1):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1~4):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.1~3.9):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.2~3.8):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.3~3.7):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.4~3.6):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.5~3.5):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.6~3.4):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.7~3.3):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.8~3.2):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.9~3.1):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (2~3):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.5~3.5):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.6~3.4):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.7~3.3):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.8~3.2):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.9~3.1):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1~3):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.1~2.9):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.2~2.8):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.3~2.7):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.4~2.6):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.5~2.5):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1~5):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.1~4.9):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.2~4.8):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.3~4.7):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.4~4.6):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.5~4.5):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.6~4.4):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.7~4.3):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.8~4.2):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1.9~4.1):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (2~4):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (2.1~3.9):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (2.2~3.8):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (2.3~3.7):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (2.4~3.6):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (2.5~3.5):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.5~2):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.6~1.9):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.7~1.8):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.8~1.7):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (0.9~1.6):1 ratio combination,
It is preferred that bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as (1~1.5):1 ratio combination；
Specifically, for example preferred bamboo-leaves flavones and γ-aminobutyric acid are using weight ratio as 0.5:1、0.6:1、0.7:1、0.8:
1、0.9:1、1:1、1.1:1、1.2:1、1.3:1、1.4:1、1.5:1、1.6:1、1.7:1、1.8:1、1.9:1、2:1、2.1:1、
2.2:1、2.3:1、2.4:1、2.5:1、2.6:1、2.7:1、2.8:1、2.9:1、3:1、3.1:1、3.2:1、3.3:1、3.4:1、
3.5:1、3.6:1、3.7:1、3.8:1、3.9:1、4:1、4.1:1、4.2:1、4.3:1、4.4:1、4.5:1、4.6:1、4.7:1、
4.8:1、4.9:1、5:1, etc.；
Also containing granule auxiliary material in the granule composite, the granule auxiliary material include it is following it is one or more into
Point：Fructose, xylitol, oligofructose, polyfructosan, xylo-oligosaccharide, polydextrose, mannitol, sucrose, inverted sugar（That is grape
The equal amount of mixture of sugar and fructose）, glucose, resistant dextrin, D-sorbite, maltose, isomalt, oligomeric sweet dew
Sugar, solid polyethylene glycol（Such as polyethylene glycol-4000, polyethylene glycol -12000, polyethylene glycol-6000, Polyethylene glycol-2000
Deng）, dextrin, cyclodextrin, maltodextrin, hydroxypropyl-β-cyclodextrin, microcrystalline cellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose
Element, pregelatinized starch, starch, starch sugar, lactose, vegetable fat powder, milk powder, plant protein powder, coffee, sodium carboxymethyl starch, albumen
Sugar, Sucralose, Aspartame, acesulfame potassium, stachyose, neotame, stevioside, wherein the content of granule auxiliary material is with weight ratio
Meter is more than 30%, and the preferably content of granule auxiliary material is more than 45% with weight ratio meter, and preferably the content of granule auxiliary material is with weight ratio
Meter is more than 60%；
Further, the present invention provides a kind of preparation method of the granule containing bamboo-leaves flavones and γ-aminobutyric acid, it
Including：γ-aminobutyric acid, bamboo-leaves flavones with granule auxiliary material are uniformly mixed respectively, then with ethanol water wet granulation, are done
Dry, whole grain, the wherein content of granule auxiliary material are more than 30% with weight ratio meter；Particularly, the present invention provides a kind of yellow containing the leaf of bamboo
The preparation method of ketone and γ-aminobutyric acid granule, it includes：
(1) dispensing：Bamboo-leaves flavones, γ-aminobutyric acid are weighed by formula, first bamboo-leaves flavones are added in granule auxiliary material and are mixed
It closes uniformly, adds γ-aminobutyric acid and be uniformly mixed, it is preferred to use equal increments hybrid mode is uniformly mixed；
(2) pelletize：By prepared material in (1) with 75% ethanol solution softwood, wet granulation, 45~70 DEG C of dryings,
Whole grain；
(3) pack, examine to get granule of the present invention containing bamboo-leaves flavones and γ-aminobutyric acid.
Further, capsule can be obtained in Capsules shell or by above-mentioned granule by above-mentioned granule is filling
It is tabletted by tablet forming technique.
Further, the present invention also provides bamboo-leaves flavones and the composition of γ-aminobutyric acid in following application：
The pharmaceutical composition of bamboo-leaves flavones of the present invention and γ-aminobutyric acid is used to prepare lowering blood pressure and blood fat, the protection heart
Application in the drug of the cerebrovascular or treatment cardiovascular and cerebrovascular disease, the risk caused by preparing reduction and cardiovascular and cerebrovascular disease occurs
Application in drug, etc..
For specific embodiment in the implementation process of the present invention, those of ordinary skill in the art are not departing from the present invention's
The various embodiments generated on the basis of scope and spirits and modification are obvious and are easy to perform.It is logical
It crosses the following examples to be further elaborated with come application to the present invention etc., it is not intended that limit of the embodiment to the present invention
System.
Embodiment 1, the composite tablet of bamboo-leaves flavones and γ-aminobutyric acid and its preparation
Recipe quantity by weight percentage, contains：
Bamboo-leaves flavones 10%~50% are preferably 40%,
γ-aminobutyric acid 10%~50% is preferably 20%,
Mannitol 10%~40% is preferably 32%,
Sodium carboxymethyl starch 1%~10% is preferably 5%,
Appropriate hydroxypropyl cellulose aqueous solution,
It is preferred that 2.5% hydroxypropyl cellulose aqueous solution, 2% is calculated as with hydroxypropyl cellulose,
Magnesium stearate 0.5%~2% is preferably 1%；
Its preparation method includes：Bamboo-leaves flavones, γ-aminobutyric acid, mannitol, sodium carboxymethyl starch are crossed into 80 mesh respectively
Sieve preferably crosses 100 mesh, after being weighed by recipe quantity, γ-aminobutyric acid, bamboo-leaves flavones is uniformly mixed, and adds in mannitol and carboxylic first
Base sodium starch after mixing, adds in hydroxypropyl cellulose aqueous solution and softwood is made, crosses the granulation of 24 mesh sieves, 45~60 DEG C of dryings
Afterwards, 20 mesh sieve whole grain, adds in the magnesium stearate of recipe quantity, mixing, tabletting to get.
Embodiment 2, the compound granule of bamboo-leaves flavones and γ-aminobutyric acid and its preparation
Recipe quantity by weight percentage, contains：
Bamboo-leaves flavones 0.5%~20% are preferably 10%,
γ-aminobutyric acid 0.5%~15% is preferably 5%,
Granule auxiliary material 65%~99% is preferably fructose 85%；
Wherein described granule auxiliary material includes following one or more ingredients：Fructose, xylitol, oligofructose, poly fruit
Sugar, xylo-oligosaccharide, polydextrose, mannitol, sucrose, inverted sugar（That is the equal amount of mixture of glucose and fructose）, it is glucose, anti-
Property dextrin, D-sorbite, maltose, isomalt, Oligomeric manna sugar, solid polyethylene glycol（Such as polyethylene glycol-
4000th, polyethylene glycol -12000, polyethylene glycol-6000, Polyethylene glycol-2000 etc.）, dextrin, cyclodextrin, maltodextrin, hydroxypropyl
Group-beta-cyclodextrin, microcrystalline cellulose, carboxymethyl cellulose, hypromellose, pregelatinized starch, starch, starch sugar, breast
Sugar, vegetable fat powder, milk powder, plant protein powder, coffee, sodium carboxymethyl starch, protein sugar, Sucralose, Aspartame, acesulfame potassium,
Stachyose, neotame, stevioside are most preferably fructose or/and oligofructose, polyfructosan；
Its preparation method includes：Leaf flavones, γ-aminobutyric acid, bamboo granule auxiliary material are crossed into 80 mesh sieves, preferably mistake respectively
Bamboo-leaves flavones after being weighed by recipe quantity, are first uniformly mixed by 100 mesh with granule auxiliary material, then add in γ-aminobutyric acid mixing
After uniformly, with 75% ethanol solution wet granulation, 45~70 DEG C of dryings, whole grain packaging, examine to get.It further, can will be upper
State that granule is filling to obtain capsule or above-mentioned granule is tabletted by tablet forming technique in Capsules shell.
Embodiment 3, the compound capsule of bamboo-leaves flavones and γ-aminobutyric acid and its preparation
Recipe quantity by weight percentage, contains：
Bamboo-leaves flavones 15%~45% are preferably 35%,
γ-aminobutyric acid 10%~45% is preferably 35%,
Mannitol 10%~25% is preferably 13%,
Pregelatinized starch 8%~25% is preferably 10%,
Sodium carboxymethyl starch 1%~15% is preferably 5%,
The ethanol solution of polyvinylpyrrolidone is appropriate, preferably using polyvinylpyrrolidone as 1%,
Magnesium stearate 0.5%~2% is preferably 1%；
Its preparation method includes：By bamboo-leaves flavones, γ-aminobutyric acid, mannitol, pregelatinized starch, sodium carboxymethyl starch
80 mesh sieves are crossed respectively, are preferably crossed 100 mesh sieves, after being weighed by recipe quantity, are first uniformly mixed bamboo-leaves flavones and γ-aminobutyric acid,
A mixed-powders are obtained, for use；Separately mannitol, pregelatinized starch, sodium carboxymethyl starch are uniformly mixed, obtain B mixed-powders,
Then A mixed-powders and B mixed-powders are sufficiently mixed and uniformly, add in the ethanol solution of polyvinylpyrrolidone softwood is made,
The granulation of 20 mesh sieves, 45~70 DEG C of drying are crossed, dry particl crosses 18 mesh sieve whole grains, and stiffened fatty acid magnesium is uniformly mixed, and is filled to capsulae vacuus,
To obtain the final product.
Embodiment 4, the compound granule of bamboo-leaves flavones and γ-aminobutyric acid and its preparation
Recipe quantity by weight percentage, contains：
Bamboo-leaves flavones 0.5%~20% are preferably 10%,
γ-aminobutyric acid 0.5%~20% is preferably 10%,
Maltodextrin 3%~10% is preferably 7%,
Other granule auxiliary materials 50%~96% are preferably fructose 73%；
Wherein described other granule auxiliary materials include following one or more ingredients：It is fructose, xylitol, oligofructose, more
Fructooligosaccharides, xylo-oligosaccharide, polydextrose, mannitol, sucrose, inverted sugar（That is the equal amount of mixture of glucose and fructose）, grape
Sugar, resistant dextrin, D-sorbite, maltose, isomalt, Oligomeric manna sugar, solid polyethylene glycol, dextrin, cyclodextrin,
Hydroxypropyl-β-cyclodextrin, microcrystalline cellulose, carboxymethyl cellulose, hypromellose, pregelatinized starch, starch, starch
Sugar, lactose, vegetable fat powder, milk powder, plant protein powder, coffee, sodium carboxymethyl starch, protein sugar, Sucralose, Aspartame, peace
Honey, stachyose, neotame, stevioside are matched, is most preferably fructose or/and oligofructose, polyfructosan；
Its preparation method includes：Bamboo-leaves flavones, γ-aminobutyric acid, maltodextrin, other granule auxiliary materials are crossed 80 respectively
Mesh sieve preferably crosses 100 mesh, after being weighed by recipe quantity, γ-aminobutyric acid, bamboo-leaves flavones, maltodextrin, other granules is auxiliary
Material is uniformly mixed, with 75% ethanol solution wet granulation, 45~70 DEG C of dryings, whole grain packaging, examine to get.
The composition of embodiment 5, bamboo-leaves flavones and γ-aminobutyric acid is in the collaboration of blood pressure lowering and protection treating cardiac and cerebral vascular diseases
Effect
Method：Using spontaneous hypertension rat (SHR) test group, if Normal group (feeding basal feed), test group (are fed
Basal feed, and γ-aminobutyric acid or/and bamboo-leaves flavones are fed respectively daily), every group is 10 rats, and daily gavage connects
Stop gavage after 2 weeks continuous and continue observation 1 week, using noninvasive arteria caudalis hemodynamometry.
Statistical procedures:Data using SPSS statistical softwares analyze, all data withIt represents.
Experiment packet：
(1) Normal group：Arm's length basis feed is fed with；
(2) γ-aminobutyric acid group:Basal feed is fed with, and gavages the γ-aminobutyric acid of 0.8g/KG daily；
(3) bamboo-leaves flavones group:Basal feed is fed with, and gavages the bamboo-leaves flavones of 0.8g/KG daily；
(4) the composition group of bamboo-leaves flavones and γ-aminobutyric acid:Basal feed be fed with, and gavage daily bamboo-leaves flavones with
The composition 0.8g/KG of γ-aminobutyric acid, the wherein weight ratio of bamboo-leaves flavones and γ-aminobutyric acid are 1:1、2:1、3:1、5:
1。
It the results are shown in Table 1.
1 bamboo-leaves flavones of table and the composition of γ-aminobutyric acid in terms of blood pressure lowering synergistic effect (n=10, mmHg,)
*：The p compared with γ-aminobutyric acid group, bamboo-leaves flavones group<0.05；
#：The p compared with γ-aminobutyric acid group, bamboo-leaves flavones group<0.01.
Conclusion：Bamboo-leaves flavones of the present invention and the composition of γ-aminobutyric acid have in Hypertensive Rats (SHR) experiment
The effect of notable blood pressure lowering compared with the γ-aminobutyric acid group, bamboo-leaves flavones group of same dose, has significance difference exclusive or very
Significant difference, p<0.05 or p<0.01；Show the composition of bamboo-leaves flavones of the present invention and γ-aminobutyric acid in blood pressure lowering side
The good synergistic effect in face, the i.e. present composition have outstanding blood pressure lowering, protection cardiovascular and cerebrovascular, reduce generation heart and brain blood
Synergistic effect in terms of risk caused by pipe disease.
The composition of embodiment 6, bamboo-leaves flavones and γ-aminobutyric acid is in reducing blood lipid and the collaboration of protection treating cardiac and cerebral vascular diseases
Effect
Method：Using High fat diet rats model, if Normal group (feeding basal feed), model control group (feed feeding high in fat
Material), test group (feed high lipid food, and feed bamboo-leaves flavones or/and γ-aminobutyric acid respectively daily), be continuously fed with 30d, take
Tail blood measures its serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), low-density lipoprotein
(LDL-C) it is horizontal, and atherogenic index (AI) is further calculated,
AI=[T-CHOL (TC)-high-density lipoprotein (HDL-C)]/high-density lipoprotein (HDL-C).
Animal：Cleaning grade SD male rats 40,200~250g of weight, every group of 8 rats.
High lipid food：Including 80% normal diet, 2% cholesterol, 8% yolk powder, 10% lard.
Statistical procedures:Data using SPSS17.0 statistical softwares analyze, all data withIt represents.
Experiment packet：
(1) Normal group：Arm's length basis feed is fed with；
(2) model control group:High lipid food is fed with；
(3) bamboo-leaves flavones group:High lipid food is fed with, and gavages the bamboo-leaves flavones of 0.75g/KG daily；
(4) γ-aminobutyric acid group:High lipid food is fed with, and gavages the γ-aminobutyric acid of 0.75g/KG daily；
(5) the composition group of bamboo-leaves flavones and γ-aminobutyric acid:High lipid food be fed with, and gavage daily bamboo-leaves flavones with
The composition 0.75g/KG of γ-aminobutyric acid, the wherein γ-aminobutyric acid of the bamboo-leaves flavones of 0.5g/KG and 0.25g/KG, i.e. bamboo
The weight ratio of leaf flavones and γ-aminobutyric acid is 2:1.
It the results are shown in Table 2.
2 bamboo-leaves flavones of table and the composition of γ-aminobutyric acid in terms of reducing blood lipid synergistic effect (n=8, mmol/L,)
*：The p compared with bamboo-leaves flavones group, γ-aminobutyric acid group<0.05；
##：The p compared with bamboo-leaves flavones group, γ-aminobutyric acid group<0.01.
Conclusion：Bamboo-leaves flavones of the present invention and the composition of γ-aminobutyric acid have aobvious in the experiment of SD rats hyperlipidemia model
The effect for reducing blood fat and promoting high-density lipoprotein cholesterol is write, it is yellow with bamboo-leaves flavones group, the leaf of bamboo in terms of TC, TG is reduced
Ketone group compares, and has significant difference, p<0.05；In terms of reducing LDL-C and promoting HDL-C, with bamboo-leaves flavones group, bamboo-leaves flavones
Group compares, and has very significant difference, p<0.01；On the other hand, atherogenic index AI values are the weighing apparatuses that international medical community is formulated
An index of Degree of arteriosclerosis is measured, reflects the degree of atherosclerosis, the smaller journey for illustrating artery sclerosis of numerical value
Degree is lighter, triggers dangerous lower, the AI values of the composition of bamboo-leaves flavones and γ-aminobutyric acid and the bamboo of cardiovascular and cerebrovascular diseases
Leaf flavones group, γ-aminobutyric acid group compare, and have very significant difference, p<0.01.
The composition of bamboo-leaves flavones of the present invention and γ-aminobutyric acid is shown in reducing blood lipid and inhibits artery artery sclerosis
There is outstanding reducing blood lipid, protection cardiovascular and cerebrovascular, reduction cardiovascular and cerebrovascular disease occurs and leads for good action, the i.e. present composition
Synergistic effect in terms of the risk of cause.
The composition of bamboo-leaves flavones and γ-aminobutyric acid described in embodiment 7, embodiment 1 to embodiment 4 is at following aspects
Application：
Application in the drug for preparing lowering blood pressure and blood fat, protection cardiovascular and cerebrovascular or treatment cardiovascular and cerebrovascular disease；
Preparing the application in reducing the drug of risk caused by generation cardiovascular and cerebrovascular disease.
Claims (4)
1. the composite tablet of a kind of bamboo-leaves flavones and γ-aminobutyric acid, recipe quantity by weight percentage, contains：
Bamboo-leaves flavones 40%,
γ-aminobutyric acid 20%,
Mannitol 32%,
Sodium carboxymethyl starch 5%,
2.5% hydroxypropyl cellulose aqueous solution 2%, in terms of hydroxypropyl cellulose,
Magnesium stearate 1%；
Its preparation method includes：Bamboo-leaves flavones, γ-aminobutyric acid, mannitol, sodium carboxymethyl starch are crossed into 80 mesh sieves respectively, pressed
After recipe quantity weighs, γ-aminobutyric acid, bamboo-leaves flavones are uniformly mixed, add in mannitol and sodium carboxymethyl starch, are uniformly mixed
Afterwards, add in hydroxypropyl cellulose aqueous solution and softwood is made, cross the granulation of 24 mesh sieves, after 45~60 DEG C of dryings, 20 mesh sieve whole grains add in
The magnesium stearate of recipe quantity, mixing, tabletting to get.
2. the compound granule of a kind of bamboo-leaves flavones and γ-aminobutyric acid, recipe quantity by weight percentage, contains：
Bamboo-leaves flavones 10%,
γ-aminobutyric acid 5%,
Granule auxiliary material 85%；
Wherein described granule auxiliary material includes following one or more ingredients：It is fructose, xylitol, oligofructose, xylo-oligosaccharide, poly-
Glucose, mannitol, sucrose, glucose, resistant dextrin；
Its preparation method includes：Bamboo-leaves flavones, γ-aminobutyric acid, granule auxiliary material are crossed into 80 mesh sieves respectively, weighed by recipe quantity
Afterwards, first bamboo-leaves flavones with granule auxiliary material are uniformly mixed, then add in γ-aminobutyric acid after mixing, it is molten with 75% ethyl alcohol
Liquid wet granulation, 45~70 DEG C of dryings, whole grain packaging, examine to get.
3. the compound capsule of a kind of bamboo-leaves flavones and γ-aminobutyric acid, recipe quantity by weight percentage, contains：
Bamboo-leaves flavones 35%,
γ-aminobutyric acid 35%,
Mannitol 13%,
Pregelatinized starch 10%,
Sodium carboxymethyl starch 5%,
The ethanol solution 1% of polyvinylpyrrolidone, in terms of polyvinylpyrrolidone,
Magnesium stearate 1%；
Its preparation method includes：By bamboo-leaves flavones, γ-aminobutyric acid, mannitol, pregelatinized starch, sodium carboxymethyl starch difference
80 mesh sieves are crossed, after being weighed by recipe quantity, are first uniformly mixed bamboo-leaves flavones and γ-aminobutyric acid, obtain A mixed-powders, for use；
Separately mannitol, pregelatinized starch, sodium carboxymethyl starch are uniformly mixed, obtain B mixed-powders, then mixes A mixed-powders with B
It closes powder and is sufficiently mixed and uniformly, add in the ethanol solution of polyvinylpyrrolidone and be made softwood, cross 20 mesh sieves and pelletize, 45~70 DEG C
Drying, dry particl crosses 18 mesh sieve whole grains, and stiffened fatty acid magnesium is uniformly mixed, fill to capsulae vacuus to get.
4. the compound granule of a kind of bamboo-leaves flavones and γ-aminobutyric acid, recipe quantity by weight percentage, contains：
Bamboo-leaves flavones 10%,
γ-aminobutyric acid 10%,
Maltodextrin 7%,
Other granule auxiliary materials 73%；
Wherein described other granule auxiliary materials include following one or more ingredients：Fructose, xylitol, oligofructose, oligomeric wood
Sugar, polydextrose, mannitol, sucrose, glucose, resistant dextrin；
Its preparation method includes：Bamboo-leaves flavones, γ-aminobutyric acid, maltodextrin, other granule auxiliary materials are crossed into 80 mesh respectively
Sieve, after being weighed by recipe quantity, γ-aminobutyric acid, bamboo-leaves flavones, maltodextrin, other granule auxiliary materials are uniformly mixed, and are used
75% ethanol solution wet granulation, 45~70 DEG C of dryings, whole grain packaging, examine to get.
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