CN104840763A - Medicine for treating rheumatoid bone diseases and preparation method thereof - Google Patents
Medicine for treating rheumatoid bone diseases and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating rheumatoid bone diseases. The medicine is prepared by extracting and preparing traditional Chinese medicine composition and mixing the traditional Chinese medicine composition with a western medicine composition, wherein the traditional Chinese medicine composition comprises the components as follows: Chinese angelica, clematis root, cinnamon, common club moss herb, suberect spatholobus stem, Chinese taxillus twig, processed Sichuan aconite root, prepared kusnezoff monkshood root, processed semen strychni, pseudo-ginseng, jasmine, safflower, Chinese wolfberry, szechuan lovage rhizome, danshen, herba lycopi, cowherb seed, garden balsam, diverse wormwood herb, bletilla striata, Chinese arborvitae twig, folium artemisiae argyi, cattail pollen, red peanut coating, tamariskoid spikemoss herb, sophora flower, sophora fruit, camellia flower, sanguisorba officinalis, veronica undulata and herba orostachyos; the western medicine composition comprises the components as follows: diclofenac sodium, aspirin and phenacetin. According to the medicine for treating rheumatoid bone diseases, the rheumatoid bone disease symptoms can be quickly alleviated; the medicine is small in poor reaction, and has a good immunity regulating function and a good long-term curative effect.
Description
Technical field
Invention relates to pharmaceutical technology sectors, is specifically related to a kind of medicine for the treatment of rheumatic osteopathia and preparation method thereof.
Background technology
Rheumatic osteopathia comprises modern various noun sciatica, scapulohumeral periarthritis, prolapse of lumbar intervertebral disc, splashes out, lumbago and skelalgia, hyperosteogeny, numb limbs and tense tendons etc., motherland's medical science thinks that mainly anemofrigid-damp arthralgia attacks meridians, blocking barrier, think that controlling wind first controls blood, blood wind is from going out, and fiber crops have phlegm-damp, and wood is thrombosis, total theory is deficiency of qi and blood, circulates not smooth.Mainly caused by liver and kidney deficiency, thus with in invigorating liver and kidney, curing rheumatism cold and heat, and reach the object of radical cure.Because the medicine for the treatment of lumbago and skelalgia is various, totally be divided into Chinese and Western two class, the main pain relieving of Western medicine, cannot effect a radical cure, long-term taking, easy addiction, in recent years, Chinese medicine has achieved certain achievement and gratifying progress in rheumatism treatment field, but with modern medicine develop ratio rapidly, relatively also fall behind a lot, also have much Chinese medicine not reach the object of healing.
Chinese patent CN201410255761.1 discloses a kind of medicine for the treatment of rheumatic osteopathia, it is with Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Clematidis, Rhizoma Corydalis, Radix Gentianae Macrophyllae, Radix Dipsaci, Herba Asari, Rhizoma Zingiberis, the Radix Astragali, Radix Cyathulae, Radix Salviae Miltiorrhizae, Scolopendra, Pheretima, Fructus Chaenomelis, Saussurea lappa Clarke, Radix Et Rhizoma Rhei, the Rhizoma Atractylodis Macrocephalae, Radix Bupleuri, Ramulus Cinnamomi, the Cortex Eucommiae, Radix Glycyrrhizae, Massa Medicata Fermentata, Caulis Spatholobi, Poria for raw material, and crushed after being dried makes powder or capsule, pill.This medicine is used for the treatment of the diseases such as rheumatic osteopathia, has the effects such as antiinflammatory, pain relieving, relaxing muscles and tendons and activating QI and blood in the collateral, blood circulation promoting and blood stasis dispelling, softening bony spur, and the most outstanding feature is that treating both the principal and secondary aspects of a disease, long-term effect are good.But medicine prepared by the method is larger to gastrointestinal stimulation, is not suitable for life-time service.
Chinese patent CN201310233315.6 discloses a kind of medicament for the treatment of rheumatic osteopathia, and it comprises: the first pharmaceutical composition, and it is made up of the material of following weight proportioning: Realgar, Mylabris and Herba Asari; And second pharmaceutical composition, it is made up of the material of following weight proportioning: Margarita, Borneolum Syntheticum, Cinnabaris and Radix Notoginseng.The medicament for the treatment of rheumatic osteopathia of the present invention has the advantages that cost is low, preparation is easy, toxic and side effects is little, curative effect shows.But pharmaceutical effectiveness prepared by the method is poor, take effect slow.
Therefore be badly in need of a kind of rapid mitigation symptoms, adverse effect be little, the medicine for the treatment of rheumatic osteopathia that immunity moderation function, long-term efficacy are good.
Summary of the invention
Invention, for the problems referred to above, provides a kind of medicine for the treatment of rheumatic osteopathia and preparation method thereof, according to the combination of Chinese and Western medicine, its drug-specific is worked for rheumatic osteopathia, has prescription science, preparation method is simple, processing cost is low, evident in efficacy feature.
In order to solve the problems of the technologies described above, the present invention takes following technical scheme:
Treat a medicine for rheumatic osteopathia, medicine comprises Chinese medicine composition and Western medicine compound, and medicine is after Chinese medicine composition extracts preparation and Western medicine compound is mixed, and Chinese medicine composition comprises: Radix Angelicae Sinensis, Radix Clematidis, Cortex Cinnamomi, Herba Lycopodii, Caulis Spatholobi, Herba Taxilli, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Semen Strychni (processed), Radix Notoginseng, Fructus Gardeniae, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, red-face role's clothing, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos, Chinese medicine composition needs through sterilizing process before extraction, and sterilizing method is that the sterilization of Co60 radiation sterilizing is combined with ultraviolet irradiation sterilizing, Radix Angelicae Sinensis, Radix Clematidis, Cortex Cinnamomi, Herba Lycopodii, Caulis Spatholobi, Herba Taxilli, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Semen Strychni (processed) adopts the sterilization of Co60 radiation sterilizing, Radix Notoginseng, Fructus Gardeniae, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, red-face role's clothing, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos adopts ultraviolet irradiation sterilizing, and described Western medicine compound comprises: diclofenac sodium, aspirin, phenacetin, Chinese medicine composition is made up of following weight parts: Radix Angelicae Sinensis 10 parts ~ 15 parts, Radix Clematidis 10 parts ~ 15 parts, Cortex Cinnamomi 10 parts ~ 15 parts, Herba Lycopodii 25 parts ~ 35 parts, Caulis Spatholobi 25 parts ~ 35 parts, Herba Taxilli 25 parts ~ 35 parts, Radix Aconiti Preparata 4 parts ~ 5 parts, Radix Aconiti Kusnezoffii Preparata 4 parts ~ 5 parts, Semen Strychni (processed) 2 parts ~ 3 parts, Radix Notoginseng 40 parts ~ 50 parts, Fructus Gardeniae 40 parts ~ 50 parts, 25 parts ~ 35 parts, Flos Carthami, Fructus Lycii 10 parts ~ 15 parts, Rhizoma Chuanxiong 4 parts ~ 5 parts, Radix Salviae Miltiorrhizae 4 parts ~ 5 parts, Herba Lycopi 2 parts ~ 3 parts, Semen Vaccariae 1 part ~ 5 parts, Semen Impatientis 4 parts ~ 5 parts, Herba Artemisiae Anomalae 4 parts ~ 5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 2 parts ~ 3 parts, Cacumen Platycladi 1 part ~ 5 parts, Folium Artemisiae Argyi 4 parts ~ 5 parts, Pollen Typhae 4 parts ~ 5 parts, 2 parts ~ 3 parts, red-face role's clothing, Herba Selaginellae 1 part ~ 5 parts, 4 parts ~ 5 parts, Flos Sophorae, the Fructus Sophorae 4 parts ~ 5 parts, Flos Camelliae Japonicae 2 parts ~ 3 parts, Radix Sanguisorbae 1 part ~ 5 parts, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae) 4 parts ~ 5 parts, Herba Orostachyos 1 part ~ 5 parts.
Further, the sterilization of Co60 radiation sterilizing is: 6kGy dosage 60Co-gamma-ray irradiation is sterilized.
Further, ultraviolet irradiation sterilizing was: with 20W low-ozone straight tube ultraviolet disinfection lamp process 2 hours.
Further, Western medicine compound comprises by weight: diclofenac sodium 0.1 part ~ 0.3 part, aspirin 0.1 part ~ 0.3 part, phenacetin 0.1 part ~ 0.3 part.
Further, Western medicine compound comprises by weight: diclofenac sodium 0.1 part, aspirin 0.2 part, phenacetin 0.3 part.
Further, Chinese medicine composition is made up of following weight parts: Radix Angelicae Sinensis 15 parts, Radix Clematidis 15 parts, Cortex Cinnamomi 10 parts, Herba Lycopodii 30 parts, Caulis Spatholobi 30 parts, Herba Taxilli 30 parts, Radix Aconiti Preparata 5 parts, Radix Aconiti Kusnezoffii Preparata 5 parts, Semen Strychni (processed) 3 parts, Radix Notoginseng 45 parts, Fructus Gardeniae 45 parts, 30 parts, Flos Carthami, Fructus Lycii 13.5 parts, Rhizoma Chuanxiong 4 parts, Radix Salviae Miltiorrhizae 4 parts, Herba Lycopi 2 parts, Semen Vaccariae 1 part, Semen Impatientis 5 parts, Herba Artemisiae Anomalae 4 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 2.5 parts, Cacumen Platycladi 1 part, Folium Artemisiae Argyi 4.5 parts, Pollen Typhae 5 parts, 2 parts, red-face role's clothing, Herba Selaginellae 1 part, 4.5 parts, Flos Sophorae, the Fructus Sophorae 4.5 parts, Flos Camelliae Japonicae 2.5 parts, Radix Sanguisorbae 1.5 parts, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae) 4.5 parts, Herba Orostachyos 1.5 parts.
Wherein, the Main Function of each composition of said medicine is:
Radix Notoginseng has dissipating blood stasis to stop blooding, the merit of subduing swelling and relieving pain; Fructus Gardeniae has the effect of removing pathogenic heat from blood and toxic substance from the body; Flos Carthami has the energy of promoting blood circulation to restore menstrual flow, swelling and pain due to blood stasis, blood stasis costalgia, carbuncle, Fructus Lycii can nourishing the essence and strengthening QI, strengthen and carry immunity and repair ability, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae are treating blood disorders medicine, can the QI and blood regulating Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, Hong Shengyi, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos be hemorrhage, can stop blooding in time, Chinese angelica blood supplementing, invigorate blood circulation, intestine moistening, to dispel the wind, control arthralgia and numbness of the skin; Radix Clematidis wind-damp dispelling, the meridian dredging, stopping numbness pain effect are stronger; Cortex Cinnamomi dispersing cold for relieving pain, warm promoting blood circulation, ignites descending; Herba Lycopodii expelling wind and cold, controls anemofrigid-damp arthralgia, joint aches, skin numbness, tetraparesis; Caulis Spatholobi promoting the circulation of blood is enriched blood, and relaxing muscles and tendons and activating QI and blood in the collateral controls joint aches, numb hand and foot, quadriplegia; Herba Taxilli wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, deficiency of the liver and kindey waist and leg ache is particularly suitable; Radix Aconiti grass dispels the wind, cold expelling, pain relieving, very toxic, made use, the 60 minutes toxin that are decocted first reduce by half, do not affect the treatment; Semen Strychni bitter cold activating collaterals and eliminating stagnation, subduing swelling and relieving pain, poisonous, made use.This medicine simultaneously using both cold and hot drugs, Wen Tong also executes, can wind-damp dispelling with temperature, and invigorating blood circulation can pain relieving, tonify without causing stagnation, and blood is not dry, and add diclofenac sodium, aspirin, phenacetin play Chinese and Western to share curative effect higher, pain relieving is obvious.
Another object of the present invention is the preparation method providing described medicine, comprises the following steps:
Step S01: take Radix Angelicae Sinensis, Radix Clematidis, Cortex Cinnamomi, Herba Lycopodii, Caulis Spatholobi, Herba Taxilli, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Semen Strychni (processed) on request, sterilizes through Co60 radiation sterilizing;
Step S02: take Radix Notoginseng, Fructus Gardeniae, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, Hong Shengyi, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos employing ultraviolet irradiation sterilizing on request, mix with the medical material after step S01 process after process, obtain mixing medical material;
Step S03: decoct 60 minutes by adding mixing medical material 8 times ~ 12 times amount pure water in Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, then Radix Angelicae Sinensis, Radix Clematidis, Cortex Cinnamomi, Herba Lycopodii, Caulis Spatholobi, Herba Taxilli, Semen Strychni (processed), Radix Notoginseng, Fructus Gardeniae, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, Hong Shengyi, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos is added, continue decoction 30 minutes, 30 minutes are decocted again after being cooled to room temperature, be cooled to room temperature, filter, obtain filtrate;
Step S04: the filtrate reduced in volume of step S03 is become clear paste, is spray dried to fine powder; Or concentrating under reduced pressure becomes thick paste, after vacuum drying, be ground into fine powder;
Step S05: by the fine powder of step S04 and Western medicine compound mixing, obtain mixed powder;
Step S06: the mixed powder of step S05 is added adjuvant and granulates, make required granule, or pill, or soft capsule, or capsule, or tablet.
Further, in step S04, described clear paste is: 55 DEG C ~ 60 DEG C time, measure relative density is the clear paste of 1.00 ~ 1.10.
Further, in step S04, described thick paste is: 55 DEG C ~ 60 DEG C time, measure relative density is the thick paste of 1.30 ~ 1.38.
Further, in step S04, the particle diameter of described fine powder is: 15 μm ~ 25 μm.
Pharmaceutically acceptable adjuvant of the present invention comprises: (1), diluent, such as starch, Icing Sugar, dextrin, lactose, pregelatinized Starch, microcrystalline cellulose, inorganic calcium salt (as calcium sulfate, calcium hydrogen phosphate, medicinal calcium carbonate etc.), mannitol etc., vegetable oil, Polyethylene Glycol etc.; (2), binding agent, such as distilled water, ethanol, starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose and ethyl cellulose, hypromellose etc.; (3), disintegrating agent, such as dried starch, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose etc.; (4), lubricant, such as magnesium stearate, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, polyethylene glycols, magnesium laurylsulfate etc.; (5), correctives, such as citric acid, sucrose etc.
Advantage of the present invention is:
1. the pharmaceutical composition in invention, the combination of Chinese and Western medicine, utilizes modern pharmaceutical technique, and adopt high efficiency disinfection technology to sterilize to raw material, preparation efficiency is higher, better quality;
2. medicine of the present invention adds diclofenac sodium, aspirin, phenacetin can ease the pain rapidly, relief of symptoms;
3. medicine of the present invention is revised on the basis of ancient prescription, makes curative effect more outstanding; Have the advantages that cost is low, preparation is easy, toxic and side effects is little, curative effect shows;
4. medicine of the present invention is containing Radix Angelicae Sinensis, Cortex Cinnamomi, Fructus Lycii, Rhizoma Chuanxiong, effective component in red sage, can immunity moderation function, long-term efficacy good.
Except object described above, feature and advantage, invent the object, the feature and advantage that also have other.To be described in further detail invention below.
Detailed description of the invention
Below provide specific embodiments of the invention, be used for being described in further detail the present invention, these embodiments only for the object of illustration, are never limited to the present invention.
Experimental technique in following embodiment, if no special instructions, is conventional method.Medicinal raw material used in following embodiment, reagent material etc., if no special instructions, be commercially available purchase product.
Embodiment 1
Crude drug forms: (unit: Kg)
Radix Angelicae Sinensis 10, Radix Clematidis 10, Cortex Cinnamomi 10, Herba Lycopodii 25, Caulis Spatholobi 25, Herba Taxilli 25, Radix Aconiti Preparata 4, Radix Aconiti Kusnezoffii Preparata 4, Semen Strychni (processed) 2, Radix Notoginseng 40, Fructus Gardeniae 40, Flos Carthami 25, Fructus Lycii 10, Rhizoma Chuanxiong 4, Radix Salviae Miltiorrhizae 4, Herba Lycopi 2, Semen Vaccariae 1, Semen Impatientis 4, Herba Artemisiae Anomalae 4, the Pseudobulbus Bletillae (Rhizoma Bletillae) 2, Cacumen Platycladi 1, Folium Artemisiae Argyi 4, Pollen Typhae 4, red-face role's clothing 2, Herba Selaginellae 1, Flos Sophorae 4, the Fructus Sophorae 4, Flos Camelliae Japonicae 2, Radix Sanguisorbae 1, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae) 4, Herba Orostachyos 1, diclofenac sodium 0.1, aspirin 0.1, phenacetin 0.1.
Prepare by the following method:
(1) Radix Angelicae Sinensis, Radix Clematidis, Cortex Cinnamomi, Herba Lycopodii, Caulis Spatholobi, Herba Taxilli, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Semen Strychni (processed) is taken on request, through 6kGy dosage
60co-gamma-ray irradiation is sterilized.
(2) Radix Notoginseng, Fructus Gardeniae, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, Hong Shengyi, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos 20W low-ozone straight tube ultraviolet disinfection lamp process 2 hours is taken on request, medical material after processing with (1) after process mixes, and obtains mixing medical material.
(3) 60 minutes are decocted by adding mixing medical material 11 times amount pure water in Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, then Radix Angelicae Sinensis, Radix Clematidis, Cortex Cinnamomi, Herba Lycopodii, Caulis Spatholobi, Herba Taxilli, Semen Strychni (processed), Radix Notoginseng, Fructus Gardeniae, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, Hong Shengyi, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos is added, continue decoction 30 minutes, 30 minutes are decocted again after being cooled to room temperature, be cooled to room temperature, filter, obtain filtrate.
(4) being become by filtrate reduced in volume in (3) 60 DEG C of mensuration relative densities is the thick paste of 1.30, and vacuum drying, sieves, and obtains the fine powder 41.85kg of 20 μm.
(5) fine powder of gained in (4) is added starch and hyprolose is appropriate, mix homogeneously with diclofenac sodium, aspirin, phenacetin, add 80% appropriate amount of ethanol and make granule, tabletting, every sheet 350mg, to obtain 122860 altogether.
Embodiment 2
Crude drug forms: (unit: 100g)
Radix Angelicae Sinensis 15, Radix Clematidis 15, Cortex Cinnamomi 10, Herba Lycopodii 30, Caulis Spatholobi 30, Herba Taxilli 30, Radix Aconiti Preparata 5, Radix Aconiti Kusnezoffii Preparata 5, Semen Strychni (processed) 3, Radix Notoginseng 45, Fructus Gardeniae 45, Flos Carthami 30, Fructus Lycii 13.5, Rhizoma Chuanxiong 4, Radix Salviae Miltiorrhizae 4, Herba Lycopi 2, Semen Vaccariae 1, Semen Impatientis 5, Herba Artemisiae Anomalae 4, the Pseudobulbus Bletillae (Rhizoma Bletillae) 2.5, Cacumen Platycladi 1, Folium Artemisiae Argyi 4.5, Pollen Typhae 5, red-face role's clothing 2, Herba Selaginellae 1, Flos Sophorae 4.5, the Fructus Sophorae 4.5, Flos Camelliae Japonicae 2.5, Radix Sanguisorbae 1.5, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae) 4.5, Herba Orostachyos 1.5, diclofenac sodium 0.1, aspirin 0.2, phenacetin 0.3.
Preparation method is as follows:
(1) Radix Angelicae Sinensis, Radix Clematidis, Cortex Cinnamomi, Herba Lycopodii, Caulis Spatholobi, Herba Taxilli, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Semen Strychni (processed) is taken on request, through 6kGy dosage
60co-gamma-ray irradiation is sterilized.
(2) Radix Notoginseng, Fructus Gardeniae, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, Hong Shengyi, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos 20W low-ozone straight tube ultraviolet disinfection lamp process 2 hours is taken on request, medical material after processing with (1) after process mixes, and obtains mixing medical material.
(3) 60 minutes are decocted by adding mixing medical material 10 times amount pure water in Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, then Radix Angelicae Sinensis, Radix Clematidis, Cortex Cinnamomi, Herba Lycopodii, Caulis Spatholobi, Herba Taxilli, Semen Strychni (processed), Radix Notoginseng, Fructus Gardeniae, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, Hong Shengyi, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos is added, continue decoction 30 minutes, 30 minutes are decocted again after being cooled to room temperature, be cooled to room temperature, filter, obtain filtrate.
(4) being become by filtrate reduced in volume in (3) 60 DEG C of mensuration relative densities is the clear paste of 1.06, and spraying dry, sieves, and obtains the fine powder 4.975kg of 15 μm.
(5) fine powder of gained in (4) is added calcium phosphate and calcium hydrogen phosphate is appropriate, mix homogeneously with diclofenac sodium, aspirin, phenacetin, add 80% appropriate amount of ethanol and make granule, tabletting, every sheet 350mg, to obtain 14400 altogether.
Embodiment 3
Raw material forms: (unit: Kg)
Radix Angelicae Sinensis 15, Radix Clematidis 15, Cortex Cinnamomi 15, Herba Lycopodii 35, Caulis Spatholobi 35, Herba Taxilli 35, Radix Aconiti Preparata 5, Radix Aconiti Kusnezoffii Preparata 5, Semen Strychni (processed) 3, Radix Notoginseng 50, Fructus Gardeniae 50, Flos Carthami 35, Fructus Lycii 15, Rhizoma Chuanxiong 5, Radix Salviae Miltiorrhizae 5, Herba Lycopi 3, Semen Vaccariae 5, Semen Impatientis 5, Herba Artemisiae Anomalae 5, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3, Cacumen Platycladi 5, Folium Artemisiae Argyi 5, Pollen Typhae 5, red-face role's clothing 3, Herba Selaginellae 5, Flos Sophorae 5, the Fructus Sophorae 5, Flos Camelliae Japonicae 3, Radix Sanguisorbae 5, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae) 5, Herba Orostachyos 5, diclofenac sodium 0.3, aspirin 0.3, phenacetin 0.3.
Preparation method is as follows:
(1) Radix Angelicae Sinensis, Radix Clematidis, Cortex Cinnamomi, Herba Lycopodii, Caulis Spatholobi, Herba Taxilli, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Semen Strychni (processed) is taken on request, through 6kGy dosage
60co-gamma-ray irradiation is sterilized.
(2) take Radix Notoginseng on request, Fructus Gardeniae, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, Hong Shengyi, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos adopt 20W low-ozone straight tube ultraviolet disinfection lamp process 2 hours, medical material after processing with (1) after process mixes, and obtains mixing medical material.
(3) 60 minutes are decocted by adding mixing medical material 9 times amount pure water in Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, then Radix Angelicae Sinensis, Radix Clematidis, Cortex Cinnamomi, Herba Lycopodii, Caulis Spatholobi, Herba Taxilli, Semen Strychni (processed), Radix Notoginseng, Fructus Gardeniae, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, Hong Shengyi, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos is added, continue decoction 30 minutes, 30 minutes are decocted again after being cooled to room temperature, be cooled to room temperature, filter, obtain filtrate.
(4) being become by filtrate reduced in volume in (3) 60 DEG C of mensuration relative densities is the thick paste of 1.35, and vacuum drying, pulverize, sieve the fine powder 59.25Kg obtaining 25 μm.
(5) fine powder obtained in (4) is added Cera Flava, hydrogenated palm oil, soybean phospholipid fully stir, mix homogeneously with diclofenac sodium, aspirin, phenacetin, leave standstill, evacuation, treat that in medicinal liquid, bubble is removed substantially, with the glue pelleting changed, every dress 400mg compacting, is total to obtain 200000.
Embodiment 4
Raw material forms: (unit: Kg)
Radix Angelicae Sinensis 12.5, Radix Clematidis 12.5, Cortex Cinnamomi 12.5, Herba Lycopodii 30, Caulis Spatholobi 30, Herba Taxilli 30, Radix Aconiti Preparata 4.5, Radix Aconiti Kusnezoffii Preparata 4.5, Semen Strychni (processed) 2.5, Radix Notoginseng 45, Fructus Gardeniae 45, Flos Carthami 30, Fructus Lycii 13.5, Rhizoma Chuanxiong 4.5, Radix Salviae Miltiorrhizae 4.5, Herba Lycopi 2.5, Semen Vaccariae 3, Semen Impatientis 4.5, Herba Artemisiae Anomalae 4.5, the Pseudobulbus Bletillae (Rhizoma Bletillae) 2.5, Cacumen Platycladi 3, Folium Artemisiae Argyi 4.5, Pollen Typhae 4.5, red-face role's clothing 2.5, Herba Selaginellae 3, Flos Sophorae 4.5, the Fructus Sophorae 4.5, Flos Camelliae Japonicae 2.5, Radix Sanguisorbae 3, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae) 4.5, Herba Orostachyos 3, diclofenac sodium 0.2, aspirin 0.2, phenacetin 0.2.
Preparation method is as follows:
(1) Radix Angelicae Sinensis, Radix Clematidis, Cortex Cinnamomi, Herba Lycopodii, Caulis Spatholobi, Herba Taxilli, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Semen Strychni (processed) is taken on request, through 6kGy dosage
60co-gamma-ray irradiation is sterilized.
(2) Radix Notoginseng, Fructus Gardeniae, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, Hong Shengyi, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos 20W low-ozone straight tube ultraviolet disinfection lamp process 2 hours is taken on request, medical material after processing with (1) after process mixes, and obtains mixing medical material.
(3) 60 minutes are decocted by adding mixing medical material 9 times amount pure water in Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, then Radix Angelicae Sinensis, Radix Clematidis, Cortex Cinnamomi, Herba Lycopodii, Caulis Spatholobi, Herba Taxilli, Semen Strychni (processed), Radix Notoginseng, Fructus Gardeniae, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, Hong Shengyi, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos is added, continue decoction 30 minutes, 30 minutes are decocted again after being cooled to room temperature, be cooled to room temperature, filter, obtain filtrate.
(4) being become by filtrate reduced in volume in (3) 58 DEG C of mensuration relative densities is the clear paste of 1.07, and spraying dry, sieve the fine powder 50.7Kg obtaining 23 μm.
(5) fine powder obtained in (4) is added calcium phosphate and calcium hydrogen phosphate appropriate, mix homogeneously with diclofenac sodium, aspirin, phenacetin, add 78% appropriate amount of ethanol and make granule, drying, granulate, incapsulates, every 350mg, is total to obtain 145000.
In conjunction with the various embodiments described above, medicine of the present invention pharmaceutically acceptable adjuvant comprises: diluent, binding agent, disintegrating agent, lubricant and correctives, be specially: 1, the optional starch of diluent, Icing Sugar, dextrin, lactose, pregelatinized Starch, microcrystalline cellulose, inorganic calcium salt (as calcium sulfate, calcium hydrogen phosphate, medicinal calcium carbonate etc.), mannitol etc., vegetable oil, Polyethylene Glycol etc.; 2, the optional distilled water of binding agent, ethanol, starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose and ethyl cellulose, hypromellose etc.; 3, the optional dried starch of disintegrating agent, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose etc.; 4, the optional magnesium stearate of lubricant, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, polyethylene glycols, magnesium laurylsulfate etc.; 5, the optional citric acid of correctives, sucrose etc.
Following experimental example 1,2 is the pharmacodynamics test of medicine provided by the invention (medicine prepared for embodiment 2), wherein:
Given the test agent: medicine (physical behavior: dark brown powder) prepared by embodiment 2, slowly soaks molten with 50 DEG C of distilled water, until by mouse stomach device, and obtained solution;
Blank medicine: 0.9% sodium chloride sterile solution for injection (specification: 250ml/ bottle, physical behavior: colourless transparent liquid), purchased from Jingxi district, Xi'an company limited of Double-Crane Pharmaceutical Co., Ltd, the accurate word H20023017 of traditional Chinese medicines, product batch number 2013011.
Bacterial suspension: after staphylococcus aureus, escherichia coli, streptococcus agalactiae broth bouillon are cultivated 18 hours, getting 100 μ l is spread evenly across on flat board, cultivate scraping lawn after 18 hours for 37 DEG C, be dissolved in sterile saline, the centrifugal 20min of 2500r/min, after continuous three times, bacterial precipitation is dissolved in sterile saline, makes 106CFU/ml bacterial suspension, mix three kinds of bacteria suspensions.
Animal subject is healthy kunming mouse (body weight 18 ~ 42g), all hands over large medical college experimental animal center purchased from Xi'an, occupancy permit SYXK (Shan) 2009-004.Before and after administration, freely drink water, room temperature 20 DEG C ~ 25 DEG C, laboratory relative humidity 50% ~ 70%.
During test, control room temperature: 20 ~ 22 DEG C, relative humidity: 60% ~ 70%.
Test kit: TNF-α is purchased from Xi Tang bio tech ltd, Shanghai; NAGase builds up Bioengineering Research Institute purchased from Nanjing.
experimental example 1
The antiinflammatory action of medicine of the present invention
The present embodiment has investigated the antiinflammatory action of medicine xylol induced mice auricle edema prepared by embodiment 2.
By animal subject healthy mice 66, be divided into 6 groups at random by body weight, that is: blank group (normal saline 0.2ml/10g); The basic, normal, high dosage group of embodiment 2 medicine (1,2,3g/kg); Positive controls I and II (respectively gavage positive control medicine I and II, 1.0g/kg).
Medication and process: by above-mentioned dosage to animal subject gastric infusion, successive administration 7 days, every day 1 time, volume is 20ml/kg; After last administration 1 hour, animal subject etherization, at the front and back two sided coatings proinflammatory agent dimethylbenzene of auris dextra, every mice 0.02ml, left ear did not do any process.After 4 hours, by sacrifice of animal, cut ears 8mm diameter card punch and lay round auricle at same position respectively, scales/electronic balance weighing.
Swelling computing formula: swelling=auris dextra sheet weight-left auricle weight
Table 1 xylol induced mice auricle edema affect result (x ± SD)
Note: * representative is compared with blank group, significant difference, p < 0.05.
From table 1 result, the basic, normal, high dosage of medicine prepared by embodiment 2 has the significance difference opposite sex (p<0.05) to mice auricle swelling compared with normal saline.Experimental result shows: medicine of the present invention has significant antiinflammatory action.
experimental example 2the antibacterial action of medicine of the present invention
The present embodiment has investigated the medicine of embodiment 2 preparation to the therapeutical effect of antibacterial induced mice wound inflammation.
The mice of the 10th day 45 points of age of sucking in puerperium is divided into 5 groups at random, often organizes 9.First group is model group, within first 5 days, does not do any process, and within the 6th day, every mouse thymus injection 0.05ml concentration is 106CFU/ml bacterial suspension; Second group is treatment group, and every mice takes the medicine of embodiment 2 preparation, every day 2 times, each 0.3ml/10g, gavage process, successive administration 5 days, and the 6th day every mice the 4th pair of thymus injection 0.05ml concentration is 106CFU/ml bacterial suspension.3rd group is blank group, is left intact.
After thymus bacterial injection suspension 12 hours, according to following standard naked-eye observation curative effect.
Effective: infected area is red, swollen, heat obviously disappears; Wherein criterion of cure is that infected area is red, swollen, hot, pain disappears, and muscle perusal is normal.
Invalid: infected area is red, swollen, hot, pain is still without obviously alleviating phenomenon; Or animal dead.
Mouse orbit sacrificed by exsanguination subsequently, blood leaves standstill the centrifugal 20min of 2500r/min after 2h, and separation of serum, with kit measurement TNF-alpha content and NAGase vigor.Open abdominal cavity, be separated infected area tissue, tissue 10% neutral formalin in infected area is fixed, for pathological section; And infected area tissue is weighed, normal saline is added by 1:9 (W/V), ice bath homogenate, aseptic part 10% homogenate of getting does count of bacteria, separately get the centrifugal 40min of partial homogenate liquid 2500r/min, supernatant normal saline dilution becomes 1% homogenate, with kit measurement TNF-alpha content and NAGase vigor.
Table 2 is group mice cure rate, effective percentage, inefficiency and mortality rate (%) respectively
Note: * * representative is compared with model group, difference is extremely remarkable, p < 0.01.
As can be seen from Table 2, treatment group effective percentage is 89%, and cure rate is 78%, compares have extremely significant diversity with model group.
TNF-alpha content (x ± SD) in table 3 infected area tissue and serum
Note: compared with blank group mice, it is extremely remarkable that * * represents difference, p < 0.01; Compared with model group mice, it is extremely remarkable that b represents difference, p < 0.01.
From table 3 result, model group is compared with blank group, TNF-alpha levels in mouse infection district tissue significantly improves (p < 0.01), illustrate that infected area tissue bacterial infections causes TNF-alpha levels in the mammary gland tissue of infection significantly to raise, and the TNF-alpha levels in serum slightly raises.Treatment group compares with model group, and the TNF-alpha levels in the tissue of infected area obviously reduces (p < 0.01), and the TNF-alpha levels in serum slightly reduces, close to blank group.Visible medicine of the present invention effectively can reverse the change of the TNF-alpha levels caused because of bacteriological infection, thus can suppress the inflammatory reaction of the infected area tissue infected, and minimizing is oozed out.
NAGase vigor (x ± SD) in table 4 mammary gland tissue and serum
Note: compared with control group mice, it is extremely remarkable that * * represents difference, p < 0.01; Compared with model group mice, it is extremely remarkable that b represents difference, p < 0.01.
From table 4 result, model group is compared with blank group, mouse infection district tissue and serum in NAGase vigor all there is the pole significance difference opposite sex (p < 0.01), illustrate that infected area tissue bacterial infections causes the remarkable rising of NAGase vigor in the infected area tissue of infection, and the NAGase vigor in serum reduces.Treatment group compares with model group, and the NAGase vigor in the tissue of infected area obviously reduces (p < 0.01), and the NAGase vigor in serum obviously raises (p < 0.01).Visible medicine of the present invention effectively can reverse the change of the NAGase vigor caused because of bacteriological infection.
Consolidated statement 2 ~ 4 result is visible, and medicine of the present invention effectively can reduce NAGase vigor in the mouse infection district tissue caused because of bacteriological infection and TNF-alpha levels, has good therapeutic effect for the inflammatory reaction in the tissue of infected area.
In a word, compared with the prior art, medicine of the present invention, prescription is simplified, but the effect that there is remarkable blood circulation promoting and blood stasis dispelling, effectively prevent slough from causing inflammation, have good curative effect to each rheumatoid osteopathia, and safety is better, preparation method is simpler.
These are only the preferred embodiment of invention, be not limited to invention, for a person skilled in the art, invention can have various modifications and variations.Within all spirit in invention and principle, any amendment done, equivalent replacement, improvement etc., within the protection domain that all should be included in invention.
Claims (10)
1. treat a medicine for rheumatic osteopathia, it is characterized in that, described medicine comprises Chinese medicine composition and Western medicine compound, and described medicine is after Chinese medicine composition extracts preparation and Western medicine compound is mixed, and described Chinese medicine composition comprises: Radix Angelicae Sinensis, Radix Clematidis, Cortex Cinnamomi, Herba Lycopodii, Caulis Spatholobi, Herba Taxilli, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Semen Strychni (processed), Radix Notoginseng, Fructus Gardeniae, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, red-face role's clothing, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos, described Chinese medicine composition needs through sterilizing process before extraction, and described sterilizing method is that the sterilization of Co60 radiation sterilizing is combined with ultraviolet irradiation sterilizing, described Radix Angelicae Sinensis, Radix Clematidis, Cortex Cinnamomi, Herba Lycopodii, Caulis Spatholobi, Herba Taxilli, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Semen Strychni (processed) adopts the sterilization of Co60 radiation sterilizing, described Radix Notoginseng, Fructus Gardeniae, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, red-face role's clothing, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos adopts ultraviolet irradiation sterilizing, and described Western medicine compound comprises: diclofenac sodium, aspirin, phenacetin, described Chinese medicine composition is made up of following weight parts: Radix Angelicae Sinensis 10 parts ~ 15 parts, Radix Clematidis 10 parts ~ 15 parts, Cortex Cinnamomi 10 parts ~ 15 parts, Herba Lycopodii 25 parts ~ 35 parts, Caulis Spatholobi 25 parts ~ 35 parts, Herba Taxilli 25 parts ~ 35 parts, Radix Aconiti Preparata 4 parts ~ 5 parts, Radix Aconiti Kusnezoffii Preparata 4 parts ~ 5 parts, Semen Strychni (processed) 2 parts ~ 3 parts, Radix Notoginseng 40 parts ~ 50 parts, Fructus Gardeniae 40 parts ~ 50 parts, 25 parts ~ 35 parts, Flos Carthami, Fructus Lycii 10 parts ~ 15 parts, Rhizoma Chuanxiong 4 parts ~ 5 parts, Radix Salviae Miltiorrhizae 4 parts ~ 5 parts, Herba Lycopi 2 parts ~ 3 parts, Semen Vaccariae 1 part ~ 5 parts, Semen Impatientis 4 parts ~ 5 parts, Herba Artemisiae Anomalae 4 parts ~ 5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 2 parts ~ 3 parts, Cacumen Platycladi 1 part ~ 5 parts, Folium Artemisiae Argyi 4 parts ~ 5 parts, Pollen Typhae 4 parts ~ 5 parts, 2 parts ~ 3 parts, red-face role's clothing, Herba Selaginellae 1 part ~ 5 parts, 4 parts ~ 5 parts, Flos Sophorae, the Fructus Sophorae 4 parts ~ 5 parts, Flos Camelliae Japonicae 2 parts ~ 3 parts, Radix Sanguisorbae 1 part ~ 5 parts, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae) 4 parts ~ 5 parts, Herba Orostachyos 1 part ~ 5 parts.
2. medicine according to claim 1, is characterized in that, described Co60 radiation sterilizing sterilization is: 6kGy dosage
60co-gamma-ray irradiation is sterilized.
3. medicine according to claim 1, is characterized in that, described ultraviolet irradiation sterilizing is: with 20W low-ozone straight tube ultraviolet disinfection lamp process 2 hours.
4. medicine according to claim 1, is characterized in that, described Western medicine compound comprises by weight: diclofenac sodium 0.1 part ~ 0.3 part, aspirin 0.1 part ~ 0.3 part, phenacetin 0.1 part ~ 0.3 part.
5. medicine according to claim 4, is characterized in that, described Western medicine compound comprises by weight: diclofenac sodium 0.1 part, aspirin 0.2 part, phenacetin 0.3 part.
6. medicine according to claim 1, it is characterized in that, described Chinese medicine composition is made up of following weight parts: Radix Angelicae Sinensis 15 parts, Radix Clematidis 15 parts, Cortex Cinnamomi 10 parts, Herba Lycopodii 30 parts, Caulis Spatholobi 30 parts, Herba Taxilli 30 parts, Radix Aconiti Preparata 5 parts, Radix Aconiti Kusnezoffii Preparata 5 parts, Semen Strychni (processed) 3 parts, Radix Notoginseng 45 parts, Fructus Gardeniae 45 parts, 30 parts, Flos Carthami, Fructus Lycii 13.5 parts, Rhizoma Chuanxiong 4 parts, Radix Salviae Miltiorrhizae 4 parts, Herba Lycopi 2 parts, Semen Vaccariae 1 part, Semen Impatientis 5 parts, Herba Artemisiae Anomalae 4 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 2.5 parts, Cacumen Platycladi 1 part, Folium Artemisiae Argyi 4.5 parts, Pollen Typhae 5 parts, 2 parts, red-face role's clothing, Herba Selaginellae 1 part, 4.5 parts, Flos Sophorae, the Fructus Sophorae 4.5 parts, Flos Camelliae Japonicae 2.5 parts, Radix Sanguisorbae 1.5 parts, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae) 4.5 parts, Herba Orostachyos 1.5 parts.
7. a preparation method for the medicine of the treatment rheumatic osteopathia according to any one of claim 1 to 6, is characterized in that, comprise the following steps:
Step S01: take Radix Angelicae Sinensis, Radix Clematidis, Cortex Cinnamomi, Herba Lycopodii, Caulis Spatholobi, Herba Taxilli, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Semen Strychni (processed) on request, sterilizes through Co60 radiation sterilizing;
Step S02: take Radix Notoginseng, Fructus Gardeniae, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, Hong Shengyi, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos employing ultraviolet irradiation sterilizing on request, mix with the medical material after step S01 process after process, obtain mixing medical material;
Step S03: decoct 60 minutes by adding mixing medical material 8 times ~ 12 times amount pure water in Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, then Radix Angelicae Sinensis, Radix Clematidis, Cortex Cinnamomi, Herba Lycopodii, Caulis Spatholobi, Herba Taxilli, Semen Strychni (processed), Radix Notoginseng, Fructus Gardeniae, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Vaccariae, Semen Impatientis, Herba Artemisiae Anomalae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Pollen Typhae, Hong Shengyi, Herba Selaginellae, Flos Sophorae, the Fructus Sophorae, Flos Camelliae Japonicae, Radix Sanguisorbae, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Herba Orostachyos is added, continue decoction 30 minutes, 30 minutes are decocted again after being cooled to room temperature, be cooled to room temperature, filter, obtain filtrate;
Step S04: the filtrate reduced in volume of step S03 is become clear paste, is spray dried to fine powder; Or concentrating under reduced pressure becomes thick paste, after vacuum drying, be ground into fine powder;
Step S05: by the fine powder of step S04 and Western medicine compound mixing, obtain mixed powder;
Step S06: the mixed powder of step S05 is added adjuvant and granulates, make required granule, or pill, or soft capsule, or capsule, or tablet.
8. preparation method according to claim 7, is characterized in that, in step S04, described clear paste is: 55 DEG C ~ 60 DEG C time, measure relative density is the clear paste of 1.00 ~ 1.10.
9. preparation method according to claim 7, is characterized in that, in step S04, described thick paste is: 55 DEG C ~ 60 DEG C time, measure relative density is the thick paste of 1.30 ~ 1.38.
10. preparation method according to claim 7, is characterized in that, in step S04, the particle diameter of described fine powder is: 15 μm ~ 25 μm.
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Application publication date: 20150819 |