CN104837507B - 检测真菌细胞的方法 - Google Patents

检测真菌细胞的方法 Download PDF

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Publication number
CN104837507B
CN104837507B CN201380036385.0A CN201380036385A CN104837507B CN 104837507 B CN104837507 B CN 104837507B CN 201380036385 A CN201380036385 A CN 201380036385A CN 104837507 B CN104837507 B CN 104837507B
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CN
China
Prior art keywords
targeting agent
ddao
antifungal
candida
caspofungin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201380036385.0A
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English (en)
Chinese (zh)
Other versions
CN104837507A (zh
Inventor
戴维·S·珀林
吉勒莫·加西亚-埃夫隆
阿卡迪·穆斯塔耶夫
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Rutgers State University of New Jersey
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Rutgers State University of New Jersey
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Publication of CN104837507A publication Critical patent/CN104837507A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0026—Acridine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
CN201380036385.0A 2012-05-08 2013-05-08 检测真菌细胞的方法 Expired - Fee Related CN104837507B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261644283P 2012-05-08 2012-05-08
US61/644,283 2012-05-08
PCT/US2013/040182 WO2013169932A2 (en) 2012-05-08 2013-05-08 Methods to detect a fungal cell

Publications (2)

Publication Number Publication Date
CN104837507A CN104837507A (zh) 2015-08-12
CN104837507B true CN104837507B (zh) 2018-09-04

Family

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Family Applications (1)

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CN201380036385.0A Expired - Fee Related CN104837507B (zh) 2012-05-08 2013-05-08 检测真菌细胞的方法

Country Status (7)

Country Link
US (1) US20150098905A1 (enExample)
EP (1) EP2846840A4 (enExample)
CN (1) CN104837507B (enExample)
AU (1) AU2013259519B2 (enExample)
CA (1) CA2874547A1 (enExample)
IN (1) IN2014KN02745A (enExample)
WO (1) WO2013169932A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014182927A1 (en) * 2013-05-08 2014-11-13 Rutgers, The State University Of New Jersey Near infrared label and methods of use thereof
US9700638B2 (en) 2012-05-08 2017-07-11 Rutgers, The State University Of New Jersey Near infrared label and methods of use thereof
CN104971357B (zh) * 2015-03-20 2018-04-17 南京星银药业集团有限公司 Peg修饰的棘白菌素类抗真菌药物复合物及其制备
WO2022038595A1 (en) * 2020-08-17 2022-02-24 Ramot At Tel Aviv University Ltd. Caspofungin derivatives and assays for evaluating antifungal treatment efficacy
GB202109478D0 (en) * 2021-06-30 2021-08-11 Univ Manchester Compounds and methods
CN119684270A (zh) * 2024-12-25 2025-03-25 大连理工大学 一种快速响应的镉离子长波长荧光探针及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003036299A2 (en) * 2001-10-18 2003-05-01 Gesellschaft für Biotechnologische Forschung mbH Procedure for quantitative determination of viral or bacterial particles having a cholesterol-containing envelope

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810636A (en) * 1986-12-09 1989-03-07 Miles Inc. Chromogenic acridinone enzyme substrates
US20050187161A1 (en) * 2003-09-12 2005-08-25 Board Of Regents, The University Of Texas System Biopanning as an approach to study the pathogenesis of and produce novel treatment modalities for invasive Aspergillosis
FR2888938B1 (fr) * 2005-07-21 2013-09-27 Commissariat Energie Atomique Substrats fluorescents saccharidiques, leur procede de preparation et leurs utilisations
JP5240704B2 (ja) * 2007-10-05 2013-07-17 国立大学法人群馬大学 新規蛍光化合物およびそれを用いた細胞内コレステロールの検出方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003036299A2 (en) * 2001-10-18 2003-05-01 Gesellschaft für Biotechnologische Forschung mbH Procedure for quantitative determination of viral or bacterial particles having a cholesterol-containing envelope

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Antonella Lupetti et al..Technetium-99m labelled fluconazole and antimicrobial peptides for imaging of Candida albicans and Aspergillus fumigatus infections.《European Journal of Nuclear Medicine》.2002,第29卷(第5期), *
Technetium-99m labelled fluconazole and antimicrobial peptides for imaging of Candida albicans and Aspergillus fumigatus infections;Antonella Lupetti et al.;《European Journal of Nuclear Medicine》;20020306;第29卷(第5期);第674-679页 *

Also Published As

Publication number Publication date
CA2874547A1 (en) 2013-11-14
US20150098905A1 (en) 2015-04-09
IN2014KN02745A (enExample) 2015-05-08
AU2013259519B2 (en) 2017-07-13
EP2846840A4 (en) 2015-12-30
WO2013169932A2 (en) 2013-11-14
CN104837507A (zh) 2015-08-12
AU2013259519A1 (en) 2014-12-04
EP2846840A2 (en) 2015-03-18
WO2013169932A3 (en) 2014-01-03

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Granted publication date: 20180904