CN104803665B - Anti-aging aluminum oxide ceramic and preparation method thereof - Google Patents
Anti-aging aluminum oxide ceramic and preparation method thereof Download PDFInfo
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- CN104803665B CN104803665B CN201510145003.9A CN201510145003A CN104803665B CN 104803665 B CN104803665 B CN 104803665B CN 201510145003 A CN201510145003 A CN 201510145003A CN 104803665 B CN104803665 B CN 104803665B
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- aluminium oxide
- hydroxyapatite
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- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 title abstract 4
- 230000003712 anti-aging effect Effects 0.000 title abstract 2
- 239000011224 oxide ceramic Substances 0.000 title abstract 2
- 229910052574 oxide ceramic Inorganic materials 0.000 title abstract 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 40
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 230000032683 aging Effects 0.000 claims abstract description 25
- 239000000919 ceramic Substances 0.000 claims abstract description 22
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 20
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 20
- -1 polybutylene succinate Polymers 0.000 claims abstract description 20
- 239000011787 zinc oxide Substances 0.000 claims abstract description 20
- 229920002961 polybutylene succinate Polymers 0.000 claims abstract description 19
- 239000004631 polybutylene succinate Substances 0.000 claims abstract description 19
- 229910000480 nickel oxide Inorganic materials 0.000 claims abstract description 14
- GNRSAWUEBMWBQH-UHFFFAOYSA-N oxonickel Chemical compound [Ni]=O GNRSAWUEBMWBQH-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 14
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 12
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000005751 Copper oxide Substances 0.000 claims abstract description 9
- 229910000431 copper oxide Inorganic materials 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 7
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 96
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 229910052756 noble gas Inorganic materials 0.000 claims description 6
- 150000002835 noble gases Chemical class 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 229910052698 phosphorus Inorganic materials 0.000 claims description 6
- 229910052786 argon Inorganic materials 0.000 claims description 5
- 239000011521 glass Substances 0.000 abstract description 5
- 238000005245 sintering Methods 0.000 abstract description 4
- 238000006243 chemical reaction Methods 0.000 abstract description 2
- 238000002425 crystallisation Methods 0.000 abstract description 2
- 230000008025 crystallization Effects 0.000 abstract description 2
- 239000011261 inert gas Substances 0.000 abstract 2
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 5
- 229910052802 copper Inorganic materials 0.000 description 5
- 239000010949 copper Substances 0.000 description 5
- 239000003462 bioceramic Substances 0.000 description 4
- 210000000988 bone and bone Anatomy 0.000 description 4
- 239000012620 biological material Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 229910052586 apatite Inorganic materials 0.000 description 1
- 239000011173 biocomposite Substances 0.000 description 1
- 230000033558 biomineral tissue development Effects 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- NKCVNYJQLIWBHK-UHFFFAOYSA-N carbonodiperoxoic acid Chemical compound OOC(=O)OO NKCVNYJQLIWBHK-UHFFFAOYSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 229920001083 polybutene Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012890 simulated body fluid Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical class OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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- Materials For Medical Uses (AREA)
- Compositions Of Oxide Ceramics (AREA)
Abstract
The invention discloses anti-aging aluminum oxide ceramic and a preparation method thereof. The ceramic comprises raw materials in parts by weight as follows: 80-140 parts of aluminum oxide, 10-20 parts of zinc oxide, 1-6 parts of silicon dioxide, 10-20 parts of copper oxide, 10-40 parts of nickel oxide, 10-20 parts of hydroxyapatite and 10-20 parts of polybutylene succinate. The preparation method comprises the following steps: aluminum oxide, zinc oxide, silicon dioxide, copper oxide, nickel oxide, hydroxyapatite and polybutylene succinate are added to a reaction still, an inert gas is introduced, and the mixture reacts for 3-4 h at the temperature of 1,000-1,500 DEG C and is cooled naturally. The inert gas is adopted to serve as a sintering atmosphere, a glass phase can be prevented from being generated in a crystallization position, and the glass phase is prevented from degradation and ageing in a body.
Description
Technical field
The present invention relates to biological technical field, more particularly, to a kind of ageing-resistant aluminium oxide ceramics and preparation method thereof.
Background technology
Biomaterial, including bio-vitric, bioceramic, Biocomposite material, biological coating etc., is that a class can be to skin group
Knit and repair through row, substitute and regeneration, there is the material of specific function.Because it has higher biological activity, biocompatibility
And chemical stability, research in recent years is very active.At present, increasing bioceramic is used for the displacement of tissue.
Bone Defect Repari is perplexed by materialogy always, relates generally to robustness and its biological compatibility of material.Bioceramic is a class
The biomaterial of function admirable, it has good biological activity and biocompatibility.By the circulation of body fluid, bioceramic,
Close ion exchange is there is, this ion exchange has led to mineralization, ultimately formed hydroxy carbonate between soft tissue and bone
Salt apatite layer, it can induce Bone Defect Repari and regeneration as the mineral form of normal bone tissues.Biomaterial each side
Performance is all good, but easily aging become fragile, have undesirable effect.
Content of the invention
The present invention is directed to the deficiencies in the prior art, provides a kind of ageing-resistant aluminium oxide ceramics and preparation method thereof, ageing-resistant performance is good,
Character can be kept steady in a long-term.
The present invention employs the following technical solutions：
Ageing-resistant aluminium oxide ceramics, including the raw material of following weight portion meter：80～140 parts of aluminium oxide, 10～20 parts of zinc oxide,
Silica 1～6 part, 10～20 parts of copper oxide, 10～40 parts of nickel oxide, 10～20 parts of hydroxyapatite, polybutene amber
10～20 parts of amber acid esters.
Preferably, the particle diameter of zinc oxide is 100-300nm.
Preferably, the ratio of Ca and P is 1.67 in hydroxyapatite：1.
Preferably, the relative molecular mass of polybutylene succinate is 10000～60000.
The preparation method of above-mentioned ageing-resistant aluminium oxide ceramics, comprises the following steps：By aluminium oxide, zinc oxide, silicon dioxide, oxygen
Change copper, nickel oxide, hydroxyapatite, polybutylene succinate add in reactor, are filled with noble gases, 1000～1500
DEG C reaction 3～4h, natural cooling, you can.
Preferably, noble gases are nitrogen or argon.
The present invention adopts noble gases as sintering atmosphere, can prevent glass phase at crystallization, it is to avoid glass is mutually in vivo
Occur degraded aging.
Specific embodiment
With reference to specific embodiment, the present invention is further described in detail.
Embodiment 1
Ageing-resistant aluminium oxide ceramics, including the raw material of following weight portion meter：80 parts of aluminium oxide, 10 parts of zinc oxide, silicon dioxide
1 part, 10 parts of copper oxide, 10 parts of nickel oxide, 10 parts of hydroxyapatite, 10 parts of polybutylene succinate.
The particle diameter of zinc oxide is 100nm.
In hydroxyapatite, the ratio of Ca and P is 1.67：1.
The relative molecular mass of polybutylene succinate is 10000.
The preparation method of above-mentioned ageing-resistant aluminium oxide ceramics, comprises the following steps：By aluminium oxide, zinc oxide, silicon dioxide, oxygen
Change copper, nickel oxide, hydroxyapatite, polybutylene succinate add in reactor, are filled with nitrogen, react 3h at 1000 DEG C,
Natural cooling, you can.
Embodiment 2
Ageing-resistant aluminium oxide ceramics, including the raw material of following weight portion meter：140 parts of aluminium oxide, 20 parts of zinc oxide, silicon dioxide
6 parts, 20 parts of copper oxide, 40 parts of nickel oxide, 20 parts of hydroxyapatite, 20 parts of polybutylene succinate.
The particle diameter of zinc oxide is 300nm.
In hydroxyapatite, the ratio of Ca and P is 1.67：1.
The relative molecular mass of polybutylene succinate is 60000.
The preparation method of above-mentioned ageing-resistant aluminium oxide ceramics, comprises the following steps：By aluminium oxide, zinc oxide, silicon dioxide, oxygen
Change copper, nickel oxide, hydroxyapatite, polybutylene succinate add in reactor, are filled with nitrogen or argon, anti-at 1500 DEG C
Answer 4h, natural cooling, you can.
Embodiment 3
Ageing-resistant aluminium oxide ceramics, including the raw material of following weight portion meter：100 parts of aluminium oxide, 15 parts of zinc oxide, silicon dioxide
4 parts, 15 parts of copper oxide, 30 parts of nickel oxide, 15 parts of hydroxyapatite, 15 parts of polybutylene succinate.
The particle diameter of zinc oxide is 200nm.
In hydroxyapatite, the ratio of Ca and P is 1.67：1.
The relative molecular mass of polybutylene succinate is 40000.
The preparation method of above-mentioned ageing-resistant aluminium oxide ceramics, comprises the following steps：By aluminium oxide, zinc oxide, silicon dioxide, oxygen
Change copper, nickel oxide, hydroxyapatite, polybutylene succinate add in reactor, are filled with nitrogen or argon, anti-at 1200 DEG C
Answer 3.5h, natural cooling, you can.
Embodiment 4
Ageing-resistant aluminium oxide ceramics, including the raw material of following weight portion meter：130 parts of aluminium oxide, 12 parts of zinc oxide, silicon dioxide
2 parts, 12 parts of copper oxide, 20 parts of nickel oxide, 12 parts of hydroxyapatite, 18 parts of polybutylene succinate.
The particle diameter of zinc oxide is 230nm.
In hydroxyapatite, the ratio of Ca and P is 1.67：1.
The relative molecular mass of polybutylene succinate is 40000.
The preparation method of above-mentioned ageing-resistant aluminium oxide ceramics, comprises the following steps：By aluminium oxide, zinc oxide, silicon dioxide, oxygen
Change copper, nickel oxide, hydroxyapatite, polybutylene succinate add in reactor, are filled with nitrogen or argon, anti-at 1200 DEG C
Answer 3.4h, natural cooling, you can.
Comparative example 1
Same as Example 1, difference is：It is not filled with noble gases to be sintered, use air as sintering atmosphere.
Performance test
The pottery of the aluminium oxide ceramics of comparative example 1 and embodiment 1～4 is placed on after soaking 30 days in simulated body fluid, observes pottery
Surface.The Surface Edge embrittlement of comparative example 1 is yellow, and the ceramic surface of embodiment 1～4 is all unchanged.
Illustrate that the present invention has good ageing-resistant performance, this is because low oxygen pressure can reduce generation glass in sintering process
Phase, prevents from degrading aging.
The wherein several specific embodiments being only the application disclosed above, but the application is not limited to this, any this area
What technical staff can think change, all should fall in the protection domain of the application.
Claims (6)
1. ageing-resistant aluminium oxide ceramics are it is characterised in that include the raw material of following weight portion meter：80～140 parts of aluminium oxide, 10～20 parts of zinc oxide, silica 1～6 part, 10～20 parts of copper oxide, 10～40 parts of nickel oxide, 10～20 parts of hydroxyapatite, 10～20 parts of polybutylene succinate.
2. ageing-resistant aluminium oxide ceramics according to claim 1 are it is characterised in that the particle diameter of zinc oxide is 100-300nm.
3. ageing-resistant aluminium oxide ceramics according to claim 1 it is characterised in that in hydroxyapatite Ca and P ratio be 1.67：1.
4. ageing-resistant aluminium oxide ceramics according to claim 1 are it is characterised in that the relative molecular mass of polybutylene succinate is 10000～60000.
5. the preparation method based on the ageing-resistant aluminium oxide ceramics described in claim 1 is it is characterised in that comprise the following steps：Aluminium oxide, zinc oxide, silicon dioxide, copper oxide, nickel oxide, hydroxyapatite, polybutylene succinate are added in reactor, are filled with noble gases, react 3～4h, natural cooling at 1000～1500 DEG C, you can.
6. the preparation method of ageing-resistant aluminium oxide ceramics according to claim 5 is it is characterised in that noble gases are nitrogen or argon.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510145003.9A CN104803665B (en) | 2015-03-31 | 2015-03-31 | Anti-aging aluminum oxide ceramic and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510145003.9A CN104803665B (en) | 2015-03-31 | 2015-03-31 | Anti-aging aluminum oxide ceramic and preparation method thereof |
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| CN104803665B true CN104803665B (en) | 2017-02-08 |
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| C41 | Transfer of patent application or patent right or utility model | ||
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Inventor after: Qiu Caijun Inventor before: Pan Lingen Inventor before: Liu Daxue Inventor before: Guo Yuqin |
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Effective date of registration: 20160905 Address after: 312400, Zhejiang Province, Shaoxing City, Shengzhou Province town, Keng Keng Village, Jin Heng 68 Applicant after: Shengzhou Bona Hardware Machinery Plant Address before: Wuzhong District town Suzhou city Jiangsu province 215101 gold Jinchang Road No. 360 Applicant before: Suzhou Vivotide Biotechnologies Co., Ltd. |
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Effective date of registration: 20181108 Address after: 313009 286, Shuikou Town, Shuikou village, Nanxun Town, Huzhou City, Zhejiang Patentee after: Zhejiang Hanguang Environmental Protection Technology Co., Ltd. Address before: 312400 Zhejiang, Shaoxing, Shengzhou, Gan Lin Town, small Hang Village, Jin Heng No. 68 Patentee before: Shengzhou Bona Hardware Machinery Plant |
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Effective date of registration: 20190418 Address after: 362599 Pengxiang Industrial Zone, Longxun Town, Dehua County, Quanzhou City, Fujian Province Patentee after: Fujian Dehua Chengyi Ceramics Co.,Ltd. Address before: 313009 286, Shuikou Town, Shuikou village, Nanxun Town, Huzhou City, Zhejiang Patentee before: Zhejiang Hanguang Environmental Protection Technology Co., Ltd. |