CN104801511B - Ex-situ cleaning process and clean-in-place system - Google Patents
Ex-situ cleaning process and clean-in-place system Download PDFInfo
- Publication number
- CN104801511B CN104801511B CN201410037559.1A CN201410037559A CN104801511B CN 104801511 B CN104801511 B CN 104801511B CN 201410037559 A CN201410037559 A CN 201410037559A CN 104801511 B CN104801511 B CN 104801511B
- Authority
- CN
- China
- Prior art keywords
- cleaning
- fluorescence
- milk
- clean
- cleaning solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/08—Cleaning involving contact with liquid the liquid having chemical or dissolving effect
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Dairy Products (AREA)
- Cleaning In General (AREA)
Abstract
The present invention relates to a kind of clean-in-place systems of the ex-situ cleaning process for milk-contained drink production equipment and the production equipment for milk-contained drink.Using the ex-situ cleaning process and system of the present invention, does not have to add any allogenic material, the amount of dirt in cleaning process is directly tracked, so as to control in time cleaning process.
Description
Technical field
The present invention relates to a kind of ex-situ cleaning process for milk-contained drink production equipment and for the production of milk-contained drink
The clean-in-place system of equipment.
Background technology
Milk is liked due to it is rich in nutritional ingredient by people.The main component of milk is water, remaining for solid at
Point, including protein, lactose, minerals and fat.But also therefore, the difficult storage of milk easily corruption.In order to milk drink it is fresh
Safety, it is necessary to milk sterilizing and safety packaging.
Liquid milk available on the market includes pasteurize milk and ultra high temperature short time sterilization (UHT, Ultra High-
Temperature Treatment) two kinds of milk.Pasteurised milk, can only be domestic in certain territorial scope due to being not suitable for long-distance transport
It sells.And ultra high temperature short time sterilization does not influence the nutritive value of milk, then since processing belongs to physical change so superhigh temperature
Instantaneous sterilizing processing is a kind of important sterilization process of current market sales of liquid milk.
After ultra high temperature short time sterilization processing, need to clean production equipment.And for the production containing milk product
Equipment, protide dirt are most difficult to removal.At present for ultra high temperature short time sterilization production equipment, it is preferable to use situ cleaning work
Skill（Cleaning-in-Place,CIP）, which is carried out in situ（On the spot）Cleaning.In this field, usually to milk-contained drink
Production equipment washed, pickling, alkali cleaning rinse etc..Also can work out as needed specific cleaning procedure carry out it is full-automatic or
The cleaning of semiautomatic control.Although full-automatic or Semi-automatic control system improves work efficiency compared with Manual-cleaning,
It is the pipeline for that need to clean, since the removal situation of dirt in pipeline can not be observed directly, so in existing cleaning process
In, after often leading to cleaning, still without cleaning up, or after cleaning up, still occur in the situation cleaned.
Industrial general practice is to establish cleaning using verification method：Given birth to by the normal production schedule
Then postpartum is cleaned by the cleaning planned.That is, after cleaning, pipeline is dismantled to come, passes through the side of range estimation
Method and some supplementary means are confirmed whether to reach cleaning requirement.If not up to required, by extending scavenging period, improving
Chemical concentration improves cleaning temperature to improve cleaning performance；If having reached cleaning requirement, cleaning is fixed as
Equipment management normal process（SOP）, follow-up cleaning is by this operation execution.
But in daily production because the amount of dirt can because the reasons such as the milk supply variation of milk, Seasonal conversion without
Together, so in actual production, being more than amount when process certification because of the dirt amount after the production of certain batches sometimes, by normal
SOP cleanings, dirt cannot be completely removed；And the amount when amount of dirt is less than process certification sometimes, SOP cleanings
Scavenging period be longer than actual needs, to having wasted time and the energy in cleaning.If in cleaning process, dirt
The height of horizontal abnormality at this time generally cannot remove dirt completely by a normal step, if taken measures not in time,
Equipment non-programmed halt is may result in, to reduce production efficiency.
In order to monitor the degree that cleaning carries out（Process）, probes such as temperature in use, pressure, conductivity in the art,
Chemical concentration, the temperature and pressure variation etc. that are used when cleaning are monitored.But these methods, be not directly against
The monitoring that dirt in cleaning equipment carries out, so cannot intuitively reflect the degree that cleaning carries out.Thus, it cannot be according to current
Monitored results, control wash course in time, thus may cause to extend scavenging period in some cases, and in certain feelings
Cause cleaning insufficient under condition, cleaning efficiency cannot be effectively improved.
In order to overcome the problems, such as the prior art these, it is desirable to provide a kind of ex-situ cleaning process and system do not have to addition and appoint
What allogenic material directly tracks dirt in cleaning process（Dirt）Amount, so as to control in time cleaning process.It is logical
This method and system are crossed, can track in time, understand, control wash course, be effectively improved cleaning efficiency.
Summary of the invention
There is provided herein a kind of ex-situ cleaning process of the production equipment for milk-contained drink；And for milk-contained drink
The clean-in-place system of production equipment.
There is provided herein a kind of ex-situ cleaning process of the production equipment for milk-contained drink, include the following steps：
（a）It introduces water to clean in the apparatus as the first cleaning solution, be then discharged out；
（b）Alkaline cleaning fluid is introduced as the second cleaning solution wash cycles in the apparatus, is then discharged out；
Wherein, in the cleaning, in continuous or intermittent manner, the fluorescence of alkaline cleaning fluid is measured（Density）Reading；
And when the fluorescence reading meets selected from least one following condition, terminates current cleaning step, cleaning solution is discharged：
（i）In alkaline solution cleaning step, clean cycle is averaged with fluorescence reading in previous clean cycle
The change rate of value is less than the ratio of the minimum value of fluorescence reading and maximum value in 5% and the clean cycle and is more than 90%；Or
（ii）In alkaline solution cleaning step, the fluorescence intensity reading average value of continuous two clean cycles is setting value
Twice or more when.
In ex-situ cleaning process as described herein, after the cleaning for completing alkaline cleaning fluid, it is preferably repeatedly introduced first
Cleaning solution, i.e. water, are cleaned.Water is preferably rinsed in a device as cleaning solution, is not recycled in a device.Terminate water
Water is discharged in cleaning step, the step of not needing to that water is particularly discharged, only need to close water supply system.In water cleaning step
In, in continuous or intermittent manner, the fluorescence reading of the aqueous cleaning is measured, and when the fluorescence reading meets selected from following
Condition（iii）When, terminate current cleaning step, cleaning solution is discharged：
（iii）Fluorescence reading continues to decline, the ratio of the average value of the fluorescence reading of aqueous cleaning and the fluorescence reading of water
Less than or equal to 1.2.
Further include introducing acidic cleaning solution as third cleaning solution circulation cleaning in a preferred embodiment of this paper
The step of washing, being then discharged out the third cleaning solution.After introducing the acidic cleaning solution, it can be carried out according to following order clear
It washes：（a）Water cleaning, alkaline cleaning fluid cleaning, water cleaning, acidic cleaning solution cleaning, water cleaning；Or（b）Water cleaning, acidity are clear
Washing lotion cleaning, water cleaning, alkaline cleaning fluid cleaning, water cleaning.
In a preferred embodiment, it after introducing acidic cleaning solution, in continuous or intermittent manner, measures acid
The fluorescence reading of cleaning solution, and it is selected from following condition when the fluorescence reading meets（iv）When, terminate current cleaning step, arranges
Go out cleaning solution；
（iv）When the average value of the fluorescence reading of acidic cleaning solution and the ratio of the fluorescence reading of water are more than or equal to 2.
In another preferred embodiment of this paper, when fluorescence reading meets condition（ii）Or（iv）And terminate current clear
After washing step, need to carry out additional alkaline cleaning fluid cleaning.
A kind of clean-in-place system of the production equipment for milk-contained drink, cleaning system access life is also provided herein
After producing equipment, scavenger circuit is constituted, the system comprises
Measuring station, including
Detection device, including fluorescence detector, the fluorescence reading for measuring and exporting the cleaning solution；
Data processing equipment, for handling the reading for coming from detection device；
Switching equipment is used for according to from measuring station as a result, terminating to clean, discharge cleaning solution.
In the cleaning system of the ex-situ cleaning process, which can be online or offline.
Description of the drawings
Fig. 1：On-line checking measuring station schematic layout pattern
Fig. 2：The fluorescence and Turbidity measurement result of CIP wash courses
Fig. 3：The testing result one of laboratory UHT equipment
Fig. 4：The testing result two of laboratory UHT equipment
Fig. 5：Fluorescence reading is washed after production
Fig. 6:The fluorescence reading of the alkaline cleaning fluid of the fluorescence reading of the alkaline cleaning fluid of 3.5% weight and 1.0% weight
Fig. 7:The fluorescence reading of water-washing step after the alkaline cleaning fluid of 3.5% weight
Fig. 8：The fluorescence reading of acidic cleaning solution and the alkalinity of 1.0% weight are clear after the alkaline cleaning fluid cleaning of 3.5% weight
The fluorescence reading of acidic cleaning solution after washing lotion cleaning
Fig. 9:The alkaline cleaning fluid of the turbidity and 1.0% weight of acidic cleaning solution after the alkaline cleaning fluid cleaning of 3.5% weight
The turbidity of acidic cleaning solution after cleaning
Figure 10：The fluoroscopic examination result of industrial CIP solution
Specific implementation mode
It is found by the applicant that：Allogenic material can not can be being added by the variation of the fluorescence reading of observation cleaning solution
Under the conditions of, the wash course of the protein substance (dirt) in milk-contained drink production equipment is tracked, stops being completed in time clear
The step of washing function cannot play the step of effective cleaning action completely, thus flexibly control the ex-situ cleaning process.Base
In this, a kind of ex-situ cleaning process of the production equipment for milk-contained drink is inventors herein proposed, in this way, effectively improving
The cleaning efficiency of the ex-situ cleaning process of production equipment for milk-contained drink, it is energy saving, improve cleaning performance.
In general, the production equipment for working as milk-contained drink is after a period of use, then need to clean it, with removal
Remaining dirt in equipment.At this point, first arrestment, water is introduced into equipment, by water by milk-contained drink remaining in pipeline
Ejection.
Later, as shown in Figure 1, first foundation includes the clean-in-place cycle circuit of milk-contained drink production equipment.To the original position
Cleaning solution is introduced in equipment in scavenger circuit, recycles the cleaning solution in a device, is then discharged out the cleaning solution, this process is known as
The cleaning step of one cleaning solution.Cleaning solution is introduced into equipment, until being a cleaning by the time of cleaning solution device for transferring
Step Time.In situ in cleaning, a cleaning process generally includes multiple cleaning steps.One clean cycle refers to clear
Washing lotion recycles one week in equipment to be cleaned.The time of one clean cycle corresponds to the cleaning solution in equipment to be cleaned
Recycle the time used in one week.For the production equipment of milk-contained drink, once establishing its clean cycle circuit, then a cleaning follows
The flow velocity etc. that the time of ring, cleaning solution recycle in a device can pass through device parameter, such as the pump of driving cleaning solution and cleaning
Volume is recycled, is directly determined." average value of fluorescence reading in clean cycle " refers to the institute within a clean cycle period
The average value of the fluorescence reading of reading.
In one embodiment, water is first introduced in scavenger circuit, is rinsed with water equipment, it is complete after continuing for some time
The cleaning solution is discharged entirely；It is set to be recycled in scavenger circuit next, being introduced into alkaline cleaning fluid, after continuing for some time, discharge
The cleaning solution；In the cleaning process, the fluorescence reading of alkaline cleaning fluid is measured, when the fluorescence reading meets selected from following
When at least one condition, terminate current cleaning step, cleaning solution is discharged：
（i）In alkaline cleaning fluid cleaning step, fluorescence reading is flat in a clean cycle and previous clean cycle
The change rate of mean value is less than the ratio of the minimum value of fluorescence reading and maximum value in 5% and the clean cycle and is more than 90%；Or
（ii）In alkaline cleaning fluid cleaning step, the average value of the fluorescence reading of continuous two clean cycles is setting value
Twice or more.
When " setting value " refers to cleaning verification technique, the average value of fluorescence reading in the last one clean cycle.
Cleaning verification technique is referred in the ex-situ cleaning process for beginning to use this paper as known in the art（Method）Before, industrial
On generally use be used for establishing the verification method of cleaning：After being produced by the normal production schedule, institute is then pressed
The cleaning of plan is cleaned, and after cleaning, pipeline is dismantled to come, passes through the method for range estimation and some supplementary means
To be confirmed whether to reach cleaning requirement.If having reached cleaning requirement, according to the cleaning verification technique, cleaning is consolidated
It is set to equipment management normal process（SOP）, follow-up cleaning is by this operation execution, the last one clean cycle at the end of cleaning at this time
In the average value of fluorescence reading be " setting value ".
According to herein, the cleaning step of alkaline cleaning fluid can be continued, until the fluorescence reading of the alkaline cleaning fluid meets
Above-mentioned condition（i）Or（ii）.
About condition (i), in alkaline cleaning fluid cleaning step, a clean cycle and fluorescence in previous clean cycle
The change rate of the average value of reading be less than 5%, preferably smaller than 4%, and in the clean cycle fluorescence reading minimum value and maximum value
Ratio be more than 90%, preferably greater than 95%.It is not limited to theory, it is believed that when meeting condition（i）When, show protein-based in equipment
Substance by the physics and chemical action with cleaning solution, is cleaned, cleaning step, especially for protein substantially
The cleaning step of substance is over.
When meeting condition（ii）, i.e., in alkaline cleaning fluid clean cycle, the fluorescence reading of continuous two clean cycles
When average value is twice or more of setting value, it is not limited to theory, it is believed that show the cleaning ability of alkaline cleaning fluid at this time not
Enough, dirt cannot be effectively removed by continuing cleaning.Therefore, it is necessary to stop current clean cycle immediately, it is replaced and cleaned scheme, example
It such as adds new alkaline cleaning fluid, the concentration for improving alkaline cleaning fluid, improve cleaning temperature.
In a preferred embodiment, further include that alkalinity cleaning is discharged after alkaline cleaning fluid recycles a period of time
Liquid, the then repeatedly cleaning of the first cleaning solution and/or the second cleaning solution, until the fluorescence reading of alkaline cleaning fluid meets above-mentioned item
Part (i) or (ii).
Further include the fluorescence reading for measuring aqueous cleaning in above-mentioned cleaning process.It has been found that measurement can be passed through
The fluorescence reading of aqueous cleaning, preferably measure alkaline cleaning fluid step after aqueous cleaning fluorescence reading whether meet it is following
Condition（iii）, and monitor whether cleaning process is completed：
（iii）The fluorescence reading of aqueous cleaning continues to decline, the average value of the fluorescence reading of aqueous cleaning and the fluorescence of water
The ratio of reading is less than or equal to 1.2, is preferably smaller than equal to 1.1, more preferably less than or equal to 1.05.It is not limited to theory, it is believed that this
Although when system in still contain protein substance, substantially close to the fluorescence reading of water for cleaning, substantially meet life
Production requires.When higher than this value, needs to continue to introduce cleaning solution, such as aqueous cleaning or alkaline cleaning fluid, be cleaned.
In a preferred embodiment of this paper, a kind of situ cleaning of the production equipment for milk-contained drink is provided
Technique includes the following steps：
（a）It introduces water to be cleaned in the apparatus as the first cleaning solution, be then discharged out；
（b）Alkaline cleaning fluid is introduced as the second cleaning solution wash cycles in the apparatus, is then discharged out；
（c）Optionally repeat step（a）And/or（b）,
Wherein, in the cleaning process, in continuous or intermittent manner, the fluorescence reading of cleaning solution is measured；And work as
When the fluorescence reading is met selected from least one following condition, terminates current clean cycle, cleaning solution is discharged：
（i）In alkaline cleaning fluid cleaning step, fluorescence reading is flat in a clean cycle and previous clean cycle
The change rate of mean value is less than the ratio of the minimum value of fluorescence reading and maximum value in 5% and the clean cycle and is more than 90%；
（ii）In alkaline cleaning fluid cleaning step, the average value of the fluorescence intensity reading of continuous two clean cycles is to set
Twice or more of definite value；
（iii）The fluorescence reading of aqueous cleaning continues to decline, the average value of the fluorescence reading of aqueous cleaning and the fluorescence of water
The ratio of reading is less than or equal to 1.2.
Further include introducing acidic cleaning solution to carry out circulation cleaning in a device as third cleaning solution in ex-situ cleaning process
The step of washing, being then discharged out.In order to improve the cleaning efficiency of cleaning solution, usually in the clear of alkaline cleaning fluid and acidic cleaning solution
Between washing, water cleaning step is carried out to equipment（Alternatively referred to as water rinsing step）.Therefore, described after introducing third cleaning solution
Three kinds of cleaning solutions are preferably cleaned according to following order：（a）Water cleaning, alkaline cleaning fluid cleaning, water cleaning, acidic cleaning solution
Cleaning, water cleaning；Or（b）Water cleaning, acidic cleaning solution cleaning, water cleaning, alkaline cleaning fluid cleaning, water cleaning.It is above-mentioned clear
Washing step can repeat.
It is found by the applicant that the fluorescence reading when acidic cleaning solution meets following condition（iv）When,
（iv）The average value of acidic cleaning solution fluorescence reading and the ratio of the fluorescence reading of water are more than or equal to 2
The cleaning of cleaning step before showing, especially alkaline cleaning fluid cannot effectively reach the cleaning required in advance
As a result, needing to terminate current clean cycle at this time, alkaline cleaning fluid cleaning is re-started.When necessary, it tears pipe open and checks cleaning pipe
Road.
In cleaning process, as needed, the cleaning step of one or more of which cleaning solution can be repeated.It is preferred that one
Cleaning process includes multiple cleaning steps, optionally repeats the cleaning step.It is preferred that when only including water and alkaline cleaning fluid
When, it can repeat to clean with the sequence of water, alkaline cleaning fluid.It, can be with when including water, alkaline cleaning fluid, acidic cleaning solution
Water, alkaline cleaning fluid, water, acidic cleaning solution, water；Or water, acidic cleaning solution, water, alkaline cleaning fluid, water sequence repeat into
Row.It is preferred that the adjacent cleaning solution introduced twice is different cleaning solution.It is further preferred that in the clear of alkaline cleaning fluid and acidic cleaning solution
It washes between step and is spaced apart by water cleaning step.
According to the prior art, those skilled in the art can establish the scavenger circuit for ex-situ cleaning process.Work as cleaning
After circuit is established, cleaning solution driving equipment and clean cycle volume are depended on, at this time the flow velocity of cleaning solution, clean cycle one week
Time determines substantially.Generally, the flow velocity of cleaning solution is 1-6 meter per seconds, preferably 1.5-5 meter per seconds.
In one embodiment, the temperature of the cleaning solution in cleaning process is 50-150 DEG C, preferably 80-140 DEG C, more
Preferably 80-130 DEG C.
Congratulated by cleaning as described herein, the fluorescence reading of cleaning solution can be detected at any time, dirt can be monitored at any time
Wash course, and according to such as condition (i)-(iv), stop cleaning step immediately.Therefore, in methods herein, when cleaning
Between be by monitoring fluorescence reading by determination.In general, the duration of each cleaning step is, for example, 20 minutes, 30 points
Clock, 50 minutes or 1 hour.The duration depends on the dirt accumulation degree of the equipment for needing the to clean, scale of equipment, clear
The concentration etc. of dilution.If the accumulation of equipment dirt is serious, cleaning step duration is long.
For the acidic cleaning solution in the ex-situ cleaning process of the production equipment of milk-contained drink, institute in alkaline cleaning fluid pickling
The bronsted lowry acids and bases bronsted lowry used is common acid or alkali in ex-situ cleaning process, is clear for those skilled in the art.The acid includes,
But it is not limited to, nitric acid, phosphoric acid, sulfamic acid, hydroxyacetic acid, acetic acid, citric acid, sulfuric acid, lactic acid, glutaric acid, gluconic acid etc..
In use, the acid, which is dissolved in the water, obtains the acidic cleaning solution.The concentration of acidic cleaning solution is also art technology
What personnel can determine as needed, usually 0.1-5wt%.The pH value of acidic cleaning solution is usually in the range of 0.5-3.
Include, but are not limited to sodium hydroxide, potassium hydroxide, triethanolamine, two for the alkali used in alkaline cleaning fluid
Ethanol amine, monoethanolamine, sodium carbonate, potassium carbonate, sodium metasilicate, sodium metasilicate, potassium silicate etc..Those skilled in the art being capable of basis
It needs to be determined that the alkali needed.In use, being dissolved in water the alkali to get to required alkaline cleaning fluid.Alkaline cleaning fluid
Concentration be that those skilled in the art can determine according to ex-situ cleaning process, usually 0.1-5wt%.In general, alkalinity cleaning
The pH value of liquid is preferably in the range of 10-13.5.
Cleaning solution can be by the way that the acid or alkali and water to be introduced between in equipment to be cleaned, in equipment to be cleaned
Form acidic cleaning solution or alkaline cleaning fluid.
About the relationship of fluorescence reading and protein substance, it is not limited to theory, it is believed that fluorescence reading is with protein
The increase of the concentration of substance and increase.Fluorescence reading and the concentration of protein substance are linearly related.Therefore, it is read according to fluorescence
Linear relationship between number and the concentration of protein substance, the fluorescence reading value obtained based on detection, it may be determined that in equipment
The wash course of protein substance.
The method and fluorescence detector of measurement fluorescence reading are for example with reference to United States Patent (USP) US6,369,894B1（2002 4
The moon 9 authorized, Nalco Chemical Company）And US6,255,118B1 (mandate on July 3rd, 2001, Nalco
Chemical Company), the full patent texts are incorporated herein by reference.
Measurement for fluorescence reading, it has been found that for cleaned in production equipment get off containing protein-based
The cleaning solution of substance is needed the cleaning solution first in 250-500nm, preferably 280-370nm, the wavelength of more preferable 320-365nm
It is excited；And in 320-500nm, preferably 340-480nm, the fluorescence of the wavelength measurement cleaning solution of more preferable 400-470nm
Reading.It is found by the applicant that：By adjusting testing conditions, such as excitation wavelength and Detection wavelength, it can effectively optimize fluorescence reading
With the correlation of protein substance, accuracy in detection and sensitivity are improved.
The fluorescence reading of cleaning solution can progressively reach stabilization, such as be gradually increasing and tend towards stability with the progress of cleaning
It is either gradually reduced close（Clearly）The fluorescence reading of water.After fluorescence reading reaches and stablizes, show that there is no protein-based
Substance is cleaned, and can stop the cleaning step for the protein substance.
As previously mentioned, the dirt in production equipment is a kind of compound multilayered structure, including mineral contaminants and protein-based
Dirt and some micro impurity.For the dirt of inorganic species, it is preferably introduced into acidic cleaning solution and carries out additional cleaning.
It in cleaning, removes in addition to protein substance is cleaned, also inorganic foulants and is wrapped up on a small quantity by inorganic matter
Carbohydrate be removed, so cleaning solution can become cloudy in cleaning process.It is preferably clear by detecting for this phenomenon
The turbidity of cleaning solution changes and is monitored during washing.Detection for turbidity can use turbidity tester, such as Hash
DR/890 multifunctional testers take cleaning solution to carry out a turbidity test at regular intervals, such as one minute, then will
Turbidity is plotted against time.But when the turbidity to alkaline cleaning step is tested, it has been found that turbidity can be with scavenging period
Extend and is substantially reduced.Applicant has found that the turbidity of cleaning solution after a certain time can be with by experiment, such as beaker test
The extension of scavenging period and decline.Therefore, in order to reach better Turbidity measurement as a result, it is preferred that control detection turbidity when cleaning solution
Temperature and time be steady state value.In addition, it has been found that being directed to the cleaning of nonprotein substance, preferably monitoring is acid clear
The turbidity of washing lotion.When measuring the turbidity of acidic cleaning solution, preferably the turbid of cleaning solution is measured in identical temperature and identical time
Degree.Whether the detection for turbidity value, can be determined by one skilled in the art to clean and be completed.It is preferred that when turbidity value
When variation is less than 10%, indicate that other dirts of non-protein are no longer able to be cleaned, cleaning step terminates.
During the fluorescence reading or the turbidity that detect cleaning solution, the interval time between measuring every time can be according to used
Model of measuring apparatus etc. determines.Interval time is, for example, 1 second to 6 minutes, in order to obtain more accurate figure, preferably measurement interval
Time wants short, such as interval is extremely spaced 30 seconds for 5 seconds, more preferably continuous detection.
To those skilled in the art, other conditions, such as more adjacent alkali cleaning twice cleaning can also be used to follow
The difference of the integral area of the fluorescence reading of ring, for judging whether the cleaning containing protein-based dirt is finished.
A kind of measuring station of the ex-situ cleaning process for the production equipment for milk-contained drink is also provided herein, including
Detection device, including fluorescence detector, the fluorescence reading of the cleaning solution for the cycle；
Data processing equipment, for handling the reading for coming from detection device.
In a preferred embodiment, a kind of clean-in-place system of the production equipment to milk-contained drink is provided,
After the cleaning system accesses production equipment, scavenger circuit is constituted, the system comprises measuring stations, including
Detection device, including fluorescence detector, the fluorescence reading for measuring and exporting the cleaning solution sample；
Data processing equipment, for handling the reading for coming from detection device；
Switching equipment is used for according to from measuring station as a result, end cleaning step, is discharged cleaning solution.
It is preferred that further including being respectively provided with cleaning chemicals in the cleaning system（That is bronsted lowry acids and bases bronsted lowry）With the source of bank savings and cleaning solution of water
Supply equipment, for supplying cleaning chemicals and water to equipment to be cleaned from the source of bank savings and cleaning solution being driven to recycle.
In an embodiment of this paper, a kind of situ cleaning system of the production equipment for milk-contained drink is provided
System after the cleaning system accesses production equipment, constitutes scavenger circuit, the system comprises
Cleaning solution driving equipment, for driving cleaning solution to be recycled in production equipment；
Detection device, including fluorescence detector, the fluorescence reading of the cleaning solution for the cycle；
Data processing equipment, for handling the reading for coming from detection device；
Switching equipment, for according to from data processing equipment as a result, switching clean cycle,
Wherein when the data of processing when meet include a following condition when, switching situ cleaning step：
（i）In alkaline cleaning fluid cleaning step, fluorescence reading is flat in a clean cycle and previous clean cycle
The change rate of mean value is less than the ratio of the minimum value of fluorescence reading and maximum value in 5% and the clean cycle and is more than 90%；
（ii）In alkaline cleaning fluid cleaning step, the fluorescence intensity reading average value of continuous two clean cycles is more than to set
Twice or more of definite value；
（iii）The fluorescence reading of aqueous cleaning continues to decline, the average value of the fluorescence reading of aqueous cleaning and the fluorescence of water
The ratio of reading is less than or equal to 1.2；
（iv）The average value of the fluorescence reading of acidic cleaning solution and the ratio of the fluorescence reading of water are more than or equal to 2.
Cleaning solution driving equipment is to drive cleaning solution returning in the ex-situ cleaning process of the production equipment including milk-contained drink
The equipment recycled in road, typically pumps.
Detection device is also measuring apparatus, includes the fluorescence detector of the fluorescence reading for measuring cleaning solution.Generally make
With the instrument and method for example as described in United States Patent (USP) US6,255,118B1 and US6,369,894B1.It is preferred that being set to
Detection device in measuring station further includes transmissometer, measures the turbidity of the cleaning solution of sample introduction.
Data processing equipment is will to measure obtained fluorescence reading by data processing equipment or turbidity value is handled, and is obtained
To the fluorescence reading or turbidity value that can be used for being compared, such as obtain the flat of fluorescence reading in clean cycle or turbidity value
It can at any time be compared by mean value；Or the collection of illustrative plates of fluorescence reading or turbidity to the time can be exported, for intuitively
It is compared.When measurement result meets for example including a kind of following condition, switching equipment can be used to switch cleaning step,
Such as stop or remind or be converted to new cleaning step：
（i）In alkaline cleaning fluid cleaning step, fluorescence reading is flat in a clean cycle and previous clean cycle
The change rate of mean value be less than 5%, preferably smaller than 4%, more preferably less than 3% and the clean cycle in fluorescence reading minimum value with most
The ratio being worth greatly is more than 90%, preferably greater than 95%, more preferably greater than 98%；
（ii）In alkaline cleaning fluid cleaning step, the fluorescence intensity reading average value of continuous two clean cycles is more than to set
Twice or more of definite value, preferably 1.5 times or more；
（iii）The fluorescence reading of aqueous cleaning continues to decline, the average value of the fluorescence reading of aqueous cleaning and the fluorescence of water
The ratio of reading is less than or equal to 1.2；
（iv）The average value of the fluorescence reading of acidic cleaning solution and the ratio of the fluorescence reading of water are more than or equal to 2.
Equipment for switching situ cleaning step according to measurement result, including the switching situ cleaning that is set in equipment
The switch of step, such as stopping situ cleaning step, prompting start new situ cleaning step etc..Herein, " switching " indicates
Terminate current cleaning step, into other cleaning steps, such as terminates alkaline cleaning fluid cleaning, it is clear to re-start new alkalinity
Washing lotion cleaning is rinsed using water, or is introduced acidic cleaning solution and cleaned.
Further include that cleaning solution is arranged to clean in the heat transmission equipment of certain temperature, observation as needed in cleaning system
The observation window etc. of liquid.
Within the system, measuring station can be online or offline.It further include one or more in off-line measurement station
A sample introduction equipment is detected cleaning solution by taking out cleaning solution.
With reference to the cleaning system of such as Fig. 1, wherein measuring station is online.In Fig. 1, the production equipment of milk-contained drink be for
The ultra high temperature short time sterilization equipment of milk.Cleaning chemical storage cylinder, compensating cylinder and charging pump in Fig. 1 constitute cleaning solution
Supply equipment.Detection device includes：Such as fluorescence detector, turbidity detector etc..Fluorescence reading can use desktop fluorescence
Instrument is tested, and the excitation wavelength and Detection wavelength described by the present invention before test is configured instrument；It also can be by retouching herein
The mode stated is adjusted excitation wavelength and Detection wavelength, is tested using hand-held fluorescence instrument.The turbidity of solution can be used and be breathed out
Uncommon DR/890 instruments or the Turbidity measuring equipment of same type are tested.Switch the switch of situ cleaning step according to measurement result
Including data processing and controller.Certainly, can also include other required equipment in measuring station, this is those skilled in the art
It can be determined according to the prior art.
Cleaning and cleaning system herein can be used for cleaning the production equipment of milk-contained drink.Herein, contain breast
Beverage includes milk and common containing milk or using milk as the beverage of primary raw material.The production equipment of milk-contained drink is for example
For ultra high temperature short time sterilization processing equipment（UHT）And any relevant device.
Following embodiment is applicant provided, the technical solution for further illustrating the present invention.Following embodiments are not
For limiting the present invention, the scope of the present invention is based on following claims, can be managed with those of ordinary skill in the art
Subject to the range of solution.Unless otherwise specified, involved numerical value, percentage herein etc. are based on weight.
Embodiment
Inventor first use glass beaker test, observe cleaning solution turbidity and fluorescence reading with wash course
Variation, to help to understand the reaction occurred in the pipeline and hold-up tank of UHT equipment.
Embodiment 1
In 1 liter of beaker, 1 liter 0.3% Conquest (the compound alkaline cleaner of skill health) solution is added, then leads to
Solution is pumped into the online fluorescence detector of skill health by piping pump（Instrument model T13DT Fluorometer）, after detection
Solution is flow back into through pipeline in beaker again.Instrument can detect and record the turbidity for flowing through solution and fluorescence reading at any time simultaneously
Variation.At about 100 seconds, the milk dirt sample through Overheating Treatment is added in beaker.Dirt can be with the extension quilt of time
Cleaning solution and stirring action remove, and dissolve in cleaning solution.After 1600 seconds, stops testing and carry out data analysis.
Experiment parameter:55 DEG C of cleaning temperature, 0.3%Conquest alkaline cleaning fluids, 280nm excitation wavelengths, 340nm fluorescence
Detection wavelength, turbidity test wavelength are 280nm.
It is found in preceding 300 seconds cleaning processes in detection process, it can by the variation of fluorescence reading and turbidity
The most of dirt of display is eluted quickly.However after about 500 seconds, the removal rate of remaining dirt is slack-off, fluorescence reading
It can monitor still there is dirt to be persistently eluted in solution.Fluorescence reading signal shows the dirt amount of the dissolving in solution clear
Later stage increase is washed (to show：Cleaning is still underway), and turbid ity signal starts to carry out and decline with cleaning, at this point, cannot have
Effect carries out the monitoring of cleaning process using turbid ity signal.Experimental result is as shown in Figure 2.
It finds according to fig. 2, the scheme for detecting fluorescence reading is that a kind of dirt amount that is cleaned getting off of monitoring changes over time
Accurately method.
Embodiment 2
1kg milk powder is dissolved in 8 liters of hot water, is stirred 30 minutes.Milk power solution is poured in test-type UHT systems,
135 DEG C are recycled, and continue 2 hours.Later, start to simulate CIP techniques, water first rinses 5 minutes, then uses at 110 DEG C
Alkali cleaning 40 minutes under CIP circulation loop patterns the compound alkaline cleaner AC-110 of the skill health of 3.5% weight, water rinse 5 points
Clock.At 85 DEG C, with the AC-55-5 pickling 20 minutes of 3% weight of acidic cleaner of skill health.Last water rinses 5 minutes.Collect alkali
Property cleaning step cleaning solution, carry out offline inspection.
The desktop version that the fluorescence reading of cleaning solution is produced by Horiba Jobin Yvon, instrument model
Fluoromax-4 measures (excitation wavelength 327nm, Detection wavelength 406nm)；Turbidity is surveyed by Hash DR/890 hand-held colorimetry analysis
Amount is No. 95 using program.
Test results are shown in figure 3.During the test, it is found that turbidity reads result will be significantly by temperature shadow
It rings.When the solution is cooled, 1/2 when reading result is hot solution.Turbidity and fluorometric investigation are carried out at the same time to same solution, sent out
Existing fluorescence reading is all more stable at different temperature.
Conclusion：Fluorescence reading testing result is within the scope of selected Detection wavelength, the measured value under condition of different temperatures
Change relatively small.But the turbidity of same solution test value under different temperature conditions changes very greatly.In actual use,
If using Turbidity measurement, need control detection temperature and time constant.The detection of fluorescence reading is more advantageous to fast and accurately
Monitoring.At the initial stage of cleaning, a large amount of dirts that loosen easily are cleaned, and fluorescence reading and turbidity value rise rapidly.But because
Cleaning solution recycles in the duct, cannot quickly be uniformly mixed, therefore peak value can all occur in fluorescence reading and turbidity reads.Then,
With the increase of cleaning solution cycle-index in scavenger circuit, solution will gradually tend to be uniform.According to fig. 3 as a result, find phase
The variation of the average value of fluorescence reading is less than 5% and in same clean cycle in adjacent clean cycle, the minimum value of fluorescence reading and most
When the ratio being worth greatly is more than 90%, cleaning process reaches balance, can terminate the cleaning step of alkaline cleaning fluid.
Embodiment 3
1kg milk powder is dissolved in 8 liters of hot water, is stirred 30 minutes.Milk power solution is poured in test-type UHT systems, 135
It DEG C is recycled, continues 3 hours.Later, start to simulate ex-situ cleaning process, water first rinses 5 minutes；Then make at 110 DEG C
With the compound alkaline cleaner AC-110 of the skill health of 3.5% weight under the open circuit mode of cleaning solution once-through alkali cleaning 30 minutes；
Water rinses 5 minutes；At 85 DEG C, with the acidic cleaner AC-55-5 pickling 20 minutes of the skill health of 3% weight；Last water rinses 5 points
Clock.The cleaning solution for collecting alkaline cleaning step, is detected.
The desktop version that the fluorescence reading of cleaning solution is produced by Horiba Jobin Yvon, instrument model
Fluoromax-4 measures (excitation wavelength 327nm, Detection wavelength 406nm)；Turbidity is surveyed by Hash DR/890 hand-held colorimetry analysis
Amount is No. 95 using program.
Test results are shown in figure 4.
Conclusion：In the case where cleaning solution does not recycle, by fluoroscopic examination, find out that Fouling Cleaning is gone with being apparent from
Except the relationship of amount and time, most of loose dirt is easy to remove in the first to the second clean cycle, then a small amount of deep layer
Fine and close dirt is gradually removed again.With the extension of time, the dirt generated in test-type UHT, in cleaning in 30 minutes
In period, still there is dirt to be cleaned.In the ratio of 24-30 minutes fluorescence reading average values and entire step full-scale reading
It is 29.6%, is much larger than 5%；After cleaning, by tearing pipe inspection open, it is found that tube wall still has a small amount of dirt residual, show glimmering
Photoreading can effectively reflect the dirt residual condition in pipeline.To in actual production, it may not be necessary to tear pipe inspection open, and it is right
The cleaning situation of pipeline is monitored, and is saved in cleaning link the time it takes, is controlled cleaning step immediately.
Embodiment 4
1kg whole milk powders are dissolved in 8 liters of hot water, are stirred 30 minutes.Milk power solution is poured in small-sized UHT systems,
It is recycled at 135 DEG C, continues 2 hours.Later, start CIP techniques, first water rinse 5 minutes, then 110 DEG C of uses not
Same concentration（3.5% weight and 1% weight）Skill health compound alkaline cleaner AC-110 alkali cleanings 40 under CIP circulation loop patterns
Minute, water rinses 5 minutes.At 85 DEG C, with the acidic cleaner 3%AC-55-5 pickling 20 minutes of skill health.Last water rinses 5 points
Clock.In cleaning process, solution is first flowed through to the online fluorescence detector of skill health（Instrument model Cooling3DT
Fluorometer）, the solution after detection flow to through pipeline in UHT compensating cylinders again.
Experiment parameter:365nm excitation wavelengths, 405nm and 470nm fluoroscopic examination wavelength, turbidity test wavelength are 280nm.
By to on-line checking data analysis, under 365nm excitation wavelengths, preferably Detection wavelength is 470nm.
It washes by water after production, the fluorescence reading of water for cleaning is 4.30.According to Fig. 5, aqueous cleaning is glimmering at 265 seconds
Photoreading is 4.81, and the fluorescence reading at 300 seconds is still 4.81, i.e., 35（That is 300-265）In the time of second, aqueous cleaning
Fluorescence reading no longer change, show to be flush with water this water rinsing step there is no dirt at this time and terminated.
The measurement result of cleaning solution see the table below.
Table 1
Table 2
The result of the Tables 1 and 2 corresponds to Fig. 6.
From the point of view of two different cleaning chemicals are using concentration, by the examination criteria of setting, reach cleaning balance
Time is different.3.5%AC-110 has reached clean endpoint in the 5th clean cycle；And 1.0%AC-110 wants 7 cleanings to follow
Ring just reaches clean endpoint；This illustrates that different chemical concentration cleaning ability is different, is suggesting the high concentration in use scope
Chemical solutions can play cleaning performance faster.But it, can be by fluorescence reading detection method, really regardless of cleaning solution
When fixed cleaning terminates.
Two hours dirts generated are recycled for milk, are looked by many experiments and through opening and inspecting, discovery needs 3.5%AC-
110 could remove dirt completely in the 5th clean cycle.And in clean endpoint, the fluorescence reading of 1%AC-110 cleaning solutions
It to be significantly lower than the fluorescence reading of 3.5%AC-110 cleaning solutions, shows the dirt ratio 3.5%AC- of 1%AC-110 cleaning solutions removal
What 110 cleaning solutions removed lacks, and possible dirt is not completely removed.Through tearing pipe inspection open, 1%AC-110 cleaning solutions are by 8 cleanings
After cycle, still there is dirt residual in UHT pipelines, the result of this and fluoroscopic examination is consistent.It is indicated above that the inspection of fluorescence reading
Survey method can monitor cleaning situation, intuitively react wash course in detergent line, and thus, it is possible to save to tear pipe inspection dirt open
And etc., to finally improve cleaning efficiency.
In another set of experiments, after milk recycles two hours, the new preparation milk liquid recycling two for changing same amount is small
When, then cleaned again with 3.5%AC-110.As a result in the 3rd and the 4th clean cycle, fluorescence reading average value is both greater than
400.By alkali cleaning is stopped after being normally set in the 5th clean cycle, then after washing, pickling, water-washing step, pipe inspection is torn open
It was found that inner wall still has dirt residual.These dirts are removed by second identical CIP process is cleaned.This test shows alkali
Property cleaning solution fluorescence reading average value can reflect the dirt amount of protide in equipment, for carrying out immediately monitoring to cleaning.
Fig. 7 shows the variation of fluorescence reading in the water-washing step after being cleaned to 3.5% alkaline cleaning fluid.According to Fig. 7 institutes
Show, for the water-washing step after alkali cleaning, the fluorescence reading average value at 11 minutes is identical as the fluorescence reading of water for cleaning, table
The bright dirt washed down is all washed away.It can terminate water-washing step.
Fig. 8 is shown：For an effective caustic scrubbing step, the protein type soil ingredient of the overwhelming majority can be removed, and
In acid pickling step, then the inorganic substances class dirt of not fluorescent characteristic is mainly removed.Therefore in an effective caustic scrubbing step
Acid cleaning solution afterwards, fluorescence reading should be close with the fluorescent value of water for cleaning.Acid pickling step after 1%AC-110, because before
Still there is more protide dirt to remain after the alkali cleaning of one step, the fluorescence reading average value of acid pickling step solution is 9.68, is cleaning
With twice of the fluorescence reading 4.30 of water.Detection for acid cleaning solution fluorescence, can be to the cleaning performance of caustic scrubbing step
Inferred.If the fluorescence reading average value of acid pickling step solution is more than the fluorescence reading of water for cleaning, pipe should be torn open to clear
It washes effect and is checked or re-started alkali cleaning, to ensure that cleaning performance meets the requirement produced again.
Fig. 9 shows the result being detected to the turbidity of acidic cleaning solution.By the Turbidity measurement to pickling liquid,
Also pickling can be predicted and balance the required time.Because in different tests, the use concentration of acidic cleaner is identical, reaches clear
The time for washing equalization point is also identical.The pickling of above-mentioned two experiment all reaches balance in the third clean cycle later stage.
Embodiment 5
Industry CIP solution is collected, testing laboratory's test result is used for.Using nephelometer and fluorescence detector, from experiment
Room UHT and industrial system obtain relevant data.
Collect sample-fluorescence reading test of industry UHT cleaning solutions：Sample comes from a UHT milk production plant.Sample
Cleaning solution sample is collected at the end of CIP cleaning steps【TA-1 and TA-2（Alkali cleaning solution after different CIP cycles）；TA-3：Acid
Cleaning solution after washing】.Instrument model：Shimadzu UV-3101PC UV-VIS-NIR Spectrophotometer.Detection
Shown in the result is shown in Figure 10.
But TA-3 has low-down fluorescence response（Illustrate that protide dirt is gone in alkaline cleaning step substantially
It removes）, the COD analyses of TA-3 are 1352mg/L, and turbidity reads are 68NTU, and it is advantageous to use turbidity side to acidic cleaning step
Method.
In order to be monitored to all CIP processes, it is desirable to while fluorescence detector and nephelometer are used, to cleaning solution
Into line trace.
For offline inspection, as long as preferably being excited according to this method and Detection wavelength, fluorescent instrument is configured,
It can carry out the detection of turbidity and fluorescence.
In summary, it is found by the applicant that according to remaining protein substance in the production process of milk-contained drink in specific item
Fluorescence response property under part can be used for tracking cleaning process.Inventor is it was unexpectedly observed that for the glimmering of detection cleaning solution
It is more effective into line trace primarily directed to alkaline cleaning fluid for photoreading.Meanwhile it has been found that with Turbidity measurement phase
Than the variation of fluorescence reading is insensitive to temperature and time, it is not necessary to the temperature of cleaning solution in stringent control fluorescence reading measurement process
Degree variation, also need not strictly control the detection time interval in fluorescence reading detection process.
Any allogenic material need not be added in methods herein in cleaning solution, thus without bringing any foodsafety
The problem of aspect.Meanwhile by monitoring fluorescence reading, compared to existing monitoring method before, the monitoring of fluorescence reading is more straight
It reflects wash course with seeing, can cleaning step be stopped according to monitoring result at any time, to improve cleaning efficiency, save energy
Source.It moreover has been found that using the method and system of the present invention, wash course can be monitored at any time, need not use additional operation,
Such as tear pipe open etc..Methods and systems disclosed herein can be effective in the cleaning of the production equipment of milk-contained drink.
Claims (20)
1. a kind of clean-in-place method of production equipment for milk-contained drink, includes the following steps：
It rinses, including water is introduced into as flushing liquor and cleans the equipment in the equipment, be then discharged out the flushing liquor；
Cleaning, including introduce alkaline cleaning fluid and recycle the alkaline cleaning fluid in the apparatus；
In the cycle, in continuous or intermittent manner, the fluorescence of the protein substance in alkaline cleaning fluid is measured；And
After the fluorescence, which reaches, to be stablized, alkaline cleaning fluid is discharged.
2. the clean-in-place method of the production equipment according to claim 1 for milk-contained drink, wherein reusing punching
Washing lotion is rinsed.
3. the clean-in-place method of the production equipment according to claim 2 for milk-contained drink, further includes：
Measure the fluorescence of the protein substance in the flushing liquor；
The mean fluorecence of multiple fluorescence readings of the flushing liquor is measured, and measures the ratio of the fluorescence of the mean fluorecence and water；
With
When the ratio is less than or equal to 1.2, the flushing liquor is discharged.
4. the clean-in-place method of the production equipment according to claim 1 for milk-contained drink further includes introducing acidity
Cleaning solution recycles the acidic cleaning solution in the apparatus, is then discharged out the acidic cleaning solution.
5. the clean-in-place method of the production equipment according to claim 4 for milk-contained drink further includes measuring acidity
The fluorescence of protein substance in cleaning solution；
The mean fluorecence of multiple fluorescence readings of the acidic cleaning solution is measured, and measures the ratio of the fluorescence of the mean fluorecence and water
Value；With
When the ratio is more than or equal to 2, the acidic cleaning solution is discharged.
6. the clean-in-place method of the production equipment according to claim 5 for milk-contained drink further includes working as the acid
Property cleaning solution mean fluorescence readings and the ratio of fluorescence of water when being more than or equal to 2, carry out additional alkaline cleaning fluid cleaning.
7. the clean-in-place method of the production equipment according to claim 4 for milk-contained drink, wherein in the following order
Add flushing liquor or cleaning solution：
Water, alkaline cleaning fluid, water, acidic cleaning solution and water；Or
Water, acidic cleaning solution, water, alkaline cleaning fluid and water.
8. the clean-in-place method of the production equipment according to claim 1 for milk-contained drink, wherein cleaning in 50-
It is carried out at a temperature of 150 DEG C.
9. the clean-in-place method according to claim 1,3 or 5 any one of them for the production equipment of milk-contained drink, wherein
During measuring fluorescence, the flushing liquor or cleaning solution are excited with the wavelength of 250-500nm.
10. the clean-in-place method according to claim 1,3 or 5 any one of them for the production equipment of milk-contained drink,
In protein substance in flushing liquor or cleaning solution described in the wavelength measurement of 320-500nm fluorescence.
11. the clean-in-place method of the production equipment according to claim 7 for milk-contained drink further includes being circulated throughout
In journey in continuous or intermittent manner, the turbidity of cleaning solution is measured.
12. the clean-in-place method according to claim 1 or 11 any one of them for the production equipment of milk-contained drink, wherein
In intermittent mode, the interval between measurement is 1 second to 6 minutes.
13. the clean-in-place method of the production equipment according to claim 11 for milk-contained drink, wherein measuring cleaning
The turbidity of liquid includes the turbidity for measuring acidic cleaning solution.
14. the clean-in-place method of the production equipment according to claim 1 for milk-contained drink, wherein when following situations
When generation, fluorescence reaches stable：
The mean fluorescence readings of previous cycle compared with the mean fluorecence in preceding cycle change rate be less than 5% and previous cycle most
Small fluorescence and the ratio of maximum fluorescence are more than 90%；Or
Mean fluorescence readings between two adjacent circulations are at least twice of setting value.
15. the clean-in-place method of the production equipment according to claim 14 for milk-contained drink further includes when two
When mean fluorescence readings between adjacent circulation are less than twice of setting value, additional alkaline cleaning fluid cleaning is carried out.
16. a kind of for as described in claim 1 for the measurement in the clean-in-place method of the production equipment of milk-contained drink
It stands, including：
Detection device, including fluorescence detector are used to measure the fluorescence of the protein substance in cyclic process in cleaning solution
Reading；With
Data processing equipment is used to handle the reading for coming from detection device.
17. the original position according to claim 16 for as described in claim 1 for the production equipment of milk-contained drink
Measuring station in cleaning method, wherein detection device further include nephelometer.
18. a kind of system for being used for as described in claim 1 in the clean-in-place method of the production equipment of milk-contained drink,
After the cleaning system accesses production equipment, scavenger circuit is constituted, the system comprises：
Measuring station, including：
Detection device, including fluorescence detector, fluorescence for measuring the protein substance in cleaning solution simultaneously export fluorescence reading
Number；
Data processing equipment, for handling the reading for coming from detection device；
Switching equipment, according to from measuring station as a result, end cleaning step, is discharged cleaning solution.
19. the original position according to claim 18 for as described in claim 1 for the production equipment of milk-contained drink
System in cleaning method, wherein the measuring station is online or offline.
20. the original position according to claim 18 for as described in claim 1 for the production equipment of milk-contained drink
System in cleaning method, wherein the detection device further includes nephelometer.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810922871.7A CN109158366B (en) | 2014-01-26 | 2014-01-26 | In-situ cleaning process and in-situ cleaning system |
| CN201410037559.1A CN104801511B (en) | 2014-01-26 | 2014-01-26 | Ex-situ cleaning process and clean-in-place system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410037559.1A CN104801511B (en) | 2014-01-26 | 2014-01-26 | Ex-situ cleaning process and clean-in-place system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810922871.7A Division CN109158366B (en) | 2014-01-26 | 2014-01-26 | In-situ cleaning process and in-situ cleaning system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104801511A CN104801511A (en) | 2015-07-29 |
| CN104801511B true CN104801511B (en) | 2018-09-18 |
Family
ID=53686948
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410037559.1A Active CN104801511B (en) | 2014-01-26 | 2014-01-26 | Ex-situ cleaning process and clean-in-place system |
| CN201810922871.7A Active CN109158366B (en) | 2014-01-26 | 2014-01-26 | In-situ cleaning process and in-situ cleaning system |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810922871.7A Active CN109158366B (en) | 2014-01-26 | 2014-01-26 | In-situ cleaning process and in-situ cleaning system |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN104801511B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102218579B1 (en) * | 2015-12-08 | 2021-02-22 | 후지 덴키 가부시키가이샤 | Drink dispensing apparatus |
| CN106387047A (en) * | 2016-08-31 | 2017-02-15 | 四川新华西乳业有限公司 | CIP (Clean in Place) cleaning method for dairy production line |
| CN106345743A (en) * | 2016-10-31 | 2017-01-25 | 广西大学 | Waste aluminum alloy automatic cleaning device |
| CN106862180B (en) * | 2017-01-24 | 2019-01-01 | 浙江恒天凡腾科技股份有限公司 | A kind of CIP on-line cleaning system control method |
| CN110394336A (en) * | 2019-07-09 | 2019-11-01 | 上海青赛生物科技有限公司 | A kind of clean-in-place method |
| CN111451223A (en) * | 2020-04-29 | 2020-07-28 | 中电华创(苏州)电力技术研究有限公司 | Online cleaning device and method for water vapor sampling system |
| CN116991146B (en) * | 2023-09-26 | 2023-12-01 | 恒超源洗净科技(深圳)有限公司 | Control method and system of ultrasonic cleaning device |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1596299A (en) * | 2002-02-25 | 2005-03-16 | 西巴特殊化学品控股有限公司 | Process for the treatment of textile fibre materials |
| CN102781592A (en) * | 2009-12-18 | 2012-11-14 | 化学工业有限公司 | Product and process for simultaneous cleaning, painting, and impregnation of an aqueous base for plastic pieces |
| CN103003485A (en) * | 2010-04-12 | 2013-03-27 | 塞罗斯有限公司 | Method to clean a moistened soiled substrate with polymeric particles |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1001158C2 (en) * | 1995-09-08 | 1997-03-11 | Maasland Nv | Method for cleaning a milk line system. |
| US6767408B2 (en) * | 2002-12-18 | 2004-07-27 | Hydrite Chemical Co. | Monitoring device and method for operating clean-in-place system |
| US20060286676A1 (en) * | 2005-06-17 | 2006-12-21 | Van Camp James R | Fluorometric method for monitoring a clean-in-place system |
| GB0611218D0 (en) * | 2006-06-08 | 2006-07-19 | Unilever Plc | Detergent compositions |
| CN101406887B (en) * | 2007-10-12 | 2010-05-19 | 广州泰成生化科技有限公司 | In situ cleaning method |
| CN201514380U (en) * | 2008-11-19 | 2010-06-23 | 苏州纳凯科技有限公司 | Device for quickly detecting protein content in liquid samples based on fluorescent technique |
| CN101862741A (en) * | 2009-04-17 | 2010-10-20 | 娄底市裕德科技有限公司 | Washing method of improved turbid circulating water system water supply main pipe |
| CN201558836U (en) * | 2009-12-28 | 2010-08-25 | 中国船舶重工集团公司第七�三研究所 | CIP (Cleaning In Place) automatic cleaning device |
-
2014
- 2014-01-26 CN CN201410037559.1A patent/CN104801511B/en active Active
- 2014-01-26 CN CN201810922871.7A patent/CN109158366B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1596299A (en) * | 2002-02-25 | 2005-03-16 | 西巴特殊化学品控股有限公司 | Process for the treatment of textile fibre materials |
| CN102781592A (en) * | 2009-12-18 | 2012-11-14 | 化学工业有限公司 | Product and process for simultaneous cleaning, painting, and impregnation of an aqueous base for plastic pieces |
| CN103003485A (en) * | 2010-04-12 | 2013-03-27 | 塞罗斯有限公司 | Method to clean a moistened soiled substrate with polymeric particles |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104801511A (en) | 2015-07-29 |
| CN109158366B (en) | 2021-08-24 |
| CN109158366A (en) | 2019-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104801511B (en) | Ex-situ cleaning process and clean-in-place system | |
| US6767408B2 (en) | Monitoring device and method for operating clean-in-place system | |
| CN101947520B (en) | Automatic cleaning method maintaining stable cleaning effect and cleaning machine | |
| CN106525905B (en) | The monitoring water quality on line system cleaned and demarcated automatically with electrode | |
| CN201628641U (en) | Continuous automatic sampling device for monitoring water quality | |
| US20080142041A1 (en) | Process for cleaning an installation | |
| CN105008901A (en) | Method and system for operating a cip pre-flush step using fluorometric measurements of soil content | |
| JP2018501491A (en) | Device for maintaining sensor accuracy | |
| CN205200055U (en) | Full -automatic glassware cleaning machine of on -line monitoring conductivity | |
| CA2611025C (en) | Fluorometric method for monitoring a clean-in-place system | |
| CN103884817A (en) | Dynamic simulation test device for chemically cleaning power station boiler and fabrication and test methods of test device | |
| CN109099758A (en) | A kind of heat exchanger online backwashing system and purging method | |
| KR20120025105A (en) | Test device for head loss of filter and test method thereof | |
| JPH08243520A (en) | Equipment washing method and device for executing the same | |
| CN209263781U (en) | A kind of heat exchanger online backwashing system | |
| CN208194121U (en) | Reverse osmosis membrane on-line cleaning system | |
| CN105699602A (en) | Judgment method of cleaning capability of cleaning liquid, monitoring method and system | |
| CN109332324A (en) | A kind of automatic CIP system and its control method | |
| CN103543160A (en) | Thread defect detection method | |
| CN104614590A (en) | Continuous online hydrogen conductivity measurement device | |
| CN204422653U (en) | The continuous on-line measurement device of hydrogen conductivity | |
| CN209432817U (en) | A kind of water quality on-line detector | |
| CN106178964A (en) | A kind of NF membrane cleans device | |
| JP2010142767A (en) | Fluid work monitoring apparatus | |
| JP3341160B2 (en) | Food and other product manufacturing equipment with automatic cleaning equipment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |