CN104797585B - 氨基咪唑并哒嗪 - Google Patents

氨基咪唑并哒嗪 Download PDF

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Publication number
CN104797585B
CN104797585B CN201380060430.6A CN201380060430A CN104797585B CN 104797585 B CN104797585 B CN 104797585B CN 201380060430 A CN201380060430 A CN 201380060430A CN 104797585 B CN104797585 B CN 104797585B
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CN
China
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group
cycloalkyl
alkyl
compound
nhr
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Expired - Fee Related
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CN201380060430.6A
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English (en)
Chinese (zh)
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CN104797585A (zh
Inventor
L.佐恩
K.艾斯
V.舒尔策
D.休兹尔
F.皮尤勒
P.利诺
U.博默
K.彼得森
A.黑格巴思
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Bayer Pharma AG
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Bayer Pharma AG
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380060430.6A 2012-11-19 2013-11-14 氨基咪唑并哒嗪 Expired - Fee Related CN104797585B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12193192 2012-11-19
EP12193192.7 2012-11-19
PCT/EP2013/073793 WO2014076162A1 (en) 2012-11-19 2013-11-14 Aminoimidazopyridazines

Publications (2)

Publication Number Publication Date
CN104797585A CN104797585A (zh) 2015-07-22
CN104797585B true CN104797585B (zh) 2017-08-15

Family

ID=47177840

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380060430.6A Expired - Fee Related CN104797585B (zh) 2012-11-19 2013-11-14 氨基咪唑并哒嗪

Country Status (8)

Country Link
US (1) US9783543B2 (enExample)
EP (1) EP2920176B1 (enExample)
JP (1) JP2015537017A (enExample)
CN (1) CN104797585B (enExample)
CA (1) CA2891644A1 (enExample)
ES (1) ES2646916T3 (enExample)
HK (1) HK1208025A1 (enExample)
WO (1) WO2014076162A1 (enExample)

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US9730929B2 (en) 2011-06-01 2017-08-15 Bayer Intellectual Property Gmbh Substituted aminoimidazopyridazines
UA117092C2 (uk) 2011-09-06 2018-06-25 Байєр Інтеллектуал Проперті Гмбх Амінозаміщені імідазопіридазини
ES2650915T3 (es) 2011-12-12 2018-01-23 Bayer Intellectual Property Gmbh Imidazopiridazinas amino-sustituidas
JP6173426B2 (ja) 2012-03-29 2017-08-02 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ アミノ置換イミダゾピリダジン
CN104321326B (zh) 2012-04-04 2017-05-31 拜耳医药股份有限公司 氨基取代的咪唑并哒嗪
US9783543B2 (en) 2012-11-19 2017-10-10 Bayer Pharma Aktiengesellschaft Aminoimidazopyridazines
EP2943485B1 (en) 2013-01-14 2017-09-20 Incyte Holdings Corporation Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
HUE050215T2 (hu) 2013-01-15 2020-11-30 Incyte Holdings Corp Pim kináz inhibitorokként hasznos tiazolkarboxamid és piridinkarboxamid vegyületek
EP2951181A1 (en) 2013-01-30 2015-12-09 Bayer Pharma Aktiengesellschaft Amidoimidazopyridazines as mknk-1 kinase inhibitors
TW201605866A (zh) 2013-08-23 2016-02-16 英塞特公司 可用作ｐｉｍ激酶抑制劑之呋喃并－及噻吩并－吡啶甲醯胺化合物
EP3092242A1 (en) 2014-01-09 2016-11-16 Bayer Pharma Aktiengesellschaft Amido-substituted imidazopyridazines useful in the treatment of hyper-proliferative and/or angiogenesis disorders
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016010897A1 (en) 2014-07-14 2016-01-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
DK3285809T3 (da) 2015-04-20 2019-11-18 Effector Therapeutics Inc Inhibitorer af immunkontrolpunktsmodulatorer til anvendelse i behandling af kræft og infektioner.
US9540347B2 (en) 2015-05-29 2017-01-10 Incyte Corporation Pyridineamine compounds useful as Pim kinase inhibitors
TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
WO2017059251A1 (en) 2015-10-02 2017-04-06 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
CN105548420B (zh) * 2015-12-30 2019-08-02 上海泽润生物科技有限公司 Mops残留量的检测方法
US20170191136A1 (en) 2015-12-31 2017-07-06 Effector Therapeutics, Inc. Mnk biomarkers and uses thereof
WO2017157418A1 (en) 2016-03-15 2017-09-21 Bayer Pharma Aktiengesellschaft Combination of mknk1-inhibitors
WO2019113487A1 (en) 2017-12-08 2019-06-13 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms

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Publication number Priority date Publication date Assignee Title
US20070093490A1 (en) * 2005-09-02 2007-04-26 Olaf Prien Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments
WO2007147646A1 (de) * 2006-06-21 2007-12-27 Bayer Schering Pharma Aktiengesellschaft OXO-SUBSTITUIERTE IMIDAZO[1,2b]PYRIDAZINE, DEREN HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL
CN103717604A (zh) * 2011-06-01 2014-04-09 拜耳知识产权有限责任公司 取代的氨基咪唑并哒嗪
CN103764656A (zh) * 2011-06-22 2014-04-30 拜耳知识产权有限责任公司 杂环基氨基咪唑并哒嗪
CN104114559A (zh) * 2011-12-12 2014-10-22 拜耳知识产权有限责任公司 氨基取代的咪唑并哒嗪

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CN104321326B (zh) 2012-04-04 2017-05-31 拜耳医药股份有限公司 氨基取代的咪唑并哒嗪
US9783543B2 (en) 2012-11-19 2017-10-10 Bayer Pharma Aktiengesellschaft Aminoimidazopyridazines
EP2951181A1 (en) 2013-01-30 2015-12-09 Bayer Pharma Aktiengesellschaft Amidoimidazopyridazines as mknk-1 kinase inhibitors
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Publication number Priority date Publication date Assignee Title
US20070093490A1 (en) * 2005-09-02 2007-04-26 Olaf Prien Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments
WO2007147646A1 (de) * 2006-06-21 2007-12-27 Bayer Schering Pharma Aktiengesellschaft OXO-SUBSTITUIERTE IMIDAZO[1,2b]PYRIDAZINE, DEREN HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL
CN103717604A (zh) * 2011-06-01 2014-04-09 拜耳知识产权有限责任公司 取代的氨基咪唑并哒嗪
CN103764656A (zh) * 2011-06-22 2014-04-30 拜耳知识产权有限责任公司 杂环基氨基咪唑并哒嗪
CN104114559A (zh) * 2011-12-12 2014-10-22 拜耳知识产权有限责任公司 氨基取代的咪唑并哒嗪

Also Published As

Publication number Publication date
WO2014076162A1 (en) 2014-05-22
EP2920176B1 (en) 2017-09-13
CN104797585A (zh) 2015-07-22
US9783543B2 (en) 2017-10-10
JP2015537017A (ja) 2015-12-24
HK1208025A1 (en) 2016-02-19
US20150291599A1 (en) 2015-10-15
EP2920176A1 (en) 2015-09-23
ES2646916T3 (es) 2017-12-18
CA2891644A1 (en) 2014-05-22

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