CN104793293A - Optical fiber adjusting and fixing device, fluorescent light collecting device and implementing method - Google Patents
Optical fiber adjusting and fixing device, fluorescent light collecting device and implementing method Download PDFInfo
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- CN104793293A CN104793293A CN201510218628.3A CN201510218628A CN104793293A CN 104793293 A CN104793293 A CN 104793293A CN 201510218628 A CN201510218628 A CN 201510218628A CN 104793293 A CN104793293 A CN 104793293A
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- optical fiber
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- collection optical
- driven pinion
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/42—Coupling light guides with opto-electronic elements
- G02B6/4296—Coupling light guides with opto-electronic elements coupling with sources of high radiant energy, e.g. high power lasers, high temperature light sources
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/0001—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems
- G02B6/0005—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being of the fibre type
- G02B6/001—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being of the fibre type the light being emitted along at least a portion of the lateral surface of the fibre
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/26—Optical coupling means
- G02B6/262—Optical details of coupling light into, or out of, or between fibre ends, e.g. special fibre end shapes or associated optical elements
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- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Optical Couplings Of Light Guides (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The invention provides an optical fiber adjusting and fixing device, a fluorescent light collecting device and an implementing method. The position of a fluorescent light collecting optical fiber can be adjusted through the optical fiber adjusting and fixing device, so that good fluorescent light signals are acquired; the optical fiber adjusting and fixing device is convenient and flexible and is easy to operate; an interface of an optical fiber of the fluorescent light collecting device is an SM905 interface, and different excitation light sources can be changed according to different requirements on wavelengths, power and the like; and the fluorescent light collecting optical fiber is a side light exiting optical fiber, influences of reflecting light of the vertical incident excitation light sources can be reduced effectively, and signal to noise ratio of fluorescent light signals is improved.
Description
Technical field
The present invention relates to optical instrument manufacture and enforcement field, especially a kind of optical fiber regulates stationary installation and phosphor collection device and implementation method.
Background technology
In recent years, the incidence of disease of cutaneum carcinoma is in rising trend in many countries.Although cutaneum carcinoma incidence of disease in yellow is not high, in white people, but there is the higher incidence of disease.Be modal cancer in U.S.'s cutaneum carcinoma, nearly 800,000 white people's morbidities, account for 1% in all number of cancer deaths every year.
The goldstandard of current diagnosing tumor carries out pathological anatomy and histocytology diagnosis.But the pathological diagnosis of non-quantized exist operating process loaded down with trivial details, the drawback such as to be affected by human factors.And spectral detection has the feature such as Noninvasive, Fast nondestructive evaluation, the Fast nondestructive evaluation of biological tissue can be realized, therefore, be subject to extensive concern in Photobiology field.The spectral technique of what Recent study was more be applied to diagnosing tumor mainly contains fluorescence spectroscopy technique, Raman spectroscopy, infrared spectrum technology and optoacoustic spectroscopy etc.
Because fluorescence spectrum can reflect the various color base of organization internal, by analyzing its spectral shape and the isoparametric change of intensity, lesion tissue can be predicted.Current fluorescence spectrophotometer mainly adopts the method for transmission-type and reflective phosphor collection.Transmission-type phosphor collection can be divided into again the mode of side collection and vertical collection fluorescence.Human skin tissue, primarily of epidermis, corium and subcutaneous fat composition, incides the light beam of skin surface, is first directly reflected by keratoderma; And most of incident light enters epidermis and the corium of skin histology successively after being reflected by skin surface, and by skin histology scattering and absorption, wherein a part of light is entered air by returning to skin surface after Multiple Scattering; In addition, the fluorescent material in skin is sent fluorescence by after the excitation of specific wavelength, also can return skin surface and enter in air after Multiple Scattering.And the excitating light strength reflected is much larger than fluorescence intensity, so the method for cutaneum carcinoma phosphor collection mainly adopts vertical exciting light at present, the reflective method of collecting optical fiber parallel with excitation fiber carries out phosphor collection, and then the reflected light reducing exciting light enters phosphor collection optical fiber, then improve the signal to noise ratio (S/N ratio) of collecting fluorescence by adjusting the variablees such as the distance of distance, optical fiber and the focus of collecting optical fiber and excitation fiber.Traditional reflective phosphor collection mode, normally fixes excitation fiber and collects the distance of optical fiber, by excitation fiber with collect optical fiber set on an optical fiber, adjust fluorescence signal to noise ratio (S/N ratio) by the distance of adjustment optical fiber and skin.But the fluorescence of traditional reflective phosphor collection often or the reflected light of the light source that can be excited flooded, and can not collect good fluorescence information.
Therefore, study the impact of a kind of stimulated luminescence reflected light little, and fiber position is adjustable, and then collects the phosphor collection device of good fluorescence signal, there is important more practical value.
Summary of the invention
Technical matters to be solved by this invention is to provide a kind of optical fiber to regulate stationary installation.
Another technical matters to be solved by this invention is to provide has the phosphor collection device that above-mentioned optical fiber regulates stationary installation.
Another technical matters to be solved by this invention is the implementation method of the phosphor collection function providing above-mentioned phosphor collection device.
For solving the problems of the technologies described above, technical scheme of the present invention is:
A kind of optical fiber regulates stationary installation, comprise chassis, gear wheel, driver pinion, first driven pinion, second driven pinion, 3rd driven pinion, sprocket gear bar, first gear bar, second gear article and the 3rd gear article, described gear wheel, driver pinion, first driven pinion, second driven pinion and the 3rd driven pinion are fixed with chassis homonymy respectively, described gear wheel respectively with described driver pinion, first driven pinion, second driven pinion and the 3rd driven pinion are fixed in engaged gears mode, described sprocket gear bar and described driver pinion are fixed in engaged gears mode, described first gear bar and described first driven pinion are fixed in engaged gears mode, described second gear bar and described second driven pinion are fixed in engaged gears mode, described 3rd gear article is fixed in engaged gears mode with described 3rd driven pinion.
Preferably, above-mentioned optical fiber regulates stationary installation, and described chassis is provided with four grooves, and described sprocket gear article, the first gear article, the second gear article and a 3rd gear article correspondence are arranged in groove, and are slidably connected along groove direction and described chassis.
Preferably, above-mentioned optical fiber regulates stationary installation, and described sprocket gear article, the first gear article, the second gear article and the 3rd gear article are uniformly distributed in described gear wheel surrounding.
A kind of have the phosphor collection device that above-mentioned optical fiber regulates stationary installation, comprise laser instrument, exciting light conduction optical fiber, SM905 coupling fiber interface, optical fiber described in claim 1 regulates stationary installation, first phosphor collection optical fiber, second phosphor collection optical fiber, 3rd phosphor collection optical fiber, 4th phosphor collection optical fiber and fiber coupling device, described optical fiber regulates stationary installation to be provided with SM905 coupling fiber interface, described laser instrument is connected with described SM905 coupling fiber interface one end by exciting light conduction optical fiber, described first phosphor collection optical fiber, second phosphor collection optical fiber, 3rd phosphor collection optical fiber and the 4th phosphor collection optical fiber are side light-coming out optical fiber, wherein, described first phosphor collection optical fiber is fixed on described optical fiber and regulates on the sprocket gear bar of stationary installation, described second phosphor collection optical fiber is fixed on described optical fiber and regulates on the first gear bar of stationary installation, described 3rd phosphor collection optical fiber is fixed on described optical fiber and regulates on second gear article of stationary installation, described 4th phosphor collection optical fiber is fixed on described optical fiber and regulates on the 3rd gear article of stationary installation, described fiber coupling device respectively with described first phosphor collection optical fiber, second phosphor collection optical fiber, 3rd phosphor collection optical fiber is connected with the 4th phosphor collection fibre circuit.
The implementation method of the phosphor collection function of above-mentioned phosphor collection device, concrete methods of realizing is:
(1), after laser instrument produces excitation source, this excitation source is coupled into SM905 interface after exciting light conduction fiber optic conduction, and is radiated at lesions position;
(2) adjust optical fiber and regulate stationary installation, alignd with the center of lesions position in its center, and make the distance between optical fiber and skin remain on 1 ~ 3mm, concrete method of adjustment is: after lesions position is stimulated exciting of light source, the fluorescence at the position that generation fluorescence intensity is high enters the first phosphor collection optical fiber with the angle of angle [alpha] 2, second phosphor collection optical fiber, after 3rd phosphor collection optical fiber and the 4th phosphor collection optical fiber, then fiber coupling device is coupled into, the fluorescence received is coupled into spectrometer, carry out the detection of fluorescence spectrum, as α 3=30 °, by regulating driver pinion, make it drive bull gear drive and drive sprocket gear bar to move, bull gear drive process drives again the first driven pinion, second driven pinion and the motion of the 3rd driven pinion, and then drive the first gear bar, second gear article and article motion of the 3rd gear, thus make the first phosphor collection optical fiber of being fixed thereon, second phosphor collection optical fiber, relevant position adjustment made by 3rd phosphor collection optical fiber and the 4th phosphor collection optical fiber, finally make the fluorescence at the position that fluorescence intensity is high, with the angle of angle [alpha] 2=60 by the first phosphor collection optical fiber, second phosphor collection optical fiber, 3rd phosphor collection optical fiber and the 4th phosphor collection optical fiber are collected, fluorescence as much as possible can be propagated in optical fiber with directional light or the angle being greater than critical angle, improve the signal to noise ratio (S/N ratio) of fluorescence, wherein, α 2 is the angles sending fluorescence and focus plane, α 3 is shear-face angle of side light-coming out optical fiber.
The invention has the beneficial effects as follows:
Above-mentioned optical fiber regulates stationary installation, can regulate the position of phosphor collection optical fiber, and then gather best fluorescence signal; Convenient, flexible, simple to operate; Above-mentioned phosphor collection device, the interface of the optical fiber of employing is SM905 interface, can change different excitation sources according to different demands (wavelength, power etc.); The phosphor collection optical fiber adopted is side light-coming out optical fiber, can effectively reduce the impact of the reflected light of the excitation source of vertical incidence, improves the signal to noise ratio (S/N ratio) of fluorescence signal.
Accompanying drawing explanation
Fig. 1 is the structural representation that optical fiber of the present invention regulates stationary installation;
Fig. 2 is the structural representation of phosphor collection device of the present invention;
Fig. 3 is that this illustrates the operating diagram of the phosphor collection optical fiber of described phosphor collection device.
In figure: 1-laser instrument 2-exciting light conduction optical fiber 3-SM905 coupling fiber interface 4-optical fiber regulates stationary installation 4-1-1-driver pinion 4-1-2-first driven pinion 4-1-3-second driven pinion 4-1-4-the 3rd driven pinion 4-2-gear wheel 4-3-1-sprocket gear article 4-3-2-first gear article 4-3-3-second gear article 4-3-4-the 3rd gear article 5-phosphor collection optical fiber 5-1-first phosphor collection optical fiber 5-2-second phosphor collection optical fiber 5-3-the 3rd phosphor collection optical fiber 5-4-the 4th phosphor collection optical fiber 6-fiber coupling device 7-focus
α 1 beats the reflection angle at optical fiber for fluorescence,
α 2 is the angles sending fluorescence and focus plane,
α 3 is the shear-face angle of side light-coming out optical fiber.
Embodiment
In order to make those skilled in the art better understand technical scheme of the present invention, below in conjunction with the drawings and the specific embodiments, technical scheme of the present invention is described in further detail.
Embodiment 1
As shown in Figure 1, described optical fiber regulates stationary installation, comprises chassis (omission accompanying drawing), gear wheel 4-2, driver pinion 4-1-1, first driven pinion 4-1-2, second driven pinion 4-1-3, 3rd driven pinion 4-1-4, sprocket gear bar 4-3-1, first gear bar 4-3-2, second gear article 4-3-3 and the 3rd gear article 4-3-4, described gear wheel, driver pinion, first driven pinion, second driven pinion and the 3rd driven pinion are fixed with chassis homonymy respectively, and described chassis is provided with four grooves, described sprocket gear bar, first gear bar, second gear article and a 3rd gear article correspondence are arranged in groove, and are slidably connected along groove direction and described chassis, described gear wheel respectively with described driver pinion, first driven pinion, second driven pinion and the 3rd driven pinion are fixed in engaged gears mode, described sprocket gear bar and described driver pinion are fixed in engaged gears mode, described first gear bar and described first driven pinion are fixed in engaged gears mode, described second gear bar and described second driven pinion are fixed in engaged gears mode, described 3rd gear article is fixed in engaged gears mode with described 3rd driven pinion, and described sprocket gear bar, first gear bar, second gear article and the 3rd gear article are uniformly distributed in described gear wheel surrounding.
Embodiment 2
As shown in Figure 2, described have the phosphor collection device that above-mentioned optical fiber regulates stationary installation, comprise laser instrument 1, exciting light conduction optical fiber 2, SM905 coupling fiber interface 3, optical fiber described in claim 1 regulates stationary installation 4, first phosphor collection optical fiber 5-1, second phosphor collection optical fiber 5-2, 3rd phosphor collection optical fiber 5-3, 4th phosphor collection optical fiber 5-4 and fiber coupling device 6, described optical fiber regulates stationary installation to be provided with SM905 coupling fiber interface, described laser instrument is connected with described SM905 coupling fiber interface one end by exciting light conduction optical fiber, described first phosphor collection optical fiber, second phosphor collection optical fiber, 3rd phosphor collection optical fiber and the 4th phosphor collection optical fiber are side light-coming out optical fiber, wherein, described first phosphor collection optical fiber is fixed on described optical fiber and regulates on the sprocket gear bar of stationary installation, described second phosphor collection optical fiber is fixed on described optical fiber and regulates on the first gear bar of stationary installation, described 3rd phosphor collection optical fiber is fixed on described optical fiber and regulates on second gear article of stationary installation, described 4th phosphor collection optical fiber is fixed on described optical fiber and regulates on the 3rd gear article of stationary installation, described fiber coupling device respectively with described first phosphor collection optical fiber, second phosphor collection optical fiber, 3rd phosphor collection optical fiber is connected with the 4th phosphor collection fibre circuit.By regulating described optical fiber to regulate the driver pinion of stationary installation can drive the rotation of other gears, and then the effect regulating each gear bar can be played, to reach the effect regulating each phosphor collection fiber position be fixed on gear bar.As shown in Figure 3, the be excited fluorescence of the generation after optical excitation of focus 7 is collected by each phosphor collection optical fiber 5.
The implementation method of the phosphor collection function of above-mentioned phosphor collection device, concrete methods of realizing is:
(1), after laser instrument produces excitation source, this excitation source is coupled into SM905 interface after exciting light conduction fiber optic conduction, and is radiated at lesions position;
(2) adjust optical fiber and regulate stationary installation, alignd with the center of lesions position in its center, and make the distance between optical fiber and skin remain on 1 ~ 3mm, concrete method of adjustment is: after the fluorescence at the high position of generation fluorescence intensity after lesions position is stimulated exciting of light source enters the first phosphor collection optical fiber, the second phosphor collection optical fiber, the 3rd phosphor collection optical fiber and the 4th phosphor collection optical fiber with the angle of angle [alpha] 2, then fiber coupling device is coupled into, the fluorescence received is coupled into spectrometer, carries out the detection of fluorescence spectrum.As shown in Figure 3, as α 3=30 °, by regulating driver pinion, make it drive bull gear drive and drive sprocket gear bar to move, bull gear drive process drives again the first driven pinion, second driven pinion and the motion of the 3rd driven pinion, and then drive the first gear bar, second gear article and article motion of the 3rd gear, thus make the first phosphor collection optical fiber of being fixed thereon, second phosphor collection optical fiber, relevant position adjustment made by 3rd phosphor collection optical fiber and the 4th phosphor collection optical fiber, finally make the fluorescence at the position that fluorescence intensity is high, with the angle of angle [alpha] 2=60 by the first phosphor collection optical fiber, second phosphor collection optical fiber, 3rd phosphor collection optical fiber and the 4th phosphor collection optical fiber are collected, fluorescence as much as possible can be propagated in optical fiber with directional light or the angle being greater than critical angle, improve the signal to noise ratio (S/N ratio) of fluorescence, wherein, α 2 is the angles sending fluorescence and focus plane, α 3 is shear-face angle of side light-coming out optical fiber.
Visible, described phosphor collection device is by excitation light source excites lesions position, adopt side light-coming out optical fiber to carry out the phosphor collection in skin focus region, by phosphor collection optical fiber, the fluorescence excited is coupled on an optical fiber, decreases the interference of exciting light reflected light to collected fluorescence signal; Phosphor collection fiber position is adjustable, achieves the optimum choice of phosphor collection signal, improves signal to noise ratio (S/N ratio).
The above-mentioned detailed description regulating stationary installation and phosphor collection device and implementation method to carry out to this kind of optical fiber with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (5)
1. an optical fiber regulates stationary installation, it is characterized in that: comprise chassis, gear wheel, driver pinion, first driven pinion, second driven pinion, 3rd driven pinion, sprocket gear bar, first gear bar, second gear article and the 3rd gear article, described gear wheel, driver pinion, first driven pinion, second driven pinion and the 3rd driven pinion are fixed with chassis homonymy respectively, described gear wheel respectively with described driver pinion, first driven pinion, second driven pinion and the 3rd driven pinion are fixed in engaged gears mode, described sprocket gear bar and described driver pinion are fixed in engaged gears mode, described first gear bar and described first driven pinion are fixed in engaged gears mode, described second gear bar and described second driven pinion are fixed in engaged gears mode, described 3rd gear article is fixed in engaged gears mode with described 3rd driven pinion.
2. optical fiber according to claim 1 regulates stationary installation, it is characterized in that: described chassis is provided with four grooves, described sprocket gear article, the first gear article, the second gear article and a 3rd gear article correspondence are arranged in groove, and are slidably connected along groove direction and described chassis.
3. optical fiber according to claim 1 regulates stationary installation, it is characterized in that: described sprocket gear article, the first gear article, the second gear article and the 3rd gear article are uniformly distributed in described gear wheel surrounding.
4. one kind has the phosphor collection device that optical fiber described in claim 1 regulates stationary installation, it is characterized in that: comprise laser instrument, exciting light conduction optical fiber, SM905 coupling fiber interface, optical fiber described in claim 1 regulates stationary installation, first phosphor collection optical fiber, second phosphor collection optical fiber, 3rd phosphor collection optical fiber, 4th phosphor collection optical fiber and fiber coupling device, described optical fiber regulates stationary installation to be provided with SM905 coupling fiber interface, described laser instrument is connected with described SM905 coupling fiber interface one end by exciting light conduction optical fiber, described first phosphor collection optical fiber, second phosphor collection optical fiber, 3rd phosphor collection optical fiber and the 4th phosphor collection optical fiber are side light-coming out optical fiber, wherein, described first phosphor collection optical fiber is fixed on described optical fiber and regulates on the sprocket gear bar of stationary installation, described second phosphor collection optical fiber is fixed on described optical fiber and regulates on the first gear bar of stationary installation, described 3rd phosphor collection optical fiber is fixed on described optical fiber and regulates on second gear article of stationary installation, described 4th phosphor collection optical fiber is fixed on described optical fiber and regulates on the 3rd gear article of stationary installation, described fiber coupling device respectively with described first phosphor collection optical fiber, second phosphor collection optical fiber, 3rd phosphor collection optical fiber is connected with the 4th phosphor collection fibre circuit.
5. the implementation method of the phosphor collection function of phosphor collection device described in claim 4, is characterized in that: concrete methods of realizing is:
(1), after laser instrument produces excitation source, this excitation source is coupled into SM905 interface after exciting light conduction fiber optic conduction, and is radiated at lesions position;
(2) adjust optical fiber and regulate stationary installation, alignd with the center of lesions position in its center, and make the distance between optical fiber and skin remain on 1-3mm, concrete method of adjustment is: after lesions position is stimulated exciting of light source, the fluorescence at the position that generation fluorescence intensity is high enters the first phosphor collection optical fiber with the angle of angle [alpha] 2, second phosphor collection optical fiber, after 3rd phosphor collection optical fiber and the 4th phosphor collection optical fiber, then fiber coupling device is coupled into, the fluorescence received is coupled into spectrometer, carry out the detection of fluorescence spectrum, as α 3=30 °, by regulating driver pinion, make it drive bull gear drive and drive sprocket gear bar to move, bull gear drive process drives again the first driven pinion, second driven pinion and the motion of the 3rd driven pinion, and then drive the first gear bar, second gear article and article motion of the 3rd gear, thus make the first phosphor collection optical fiber of being fixed thereon, second phosphor collection optical fiber, relevant position adjustment made by 3rd phosphor collection optical fiber and the 4th phosphor collection optical fiber, finally make the fluorescence at the position that fluorescence intensity is high, with the angle of angle [alpha] 2=60 ° by the first phosphor collection optical fiber, second phosphor collection optical fiber, 3rd phosphor collection optical fiber and the 4th phosphor collection optical fiber are collected, fluorescence as much as possible can be propagated in optical fiber with directional light or the angle being greater than critical angle, improve the signal to noise ratio (S/N ratio) of fluorescence, wherein, α 2 is the angles sending fluorescence and focus plane, α 3 is shear-face angle of side light-coming out optical fiber.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510218628.3A CN104793293A (en) | 2015-04-30 | 2015-04-30 | Optical fiber adjusting and fixing device, fluorescent light collecting device and implementing method |
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| CN201510218628.3A CN104793293A (en) | 2015-04-30 | 2015-04-30 | Optical fiber adjusting and fixing device, fluorescent light collecting device and implementing method |
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Cited By (3)
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| CN107436299A (en) * | 2017-07-25 | 2017-12-05 | 苏州德锐特成像技术有限公司 | A kind of bioluminescence imaging brightness automatically analyzes the method and apparatus of regulation |
| CN110167419A (en) * | 2016-12-27 | 2019-08-23 | 德普伊新特斯产品公司 | For providing system, the method and apparatus of illumination in endoscope imaging circumstances |
| CN113223817A (en) * | 2021-05-14 | 2021-08-06 | 国家电网有限公司 | Transformer convenient to install |
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Application publication date: 20150722 |