CN104788329A - Method for extracting and preparing calcium amino acid chelate and strontium amino acid chelate from coral skeletons - Google Patents
Method for extracting and preparing calcium amino acid chelate and strontium amino acid chelate from coral skeletons Download PDFInfo
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- CN104788329A CN104788329A CN201510119475.7A CN201510119475A CN104788329A CN 104788329 A CN104788329 A CN 104788329A CN 201510119475 A CN201510119475 A CN 201510119475A CN 104788329 A CN104788329 A CN 104788329A
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Abstract
The invention discloses a method for extracting and preparing calcium amino acid chelate and strontium amino acid chelate from coral skeletons. The method comprises the steps: soaking the coral skeletons with deionized water, then scrubbing to remove silt and other adsorption materials on the surface of the coral skeletons, drying, pulverizing, and thus obtaining a coral skeleton powder for synthesis of calcium amino acid chelate and strontium amino acid chelate; adding the coral skeleton powder into dilute hydrochloric acid, dissolving and transforming into calcium chloride, filtering to obtain a coral skeleton filtrate, mixing aspartic acid with the coral skeleton filtrate, and carrying out a chelating reaction; and carrying out low temperature re-crystallization on the chelating reaction product with absolute ethyl alcohol, and carrying out suction filtration to obtain calcium amino acid chelate and strontium amino acid chelate. With reasonable use of the coral skeletons, the nutritional value of life elements in the coral skeletons is fully played. The calcium amino acid chelate and strontium amino acid chelate composition obtained by the method has the advantages of high absorption rate and low price, and besides, also has calcium supplement and many other health-care characteristics.
Description
Technical field:
The invention belongs to the higher value application of oceanic resources and recycle field, being specifically related to a kind of to delete bone for raw material extraction Preparation of amino acid chelating calcium and the method for strontium.
Background technology:
In bioelement, human body needs major element and 18 medium trace element in 11.These elements will reach certain running balance in human body could be healthy.Calcium belongs to major element, and strontium, manganese, iron etc. belong to trace element.The ratio of these trace elements in coral bone and needed by human body ratio are closely.Therefore, take in the bioelement in coral bone, the bioelement in human body can be made to reach balance, reduce disease risks.
Calcium is one of human essential elements, and be the important component forming skeleton, tooth, muscle tissue, human body calcium deficiency physiological dysfunctions will occur.It is one of main path solving calcium deficiency problem that diet is replenished the calcium.At present, in food, widely used calcium-supplementing preparation majority is calcium salt, as calcium phosphate, calcium carbonate, calglucon, calcium acetate, calcium lactate etc., but the shortcomings such as ubiquity specific absorption low (<40%).And calcium amino acid chelate is little and more and more in widespread attention because being easy to absorb (specific absorption >90%), toxicity.
The mankind often ignore supplementing of strontium.Human body institute in a organized way in all contain strontium, strontium is the normal integral part of skeleton and tooth, is mainly gathered in ossified vigorous place, can strong bone.Strontium is also relevant with cardiovascular diseases with nervimuscular excitement, and strontium can anti-angiocardiopathy, promotes the metabolism of human body.It is about 1.9mg that human body often takes in strontium element amount day by day.Medically, apply strontium bromide, strontium iodide, strontium salicylate, strontium lactate can treat urticaria, the illness such as tic that fash, thyroid dysfunction cause.In the food of the mankind, strontium will concentrate in coarse food grain, and the intracutaneous of roots vegetable, and these foods are taken in by the mankind fewer and fewerily.
Ba and U containing much lower amounts in the bone (as oyster etc.) of the cultivation sea-food of nature seawater and coral bone, although these constituent contents are low, is not assessed fully to the risk of HUMAN HEALTH.And there is no the Harmful Trace Elements such as Ba and U in the artificial seawater cultivating coral, the coral bone in artificial seawater can't detect these harmful elements.Bioelement in cultivation coral bone and amino acid combine can prepare replenishing the calcium and mending the healthcare products of strontium of high, the nontoxic and cheapness of specific absorption.And chelating calcium and strontium is extracted from cultivation coral, can not be formed ecotope and destroy.
Summary of the invention:
The object of this invention is to provide a kind of method extracting Preparation of amino acid chelating calcium and strontium from coral bone, it is characterized in that, comprise the following steps:
(1), the pre-treatment of coral bone: will coral bone deionized water soak after scrub adsorptives such as removing coral bone surface silt, dry, pulverize, must be used for the coral bone powder of synthesizing amino acid chelating calcium and strontium;
(2), the synthesis of calcium amino acid chelate and strontium: coral bone powder step (1) obtained, adds diluted hydrochloric acid dissolution and be converted into calcium chloride, filters to obtain coral bone filtrate, is mixed by aspartic acid carry out chelatropic reaction with coral bone filtrate;
(3), the purified crystals of calcium amino acid chelate and strontium: use dehydrated alcohol to carry out low temperature recrystallization to the product of chelatropic reaction in step (2), after recrystallization, suction filtration obtains calcium amino acid chelate and strontium.
Described coral bone is preferably from free of contamination coral bone, and because coral bone pollutes very responsive to task, therefore coral bone is not containing any organic contamination, not containing toxic heavy metal in the water body of cultivation coral, as Ba and U etc.
Immersion described in step (1), preferably soaks 1h.
Dilute hydrochloric acid described in step (2), is preferably 1 ~ 5N dilute hydrochloric acid.
Preferably, in step (2), aspartic acid and coral bone filtrate mol ratio are 2:1.
Chelatropic reaction described in step (2), preferred reaction conditions is: 35 DEG C, pH=8, reacts 2 hours.
Adopt the metal content of the product after EDS energy spectrum detection dehydrated alcohol low temperature recrystallization, find containing calcium amino acid chelate >=85%, chelating amino acids strontium >=3%, and other bioelements containing much lower amounts are as magnesium, iron, boron, cobalt etc. (<1%), wherein, the content of Mn, Fe is 0.3-1%, can meet the health demand of the mankind.
Appropriate application coral bone of the present invention, gives full play to the nutritive value of bioelement in coral bone.The calcium amino acid chelate obtained by method of the present invention and strontium composition have the high and advantage of cheapness of specific absorption, meanwhile, also have plurality kinds of health care features such as replenishing the calcium.
Embodiment:
Following examples further illustrate of the present invention, instead of limitation of the present invention.
Embodiment 1:
(1), from artificial seawater culturing jar, dendritic Acropora (0.5 kilogram) is pulled out, adsorptives such as removing coral bone surface silt is scrubbed after coral bone deionized water is soaked 1 hour, through 60 DEG C of oven dry, pulverize, must be used for the coral bone powder of synthesizing amino acid chelating calcium and strontium;
(2) the coral bone powder, will obtained in (1), add 1 ~ 5N diluted hydrochloric acid dissolution and be converted into calcium chloride (1 liter), filter to obtain coral bone filtrate, be that 2:1 prepares burden by aspartic acid and coral bone filtrate mol ratio, 35 DEG C, reaction 2 hours under pH=8 condition, carry out chelatropic reaction;
(3), use dehydrated alcohol to carry out low temperature recrystallization to the product of chelatropic reaction in (2), suction filtration obtains calcium amino acid chelate and strontium.
Crystallization detects: the metal content adopting the product after EDS energy spectrum detection dehydrated alcohol low temperature recrystallization.Result is as shown in table 1.
Table 1. metal content
Embodiment 2:
(1) block coral (0.5 kilogram), is pulled in artificial seawater culturing jar out, adsorptives such as removing coral bone surface silt is scrubbed after coral bone deionized water is soaked 1 hour, through 60 DEG C of oven dry, pulverize, must be used for the coral bone powder of synthesizing amino acid chelating calcium and strontium;
(2) the coral bone powder, will obtained in (1), add 1 ~ 5N diluted hydrochloric acid dissolution and be converted into calcium chloride (1 liter), filter to obtain coral bone filtrate, be that 2:1 prepares burden by aspartic acid and coral bone filtrate mol ratio, 35 DEG C, reaction 2 hours under pH=8 condition, carry out chelatropic reaction;
(3), use dehydrated alcohol to carry out low temperature recrystallization to the product of chelatropic reaction in (2), suction filtration obtains calcium amino acid chelate and strontium.
Crystallization detects: the metal content adopting the product after EDS energy spectrum detection dehydrated alcohol low temperature recrystallization.Result is as shown in table 1.
Claims (6)
1. from coral bone, extract the method for Preparation of amino acid chelating calcium and strontium, it is characterized in that, comprise the following steps:
(1), the pre-treatment of coral bone: will coral bone ionized water soak after scrub adsorptives such as removing coral bone surface silt, dry, pulverize, must be used for the coral bone powder of synthesizing amino acid chelating calcium and strontium;
(2), the synthesis of calcium amino acid chelate and strontium: coral bone powder step (1) obtained, adds diluted hydrochloric acid dissolution and be converted into calcium chloride, filters to obtain coral bone filtrate, is mixed by aspartic acid carry out chelatropic reaction with coral bone filtrate;
(3), the purified crystals of calcium amino acid chelate and strontium: use dehydrated alcohol to carry out low temperature recrystallization to the product of chelatropic reaction in step (2), suction filtration obtains calcium amino acid chelate and strontium.
2. the method extracting Preparation of amino acid chelating calcium and strontium from coral bone according to claim 1, is characterized in that, described coral bone is from free of contamination coral bone.
3. the method extracting Preparation of amino acid chelating calcium and strontium from coral bone according to claim 1, is characterized in that, the immersion described in step (1), and soak time is 1h.
4. the method extracting Preparation of amino acid chelating calcium and strontium from coral bone according to claim 1, is characterized in that, the dilute hydrochloric acid described in step (2), is 1 ~ 5N dilute hydrochloric acid.
5. the method extracting Preparation of amino acid chelating calcium and strontium from coral bone according to claim 1, is characterized in that, in step (2), aspartic acid and coral bone filtrate mol ratio are 2:1.
6. the method extracting Preparation of amino acid chelating calcium and strontium from coral bone according to claim 1, is characterized in that, the chelatropic reaction described in step (2), and reaction conditions is: 35 DEG C, pH=8, reacts 2 hours.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510119475.7A CN104788329B (en) | 2015-03-18 | 2015-03-18 | Method for extracting and preparing calcium amino acid chelate and strontium amino acid chelate from coral skeletons |
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| CN201510119475.7A CN104788329B (en) | 2015-03-18 | 2015-03-18 | Method for extracting and preparing calcium amino acid chelate and strontium amino acid chelate from coral skeletons |
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| CN104788329A true CN104788329A (en) | 2015-07-22 |
| CN104788329B CN104788329B (en) | 2017-01-11 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108689518A (en) * | 2017-09-22 | 2018-10-23 | 郑进 | A kind of biological element mineralization device |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05161480A (en) * | 1991-10-14 | 1993-06-29 | Fujitsukusu Kk | Amino acid-containing calcium composition and calcium beverage containing the same composition |
| CN104086454A (en) * | 2014-07-22 | 2014-10-08 | 福州大学 | Glutamic acid chelated calcium product prepared from shell and preparation method thereof |
-
2015
- 2015-03-18 CN CN201510119475.7A patent/CN104788329B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05161480A (en) * | 1991-10-14 | 1993-06-29 | Fujitsukusu Kk | Amino acid-containing calcium composition and calcium beverage containing the same composition |
| CN104086454A (en) * | 2014-07-22 | 2014-10-08 | 福州大学 | Glutamic acid chelated calcium product prepared from shell and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 李翠芹等: "氨基酸螯合钙的研究进展", 《食品研究与开发》 * |
| 王金龙等: "钙制剂的进展", 《中国医院药学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108689518A (en) * | 2017-09-22 | 2018-10-23 | 郑进 | A kind of biological element mineralization device |
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