CN104784400A - Stomach-invigorating and distension-relieving tablet and preparation method thereof - Google Patents
Stomach-invigorating and distension-relieving tablet and preparation method thereof Download PDFInfo
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- CN104784400A CN104784400A CN201510220499.1A CN201510220499A CN104784400A CN 104784400 A CN104784400 A CN 104784400A CN 201510220499 A CN201510220499 A CN 201510220499A CN 104784400 A CN104784400 A CN 104784400A
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Abstract
The invention belongs to the field of traditional Chinese medicines and discloses a stomach-invigorating and distension-relieving tablet. The stomach-invigorating and distension-relieving tablet contains hawthorn, medicated leaven, endothelium corneum gigeriae galli, dried tangerine or orange peel, bighead atractylodes rhizome, poria cocos, ginger processed pinellia and fructus aurantii. A preparation method of the stomach-invigorating and distension-relieving tablet comprises the following steps: taking a part of hawthorn, dried tangerine or orange peel and endothelium corneum gigeriae galli and grinding into fine powder for later use; grinding the rest of hawthorn and other raw materials into coarse powder, decocting with water twice, mixing decocted fluids, filtering and then concentrating; and adding the fine powder and a right amount of starch, uniformly mixing, drying into dry extract, smashing, pelletizing by adopting diluted syrup, adding magnesium stearate, uniformly mixing, tabletting, and coating. The stomach-invigorating and distension-relieving tablet provided by the invention has definite curative effect on diseases such as stomach distension and functional dyspepsia and produces small side effect; meanwhile, the preparation method of the stomach-invigorating and distension-relieving tablet is simple and easy to operate, and preparation cost can be effectively reduced.
Description
Technical field
The invention belongs to tcm field, be specifically related to a kind of stomach invigorating flatulence relieving tablet and preparation method thereof.
Background technology
Functional dyspepsia (FD) refers to have the malaise symptoms such as big belly, upper abdominal pain, early full belch, inappetence, Nausea and vomiting, epigastrium burn feeling, and the one group of clinical syndrome causing the organic disease of these symptoms is got rid of through coherence check, in May, 2006, U.S.'s gastrointestinal disease association issued RomeⅢdiagnostic criteria, and two hypotypes are divided into based on clinical manifestation and pathophysiology exception, namely to the relevant uncomfortable after the meal syndrome of feed and the Upper abdominal pain syndrome irrelevant with feed, amphitypy can while and deposit.Its cause of disease and pathogenesis are not yet clear so far, think relevant with upper gastrointestinal dyskinesis, delayed gastric emptying, helicobacter pylori infections, visceral paraesthesia, spirit and stressors at present.FD is Digestive System Department commonly encountered diseases, domestic and international survey data display sickness rate does not reach 20-41% not etc., account for about 50% of Digestive System Department Number of Outpatients, it is one of clinical modal internal disease, current doctor trained in Western medicine there is no specific therapy for primary disease, how gives psychotherapy, acid inhibitor and dynamics-promoting medicine according to its clinical manifestation or the two applies simultaneously, and wherein Dispersible Mosapride citrate tablets is as digestive tract power medicine, be treat uncomfortable syndromic important drugs after the meal, but effect is often not ideal enough.Though primary disease does not jeopardize patients ' lives, Relapse rate, delay is difficult, brings huge discomfort and stress to patient, and the medical resource of at substantial.A large amount of clinical datas shows the advantage that the treatment of the traditional Chinese medical science to FD has determined curative effect, side effect little.
Summary of the invention
An object of the present invention is for solving above-mentioned problems of the prior art, and provide a kind of stomach invigorating flatulence relieving tablet flatulence, functional dyspepsia disease being had to definite curative effect, this stomach invigorating flatulence relieving tablet good effect, side effect is little.There is provided a kind of preparation method of stomach invigorating flatulence relieving tablet, can prepare above-mentioned stomach invigorating flatulence relieving tablet by the method, the method is simple and easy to operate, effectively reduces preparation cost simultaneously.
The invention provides a kind of stomach invigorating flatulence relieving tablet, its component comprises Fructus Crataegi 183 ~ 193 parts, Massa Medicata Fermentata 89 ~ 99 parts, Endothelium Corneum Gigeriae Galli 28 ~ 38 parts, Pericarpium Citri Reticulatae 89 ~ 99 parts, the Rhizoma Atractylodis Macrocephalae 89 ~ 99 parts, 89 ~ 99 parts, Poria, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 70 ~ 80 parts and Fructus Aurantii 89 ~ 99 parts with weight parts.
Further, stomach invigorating flatulence relieving tablet preferred ingredient provided by the invention comprises Fructus Crataegi 188 parts, Massa Medicata Fermentata 94 parts, Endothelium Corneum Gigeriae Galli 33 parts, Pericarpium Citri Reticulatae 94 parts, the Rhizoma Atractylodis Macrocephalae 94 parts, 94 parts, Poria, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 75 parts and Fructus Aurantii 94 parts with weight parts.
The invention provides a kind of preparation method of stomach invigorating flatulence relieving tablet, comprise the following steps:
(1) take medical material by above-mentioned parts by weight, get Fructus Crataegi 75 parts, Pericarpium Citri Reticulatae 94 parts, Endothelium Corneum Gigeriae Galli 33 parts, is ground into fine powder for subsequent use;
(2) residue pulverizing medicinal materials is become coarse powder, add up the soak by water twice of component 8 times of weight portions, merge decoction liquor;
(3) decoction liquor being filtered, be concentrated into relative density at 80 DEG C is 1.15 ~ 1.30, adds described fine powder and appropriate amount of starch, mixes, is dried to dry cream;
(4) by broken for gained dried cream powder, make granule with rare syrup, dry;
(5) get gained granule, add the mixing of appropriate magnesium stearate, tabletting, coating and get final product.
Further, decoct twice finger first time decoction 2 hours in above-mentioned steps (2), second time decocts 2 hours.
Further, in above-mentioned steps (4), oven dry refers to dry at 50 ~ 60 DEG C.
Spleen invigorating flatulence relieving tablet provided by the invention is according to theory of Chinese medical science, the prescription that long-pending clinical experience is for many years drafted.Be made up of Fructus Crataegi, Fructus Aurantii, Massa Medicata Fermentata, Poria, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Endothelium Corneum Gigeriae Galli, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), all medicines share treatment functional dyspepsia, abdominal distention etc.Wherein Fructus Crataegi is containing tartaric acid, Crataegolic acid, flavonoid, saccharide and glycoside etc., can increase the secretion of digestive enzyme in stomach.Massa Medicata Fermentata has the effect of the stomach function regulating that helps digestion, and demonstrate,proves for eating accumulation.Poria, nature and flavor are sweet, light, flat, GUIXIN, spleen, kidney channel, promoting diuresis to eliminate damp pathogen, spleen-benefiting mind-tranquilizing.Endothelium Corneum Gigeriae Galli is mainly used in helping digestion.The Rhizoma Atractylodis Macrocephalae, nature and flavor are bitter, sweet, warm, return spleen, stomach warp, invigorating the spleen and benefiting QI, dampness profit fire.Pericarpium Citri Reticulatae, nature and flavor are bitter, pungent, warm, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, effect of drying dampness to eliminate phlegm.Fructus Aurantii has effect of circulation of qi promoting intestinal stasis relieving.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) has effect of the preventing or arresting vomiting that reduces phlegm, eliminating stagnation.All medicines share has digestion-promoting spleen-invigorating, dampness removing, clears phlegm.
Beneficial effect of the present invention is: the common easy acquisition of stomach invigorating flatulence relieving tablet medical material provided by the invention, can effectively treat the symptom such as flatulence and functional dyspepsia, side effect is little, and the Preparation equipment method step provided is simple, without the need to main equipment, effectively preparation cost can be reduced.
Detailed description of the invention
The invention provides a kind of stomach invigorating flatulence relieving tablet, its component comprises Fructus Crataegi 183 ~ 193 parts, Massa Medicata Fermentata 89 ~ 99 parts, Endothelium Corneum Gigeriae Galli 28 ~ 38 parts, Pericarpium Citri Reticulatae 89 ~ 99 parts, the Rhizoma Atractylodis Macrocephalae 89 ~ 99 parts, 89 ~ 99 parts, Poria, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 70 ~ 80 parts and Fructus Aurantii 89 ~ 99 parts with weight parts.
Further, stomach invigorating flatulence relieving tablet preferred ingredient provided by the invention comprises Fructus Crataegi 188 parts, Massa Medicata Fermentata 94 parts, Endothelium Corneum Gigeriae Galli 33 parts, Pericarpium Citri Reticulatae 94 parts, the Rhizoma Atractylodis Macrocephalae 94 parts, 94 parts, Poria, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 75 parts and Fructus Aurantii 94 parts with weight parts.
The invention provides a kind of preparation method of stomach invigorating flatulence relieving tablet, comprise the following steps:
(1) take medical material by above-mentioned parts by weight, get Fructus Crataegi 75 parts, Pericarpium Citri Reticulatae 94 parts, Endothelium Corneum Gigeriae Galli 33 parts, is ground into fine powder for subsequent use;
(2) residue pulverizing medicinal materials is become coarse powder, add up the soak by water twice of component 8 times of weight portions, merge decoction liquor;
(3) decoction liquor being filtered, be concentrated into relative density at 80 DEG C is 1.15 ~ 1.30, adds described fine powder and appropriate amount of starch, mixes, is dried to dry cream;
(4) by broken for gained dried cream powder, make granule with rare syrup, dry;
(5) get gained granule, add the mixing of appropriate magnesium stearate, tabletting, coating and get final product.
Hereafter will describe content of the present invention in conjunction with specific embodiments in detail.It should be noted that the combination of technical characteristic or the technical characteristic described in following embodiment should not be considered to isolated, they can mutually be combined thus be reached better technique effect.
Embodiment 1
The stomach invigorating flatulence relieving tablet formula that this enforcement adopts is: Fructus Crataegi 188g, Massa Medicata Fermentata 94g, Endothelium Corneum Gigeriae Galli 33g, Pericarpium Citri Reticulatae 94g, Rhizoma Atractylodis Macrocephalae 94g, Poria 94g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 75g, Fructus Aurantii 94g,
Preparation method: get Fructus Crataegi 75g, Pericarpium Citri Reticulatae 94g, Endothelium Corneum Gigeriae Galli 33g, is ground into 100 order fine powders for subsequent use.Residue Fructus Crataegi and all the other each tastes are ground into 10 order coarse powder, add 8 times of soak by water twice, first time 2h, and second time 2h, merges decoction liquor, be concentrated into relative density 1.15 ~ 1.30 (80 DEG C) after filtration.Add above-mentioned fine powder, starch is appropriate, mixing, is dried to dry cream, pulverizes, granulates with rare syrup through 14 ~ 16 mesh sieves, 50 ~ 60 DEG C of oven dry, with 14 mesh sieve granulate, adds 1% magnesium stearate and mixes, tabletting, every sheet 0.3g, coating, makes 1000 and get final product.Dosage is 4 pieces/times, 3 times/day, takes in 1 hour before the meal.
Compliance test result: the oral mosapride citrate of matched group (Chengdu Kang Hong Pharmaceutical is produced, 5mg/ sheet), 5mg/ time, took in 1 hour before the meal for 3 times/day.It within 4 weeks, is 1 course for the treatment of.The Chinese and western drugs of treatments period forbidding other treatment functional dyspepsia.Before starting to take medicine, the tcm symptom of the 4th week record patient is marked and measures fed standard gastric emptying rate after the meal in 1 week and after taking medicine respectively.
This case is all selected from hospital Digestive System Department out-patient, observes 300 examples altogether, is divided into treatment group 150 example by random number method, matched group 150 example.Wherein treatment group man 72 example, female 78 example, age 18-75 year (median 52.5 years old), the course of disease 7-180 month (median 11 months).Matched group man 76 example, female 74 example, age 18-73 year (median 51.5 years old), the course of disease 6-190 month (median 10 months).Two groups of patients comparing difference not statistically significant in sex, age, the course of disease, severity extent etc., P>0.05, has comparability.
Curative effect determinate standard: stop card setting primary symptom according in " new Chinese medicine guideline of clinical investigations " 2002 editions and " Chinese Internal Medicine " relevant feeling of fullness diet.Primary symptom is according to normal (0 point), slight (2 points), moderate (4 points), severe (6 points of settings increase progressively score value).1. computational methods (nimodipine method): total mark × 100% before therapeutic index=(before treatment the rear total mark of total mark-treatment)/treatment.2. efficacy assessment standard: clinical cure: therapeutic index (integrated value reduction) >=95%; Effective: therapeutic index (integrated value reduction) 70%-95%; Effective: therapeutic index (integrated value reduction) 30%-70%; Invalid: therapeutic index (integrated value reduction) <30%.The assay method of gastric emptying rate: adopt light tight line index thing detection method, patient is fed standard meal on an empty stomach, takes barium bar 20 (length 10mm simultaneously, diameter 1mm, heavy 2mg), enter test-meal in 10 minutes, take the photograph abdominal part after 5 hours and found position plain film, calculate gastric residue barium number.Gastric emptying rate=(total grain number-gastric residue barium bar grain number)/total grain number × 100%.
A table 1 liang group tcm symptom compares (example (rate %))
﹡: compare P<0.05 with matched group
A table 2 liang group gastric emptying rate compares (%, χ ± s)
﹡: compare P<0.01 with before treatment; ﹡ ﹡: compare P>0.05 with to treatment
Interpretation of result: after taking medicine 4 weeks, treatment group compares with matched group tcm symptom, and difference has statistical significance (P<0.05), in table 1; Treatment group and matched group gastric emptying rate significantly improve (P<0.01) before all comparatively treating, and treatment group compares with matched group Emptying Rate without significant difference (P>0.05), in table 2.As can be seen from Table 1, the total effective rate of the stomach invigorating flatulence relieving tablet that embodiment provides is 90%, and higher than the total effective rate 78% of matched group, in matched group, diarrhoea appears in 11 examples simultaneously, and xerostomia appears in 7 examples, and 2 examples occur that transient glutamic oxaloacetic transaminase, GOT raises; There is acid regurgitation in treatment group 4 example, xerostomia appears in 2 examples.As can be seen here, the untoward reaction rate for the treatment of group is lower than matched group, demonstrates the side effect of this stomach invigorating flatulence relieving tablet little.
Although give some embodiments of the present invention, it will be understood by those of skill in the art that without departing from the spirit of the invention herein, can change embodiment herein.Above-described embodiment is exemplary, should using embodiment herein as the restriction of interest field of the present invention.
Claims (5)
1. a stomach invigorating flatulence relieving tablet, it is characterized in that, its component comprises Fructus Crataegi 183 ~ 193 parts, Massa Medicata Fermentata 89 ~ 99 parts, Endothelium Corneum Gigeriae Galli 28 ~ 38 parts, Pericarpium Citri Reticulatae 89 ~ 99 parts, the Rhizoma Atractylodis Macrocephalae 89 ~ 99 parts, 89 ~ 99 parts, Poria, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 70 ~ 80 parts and Fructus Aurantii 89 ~ 99 parts with weight parts.
2. a kind of stomach invigorating flatulence relieving tablet as claimed in claim 1, is characterized in that, its component comprises Fructus Crataegi 188 parts, Massa Medicata Fermentata 94 parts, Endothelium Corneum Gigeriae Galli 33 parts, Pericarpium Citri Reticulatae 94 parts, the Rhizoma Atractylodis Macrocephalae 94 parts, 94 parts, Poria, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 75 parts and Fructus Aurantii 94 parts with weight parts.
3. a preparation method for stomach invigorating flatulence relieving tablet, is characterized in that, comprises the following steps:
(1) take medical material by above-mentioned parts by weight, get Fructus Crataegi 75 parts, Pericarpium Citri Reticulatae 94 parts, Endothelium Corneum Gigeriae Galli 33 parts, is ground into fine powder for subsequent use;
(2) residue pulverizing medicinal materials is become coarse powder, add up the soak by water twice of component 8 times of weight portions, merge decoction liquor;
(3) decoction liquor being filtered, be concentrated into relative density at 80 DEG C is 1.15 ~ 1.30, adds described fine powder and appropriate amount of starch, mixes, is dried to dry cream;
(4) by broken for gained dried cream powder, make granule with rare syrup, dry;
(5) get gained granule, add the mixing of appropriate magnesium stearate, tabletting, coating and get final product.
4. the preparation method of a kind of stomach invigorating flatulence relieving tablet as claimed in claim 3, is characterized in that, decocts twice in described step (2), each decoction two hours.
5. the preparation method of a kind of stomach invigorating flatulence relieving tablet as claimed in claim 3, is characterized in that, dries and refer to dry at 50 ~ 60 DEG C in described step (4).
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| CN201510220499.1A CN104784400A (en) | 2015-05-04 | 2015-05-04 | Stomach-invigorating and distension-relieving tablet and preparation method thereof |
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| CN105435072A (en) * | 2015-12-25 | 2016-03-30 | 梁献彬 | Method for preparing gasteremphraxis-eliminating oral solution |
| CN111789917A (en) * | 2020-07-16 | 2020-10-20 | 李廷利 | Traditional Chinese medicine composition for improving intestinal microenvironment of patients with autism spectrum disorder and preparation method and application thereof |
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- 2015-05-04 CN CN201510220499.1A patent/CN104784400A/en active Pending
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| CN101380085A (en) * | 2008-04-16 | 2009-03-11 | 王福起 | Haw food with facilitation and health care function and preparation method thereof |
| CN102283965A (en) * | 2011-09-07 | 2011-12-21 | 中国人民解放军第三七一医院 | Chinese medicinal preparation for treating indigestion, abdominal distension and other symptoms |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105435072A (en) * | 2015-12-25 | 2016-03-30 | 梁献彬 | Method for preparing gasteremphraxis-eliminating oral solution |
| CN111789917A (en) * | 2020-07-16 | 2020-10-20 | 李廷利 | Traditional Chinese medicine composition for improving intestinal microenvironment of patients with autism spectrum disorder and preparation method and application thereof |
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