CN104771687B - The bilingual oral liquid of nine tastes is as the application for preparing treatment chronic hepatitis medicine - Google Patents
The bilingual oral liquid of nine tastes is as the application for preparing treatment chronic hepatitis medicine Download PDFInfo
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- CN104771687B CN104771687B CN201510213827.5A CN201510213827A CN104771687B CN 104771687 B CN104771687 B CN 104771687B CN 201510213827 A CN201510213827 A CN 201510213827A CN 104771687 B CN104771687 B CN 104771687B
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Abstract
The present invention relates to a kind of new application of Chinese medicine preparation, i.e. the bilingual oral liquid of nine tastes is as the application for preparing treatment chronic hepatitis medicine.The described bilingual oral liquid of nine tastes is made up of the bulk drug of following weight：Radix bupleuri 333.5g, prepared RADIX ET RHIZOMA RHEI 233.5g, sweet wormwood 333.5 g, honeysuckle 133.0g, wine moxibustion radix scutellariae 233.5g, folium isatidis 256.5g, dandelion 233.5g, Paris polyphylla 133.0g, peeling, ginger tsaoko 100.0g.Preparation method is constant.There is curative effect to chronic liver disease.Usage and dosage：Orally, a 30ml, 3 times a day, every 10ml.28 days are a course for the treatment of, and the 3-6 course for the treatment of can take effect.52 chronic hepatitis patients are taken with observation through clinic, the bilingual oral liquid of nine tastes is used for chronic hepatitis treatment, obvious effective rate 57.7%, effective percentage 28.8%, inefficiency 13.5%, and total effective rate is worthy to be popularized 86.5%.
Description
Technical field
The present invention relates to a kind of new application of Chinese medicine preparation, i.e. the bilingual oral liquid of nine tastes is as preparation treatment chronic hepatitis medicine
The application of thing.
Background technology
In the prior art, chronic hepatitis refers to that as caused by different pathogeny, the course of disease is at least continued above more than 6 months
Hepatic necrosis and inflammation, the course of disease are in fluctuation or lasting progressive, such as can progress to liver without appropriate treatment, some patientss
Hardening.Common chronic hepatitis B（Abbreviation hepatitis B）Refer to hepatitis B test positive, the course of disease exceedes half a year or onset of illness
Phase is indefinite and clinical chronic hepatitis shower.Clinical manifestation is the symptoms such as weak, sitophobia, nausea, abdominal distension, hepatalgia.
Hepatomegaly, quality are medium hardness, there is light tenderness.State of an illness severe one can be with chronic liver disease face, spider angioma, liver palms, splenomegaly, liver function
Energy can exception or persistent anomaly.Slight, moderate and severe are divided into according to clinical manifestation.And chronic hepatitis B carries and refers to hepatitis B
Test positive, no chronic hepatitis symptom, continuous more than 3 times Serum ALTs of follow-up and AST are without exception in 1 year, and liver group
Knit and check normal person.
The commercially available bilingual oral liquid of nine tastes is produced by Jilin Heng Jin medicine companies limited company, national drug standards WS3-
641（Z-091）- 2004（Z）, prescription:Radix bupleuri 333.5g, rheum officinale（It is ripe）233.5g, the g of sweet wormwood 333.5, honeysuckle
133.0g, radix scutellariae（Wine moxibustion）233.5g, folium isatidis 256.5g, dandelion 233.5g, Paris polyphylla 133.0g, tsaoko（Peeling, ginger
System）100.0g.
Preparation method：Four tastes such as the taste of the above nine, radix bupleuri, sweet wormwood, honeysuckle, tsaoko add appropriate water distillation, extract volatile oil.
The another device of the aqueous solution after distillation is collected；The five tastes such as remaining rheum officinale, radix scutellariae, folium isatidis, dandelion, Paris polyphylla add 10 times of amount water loggings 1 small
When, decoction is mixed with dregs of a decoction such as the radix bupleuri after distillation three times, 1 hour every time, merges the aqueous solution after decocting and distilling, filters,
It is 1.08-1.10 that filtrate, which is concentrated into relative density,（60℃）Clear cream, be cooled to room temperature；Ethanol is added alcohol content is stood 24 up to 65%
Hour, filtration, filtrate recycling ethanol is concentrated into relative density as 1.40（60℃）Thick paste, add water to 800ml, stand, filtration；
Stevioside 2g separately is taken, sucrose 20g, ethylparaben 1g, is dissolved in suitable quantity of water, adds in liquid to be dispensed, add with 1%
The finely dispersed volatile oil of talcum powder, mix, regulation pH value to prescribed limit, centrifugation.Supernatant is taken, adds water adjustment total amount extremely
1000ml, stir evenly, embedding, sterilize, produce.Character：This product is brownish black liquid；Gas is fragrant, sweet, slight bitter.Every 1 ml of this product contains
Rheum officinale is with rheum emodin（C15H10O5）Meter, must not be less than 0.095mg.Function is with curing mainly：Inducing diaphoresis heat-clearing, purging intense heat and detonicating.For diseases caused by external factors
Anemopyretic cold caused by wind-heat table heresy, heat in both exterior and interior, symptoms include heating or foul wind, have a headache, and have a stuffy nose, cough, runny nose, pharyngalgia or with red
It is swollen, it is thirsty or red with urinating, just do.Usage and dosage：Orally, a 20ml, 3 times a day.Every 10ml.The medicine prepare it is chronic
Application in the medicine of hepatitis has no report.
The content of the invention
The purpose of the present invention is to provide a kind of new application of the bilingual oral liquid of nine tastes for above-mentioned deficiency, i.e., nine tastes are bilingual
Oral liquid increases its indication as the application for preparing treatment chronic hepatitis medicine.
The present invention technical solution be：The bilingual oral liquid of nine tastes is as the application for preparing treatment chronic hepatitis medicine；
The described bilingual oral liquid of nine tastes is made up of the bulk drug of following weight：Radix bupleuri 333.5g, prepared RADIX ET RHIZOMA RHEI 233.5g, sweet wormwood
333.5 g, honeysuckle 133.0g, wine moxibustion radix scutellariae 233.5g, folium isatidis 256.5g, dandelion 233.5g, Paris polyphylla 133.0g,
Peeling, ginger tsaoko 100.0g.Preparation method is constant.
Function is with curing mainly：It is promoting blood circulation and removing blood stasis, it is clearing heat and detoxicating.There is curative effect to chronic liver disease.
Usage and dosage：Orally, a 30ml, 3 times a day.Every 10ml.It is within 28 days a course for the treatment of, the 3-6 course for the treatment of
Take effect.
It is an advantage of the invention that：1. the bilingual oral liquid of nine tastes has function promoting blood circulation and removing blood stasis, clearing heat and detoxicating, can not only
Anemopyretic cold is treated, and also has certain therapeutic effect in treatment chronic hepatitis；2. 52 chronic hepatitis are suffered from through clinic
Person takes observation, and the bilingual oral liquid of nine tastes is used for chronic hepatitis treatment, obvious effective rate 57.7%, effective percentage 28.8%, inefficiency
13.5%, total effective rate is worthy to be popularized 86.5%.
The present invention is described in further detail below in conjunction with example below.
Embodiment
Embodiment
The bilingual oral liquid of nine tastes is as the application for preparing treatment chronic hepatitis medicine；The described bilingual oral liquid of nine tastes by with
The bulk drug of lower weight is made：Radix bupleuri 333.5g, prepared RADIX ET RHIZOMA RHEI 233.5g, sweet wormwood 333.5 g, honeysuckle 133.0g, wine moxibustion
Radix scutellariae 233.5g, folium isatidis 256.5g, dandelion 233.5g, Paris polyphylla 133.0g, tsaoko 100.0g, peeling, ginger tsaoko.
Preparation method：Four tastes such as the taste of the above nine, radix bupleuri, sweet wormwood, honeysuckle, tsaoko add appropriate water distillation, extract volatile oil.
The another device of the aqueous solution after distillation is collected；The five tastes such as remaining rheum officinale, radix scutellariae, folium isatidis, dandelion, Paris polyphylla add 10 times of amount water loggings 1 small
When, decoction is mixed with dregs of a decoction such as the radix bupleuri after distillation three times, 1 hour every time, merges the aqueous solution after decocting and distilling, filters,
It is 1.08-1.10 that filtrate, which is concentrated into relative density,（60℃）Clear cream, be cooled to room temperature；Ethanol is added alcohol content is stood 24 up to 65%
Hour, filtration, filtrate recycling ethanol is concentrated into relative density as 1.40（60℃）Thick paste, add water to 800ml, stand, filtration；
Stevioside 2g separately is taken, sucrose 20g, ethylparaben 1g, is dissolved in suitable quantity of water, adds in liquid to be dispensed, add with 1%
The finely dispersed volatile oil of talcum powder, mix, regulation pH value to prescribed limit, centrifugation.Supernatant is taken, adds water adjustment total amount extremely
1000ml, stir evenly, embedding, sterilize, produce.Character：This product is brownish black liquid；Gas is fragrant, sweet, slight bitter.Every 1 ml of this product contains
Rheum officinale is with rheum emodin（C15H10O5）Meter, must not be less than 0.095mg.
Experimental example
The bilingual oral liquid of nine tastes is as the applying clinical curative effect situation statistics for preparing treatment chronic hepatitis medicine：
1st, case counts：Chronic hepatitis 52, the age is in 29-60 one full year of life.
2nd, treatment method：Orally, a 30ml, three times per day, every 10ml.28 days are a course for the treatment of, treat 5 treatments
Journey.
3rd, chronic hepatitis curative effect judging standard：Using tcm diagnosis chronic hepatitis as standard.
It is effective：Tired alleviation, abdominal distension dull pain in liver are alleviated, and hepatic region takes on a new look without tenderness, complexion, and liver function is substantially recovered, from
Feel that symptom disappears.
Effectively：Tired to have alleviated, abdominal distension dull pain in liver has been alleviated, and hepatic region takes on a new look without obvious tenderness, complexion, liver function
It is restored, subjective symptoms disappears substantially.
It is invalid；Subjective symptoms and the liver function person of being not improved.
4th, treatment results：
| The state of an illness | Number | It is effective | Effectively | It is invalid | Total effective rate % |
| Chronic hepatitis B | 52 | 30 | 15 | 7 | 86.5 |
Clinical Practice proves：The bilingual oral liquid of nine tastes is used for chronic hepatitis treatment, and obvious effective rate 57.7% is efficient
28.8%, inefficiency 13.5%, total effective rate is worthy to be popularized 86.5%.
Claims (1)
1. the bilingual oral liquid of nine tastes is as the application for preparing treatment chronic hepatitis medicine；The described bilingual oral liquid of nine tastes is by following
The bulk drug of weight is made：Radix bupleuri 333.5g, prepared RADIX ET RHIZOMA RHEI 233.5g, sweet wormwood 333.5 g, honeysuckle 133.0g, wine process radix scutellariae
233.5g, folium isatidis 256.5g, dandelion 233.5g, Paris polyphylla 133.0g, peeling, ginger tsaoko 100.0g.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510213827.5A CN104771687B (en) | 2015-04-30 | 2015-04-30 | The bilingual oral liquid of nine tastes is as the application for preparing treatment chronic hepatitis medicine |
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| CN104771687B true CN104771687B (en) | 2018-01-05 |
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