CN104759038B - The conformal intensity modulated device and method of heavy particle radiotherapy multifunction three-dimensional - Google Patents
The conformal intensity modulated device and method of heavy particle radiotherapy multifunction three-dimensional Download PDFInfo
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Abstract
The present invention relates to the conformal intensity modulated method and device of heavy particle radiotherapy multifunction three-dimensional.A kind of conformal intensity modulated device of heavy particle radiotherapy multifunction three-dimensional, it is mainly characterized by：Include left alloy vane and right alloy vane of the collimating module by relative motion, according to projected outline of the tumor target on beam direction, adjust the radial distance of each blade and profile in the horizontal, construct conformal irradiation field；Compensating module is stacked with right rectangular slat by the left rectangular slat of relative motion and formed, according to beam energy and tumor target three-dimensional profile parameter, adjust left and right rectangular slat relatively radially distance, inner cavity surface and the conformal module after tumor target along curved surface phase conjugate are formed, wherein mutually identical rectangular slat forms its gabarit substrate.It is an advantage of the invention that realizing the automation of collimation and compensation function, the time interval of online conversion collimation configuration and conformal compensation configuration is very short, improves operating efficiency.By collimating and compensating the integration of two kinds of difference in functionalitys, the link of offline manual processing compensator is eliminated, material is saved, reduces cost.
Description
Technical field
The present invention relates to the conformal intensity modulated method and device of heavy particle radiotherapy multifunction three-dimensional.
Background technology
Malignant tumour (cancer) is a kind of common disease, frequently-occurring disease, and to the great disease of human health risk, and always
It is the problem for perplexing countries in the world." National Cancer control content " data published according to the nineteen ninety-five World Health Organization, nineteen ninety
The whole world is because the number of cancer mortality is about 6,000,000, new cases 10,000,000.The survey data for the treatment of and prevention of tumour office of China
It has been shown that, the whole nation account for the 20% of China's total toll every year because of number of cancer deaths about 1,400,000, occupy the of the various causes of death
Two, and still in the speed increase with annual 1.3%.Therefore, cancer prevention and treatment new method research be country " population and
One of main contents of health " strategic objective.According to statistics, cancer patient's five-year survival rate through distinct methods treatment is up to 45%
More than, wherein, it is by radiotherapy to have four one-tenth.In recent years, the cure rate of cancer radiation therapy and effective control rate are obvious
Improve, radiotherapy is effected a radical cure some early stage locality tumours.Simultaneously radiotherapy to the organ at position where cancer and
The reservation of its function is significant.
For a long time, radiotherapy all uses conventional therapy (electronics, X and g- rays etc.) method, and they are to some tumours
Although with it is preferable the effect of, the defects of due to its physics and biological nature, while cancer cell is killed, make adjacent healthy
Tissue causes obvious toxic side effect, or even some complication occur also by compared with macrolesion.Although radiotherapy equipment is entered
The very tight design of row, but normal structure around carcinoma and organ nevertheless suffer from the irradiation of suitable dosage.In order to avoid swollen
Normal structure (particularly sensitive to radioactive ray vital tissue and organ) around knurl sometimes must not by unnecessary damage
Accumulated dose is not reduced, causes tumor target to cannot get enough exposure doses, therefore significantly reduces the cure rate of tumour.According to
Statistics, in all conventional radiotheraphy patients, there are about 1/3 patient's local tumor and fails to be controlled；It is another to there is report to claim, in the U.S.
There are 100,000 cancer patients to cause Endodontic failure because local tumor is not controlled every year.
Proton and heavy ion are heavy charged particles, different from conventional ray：Because their quality is very big, into human body
Motion can approximation to regard straight line, proton and heavy ion as maximum in the end energy loss of range, formed in human body sharp
" Bragg " peak, ion is heavier, and this peak is narrower, formed peak before be low flat level ground, be steep tail behind peak.Thus they
There is the range of determination in human body, the size of range is decided by the size of their energy.Utilize proton and heavy ion energy loss
The property of end-of-range is concentrated on, when treating tumour, the size of proton and heavy ion energy is adjusted according to the depth of tumour,
" Bragg " peak is located at knub position, reach the maximum killing to tumour, and reach tumour to pass through just
The damage often organized is very small, and the normal structure behind tumour is hardly affected.
Measurement heavy ion dosage distribution is typically all to impinge perpendicularly on that surface is flat, enters in uniform water phantom in beam
Capable, because range is consistent, the depth-dose distribution of acquisition is typically all regular.HIB is applied to patient's body,
Purpose is to make heavy ion high dose area (Bragg peaks) parcel irradiation tumor target and make normal structure irradiated area minimum；
When irradiating tumor target using HIB, due to the inhomogeneities of human body curved surface and tissue, the water that HIB passes through is equivalent
Variable thickness causes, and causes heavy ion bragg peak inconsistent in the position of human body target area, so as to cause the irradiation of high dose area inclined
Difference, hurt normal structure or critical organ.
In order to solve this problem, on the one hand need to carry out the lateral adaptation of radiation field, radiation field is entered using collimater
Row configuration, radiation field cross-sectional edge is set to be matched with tumor target in beam direction maximal projection, i.e., by beam-based device
Irradiation field is formed, protects horizontal normal structure；On the one hand tissue compensation is carried out, Bragg peaks is adjusted on beam direction
Depth location, it is allowed to along shape be consistent with after tumor target, protects the normal structure on edge after tumor target.
Current beam-based device is mostly multi-diaphragm collimator (multi-leaf collimator), after blade configuration,
Interception and the conformal irradiation field of projected outline of the tumor target on beam direction, the line in launched field can smoothly lead in transverse direction
Cross, the line outside launched field can not be by so as to implement conformal irradiation treatment by leaf baffle.
Compensator is the individual device made according to patient's focus form and dimension, and its design parameter should be soft by treatment plan
Part system provides according to the factor such as target area reconstruction image and line incident path, and principle is：Along line incident direction, it is ensured that from benefit
The water equivalent thickness for repaying device surface any point to edge after focus is identical.Generally compensator is equivalent by light texture at present
Material such as lucite (PMMA) is process through Digit Control Machine Tool.
Current collimater and compensator are all independent individual equipments.Especially compensator processing mode is still fallen within offline
Processing method, it is necessary to treatment process in advance, it is ageing not strong.And need to process a conformal block for each each launched field,
And material can not reuse, cost is higher, and time-consuming, inefficient.Therefore exist in conformal intensity modulated technological layer improved
Necessity and feasibility.
In existing heavy particle radiotherapy, the transversal collimation of irradiation field is conformal and the tissue compensation of line longitudinal direction is (passive
Beam intensity regulation) function by collimater (diaphragm, multi-leaf optical grating etc.) and organizes compensator (wedge, lead etc.) two respectively
Individual independent equipment is realized.And at present in addition to electric multiblade optical grating collimater occurs in collimater this classification, tissue
Compensator (including wedge, lead etc.) can only rely on artificial, put position manually, and can not realize tissue compensator
Recycling.
The content of the invention
It is multi-functional that a kind of heavy particle radiotherapy is provided it is an object of the invention to avoid in place of the deficiencies in the prior art
Three-dimensional suitable-shape regulating intensity device.
A further object of the present invention is to provide a kind of conformal intensity modulated method of heavy particle radiotherapy multifunction three-dimensional.
A kind of heavy particle radiotherapy three-dimensional suitable-shape regulating for having beam-based function concurrently and organizing compensation function is provided to fill by force
Put, the rectangular slat of multi-functional conformal intensity modulated device driving energy move toward one another is mutually drawn close, and forms an indent opening and irradiation
Wild consistent, concave surface along shape (curve) phase conjugate, gabarit after tumor target with having the conformal intensity modulated mould of the tubular of substrate
Body, may be directly applied to accelerator treatment head, is automatically completed the line three-dimensional suitable-shape regulating powerful specifically changed in real time, realizes work(
The quick cyclic utilization of energy integration, automation and equipment, efficiency is improved, it is cost-effective.
To achieve the above object, the technical scheme taken of the present invention is：A kind of heavy particle radiotherapy multifunction three-dimensional is fitted
Shape adjusts intensity device, and it is mainly characterized by：Include left alloy vane and right alloy vane structure of the collimating module by relative motion
Into according to projected outline of the tumor target on beam direction, adjusting the radial distance of each blade and profile, construction in the horizontal
Conformal irradiation field；Compensating module is regularly stacked with right rectangular slat by the left rectangular slat of energy relative motion and formed, according to
Beam energy and tumor target three-dimensional profile parameter, relatively radially distance (adjusts rectangular slat to adjustment left and right rectangular slat
With the radial distance on tumor target border), composition inner cavity surface and the conformal module after tumor target along curved surface phase conjugate, its
In mutually identical rectangular slat form its gabarit substrate.
The described conformal intensity modulated device of heavy particle radiotherapy multifunction three-dimensional, described collimation alloy vane transverse width
Usually 1-5 millimeters；It is usually 1-5 millimeters to compensate rectangular slat transverse width, and longitudinal thickness is usually 1-5 millimeters.
The described conformal intensity modulated device of heavy particle radiotherapy multifunction three-dimensional, described collimating module and compensating module by
Fixed frame is fixed on the rotating base of beam axis (B) rotary motion.
The described conformal intensity modulated device of heavy particle radiotherapy multifunction three-dimensional, the alloy vane of described collimating module and
The rectangular slat of described compensating module can be along vertical beam axis (B) directionally independent radial motion..
The described conformal intensity modulated device of heavy particle radiotherapy multifunction three-dimensional, described collimating module and compensating module structure
The shape of type is that indent opening is consistent with irradiation field, and along curved surface phase conjugate after concave surface and tumor target, gabarit is from collimation
Tubular conformal intensity modulated die body of the module upper surface any point to the water equivalent thickness identical substrate on edge after tumor target.
The material of described collimating module blade is tungsten alloy, and compensating module rectangular slat material is tissueequivalentmaterial,
Including solid water or PMMA or polytetrafluoroethylene (PTFE).
The described conformal intensity modulated device of heavy particle radiotherapy multifunction three-dimensional, described collimating module, independent driving electricity
Machine drives the left alloy vane and right alloy vane independence radial displacement by drive screw.
The described conformal intensity modulated device of heavy particle radiotherapy multifunction three-dimensional, described compensating module, independent driving electricity
Machine drives the left rectangular slat and right rectangular slat independence radial displacement by drive screw.
Strong method is adjusted in a kind of conformal compensation of heavy particle radiotherapy multifunction three-dimensional, and it is mainly characterized by step and is：
(1) heavy particle radiotherapy planning system, entity tumor plan field parameter used in acquisition, including line side are utilized
Projected to maximum target area, i.e., launched field projects, beam energy and the equivalent depth of penetration of corresponding water, and incident path water is equivalent through thickness
Degree distribution, i.e., be distributed after tumor target along curved surface.
(2) conformal intensity modulated appliance arrangement configuration parameter, including collimating module resolution ratio (rectangular paddle transverse width) are obtained
And blade quantity；Compensating module resolution ratio (rectangular slat transverse width and longitudinal thickness) and rectangular slat quantity.
(3) judge whether to need to rotate with more preferable conformal, such as need to rotate, it is determined that carry out beam coordinate system after the anglec of rotation
Conversion.Otherwise, into step (4).
(4) according to beam direction, the equivalent depth of penetration of water and target area impenetrating thickness distributed constant, calculate line in launched field and mend
Path thickness distribution is repaid, and irradiation field profile and compensation net are calculated according to parameters such as conformal intensity modulated appliance arrangement configuration resolution ratio
Lattice；
(5) judge whether to need to optimize to adapt to device configuration.Such as need to optimize, then meter is optimized by the method rounded downwards
Calculate the distribution of the optimal compensation curved surface；Otherwise the configuring step (6) of three-dimensional suitable-shape regulating intensity device is entered；
(6) configuration of three-dimensional suitable-shape regulating intensity device：Blade is along slide rail radial motion, end face and irradiation field in collimating module
Stop motion during profile tangent (or reaching defined distance), vaned combination construct launched field and project conformal photograph
Launched field；In compensating module, driver drives rectangular slat along slide rail radial motion, when its end and tissue compensation grid are tangent
Stop motion when (or reaching defined distance)；Two groups of rectangular slats ultimately form the cavity of an indent, that is, form tissue
Compensation block；
(7) it is finally completed optimal three-dimensional conformal and adjusts strong form.
Beneficial effects of the present invention：
1. the automation of collimation and compensation function is realized, between the time of online conversion collimation configuration and conformal compensation configuration
Every very short, operating efficiency is improved.
2. by collimating and compensating the integration of two kinds of difference in functionalitys, the link of offline manual processing compensator is eliminated, is saved
Material has been saved, has reduced cost.
3. technical solution of the present invention no longer needs to carry out disparate modules the manual link collimated offline, reduce pendulum position and miss
Difference, improve collimation and compensate conformal precision.
4. the present invention has collimater and compensator function concurrently, compact-sized, response is rapid, can quickly be done directly heavy ion
Conformal intensity modulated treatment task.
5. the present invention has around line axial-rotation function, to adapt to most preferably collimate offset angle.
6. the present invention has start automatic displacement calibration function.
Brief description of the drawings：
Fig. 1 heavy ion three-dimensional suitable-shape regulating intensity device diagrammatic cross-sections；
Fig. 2 heavy ion three-dimensional suitable-shape regulating intensity device top views；
Fig. 3 target areas irradiation field projected outline and after along curved surface；
Fig. 4 heavy ion three-dimensional suitable-shape regulating strong method flow charts；
Along curved surface after target area projected outline and target area under Fig. 5 line launched fields；
Fig. 6 irradiation fields and compensation grid；
The actual collimation compensation configuration schematic diagram of Fig. 7 heavy ion three-dimensional suitable-shape regulating intensity devices.
Embodiment
The principle and feature of the present invention are described with reference to embodiments, the given examples are served only to explain the present invention,
It is not intended to limit the scope of the present invention.Present disclosure is described in detail below.
Embodiment 1：See Fig. 1, Fig. 2 and Fig. 3, a kind of conformal intensity modulated device of heavy particle radiotherapy multifunction three-dimensional, including
There are collimating module 1 and compensating module 2；Left alloy vane 1-1 and right alloy vane 1-2 structure of the collimating module 1 by energy relative motion
Into according to projected outline 3 of the tumor target on beam direction, adjusting the radial distance of each blade and profile, structure in the horizontal
Make conformal irradiation field；Compensating module 2 is regularly stacked by the left rectangular slat 2-1 and right rectangular slat 2-2 of energy relative motion
Form, according to beam energy and tumor target three-dimensional profile parameter, relatively radially distance (adjusts adjustment left and right rectangular slat
Rectangular slat and the radial distance on tumor target border), composition inner cavity surface and fitting along the phase conjugate of curved surface 4 after tumor target
Shape module, wherein mutually identical rectangular slat forms its gabarit substrate 5.
See Fig. 1, the described conformal intensity modulated device of heavy particle radiotherapy multifunction three-dimensional is accurate in described collimating module 1
Straight alloy vane 1-1,1-2 transverse widths are usually 1-5 millimeters；It is horizontal that rectangular slat 2-1,2-2 is compensated in the compensating module 2
Width is usually 1-5 millimeters, and longitudinal thickness is usually 1-5 millimeters.
See Fig. 2, the described conformal intensity modulated device of heavy particle radiotherapy multifunction three-dimensional, described collimating module 1 and benefit
Module 2 is repaid to be fixed on the rotating base 7 of beam axis (B) rotary motion by fixed frame 6..
The rectangular slat of the alloy vane of described collimating module and described compensating module can be along vertical beam axis
(B) directionally independent radial motion.
See Fig. 3, the shape of described collimating module 1 and the configuration of compensating module 2 is that indent opening is consistent with irradiation field 3,
Along the phase conjugate of curved surface 4 after concave surface and tumor target, gabarit, which has, to be ensured from intensity device surface any point is adjusted to tumor target
The conformal intensity modulated die body of tubular of the water equivalent thickness identical substrate 5 on edge behind area.
The material of described collimating module blade is tungsten alloy, and compensating module rectangular slat material is tissueequivalentmaterial,
Including solid water or PMMA or polytetrafluoroethylene (PTFE).
Embodiment 2：See Fig. 1, Fig. 2, described collimating module 1, independent driving motor 8 drives described by drive screw 9
Left alloy vane 1-1 and right alloy vane 1-2 independence radial displacements.
The material of described collimating module blade is tungsten alloy.
Remaining structure is same as Example 1.
Embodiment 3：See Fig. 1, Fig. 2, described compensating module 2, independent driving motor 8 drives described by drive screw 9
Left rectangular slat 2-1 and right rectangular slat 2-2 independence radial displacements.
Described compensating module rectangular slat material is tissueequivalentmaterial, including solid water or PMMA or polytetrafluoroethyl-ne
Alkene.
Remaining structure is same as Example 1.
Embodiment:4：See Fig. 4, a kind of conformal intensity modulated method of heavy particle radiotherapy multifunction three-dimensional, its step is：
(1) heavy particle radiotherapy planning system, entity tumor plan field parameter used in acquisition, including line energy are utilized
Amount and the equivalent depth of penetration of corresponding water, the projection of beam direction maximum target area, i.e. launched field project, and incident path water is equivalent through thickness
Degree distribution, i.e., be distributed after tumor target along curved surface.See flow S1, S2.
(2) conformal intensity modulated appliance arrangement configuration parameter, including collimating module resolution ratio (rectangular paddle transverse width) are obtained
And blade quantity；Compensating module resolution ratio (rectangular slat transverse width and longitudinal thickness) and rectangular slat quantity.
(3) judge whether to need to rotate with more preferable conformal, see flow S3；Such as need to rotate, it is determined that carry out after the anglec of rotation
Beam coordinate system changes, and sees flow S4.Otherwise, into step (4).
(4) according to beam direction, the equivalent depth of penetration of water and target area impenetrating thickness distributed constant, calculate line in launched field and mend
Path thickness distribution is repaid, and irradiation field profile 3 and compensation are calculated according to parameters such as conformal intensity modulated appliance arrangement configuration resolution ratio
Grid 4.See flow S5, S6.
(5) judge whether to need to optimize, to adapt to device configuration, to see flow S7.Such as need to optimize, then by rounding downwards
Method optimization calculates the distribution of the optimal compensation curved surface, sees flow S8；Otherwise the configuring step (6) of three-dimensional suitable-shape regulating intensity device is entered；
(6) configuration of three-dimensional suitable-shape regulating intensity device：Blade is along slide rail radial motion, end face and irradiation field in collimating module
Stop motion during profile tangent (or reaching defined distance), vaned combination construct launched field and project conformal photograph
Launched field；In compensating module, driver drives rectangular slat along slide rail radial motion, when its end and tissue compensation grid are tangent
Stop motion when (or reaching defined distance)；Two groups of rectangular slats ultimately form the cavity of an indent, that is, form tissue
Compensation block；See flow S9, S10.
(7) it is finally completed optimal three-dimensional conformal and adjusts strong form.
The formation of compensating module inner chamber is on the basis of compensating thickness lowest part.Allow (most upstream opening) at maximum open super
Cross specific thickness.The substrate thickness that reason is to be guaranteed at the large area at irradiation field center as far as possible meets the requirements, while also can
It is conformal more to meet three-dimension curved surface.See Fig. 3.
Experimental example：
Heavy particle radiotherapy planning system based on the CAS Institute of Modern Physics's independent development, with reference to certain reality
Body tumour CT data, we implement the application example of the present invention, described in detail below.
A. heavy particle radiotherapy planning system is utilized, entity tumor used in acquisition projects along beam direction maximum target area,
I.e. launched field projects.See Fig. 5, polygon of the irradiation field substantially in 35mm*23mm rectangular extents, irradiation field centre coordinate is
(15, -10).
B. according to the factor such as target area reconstruction image and line incident path, line compensation path thickness in launched field is calculated, is given
Go out to compensate curved surface, see Fig. 6, principle is：Along line incident direction, it is ensured that the water on edge after from compensator surface any point to focus
Equivalent thickness is identical.Then compensation grid is calculated according to rectangular slat thickness (z-axis step-length) and width (y-axis step-length).Now
The cavity of an indent is formed, sees Fig. 6.
C. stop motion when blade is along x-axis radial motion, end face and tangent launched field projection in collimating module, that is, construct
Launched field projects conformal irradiation field；In compensating module, driver drives rectangular slat along x-axis radial motion, when its end with
Stop motion when tissue compensation grid is tangent；Two groups of rectangular slats are ultimately formed with the cavity of an indent, that is, form tissue
Compensation block.The strong equipment of three-dimensional suitable-shape regulating finally collimates compensation configuration, sees Fig. 7.
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (3)
- A kind of 1. conformal intensity modulated device of heavy particle radiotherapy multifunction three-dimensional, it is characterised in that：Include collimating module by phase Left alloy vane and right alloy vane to motion, according to projected outline of the tumor target on beam direction, are adjusted in the horizontal The radial distance of whole each blade and profile, constructs conformal irradiation field；Left rectangular slat and the right side of the compensating module by relative motion Rectangular slat, which stacks, to be formed, and according to beam energy and tumor target three-dimensional profile parameter, adjustment left and right rectangular slat is with respect to footpath To distance, composition inner cavity surface and the conformal module after tumor target along curved surface phase conjugate, wherein mutually identical rectangle length Bar forms its gabarit substrate；It is 1-5 millimeters that alloy vane transverse width is collimated in described collimating module；In the compensating module It is 1-5 millimeters to compensate rectangular slat transverse width, and longitudinal thickness is 1-5 millimeters；Described collimating module and compensating module are by solid Determine frame to be fixed on around beam axis（B）On the rotating base of rotary motion；The alloy vane of described collimating module and described The rectangular slat of compensating module can be along vertical beam axis（B）Directionally independent radial motion；Described collimating module and compensation The shape of modular configuration is that indent opening is consistent with irradiation field, along curved surface phase conjugate, gabarit after concave surface and tumor target The conformal intensity modulated mould of tubular of the water equivalent thickness identical substrate on edge after from collimating module upper surface any point to tumor target Body；Described collimating module, independent driving motor drive the left alloy vane independent with right alloy vane by drive screw Radial displacement；Described compensating module, independent driving motor drive the left rectangular slat to be grown with right rectangle by drive screw Bar independence radial displacement.
- 2. the conformal intensity modulated device of heavy particle radiotherapy multifunction three-dimensional as claimed in claim 1, it is characterised in that：Described The material of collimating module blade is tungsten alloy；Compensating module rectangular slat material is tissueequivalentmaterial, including solid water or PMMA or polytetrafluoroethylene (PTFE).
- A kind of 3. conformal intensity modulated method of heavy particle radiotherapy multifunction three-dimensional, it is characterised in that step is：（1）Using heavy particle radiotherapy planning system, entity tumor plan field parameter used in acquisition, including beam energy and The corresponding equivalent depth of penetration of water, the projection of beam direction maximum target area, i.e. launched field project, incident path water equivalent impenetrating thickness point It is distributed after cloth, i.e. tumor target along curved surface；（2）Obtain conformal intensity modulated appliance arrangement configuration parameter, including collimating module resolution ratio and blade quantity；Compensating module is differentiated Rate and rectangular slat quantity；（3）Judge whether to need to rotate with more preferable conformal；Such as need to rotate, it is determined that carry out beam coordinate system after the anglec of rotation and turn Change, otherwise, into step（4）；（4）According to beam direction, the equivalent depth of penetration of water and target area impenetrating thickness distributed constant, line compensation road in launched field is calculated Footpath thickness distribution, and calculate irradiation field profile and compensation grid according to parameters such as conformal intensity modulated appliance arrangement configuration resolution ratio；（5）Judge whether to need to optimize, to adapt to device configuration, such as to need to optimize, then calculated most by the method optimization rounded downwards Good compensation curved surface distribution；Otherwise the configuring step of three-dimensional suitable-shape regulating intensity device is entered（6）；（6）The configuration of three-dimensional suitable-shape regulating intensity device：Blade is along slide rail radial motion, end face and irradiation field profile in collimating module Stop motion when tangent, vaned combination construct launched field and project conformal irradiation field；In compensating module, driver Rectangular slat is driven along slide rail radial motion, the stop motion when its end and tangent tissue compensation grid；Two groups of rectangular slats The cavity of an indent is ultimately formed, that is, forms tissue compensation block；（7）It is finally completed optimal three-dimensional conformal and adjusts strong form.
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| CN105288870B (en) * | 2015-11-03 | 2017-03-01 | 上海联影医疗科技有限公司 | A kind of calibration steps of multi-diaphragm collimator |
| CN108401422B (en) * | 2017-04-10 | 2020-12-11 | 西安大医集团股份有限公司 | Multi-leaf grating collimator control method and system |
| CN109513119B (en) * | 2018-11-12 | 2020-07-17 | 武汉大学 | Volume rotation intensity modulation radiotherapy plan collimator angle optimization method |
| CN114073828A (en) * | 2021-12-08 | 2022-02-22 | 杭州珞珈质子科技有限公司 | Dynamic mechanism, device and use method for proton intensity modulated radiation therapy |
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| CN1227762A (en) * | 1998-12-04 | 1999-09-08 | 深圳奥沃国际科技发展有限公司 | Three-dimensional conformal block for radiotherapy and its making method |
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