CN104755927A - 用于确定受试者对以自由基引起的dna损伤为特征的疾病状态的倾向的方法和分析产品 - Google Patents

用于确定受试者对以自由基引起的dna损伤为特征的疾病状态的倾向的方法和分析产品 Download PDF

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Publication number
CN104755927A
CN104755927A CN201380047021.2A CN201380047021A CN104755927A CN 104755927 A CN104755927 A CN 104755927A CN 201380047021 A CN201380047021 A CN 201380047021A CN 104755927 A CN104755927 A CN 104755927A
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China
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sample
whole blood
exposed
cancer
radiation
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CN201380047021.2A
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English (en)
Chinese (zh)
Inventor
戴安娜·安德森
摩根·纳加弗扎德
摩根·克莱夫·托马斯·德尼尔
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University of Bradford
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University of Bradford
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7004—Stress
    • G01N2800/7009—Oxidative stress
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7023—(Hyper)proliferation
    • G01N2800/7028—Cancer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Ecology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201380047021.2A 2012-09-11 2013-09-10 用于确定受试者对以自由基引起的dna损伤为特征的疾病状态的倾向的方法和分析产品 Pending CN104755927A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1216174.1A GB201216174D0 (en) 2012-09-11 2012-09-11 Method of determining a predisposition to disease states characterised by free redical induced dna damage
GB1216174.1 2012-09-11
PCT/GB2013/052365 WO2014041340A1 (en) 2012-09-11 2013-09-10 Methods of, and assay products for, determining the predisposition of a subject to disease states characterised by free radical induced dna damage

Publications (1)

Publication Number Publication Date
CN104755927A true CN104755927A (zh) 2015-07-01

Family

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Family Applications (1)

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CN201380047021.2A Pending CN104755927A (zh) 2012-09-11 2013-09-10 用于确定受试者对以自由基引起的dna损伤为特征的疾病状态的倾向的方法和分析产品

Country Status (7)

Country Link
US (1) US20150219619A1 (enExample)
EP (1) EP2895853A1 (enExample)
JP (1) JP2015529077A (enExample)
CN (1) CN104755927A (enExample)
GB (1) GB201216174D0 (enExample)
IN (1) IN2015DN02685A (enExample)
WO (1) WO2014041340A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9931634B2 (en) 2014-02-27 2018-04-03 The Regents Of The Univeristy Of California High throughput DNA damage quantification of human tissue with home-based collection device
EP4006527B1 (en) * 2019-07-25 2025-07-16 Seoul Viosys Co., Ltd Light irradiation apparatus comprising led and method of using the same
US20230383362A1 (en) 2020-10-22 2023-11-30 4D Lifetec Ag Dna damage sensitivity as a new biomarker for detection of cancer and cancer susceptibility

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007103116A2 (en) * 2006-03-02 2007-09-13 Laboratory Corporation Of America Holdings Methods and systems for evaluating health risk factors by measurement of dna damage and dna repair

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DANIEL T. SAHA ET AL: "Quantification of DNA repair capacity in whole blood of patients with head and neck cancer and healthy donors by comet assay", <MUTATION RESEARCH.GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS> *
FRANCESCA MARCON ET AL: "Assessment of individual sensitivity to ionizing radiation and DNA repair efficiency in a healthy population", <MUTATION RESEARCH> *
M.H.L. GREEN ET AL: "UV-C sensitivity of unstimulated and stimulated human lymphocytes from normal and xeroderma pigmentosum donors in the comet assay: A potential diagnostic technique", <MUTATION RESEARCH, DNA REPAIR> *
VERA GARAJ-VRHOVAC ET AL: "Comet assay in the assessment of the human genome damage induced by γ-radiation in vitro", <RADIOL ONCOL> *
张黎等: "改良彗星试验检测紫外线照射致淋巴细胞DNA损伤", 《中国公共卫生》 *
熊何健等: "紫外辐射诱导牡蛎细胞DNA损伤的单细胞凝胶电泳检测", 《云南民族大学学报(自然科学版)》 *
王睿等: "紫外辐射弓}起DNA损伤的修复", 《中国组织工程研究与临床康复》 *

Also Published As

Publication number Publication date
JP2015529077A (ja) 2015-10-05
EP2895853A1 (en) 2015-07-22
IN2015DN02685A (enExample) 2015-09-04
WO2014041340A1 (en) 2014-03-20
US20150219619A1 (en) 2015-08-06
GB201216174D0 (en) 2012-10-24

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