CN104744569A - Preparation method of goserelin - Google Patents
Preparation method of goserelin Download PDFInfo
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- CN104744569A CN104744569A CN201310728562.3A CN201310728562A CN104744569A CN 104744569 A CN104744569 A CN 104744569A CN 201310728562 A CN201310728562 A CN 201310728562A CN 104744569 A CN104744569 A CN 104744569A
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- goserelin
- preparation
- oxopro
- nhnh2
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to a preparation method of goserelin, wherein the production method comprises the following specific steps: suspending 1.0.2 mol of 5-oxoPro-His-NHNH2 in a mixed solvent of 0.9 mL of dimethylformamide and 0.7 mL of dimethylsulfoxide, at the temperature of 0 DEG C and under stirring, adding 0.8 mmol of dioxane solution with 5.7 mol/L hydrochloric acid, vigorously stirring for 5 min, and thus obtaining a clarified solution. The preparation method of goserelin is simple in preparation process and low in production cost.
Description
Technical field
The present invention relates to field prepared by medicine, especially a kind of preparation method of goserelin.
Background technology
A kind of synthesis of goserelin, the analogue of luteinizing hormone-releasing hormone, life-time service can suppress the secretion of the prolan B of hypophysis, thus causes the decline of male sex's serum testosterone and women's serum estradiol, and after drug withdrawal, this effect is reversible.Owing to being to produce in the process of goserelin at present, complicate fabrication process, production cost is high.
Summary of the invention
The technical problem to be solved in the present invention is: in order to overcome above-mentioned middle Problems existing, provide a kind of preparation method of goserelin.
The technical solution adopted for the present invention to solve the technical problems is: a kind of preparation method of goserelin, concrete steps are as follows: be suspended in by 1.0.2mol5-oxoPro-His-NHNH2 in the mixed solvent of 0.9mL dimethyl formamide and 0.7mL methyl-sulphoxide, at 0 DEG C with under stirring, add the dioxane solution of 0.8mmol5.7mol/L hydrochloric acid, vigorous stirring 5min, obtains clear soln.
The invention has the beneficial effects as follows: the preparation method of described a kind of goserelin, its preparation process is simple, and production cost is low.
Embodiment
Be described in further detail in conjunction with the present invention now.
The preparation method of a kind of goserelin of the present invention, concrete steps are as follows: be suspended in by 1.0.2mol5-oxoPro-His-NHNH2 in the mixed solvent of 0.9mL dimethyl formamide and 0.7mL methyl-sulphoxide, at 0 DEG C with under stirring, add the dioxane solution of 0.8mmol5.7mol/L hydrochloric acid, vigorous stirring 5min, obtains clear soln.
With above-mentioned according to desirable embodiment of the present invention for enlightenment, by above-mentioned description, relevant staff in the scope not departing from this invention technological thought, can carry out various change and amendment completely.The technical scope of this invention is not limited to the content on specification sheets, must determine its technical scope according to right.
Claims (1)
1. the preparation method of a goserelin, it is characterized in that concrete steps are as follows: be suspended in by 1.0.2mol5-oxoPro-His-NHNH2 in the mixed solvent of 0.9mL dimethyl formamide and 0.7mL methyl-sulphoxide, at 0 DEG C with under stirring, add the dioxane solution of 0.8mmol5.7mol/L hydrochloric acid, vigorous stirring 5min, obtains clear soln.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310728562.3A CN104744569A (en) | 2013-12-26 | 2013-12-26 | Preparation method of goserelin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310728562.3A CN104744569A (en) | 2013-12-26 | 2013-12-26 | Preparation method of goserelin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104744569A true CN104744569A (en) | 2015-07-01 |
Family
ID=53584892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310728562.3A Pending CN104744569A (en) | 2013-12-26 | 2013-12-26 | Preparation method of goserelin |
Country Status (1)
| Country | Link |
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| CN (1) | CN104744569A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114209807A (en) * | 2022-01-13 | 2022-03-22 | 南京昂谷医药科技有限公司 | Goserelin implant preparation and preparation method thereof |
-
2013
- 2013-12-26 CN CN201310728562.3A patent/CN104744569A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114209807A (en) * | 2022-01-13 | 2022-03-22 | 南京昂谷医药科技有限公司 | Goserelin implant preparation and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150701 |
|
| WD01 | Invention patent application deemed withdrawn after publication |