CN104740374A - Pharmaceutical composition for treating mild cholelithiasis - Google Patents
Pharmaceutical composition for treating mild cholelithiasis Download PDFInfo
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- CN104740374A CN104740374A CN201410609339.1A CN201410609339A CN104740374A CN 104740374 A CN104740374 A CN 104740374A CN 201410609339 A CN201410609339 A CN 201410609339A CN 104740374 A CN104740374 A CN 104740374A
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Abstract
The invention discloses a pharmaceutical composition for treating mild cholelithiasis. The pharmaceutical composition for treating mild cholelithiasis comprises the following raw materials in parts by weight: 19-21 parts of endothelium corneum gigeriae galli, 9-11 parts of white atractylodes rhizome, 14-16 parts of semen raphani, 14-16 parts of plantain herb, 14-16 parts of chrysanthemum flower, 14-16 parts of corn stigma, 9-11 parts of mint leaves, 14-16 parts of radix bupleuri, 5-7 parts of aculeate bittersweet, and 5-7 parts of tibetan saxifrage. The pharmaceutical composition for treating mild cholelithiasis disclosed by the invention aims at the etiology and pathogenesis of cholelithiasis, is based on the traditional Chinese medicine therapy, takes corneum gigeriae galli as a monarch medicine, takes white atractylodes rhizome, semen raphani, plantain herb and chrysanthemum as minister medicines, takes corn stigma, mint, radix bupleuri, aculeate bittersweet and tibetan saxifrage as assistant medicines, fundamentally removes the etiology and pathogenesis while improving the symptoms of patients, treats both symptoms and root causes, and has a total effective rate of 86%.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of pharmaceutical composition for the treatment of slight cholelithiasis.
Background technology
Cholelithiasis is mainly seen in adult, and women is more than male, and within 40 years old, sequela rate increases with the age and increases.Calculus is cholesterol calculus or the mixed calculus based on cholesterol and black bile pigment calculus.Cholelithiasis is relevant with many factors.Anyly affect cholesterol and bile acid concentration ratio changes and cause the factor of cholestasis to cause calculus.Indivedual area and ethnic resident, estrogen, obesity, gestation, high fat diet, long-term parenteral, diabetes, hyperlipemia, pacing stomach or the factor such as gastrointestinal anastomosis Post operation, terminal ileum disease and ileal resection is postoperative, liver cirrhosis, hemolytic anemia all can cause cholelithiasis.Relatively high at the cholelithiasis sickness rate in NORTHWEST CHINA area, may be relevant with dietary habit.
The traditional Chinese medical science thinks that gallbladder is " fu-viscera with clear juice ", invests liver under being positioned at right flank, and with liver phase the exterior and the interior, defeated bile and do not pass digesting and absorbing the essence of foodstuff, functionally to fall behavior suitable with logical.Any factor, when having influence on " in clear " and " lead to and fall row " of gallbladder, can be fallen ill.Following factors can cause " in clear " of gallbladder and " lead to and fall row ": (1) disorder of emotion: liver controlling conveyance and dispersion, property happiness bar reach, dredge promoting the circulation of QI machine, the secretion of bile, conveying, storage, excretion are normally carried out, to help taste to receive digesting and absorbing the essence of foodstuff, excessive anxiety and rage, feelings will are smooth, cause depression of liver-QI, catharsis is not normal, thus make that bileization is raw, conveying, abevacuation and causing a disease; (2) eating and drinking without temperance: hungry full variable, surfeit delicious food savoury, pungent pure wine etc., cause transformation and transportation of the spleen and stomach not normal, endogenous damp formation, hinders mechanism of qi, strongly fragrant and heat-transformation, hot and suffocatingly accumulates steaming mutually with turbid damp, and gallbladder internal organs loses and falls in leading to and fall ill; (3) ascarid disturbs: ascarid disturbs, make QI depression of the liver and gallbladder, catharsis is neglected one's duty, and bile excretion is smooth, heat-transformation for a long time, damp and hotly accumulates steaming, forms cholelithiasis; (4) exopathogen invasion and attack: cold temperature is uncomfortable, being invaded by exogenous pathogen, few positive disorder of QI movement, gallbladder internal organs loses and falls in logical.
The pathogenesis of primary disease is generally initial with QI depression of the liver and gallbladder.Various paathogenic factor above, can cause depression of liver-QI, courage is obstructed, abdominal and hypochondriac pain; Perverse and unreasonable manner violates stomach, therefore nausea and vomiting; Transporting and transforming function of the spleen and stomach is not normal, retention of damp-heat in the interior, then become dampness-heat in the liver and gallbladder, thus heating or alternate attack of chill and fever, bitter taste.Damp and hot friendship is steamed, and forces bile excessive, then skin, white of the eye jaundice.Abdominal and hypochondriac pain, heating are the primary symptoms of cholelithiasis, and developing into certain phase can occur jaundice.If accumulation of heat does not fall apart, then putrefaction of blood and muscle, wine forms pus.Pyretic toxicity fire-transformation, invade nutrient blood or in disturb gods, very then " exhaustion of YIN " ", YANG-depletion ".
Summary of the invention
The technical problem that basic background technology exists, the present invention proposes a kind of pharmaceutical composition for the treatment of slight cholelithiasis, for the etiology and pathogenesis of cholelithiasis, according to Chinese medical discrimination method for the treatment of, take Endothelium Corneum Gigeriae Galli as monarch drug, with the Rhizoma Atractylodis Macrocephalae, Semen Raphani, Herba Plantaginis and Flos Chrysanthemi for ministerial drug, with Stigma Maydis, Herba Menthae, Radix Bupleuri, Celastrus aceleatus Merr and Herba Saxifragae przewalskii for adjuvant drug, while improving patients symptomatic, fundamentally remove etiology and pathogenesis, treating both the principal and secondary aspects of a disease, total effective rate can reach 86%.
A kind of pharmaceutical composition for the treatment of slight cholelithiasis that the present invention proposes, its raw material comprises by weight: Endothelium Corneum Gigeriae Galli 19-21 part, Rhizoma Atractylodis Macrocephalae 9-11 part, Semen Raphani 14-16 part, Herba Plantaginis 14-16 part, Flos Chrysanthemi 14-16 part, Stigma Maydis 14-16 part, Herba Menthae 9-11 part, Radix Bupleuri 14-16 part, Celastrus aceleatus Merr 5-7 part, Herba Saxifragae przewalskii 5-7 part.
Endothelium Corneum Gigeriae Galli, referring to the gizzard inwall of a chicken, is digestive organs, for grinding food.Sweet in the mouth, property is put down, and returns spleen, stomach, small intestinal, urinary bladder channel.There is invigorating the stomach and promoting digestion, arresting seminal emission, change the effect of hard Sal Nitri.Do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission.
The Rhizoma Atractylodis Macrocephalae is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.Bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.There is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive function.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Semen Raphani is the mature seed of crucifer Radix Raphani.Property flat, acrid in the mouth, sweet.Return lung, spleen, stomach warp.There is the de-swelling that helps digestion, the function of lowering the adverse-rising QI to resolve phlegm.Breath with cough for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots.Its effect is remarkable, has the title of " rush wall fall wall ".
Herba Plantaginis, sweet in the mouth, cold in nature, return Liver Channel, kidney channel, urinary bladder channel.Energy clearing away heat and promoting diuresis, eliminates the phlegm, removing heat from blood, removing toxic substances.For edema oliguria, the puckery pain of pyretic stranguria, heat-damp in summer dysentery, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.
Flos Chrysanthemi is the head inflorescence of feverfew chrysanthemum and mutation thereof.Sweet in the mouth, property are bitter, are slightly cold.Enter lung, Liver Channel.There is dispelling wind and heat pathogens, improving eyesight, heat-clearing and toxic substances removing, effect of suppressing the hyperactive liver sun.For affection due to external wind and heat, heating, aversion to cold, headache, conjunctival congestion and swelling pain, the disease such as the dizziness that skin infection swells and ache and excessive rising of liver-YANG causes, dizzy, feeling of fullness in the head, headache.
Stigma Maydis is the zeistic style of grass.Sweet in the mouth, property is put down, and returns stomach warp, gallbladder meridian, Liver Channel, kidney channel.There is inducing diuresis to remove edema; Effect of liver heat removing function of gallbladder promoting.Cure mainly edema; Dribbling urination; Jaundice; Cholecystitis; Cholelithiasis; Hypertension; Diabetes; Galactostasis.Modern pharmacology confirms, corn stigma can promote bile excretion, reduces its viscosity, reduces its bile pigments content, thus can be used as the cholangitis patient of choleretic for uncomplicated chronic cholecystitis, bile discharge obstacle.
Herba Menthae, has another name called " lunar caustic grass ", for labiate " Herba Menthae " namely belongs to other dry herbs together, and acrid in the mouth, cool in nature, enter lung, Liver Channel.Energy dispelling wind, heat radiation, wards off dirty, removing toxic substances.Cure mainly affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.
Radix Bupleuri is the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Bitter in the mouth, cold nature.Return liver, gallbladder meridian.There is reconciling superficies and interior, soothing the liver, effect of yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.
Celastrus aceleatus Merr is the root of Celastraceae plant Celastrus aceleatus Merr.Bitter in the mouth, cool in nature.Enter liver, gallbladder, kidney three warp.There is effect of damp-clearing pain-relieving, damp eliminating function of gallbladder promoting, suppressing the hyperactive liver and subsiding YANG.Cure mainly the arthralgia that anemofrigid-damp arthralgia causes, the damp and hot bitter taste, two caused of gallbladder meridian coerces easypro, jaundice, dysuria, yellow skin, and excessive rising of liver-YANG caused dizziness, Blushing, conjunctival congestion and swelling pain etc. all over the body.
Herba Saxifragae przewalskii is the herb of the logical greatly Herba Saxifragae of saxifragaceae plant.Summer gathers, and dries for subsequent use.Bitter in the mouth, cold in nature, return stomach warp, gallbladder meridian, Liver Channel.There is liver heat removing gallbladder-heat, the function of stomach invigorating.Cure mainly hepatitis, cholecystitis, influenza is had a fever, dyspepsia.
Preferably, the weight ratio of the Rhizoma Atractylodis Macrocephalae, Semen Raphani, Herba Plantaginis and Flos Chrysanthemi is 9.8-10.8:14.2-15.6:14.4-15.2:14.9-15.2.
Preferably, its raw material comprises by weight: Endothelium Corneum Gigeriae Galli 19.3-20.1 part, Rhizoma Atractylodis Macrocephalae 9.8-10.8 part, Semen Raphani 14.2-15.6 part, Herba Plantaginis 14.4-15.2 part, Flos Chrysanthemi 14.9-15.2 part, Stigma Maydis 14.7-15.4 part, Herba Menthae 9.4-10.3 part, Radix Bupleuri 14.8-15.1 part, Celastrus aceleatus Merr 5.5-6.2 part, Herba Saxifragae przewalskii 5.9-6.4 part.
Preferably, its raw material comprises by weight: Endothelium Corneum Gigeriae Galli 20 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Semen Raphani 15 parts, Herba Plantaginis 15 parts, Flos Chrysanthemi 15 parts, Stigma Maydis 15 parts, Herba Menthae 10 parts, Radix Bupleuri 15 parts, Celastrus aceleatus Merr 6 parts, Herba Saxifragae przewalskii 6 parts.
The present invention is directed to the etiology and pathogenesis of cholelithiasis, according to Chinese medical discrimination method for the treatment of, take Endothelium Corneum Gigeriae Galli as monarch drug, the effect of the hard Sal Nitri of having, with the Rhizoma Atractylodis Macrocephalae, Semen Raphani, Herba Plantaginis and Flos Chrysanthemi are ministerial drug, invigorating the spleen and benefiting QI, dampness diuretic, help digestion de-swelling, clearing away heat and promoting diuresis, dispelling wind and heat pathogens, suppressing the hyperactive liver sun, with Stigma Maydis, Herba Menthae, Radix Bupleuri, Celastrus aceleatus Merr and Herba Saxifragae przewalskii are adjuvant drug, assist monarch drug and ministerial drug on the one hand, further liver heat removing function of gallbladder promoting detumescence, wind-dispelling heat-dissipating, suppressing the hyperactive liver and subsiding YANG, on the other hand the performance of the excessively strong dampness of monarch drug and ministerial drug is relaxed, and energy reconciling superficies and interior, soothing the liver yang invigorating, can while improving patients symptomatic, fundamentally remove etiology and pathogenesis, total effective rate can reach 86%.
Detailed description of the invention
Below, by specific embodiment, technical scheme of the present invention is described in detail.
Embodiment 1
A kind of pharmaceutical composition for the treatment of slight cholelithiasis that the present invention proposes, its raw material comprises by weight: Endothelium Corneum Gigeriae Galli 19 parts, the Rhizoma Atractylodis Macrocephalae 11 parts, Semen Raphani 14 parts, Herba Plantaginis 16 parts, Flos Chrysanthemi 16 parts, Stigma Maydis 14 parts, Herba Menthae 9 parts, Radix Bupleuri 16 parts, Celastrus aceleatus Merr 5 parts, Herba Saxifragae przewalskii 7 parts.
Embodiment 2
A kind of pharmaceutical composition for the treatment of slight cholelithiasis that the present invention proposes, its raw material comprises by weight: Endothelium Corneum Gigeriae Galli 20 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Semen Raphani 15 parts, Herba Plantaginis 15 parts, Flos Chrysanthemi 15 parts, Stigma Maydis 15 parts, Herba Menthae 10 parts, Radix Bupleuri 15 parts, Celastrus aceleatus Merr 6 parts, Herba Saxifragae przewalskii 6 parts.
Embodiment 3
A kind of pharmaceutical composition for the treatment of slight cholelithiasis that the present invention proposes, its raw material comprises by weight: Endothelium Corneum Gigeriae Galli 19.3 parts, the Rhizoma Atractylodis Macrocephalae 10.8 parts, Semen Raphani 14.2 parts, Herba Plantaginis 15.2 parts, Flos Chrysanthemi 15.2 parts, Stigma Maydis 14.7 parts, Herba Menthae 9.4 parts, Radix Bupleuri 15.1 parts, Celastrus aceleatus Merr 5.5 parts, Herba Saxifragae przewalskii 6.4 parts.
Embodiment 4
A kind of pharmaceutical composition for the treatment of slight cholelithiasis that the present invention proposes, its raw material comprises by weight: Endothelium Corneum Gigeriae Galli 21 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Semen Raphani 16 parts, Herba Plantaginis 14 parts, Flos Chrysanthemi 14 parts, Stigma Maydis 16 parts, Herba Menthae 11 parts, Radix Bupleuri 14 parts, Celastrus aceleatus Merr 7 parts, Herba Saxifragae przewalskii 5 parts.
Embodiment 5
A kind of pharmaceutical composition for the treatment of slight cholelithiasis that the present invention proposes, its raw material comprises by weight: Endothelium Corneum Gigeriae Galli 20.1 parts, the Rhizoma Atractylodis Macrocephalae 9.8 parts, Semen Raphani 15.6 parts, Herba Plantaginis 14.4 parts, Flos Chrysanthemi 14.9 parts, Stigma Maydis 15.4 parts, Herba Menthae 10.3 parts, Radix Bupleuri 14.8 parts, Celastrus aceleatus Merr 6.2 parts, Herba Saxifragae przewalskii 5.9 parts.
Select embodiment 2 to prepare medicament, three times on the one, each 15g two weeks is a course for the treatment of.Random selecting chronic cholecystitis case 100 example.After 8 courses for the treatment of, 49 examples of fully recovering altogether, effective 20 examples, effective 17 examples, invalid 14 examples.Cure rate of the present invention is 49%, and obvious effective rate is 20%, and effective percentage is 17%, and total effective rate is 86%, and inefficiency is 14%.
Curative effect determinate standard is as follows:
Recovery from illness: clinical symptoms and sign disappear completely, and gallbladder color ultrasound examination is normal;
Effective: clinical symptoms and sign disappear substantially, gallbladder color ultrasound examination meets effective standard;
Effective: clinical symptoms and sign major part disappear, and gallbladder color ultrasound examination reaches effective standard;
Invalid: clinical symptoms and sign are all not improved, even increase the weight of, gallbladder color ultrasound examination is without improvement.
The above; be only the present invention's preferably detailed description of the invention; but protection scope of the present invention is not limited thereto; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses; be equal to according to technical scheme of the present invention and inventive concept thereof and replace or change, all should be encompassed within protection scope of the present invention.
Claims (4)
1. treat the pharmaceutical composition of slight cholelithiasis for one kind, it is characterized in that, its raw material comprises by weight: Endothelium Corneum Gigeriae Galli 19-21 part, Rhizoma Atractylodis Macrocephalae 9-11 part, Semen Raphani 14-16 part, Herba Plantaginis 14-16 part, Flos Chrysanthemi 14-16 part, Stigma Maydis 14-16 part, Herba Menthae 9-11 part, Radix Bupleuri 14-16 part, Celastrus aceleatus Merr 5-7 part, Herba Saxifragae przewalskii 5-7 part.
2. treat the pharmaceutical composition of slight cholelithiasis according to claim 1, it is characterized in that, the weight ratio of the Rhizoma Atractylodis Macrocephalae, Semen Raphani, Herba Plantaginis and Flos Chrysanthemi is 9.8-10.8:14.2-15.6:14.4-15.2:14.9-15.2.
3. according to claim 1 or 2, treat the pharmaceutical composition of slight cholelithiasis, it is characterized in that, its raw material comprises by weight: Endothelium Corneum Gigeriae Galli 19.3-20.1 part, Rhizoma Atractylodis Macrocephalae 9.8-10.8 part, Semen Raphani 14.2-15.6 part, Herba Plantaginis 14.4-15.2 part, Flos Chrysanthemi 14.9-15.2 part, Stigma Maydis 14.7-15.4 part, Herba Menthae 9.4-10.3 part, Radix Bupleuri 14.8-15.1 part, Celastrus aceleatus Merr 5.5-6.2 part, Herba Saxifragae przewalskii 5.9-6.4 part.
4. according to any one of claim 1-3, treat the pharmaceutical composition of slight cholelithiasis, it is characterized in that, its raw material comprises by weight: Endothelium Corneum Gigeriae Galli 20 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Semen Raphani 15 parts, Herba Plantaginis 15 parts, Flos Chrysanthemi 15 parts, Stigma Maydis 15 parts, Herba Menthae 10 parts, Radix Bupleuri 15 parts, Celastrus aceleatus Merr 6 parts, Herba Saxifragae przewalskii 6 parts.
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| CN201410609339.1A CN104740374A (en) | 2014-10-31 | 2014-10-31 | Pharmaceutical composition for treating mild cholelithiasis |
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| CN201410609339.1A CN104740374A (en) | 2014-10-31 | 2014-10-31 | Pharmaceutical composition for treating mild cholelithiasis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728803A (en) * | 2016-12-28 | 2017-05-31 | 陕西红顶名医堂药业有限公司 | For treating chronic cholecystitis, the Chinese medicine composition of cholelithiasis and preparation method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1068039A (en) * | 1991-06-21 | 1993-01-20 | 沈亚俊 | Preparation of medicine powder for cholecystitis and cholelithiasis |
| CN102343068A (en) * | 2010-07-26 | 2012-02-08 | 丰建萍 | Traditional Chinese medicine preparation for treating gallstone |
-
2014
- 2014-10-31 CN CN201410609339.1A patent/CN104740374A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1068039A (en) * | 1991-06-21 | 1993-01-20 | 沈亚俊 | Preparation of medicine powder for cholecystitis and cholelithiasis |
| CN102343068A (en) * | 2010-07-26 | 2012-02-08 | 丰建萍 | Traditional Chinese medicine preparation for treating gallstone |
Non-Patent Citations (1)
| Title |
|---|
| 肖国士等: "《中医秘方全书（珍藏本）超值版》", 30 June 2012 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728803A (en) * | 2016-12-28 | 2017-05-31 | 陕西红顶名医堂药业有限公司 | For treating chronic cholecystitis, the Chinese medicine composition of cholelithiasis and preparation method |
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