CN104725233A - Preparation method of ethylparaben - Google Patents
Preparation method of ethylparaben Download PDFInfo
- Publication number
- CN104725233A CN104725233A CN201310718397.3A CN201310718397A CN104725233A CN 104725233 A CN104725233 A CN 104725233A CN 201310718397 A CN201310718397 A CN 201310718397A CN 104725233 A CN104725233 A CN 104725233A
- Authority
- CN
- China
- Prior art keywords
- ethylparaben
- ethyl
- preparation
- hydroxybenzoate
- catalyst
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention discloses a preparation method of ethylparaben. The method comprises the following steps: 1, adding nipagin, absolute ethyl alcohol and neodymium sesquioxide into a three-necked flask equipped with a stirrer, a thermometer and a backflow condenser, performing heating reflux for 4 hours; 2, by the end of reaction, filtering when the reaction solution is still hot, recovering a catalyst, distilling filter liquid to remove ethanol and pouring cold water to residues; performing suction filtration and drying after ethylparaben is completely separated out, thus obtaining a coarse product; recrystallizing by using ethanol to obtain an ethylparaben finished product. Neodymium sesquioxide is used as a catalyst in the preparation method of ethylparaben and has the advantages of high catalytic activity, easiness in operation and low cost. In addition neodymium sesquioxide is nontoxic and does not pollutes the environment, thus being a green catalyst.
Description
Technical field
The present invention relates to a kind of preparation method of sanitas, be specifically related to a kind of preparation method of ethyl p-hydroxybenzoate.
Background technology
Nipagin esters is also called para hydroxybenzene potassium acid esters, is the series of anticorrosion agent that purposes is the widest in the world, consumption is maximum, applying frequency is the highest at present.The advantages such as it has efficiently, low toxicity, spectrum, easily compatibility, are widely used in the aspects such as daily use chemicals, medicine, food, feed and various industrial antisepsis.The synthesis of ethyl p-hydroxybenzoate adopts P-hydroxybenzoic acid and ethanol directly to prepare under vitriol oil effect usually, but sulfuric acid has serious corrodibility, easily side reaction and contaminate environment occurs.
Summary of the invention
The object of the invention is to, provide a kind of preparation method of ethyl p-hydroxybenzoate, be catalyzer with neodymium sesquioxide, catalytic activity is high, simple to operate, corrosion-free to equipment, and cheap, nontoxic, environmentally safe, is a kind of green catalyst.
The preparation method of described ethyl p-hydroxybenzoate, comprises the following steps:
One, in the there-necked flask that agitator, thermometer, reflux exchanger are housed, Tegosept E, dehydrated alcohol and neodymium sesquioxide is added, reflux 4h;
Two, react complete, filtered while hot, reclaim catalyzer, filtrate steams ethanol, and residuum is poured in cold water, after ethyl p-hydroxybenzoate is separated out completely, and suction filtration, dry, obtain thick product, with ethyl alcohol recrystallization, obtain ethyl p-hydroxybenzoate finished product.
The preparation method of ethyl p-hydroxybenzoate provided by the invention, its beneficial effect is, be catalyzer with neodymium sesquioxide, catalytic activity is high, simple to operate, corrosion-free to equipment, and cheap, nontoxic, environmentally safe, is a kind of green catalyst.
Embodiment
Below in conjunction with an embodiment, the preparation method of ethyl p-hydroxybenzoate provided by the invention is described in detail.
Embodiment
One, in the there-necked flask that agitator, thermometer, reflux exchanger are housed, Tegosept E, dehydrated alcohol and neodymium sesquioxide is added, reflux 4h;
Two, react complete, filtered while hot, reclaim catalyzer, filtrate steams ethanol, and residuum is poured in cold water, after ethyl p-hydroxybenzoate is separated out completely, and suction filtration, dry, obtain thick product, with ethyl alcohol recrystallization, obtain ethyl p-hydroxybenzoate finished product.
Claims (1)
1. a preparation method for ethyl p-hydroxybenzoate, is characterized in that: it comprises the following steps:
One, in the there-necked flask that agitator, thermometer, reflux exchanger are housed, Tegosept E, dehydrated alcohol and neodymium sesquioxide is added, reflux 4h;
Two, react complete, filtered while hot, reclaim catalyzer, filtrate steams ethanol, and residuum is poured in cold water, after ethyl p-hydroxybenzoate is separated out completely, and suction filtration, dry, obtain thick product, with ethyl alcohol recrystallization, obtain ethyl p-hydroxybenzoate finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310718397.3A CN104725233A (en) | 2013-12-24 | 2013-12-24 | Preparation method of ethylparaben |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310718397.3A CN104725233A (en) | 2013-12-24 | 2013-12-24 | Preparation method of ethylparaben |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104725233A true CN104725233A (en) | 2015-06-24 |
Family
ID=53449717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310718397.3A Pending CN104725233A (en) | 2013-12-24 | 2013-12-24 | Preparation method of ethylparaben |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104725233A (en) |
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2013
- 2013-12-24 CN CN201310718397.3A patent/CN104725233A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150624 |