CN104721652A - Lactobacillus fermented barley meal as well as preparation method and application thereof - Google Patents
Lactobacillus fermented barley meal as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention provides lactobacillus fermented barley meal as well as a preparation method and an application thereof and belongs to the technical field of food biotechnology. Barley is fermented by virtue of lactobacillus, bioconversion of nutrient substance is realized, and lactobacillus fermented barley meal is prepared; the lactobacillus fermented barley meal can be taken as food or a food raw material which has the function of inhibiting obesity and improving insulin resistance; and contents of beta-glucan and total phenol in the obtained lactobacillus fermented barley meal are obviously higher than those of unfermented barely, and the lactobacillus fermented barley meal has the effects of maintaining body weight and reducing formation of body fat.
Description
Technical field
The invention belongs to technical field of food biotechnology, especially lactic acid bacteria fermentation Fructus Hordei Vulgaris powder and preparation method thereof and purposes.
Background technology
Improving constantly of China's economic development and living standard, people are impelled to change from simply having adequate food and clothing to health type, and out of control due to transition process Middle nutrition balance, making fat with auxotype is that the metabolism syndrome of representative becomes and affects one of topmost non-contagious chronic diseases of human health.According to incompletely statistics, over the last couple of decades, the American of about 32%, the Europe of 25% and Latin America adult have suffered from this chronic disease, and at present as the China of developing country, this phenomenon also becomes increasingly conspicuous, and number is now more than 30%.Therefore, the generation how controlling metabolism syndrome just must become the focus of numerous scientific workers research, and wherein fat and insulin resistant is the basis of metabolism syndrome, becomes the most important thing for the prevention of fat and insulin resistant and intervention.At present, to lose weight and the medicine that improves insulin resistant generally has certain toxic and side effects, therefore, find natural safe product fat with prevention and therapy, improve insulin resistant, there is larger meaning and demand.
Fructus Hordei Vulgaris is nutritious, has the features such as high protein, high dietary-fiber, low fat, low sugar.In recent years, the main uses of China Fructus Hordei Vulgaris is brewing and feed industry, and only have the Fructus Hordei Vulgaris of about 10% for edible, utilization rate is very low.There are some researches show, Fructus Hordei Vulgaris contains the various active compositions such as abundant beta glucan, flavone, polyphenol compound, hordenine, has the functions such as antioxidation, defying age, blood sugar lowering, blood fat reducing.But, the domestic and international domestic and international rarely seen report of research improving its trophic function about microbial transformation Fructus Hordei Vulgaris at present.
At present about the research of Fructus Hordei Vulgaris fermentation, Japan Patent WO2007034958 discloses the preparation method of a kind of ethanol extraction of hulled barley, alkaline extraction thing and tunning, its active component has the effect of inhibiting angiogenesis, does not study it to impact that is fat and prevention of obesity.
Article Effects of Fermented Barley on Lipid and Carnitine Profiles in C57BL/6J Mice (fermentation Fructus Hordei Vulgaris is on the impact of C57BL/6J mice lipid and carnitine), Food Science and Biotechnolog, 2012, 21 (2): 323-329, using yeast fermentation Fructus Hordei Vulgaris powder as dietary supplement, find that it can reduce obesity mice cholesterol in serum, the content of triglyceride and low density lipoprotein, LDL, simultaneously, the content of total carnitine in serum can be increased, but it is not remarkable on the impact of obesity mice body weight and triglyceride in serum.
Summary of the invention
For Shortcomings in prior art, the invention provides a kind of lactic acid bacteria fermentation Fructus Hordei Vulgaris powder and preparation method thereof and purposes, by adopting lactobacillus, Fructus Hordei Vulgaris is fermented, obtain lactic acid bacteria fermentation Fructus Hordei Vulgaris powder, in the lactic acid bacteria fermentation Fructus Hordei Vulgaris powder that the present invention obtains, beta glucan content and polyphenol content are all significantly higher than Fructus Hordei Vulgaris of not fermenting, and have the effect maintaining body weight, reduce body fat generation.
The present invention realizes above-mentioned technical purpose by following technological means.
A kind of lactic acid bacteria fermentation Fructus Hordei Vulgaris powder, it is characterized in that, comprise following component: albumen, total sugar, total phenols, total dietary fiber, beta glucan, in described lactic acid bacteria fermentation Fructus Hordei Vulgaris powder, each constituent content is:
Containing protein 14 .88 ± 0.48g, total sugar 70.6 ± 5.00g, total phenols 0.351 ± 0.005g, total dietary fiber 15.23 ± 0.15g, beta glucan 6.58 ± 0.04g in every 100g lactic acid bacteria fermentation Fructus Hordei Vulgaris powder.
The each constituent content in Fructus Hordei Vulgaris powder that do not ferment is: every 100g does not ferment in Fructus Hordei Vulgaris powder containing albumen 13.93 ± 0.03g, total sugar 80.5 ± 9.84g, total phenols 0.236 ± 0.005g, total dietary fiber 15.51 ± 0.37g, beta glucan 5.16 ± 0.15g.
The present invention also comprises a kind of preparation method of lactic acid bacteria fermentation Fructus Hordei Vulgaris powder, it is characterized in that, comprise Fructus Hordei Vulgaris shelling, pulverizing, cross 60 ~ 140 mesh sieves, must be sieved Fructus Hordei Vulgaris powder, in the described Fructus Hordei Vulgaris powder that sieves, add distilled water, lactobacillus, mix homogeneously, obtain fermented product at 20 ~ 40 DEG C of bottom fermentation 12 ~ 56h, described fermented product is carried out hot air drying, spraying dry or lyophilization and obtains lactic acid bacteria fermentation Fructus Hordei Vulgaris powder;
The quality of described sieve Fructus Hordei Vulgaris powder and distilled water is 1:(5 ~ 15);
Described viable count of lactobacillus is 1 × 10
8~ 1 × 10
10cFU/mL.
Further, described lactobacillus is Lactobacillus plantarum, Lactobacillus brevis, lactobacillus casei.
In such scheme, described in the sieve quality of Fructus Hordei Vulgaris powder and distilled water be 1:7, described viable count of lactobacillus is 1 × 10
9cFU/mL.
In such scheme, the temperature of described fermentation is 30 ~ 35 DEG C, and fermentation time is 24 ~ 48h.
The present invention also comprises lactic acid bacteria fermentation Fructus Hordei Vulgaris powder as suppression obesity and the food improving insulin resistant function.
The present invention also comprises lactic acid bacteria fermentation Fructus Hordei Vulgaris powder as suppression obesity and the raw-food material improving insulin resistant function.
During fermentable, utilize the enzyme of microorganism secretion to modify grain component, thus affect its structure, biological activity and bioavailability etc.; And utilize lactic acid bacteria fermentation corn, the content of the nutritional labeling such as water soluble dietary fiber and total phenols can be increased.
Beneficial effect of the present invention:
(1) in lactic acid bacteria fermentation Fructus Hordei Vulgaris powder of the present invention, beta glucan content, total phenol content are all significantly higher than Fructus Hordei Vulgaris of not fermenting, and can maintain body weight, reduce a large amount of generations of body fat.
(2) preparation method of lactic acid bacteria fermentation Fructus Hordei Vulgaris powder of the present invention, method is simple, and cost is low, is suitable for commercial application.
(3) lactic acid bacteria fermentation Fructus Hordei Vulgaris powder of the present invention can make staple food, leisure food or functional health care product, as fine dried noodles, wetted surface, steamed bread, bread, sausage, cookies, beverage etc., also can to join in food and without special proportion requirement, there is prevention or intervene fat and improve the function of glucose-lipid metabolism disorder.
Accompanying drawing explanation
Fig. 1 is 4 groups of SD rat body weight situations of change of the present invention.
Fig. 2 is 4 groups of SD rat body fat situations of change of the present invention.
Fig. 3 is the situation of change of 4 groups of SD feeding rats of the present invention, 14 weeks oral resistance to sugar amounts in front and back.
Fig. 4 is 4 groups of SD rat blood serum insulin situations of change of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing and specific embodiment, the present invention is further illustrated, but protection scope of the present invention is not limited to this.
1. the preparation of lactic acid bacteria fermentation Fructus Hordei Vulgaris powder
Choose fresh hulled barley, pulverizing, cross 60 ~ 140 mesh sieves, in Fructus Hordei Vulgaris powder, add the distilled water of 5 ~ 15 times of quality, preferably the distilled water of 7 times of quality, by 1 × 10
7inoculation is activated to late log phase, and (viable count reaches 1 × 10
8~ 1 × 10
10cFU/mL, preferably 1 × 10
9cFU/mL) Lactobacillus plantarum dy-1, stir 5min, 20 ~ 40 DEG C, preferably 30 DEG C of bottom fermentation 12 ~ 56h, preferred 24h, obtain fermented product, fermented product is carried out hot air drying, spraying dry or lyophilization, namely preferably freeze drying obtains lactic acid bacteria fermentation Fructus Hordei Vulgaris powder (LFB).
2. laboratory animal and rearing conditions
Cleaning grade healthy SD rat 48; 5 ~ 6 week age; about 180 ~ 200g; male, be purchased from Jiangsu University's Experimental Animal Center, process of the test meets the regulation of management of laboratory animal committee of Jiangsu Province and the protection of National Laboratory Animal welfare; rat feeding is in Jiangsu University's Experimental Animal Center Animal House: room temperature (25 ± 2) DEG C; relative humidity (55 ± 5) %, 12h/12h illumination, freely obtains food and drinking-water.
3. experimental technique
After SD rat conforms 1 week, it is matched group (NC) that 48 SD male rats are divided into 4 groups: first group at random by average weight, normal feedstuff of feeding; Second group is high fat diet group (HFD), high lipid food of feeding (73% normal feedstuff, 12% Adeps Sus domestica, 10% white sugar and 5% yolk powder); 3rd group is LFB group, feeds containing the high lipid food (3%LFB, 70% normal feedstuff, 12% Adeps Sus domestica, 10% white sugar and 5% yolk powder) of 3%LFB; For not fermenting Fructus Hordei Vulgaris (RB) group, feed containing the high lipid food (3%RB, 70% normal feedstuff, 12% Adeps Sus domestica, 10% white sugar and 5% yolk powder) of 3%RB for 4th group; Wherein high lipid food is made by oneself by seminar: add Adeps Sus domestica, white sugar and yolk powder in proportion, and after mix homogeneously, cutting is dried.
Each group of test rat is fed 14 weeks all continuously, and rat week body weight change often organized in record.Measure oral glucose tolerance; Feeding is after 14 weeks, next day, employing chloral hydrate is benumbed, abdominal aortic blood, the centrifugal 10min separation of serum of 3500rpm ,-20 DEG C of preservations, for the mensuration of blood biochemistry and serum levels of inflammatory cytokines, dissect rat get epididymal adipose tissues and stomach fat, with normal saline rinse, be filtered dry after weigh ,-80 DEG C save backup.
Oral glucose tolerance test (OGTT) method be to empty stomach rat oral gavage glucose 2g/kg, respectively at 0,0.5,1,2h time docking get blood, adopt Johnson & Johnson one-touch Basic blood glucose meter mensuration blood sugar level.
The mensuration of serum insulin content adopts insulin ELISA kit to measure.
The mensuration of blood lipid level: in rat blood serum, the content of triglyceride (TG), T-CHOL (TC), high density lipoprotein (HDL), low density lipoprotein, LDL (LDL) adopts automatic clinical chemistry analyzer to measure.
The mensuration of SD rat blood serum inflammatory factor: adopt tumor necrosis factor (TNF-α), interleukin-6 (IL-6), interleukin 10 (IL-10) and interleukin-1 beta (IL-1 β) Elisa test kit respectively, measures main inflammatory factors TNF-α, IL-6, IL-10 and IL-1 β content in SD rat blood serum.
4. experimental result
Note: each group data with
(meansigma methods ± standard deviation) represents, adopt ANOVA module in SPSS 14.0 to carry out variance analysis to test data, p<0.05 thinks to there is significant difference.
(1) the main constituent contrast of RB and LFB
Table 1 is Fructus Hordei Vulgaris powder (RB) and the main constituent contrast of lactic acid bacteria fermentation Fructus Hordei Vulgaris powder (LFB) of not fermenting, in LFB, the content of total phenols, total dietary fiber, beta glucan is all higher than RB, total sugar amount is lower than RB, so after Fructus Hordei Vulgaris fermentation, the functions of reducing sugar and reducing fat Fructus Hordei Vulgaris powder that do not ferment strengthens to some extent, also has antioxidation, defying age, the function such as anticancer simultaneously.
Table 1 Fructus Hordei Vulgaris powder (RB) and the contrast of lactic acid bacteria fermentation Fructus Hordei Vulgaris powder (LFB) Contents of Main Components
(2) four groups of SD Serum Lipids in Experimental HypercholesterolemicRats situations of change
Blood lipids horizontal abnormality changes, and can cause the abnormal accumulation of body lipid, bring out body and produce hyperlipemia, severe patient can cause the generation of atherosclerosis, coronary heart disease etc., while insulin resistant appears in obese rat, also with disorders of lipid metabolism; As seen from Table 2, compared with Normal group, HFD group rat blood serum TG (triglyceride) and TC (T-CHOL) content significantly raise, in rat blood serum, HDL (high density lipoprotein) content then significantly reduces, in rat blood serum, LDL (low density lipoprotein, LDL) content there is no the difference of significance, and this obviously adjoint with obesity hyperlipemia is relevant; After feeding 14 weeks LFB, compared with HFD group, in LFB group rat blood serum, TG and TC content reduces all significantly, and in rat blood serum, HDL content significantly raises, and LFB group rat blood serum LDL content does not have significant difference compared with HFD group.
The mensuration of table 2 four groups of SD Serum Lipids in Experimental HypercholesterolemicRats
Note: there is different alphabetic flags and then think that there is significant difference (p<0.05).
The situation of change of (3) four groups of SD rat inflammation factors
Research in recent years shows, obesity brings out insulin resistant and chronic low system inflammatory is closely related, inflammatory factor such as the secretion of interleukin (IL-1 β, IL-6), anti-inflammatory factors (IL-10), tumor necrosis factor (TNF-α) etc. of fat body increases, and table 3 is the mensuration of four groups of SD rat inflammation factors.The IL-10 of LFB group is significantly higher than HFD, RB, and IL-1 β, IL-6, TNF-α, significantly lower than HFD, RB, illustrates that LFB has the effect reducing the factor, increase anti-inflammatory factors.Therefore, LFB can produce the immune factors such as IL-1 β, IL-6 and TNF-α by suppressing body, reduces insulin resistant and produces.
TNF-α is first inflammatory molecule finding contact obesity and chronic systemic inflammation.The defect of TNF-a function can improve the balance of fat Mus insulin sensitivity and blood glucose.There are some researches show, in the serum and fatty tissue of overweight people, the expression of TNF-a, IL-1 α and IL-1 β inflammatory factor raises significantly, and the minimizing of its content also exists positive correlation with losing weight.IL-1 β and IL-6 is the important inflammatory labelling of system insulin resistant, and in blood plasma, the concentration of IL-1 β and IL-6 raises the risk that imply that mankind's type 2 diabetes mellitus to a great extent simultaneously.
The mensuration of table 3 four groups of SD rat inflammation factors
(4) four groups of SD rat body weights and body fat content situation of change
As seen from Figure 1, between the intervention period of 14 weeks, the body weight of LFB group rat is starkly lower than HFD group and RB group, and result shows, lactic acid bacteria fermentation Fructus Hordei Vulgaris powder can reduce the increase of rat body weight significantly.
As seen from Figure 2, compared with NC group, HFD group rat body fat content significantly increases, and the body weight of LFB group rat is starkly lower than HFD group and RB group, and result shows, lactic acid bacteria fermentation Fructus Hordei Vulgaris powder can reduce the increase of rat body fat significantly.
The situation of change of (5) four groups of SD feeding rats 14 weeks oral resistance to sugar amounts in front and back
Under normal circumstances, the feedstuff that animal consumption is certain, for maintaining body temperature, growth promoting effects.When excess ingestion high lipid food, energy i (in vivo) metabolic imbalance, too much energy conversion becomes fat and albumen, causes body fat, under ill physiological status or bad life style, causes the generation of insulin resistant or type 2 diabetes mellitus.
The initial symptom of insulin resistant is exactly the impaired glucose tolerance of body, Fig. 3 is the situation of change of four groups of SD feeding rats, 14 weeks oral resistance to sugar amounts in front and back, with HFD group compared with RB group, LFB group rat carbohydrate tolerance is similar to normal rats carbohydrate tolerance, maintains metastable level.
(6) four groups of SD rat blood serum insulin situations of change
Insulin is the hormone with various biological effect, to keeping the metabolic balance of body nutrient substance, maintain homeostasis there is vital effect, Fig. 4 is 4 groups of SD rat blood serum insulin situations of change of the present invention, the obese rat serum insulin levels compared with normal group of high lipid food induction compares remarkable rising, there is hyperinsulinemia, show to create insulin resistant; Feeding, after 14 weeks, compares with HFD group, and LFB group rat Langerhans islet cellulose content significantly declines; Many bibliographical informations, the beta glucan consumption rate increase in Fructus Hordei Vulgaris may reduce insulin resistant and diabetes occur.
Lactic acid bacteria fermentation Fructus Hordei Vulgaris powder can maintain body weight, reduces a large amount of generations of body fat, improves body self carbohydrate tolerance, significantly reduces the blood sugar content of high glucose and high fat rat model; Also significantly may improve the disorders of lipid metabolism of hyperlipidemia model rat, reduce the content of serum cholesterol and triglyceride, increase the content of high density lipoprotein.
Lactic acid bacteria fermentation Fructus Hordei Vulgaris powder can be used for preventing the individual generation with intervening diabetes, coronary heart disease chronic diseases, also can be used for prevention and therapy hyperlipidemia and hyperglycemia, especially to the prevention and therapy of hyperlipidemia; Hyperinsulinemia can be improved, prevention or the fat insulin resistant brought out for the treatment of.
Described embodiment is preferred embodiment of the present invention; but the present invention is not limited to above-mentioned embodiment; when not deviating from flesh and blood of the present invention, any apparent improvement that those skilled in the art can make, replacement or modification all belong to protection scope of the present invention.
Claims (7)
1. a lactic acid bacteria fermentation Fructus Hordei Vulgaris powder, is characterized in that, comprises following component: albumen, total sugar, total phenols, total dietary fiber, beta glucan, and in described lactic acid bacteria fermentation Fructus Hordei Vulgaris powder, each constituent content is:
Containing protein 14 .88 ± 0.48g, total sugar 70.6 ± 5.00g, total phenols 0.351 ± 0.005g, total dietary fiber 15.23 ± 0.15g, beta glucan 6.58 ± 0.04g in every 100g lactic acid bacteria fermentation Fructus Hordei Vulgaris powder.
2. the preparation method of a lactic acid bacteria fermentation Fructus Hordei Vulgaris powder, it is characterized in that, comprise hulled barley pulverizing, cross 60 ~ 140 mesh sieves, must be sieved Fructus Hordei Vulgaris powder, in the described Fructus Hordei Vulgaris powder that sieves, add distilled water, lactobacillus, mix homogeneously, obtain fermented product at 20 ~ 40 DEG C of bottom fermentation 12 ~ 56h, described fermented product is carried out hot air drying, spraying dry or lyophilization and obtains lactic acid bacteria fermentation Fructus Hordei Vulgaris powder;
The mass ratio of described sieve Fructus Hordei Vulgaris powder and distilled water is 1:(5 ~ 15);
Described viable count of lactobacillus is 1 × 10
8~ 1 × 10
10cFU/mL.
3. the preparation method of lactic acid bacteria fermentation Fructus Hordei Vulgaris powder as claimed in claim 2, it is characterized in that, described lactobacillus is one or more in Lactobacillus plantarum, Lactobacillus brevis, lactobacillus casei.
4. the preparation method of as claimed in claim 2 or claim 3 lactic acid bacteria fermentation Fructus Hordei Vulgaris powder, is characterized in that, described in the sieve mass ratio of Fructus Hordei Vulgaris powder and distilled water be 1:7, described viable count of lactobacillus is 1 × 10
9cFU/mL.
5. the preparation method of lactic acid bacteria fermentation Fructus Hordei Vulgaris powder as claimed in claim 2, it is characterized in that, the temperature of described fermentation is 30 ~ 35 DEG C, and fermentation time is 24 ~ 48h.
6. lactic acid bacteria fermentation Fructus Hordei Vulgaris powder as claimed in claim 1 is as suppression obesity and the food improving insulin resistant function.
7. lactic acid bacteria fermentation Fructus Hordei Vulgaris powder as claimed in claim 1 is as suppression obesity and the raw-food material improving insulin resistant function.
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| CN201510072908.8A CN104721652A (en) | 2015-02-11 | 2015-02-11 | Lactobacillus fermented barley meal as well as preparation method and application thereof |
| PCT/CN2016/070542 WO2016127749A1 (en) | 2015-02-11 | 2016-01-11 | Lactic acid bacteria fermented flour, preparation method and use thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105918822A (en) * | 2016-04-22 | 2016-09-07 | 江苏省农业科学院 | Method for preparing high-value cereal powder by utilizing lactic acid bacteria fermentation |
| CN106720761A (en) * | 2016-12-09 | 2017-05-31 | 北京市绿友食品有限公司 | A kind of lyophilized baked barley tea and preparation method thereof |
| CN106858315A (en) * | 2017-01-11 | 2017-06-20 | 江苏大学 | Vermicelli that a kind of suitable metabolic syndrome crowd eats and preparation method thereof |
| CN106889404A (en) * | 2017-01-11 | 2017-06-27 | 江苏大学 | Lactobacillus-fermented barley beverage and preparation method thereof |
| CN109170857A (en) * | 2018-09-17 | 2019-01-11 | 江南大学 | A method of making wheat grain ferment |
| CN110522034A (en) * | 2019-08-21 | 2019-12-03 | 上海交通大学 | A kind of functional food containing black barley lactobacillus ferment object and application |
| CN111493313A (en) * | 2020-04-21 | 2020-08-07 | 江苏瑞牧生物科技有限公司 | Functional barley composite whole powder based on lactobacillus fermentation and preparation method thereof |
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| CN111436474A (en) * | 2020-03-25 | 2020-07-24 | 新疆家瑞泽智慧农业科技开发有限公司 | Corn byproduct dietary fiber biscuit and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105918822A (en) * | 2016-04-22 | 2016-09-07 | 江苏省农业科学院 | Method for preparing high-value cereal powder by utilizing lactic acid bacteria fermentation |
| CN106720761A (en) * | 2016-12-09 | 2017-05-31 | 北京市绿友食品有限公司 | A kind of lyophilized baked barley tea and preparation method thereof |
| CN106858315A (en) * | 2017-01-11 | 2017-06-20 | 江苏大学 | Vermicelli that a kind of suitable metabolic syndrome crowd eats and preparation method thereof |
| CN106889404A (en) * | 2017-01-11 | 2017-06-27 | 江苏大学 | Lactobacillus-fermented barley beverage and preparation method thereof |
| CN109170857A (en) * | 2018-09-17 | 2019-01-11 | 江南大学 | A method of making wheat grain ferment |
| CN110522034A (en) * | 2019-08-21 | 2019-12-03 | 上海交通大学 | A kind of functional food containing black barley lactobacillus ferment object and application |
| CN111493313A (en) * | 2020-04-21 | 2020-08-07 | 江苏瑞牧生物科技有限公司 | Functional barley composite whole powder based on lactobacillus fermentation and preparation method thereof |
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| WO2016127749A1 (en) | 2016-08-18 |
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