CN104721621A - Pharmaceutical composition for treating peri-implantitis and application of pharmaceutical composition - Google Patents
Pharmaceutical composition for treating peri-implantitis and application of pharmaceutical composition Download PDFInfo
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- CN104721621A CN104721621A CN201510128246.1A CN201510128246A CN104721621A CN 104721621 A CN104721621 A CN 104721621A CN 201510128246 A CN201510128246 A CN 201510128246A CN 104721621 A CN104721621 A CN 104721621A
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Abstract
The invention discloses a pharmaceutical composition for treating peri-implantitis and an application of the pharmaceutical composition. The pharmaceutical composition is prepared from an active ingredient and pharmaceutical excipients, wherein the active ingredient is prepared by taking flos imperatae and euphorbia humifusa as traditional Chinese medicinal materials. The medicine composition treats the peri-implantitis by local drug delivery, alleviates inflammation, as well as symptoms such as pain, redness and swelling, bleeding and suppuration, promotes regeneration of a periodontal tissue, allows the depth of a periodontal pocket to be less, and is definite in treatment effect.
Description
Technical field
The invention belongs to technical field of Chinese medicine, in particular to a kind of externally-applied medicinal composition and application thereof for the treatment of peri-implantitis.
Background technology
Along with reaching its maturity of plantation recovery technique, plantation reparation has been widely used in the patient of local or dental pattern disappearance, but the sickness rate of peri-implantitis also increases thereupon, the bacterial micro-organism of its reason mainly in implantation body, namely due to poor oral hygiene, cause bone regeneration around implant bacterial plaque to pile up, stimulate body to produce inflammatory reaction.In addition, bad habit (smoking), periodontitis, systemic disease (as diabetes etc.) control badly also can cause peri-implantitis.Have result of study to show, smoking is all relevant to peri-implantitis with periodontal medical history, and may be the risk factor of this disease.Clinical manifestation be mainly mucosa redness, visit examine hemorrhage even pyorrhea etc.Owing to not having periodontal membrane between implantation body and bone, rapidly, can cause supporting that bone is lost, Osseointegrated implants failure, even implantation body loosens, so answer treated as soon as possible to promote that surrounding tissue returns to health status in inflammation expansion.
The treatment of peri-implantitis, mainly for infective agent, mainly to eradicate inflammation, is guaranteed that bone regeneration around implant mucosa and osseous tissue health are main target, therefore, first will be carried out scaling and subgingival debridement on dental pattern gum, to improve oral environment.Good bacterial plaque controls to be that peri-implantitis treats successful prerequisite use.Local anti-infective is one of necessary means for the treatment of peri-implantitis.Local application needs to arrive site of action rapidly when valid density, and stops time enough at site of action, just can obtain ideal clinical efficacy.
Summary of the invention
The object of the invention is to the folk remedy basis by having a toothache in treatment is furtherd investigate, the pharmaceutical composition providing a kind of effect to treat peri-implantitis more significantly and application thereof.
The object of the present invention is achieved like this:
A kind of pharmaceutical composition for the treatment of peri-implantitis, this pharmaceutical composition is prepared from by active component and pharmaceutic adjuvant, wherein by weight, described active component is prepared from through decocting extraction by the traditional Chinese medicinal material raw materials of following amount ratio: Flos Imperatae 100-130 part, Herba Cucubali 21-30 part.
Object of the present invention can also realize like this:
The pharmaceutical composition of described treatment peri-implantitis, by weight, active component is wherein prepared from through decocting extraction as raw material by Flos Imperatae 115-125 part and Herba Cucubali 24-27 part.
In a most preferred embodiment of the present invention, by weight, described active component is prepared from through decocting extraction as raw material by Flos Imperatae 120 parts and Herba Cucubali 25 parts the pharmaceutical composition of above-mentioned treatment peri-implantitis.
It should be noted that, the traditional Chinese medicinal material raw materials that pharmaceutical composition of the present invention adopts in preparation process has following source: Flos Imperatae selects the spica of grass Herba Imperatae Imperata cylindrica (L.) Beauv.var.major (Nees) C.E.Hubb., spend the 4-5 month before blooming and gather, take the spica of band stem, dry.Herba Cucubali selects raw Herba stellariae mediae Stellaria saxatilis Buch.-Ham. [S.vestita Kurz] of Caryophyllaceae Stellaria phytobezoar, is used as medicine with the aerial parts of herb, and Xia Qiucai, cleans and dry.
Chinese medicine extract of the present invention has affinity interaction to osseous tissue, the growth of periodontal pathogen can be suppressed and form the collagenase activity of periodontal pocket, not only amelioration of inflammation, can also ease the pain, red and swollen, the hemorrhage and symptom such as to suppurate, promote paradenlal tissue regeneration, make the depth shallower of periodontal pocket.Inventor is shown by the therapeutic outcome of clinical practice, adopt pharmaceutical composition of the present invention to after peri-implantitis patient treatment the 2nd, 4,8 week, the degree of depth is examined in periodontal pocket spy and sulcular bleeding index is all obviously improved, and points out this Drug therapy peri-implantitis to have definite curative effect.Therefore, another object of the present invention is to provide a kind of pharmaceutical applications, that is: the application of above-mentioned traditional Chinese medicinal material raw materials compositions in the external used medicine of preparation treatment peri-implantitis.Preferably, in medicine preparation process, described external used medicine can be ointment, gel; Be preferably externally-applied soft ointment.
Pharmaceutical composition of the present invention adopts topical treatment peri-implantitis, and it is amelioration of inflammation not only, can also ease the pain, red and swollen, the hemorrhage and symptom such as to suppurate, and promotion paradenlal tissue regeneration, makes the depth shallower of periodontal pocket, determined curative effect.In addition, local application is compared with systemic administration, and same medicine concentration dosage is less, and specificity bactericidal effect is better, and not easily produces drug resistance, and expense used significantly reduces, and has social meaning and the economic implications of highly significant.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
The preparation of embodiment 1 traditional Chinese medicine emulsifiable paste
(1) get the raw materials ready: take the Flos Imperatae 1.2kg and Herba Cucubali 0.25kg that clean up by recipe quantity, for subsequent use;
(2) decoct: decoct with water, first decocts 15 times that every tank adds water as medical material total amount, and keep 3 hours after ebuillition of heated, gained extracting solution enters settling tank through 200 order metre filter; Second decocts the water heating extraction adding medical material amount 12 times, and protect and boil 2 hours, gained extracting solution enters settling tank through 200 order metre filter;
(3) precipitate: in settling tank, extracting solution precipitates 12 hours, extract supernatant through 200 order metre filter in triple effect evaporator, precipitate is by offal treatment;
(4) it is concentrated: when to be concentrated into relative density in triple effect evaporator be 1.10 (40 DEG C of mensuration) to supernatant, by rare clear paste in 200 order metre filter suction vacuum decompressioning and concentrating tanks, be concentrated into when relative density is 1.30 ~ 1.32 (90 DEG C of mensuration) and go out cream, to in storage cream bucket, for subsequent use;
(5) dry: wherein vacuum :-0.1MPa, temperature: 78 ~ 82 DEG C, 8 hours drying times;
(6) powder is beaten: smashing fineness 80 mesh sieve, obtains clear paste powder;
(7) get 2g clear paste powder add 98g vaseline mixing grind well and get final product.
Comparative example 1: the preparation of traditional Chinese herb medicine
Step (1) is got the raw materials ready: take the Flos Imperatae 1.2kg cleaned up by recipe quantity, for subsequent use;
Step (2)-(7) are with embodiment 1.
The clinical experimental study of embodiment 2 traditional Chinese herb medicine treatment peri-implantitis
Peri-implantitis patient 46 example, has planted more than at least 1 year, implantation body's non-loosening, sulcular bleeding index >=1, and periodontal pocket is visited and examined degree of depth 4mm or have pyorrhea sinus tract.X-ray tooth sheet display implant neck has bone resorption shadow-mark district, without whole body system disease.Non-oral antibiotic or immunosuppressant in first 3 months of this experiment of patients enter, do not use in 1 month and suppress the medicine of bacterial plaque to be gargled.In all patients, wherein male 26 example, women 20 example, 35 ~ 68 years old age, average (50.3 ± 8.5) year; Be divided into test A group (23 example) and test B group (23 example) at random, during two groups of patient admits, ordinary circumstance (sex, age etc.) compares there was no significant difference, has comparability.
All first two groups of patients carry out ultrasonic scaling around plantation by the same doctor, and the Chinese medicine ointment periodontal indwelling that test A group gives to prepare according to above-described embodiment 1 formulation and technology is treated 8 weeks, within 1 week, changes dressings 1 time; The Chinese medicine ointment periodontal indwelling that test B group gives to prepare according to above-mentioned comparative example 1 formulation and technology is treated 8 weeks, within 1 week, changes dressings 1 time; Respectively at treatment before and treatment after the 2nd, 4,8 weekends by baseline inspection method inspection and record periodontal pocket visit examine the index such as the degree of depth and sulcular bleeding index, each inspection record completes by the same doctor.
Can be found out by the result of the test of table 1, test A group the 2nd, 4,8 week after the treatment, sulcular bleeding index is all obviously improved (P < 0.05), and test B group and only within 4 weeks, show certain improvement result before the treatment, bounce-back after treatment the 4th week, does not have notable difference before sulcular bleeding index and the treatment of the 8th week especially after the treatment.Visible, the improvement situation of test A group is significantly better than test B group, and what this imply that Herba Cucubali adds the local anti-infective activity that can strengthen Flos Imperatae.
The comparison of sulcular bleeding index change before and after table 1 liang group patient treatment
With with organize treat before compare,
*p < 0.05; Compare with test B group,
#p < 0.05.
Can be found out by the result of the test of table 2, test A group the 2nd, 4,8 week after the treatment, periodontal pocket spy is examined the degree of depth and is all obviously improved (P < 0.05), and test B group and only within 2 weeks, show certain improvement result before the treatment, in treatment bounce-back after the 2nd week, the periodontal pocket of the 4th, 8 week does not have notable difference before visiting and examining the degree of depth and treat especially after the treatment.Visible, the improvement situation of test A group is significantly better than test B group, this book of further illustrating Herba Cucubali add the local anti-infective activity that can strengthen Flos Imperatae.
Before and after table 2 liang group patient treatment, periodontal pocket visits the comparison (mm) of examining change in depth
With with organize treat before compare,
*p < 0.05; Compare with test B group,
#p < 0.05.
Claims (5)
1. treat the pharmaceutical composition of peri-implantitis for one kind, this pharmaceutical composition is prepared from by active component and pharmaceutic adjuvant, it is characterized in that: by weight, described active component is prepared from through decocting extraction by the traditional Chinese medicinal material raw materials of following amount ratio: Flos Imperatae 100-130 part, Herba Cucubali 21-30 part.
2. treat the pharmaceutical composition of peri-implantitis according to claim 1, it is characterized in that: by weight, described active component is prepared from through decocting extraction as raw material by Flos Imperatae 115-125 part and Herba Cucubali 24-27 part.
3. treat the pharmaceutical composition of peri-implantitis according to claim 2, it is characterized in that: by weight, described active component is prepared from through decocting extraction as raw material by Flos Imperatae 120 parts and Herba Cucubali 25 parts.
4. claim 1 or the traditional Chinese medicinal material raw materials compositions described in 2 or 3 application in the medicine of preparation treatment peri-implantitis.
5. application according to claim 4, is characterized in that: described external used medicine is ointment, gel.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510128246.1A CN104721621A (en) | 2015-03-24 | 2015-03-24 | Pharmaceutical composition for treating peri-implantitis and application of pharmaceutical composition |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010502601A (en) * | 2006-08-28 | 2010-01-28 | オムニオ・ヒーラー・アクチボラゲット | New drugs aimed at preventing and treating periodontal disease, improving healing of periodontal wounds and promoting oral hygiene |
| CN103037889A (en) * | 2010-06-16 | 2013-04-10 | 纳米智能生物医学工程株式会社 | Peptide having antimicrobial or anti-inflammatory activity and pharmaceutical composition containing same as an active ingredient |
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2015
- 2015-03-24 CN CN201510128246.1A patent/CN104721621A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010502601A (en) * | 2006-08-28 | 2010-01-28 | オムニオ・ヒーラー・アクチボラゲット | New drugs aimed at preventing and treating periodontal disease, improving healing of periodontal wounds and promoting oral hygiene |
| CN103037889A (en) * | 2010-06-16 | 2013-04-10 | 纳米智能生物医学工程株式会社 | Peptide having antimicrobial or anti-inflammatory activity and pharmaceutical composition containing same as an active ingredient |
Non-Patent Citations (3)
| Title |
|---|
| 徐伟祥等: "《最新实用家庭进补手册》", 31 May 2013 * |
| 蒋柳宏等: "仙灵骨葆对犬种植体周围炎骨整合影响的实验研究", 《新中医》 * |
| 谭兴贵等: "《中国食物药用大典》", 31 July 2013 * |
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Application publication date: 20150624 |