CN104721227B - A kind of medicinal nano silver paste and preparation method thereof - Google Patents
A kind of medicinal nano silver paste and preparation method thereof Download PDFInfo
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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Abstract
The invention discloses formula and the preparation method of a kind of high purity medical nanometer silver slurry.The present invention includes selecting a kind of specific high-purity ball-type superfine nano silver powder and the formula of medicinal nano silver paste and preparation method, wherein, the index of specific high-purity ball-type superfine nano silver powder is: silver purity: >=99.99%, silver shape: spherical, silver granuel footpath: 0.1 ~ 10nm.The formula of medicinal nano silver paste: 1～2g/L glucose, 1～2g/L nanometer silver, 996～998g/L pure water.The preparation method of medicinal nano silver paste includes: disperses, stir, be atomized, collect and take liquid.
Description
Technical field
The present invention relates to a kind of medicinal nano silver paste and preparation method thereof.
Background technology
In recent years, silver is high as biological safety, the metal material of good stability causes extensive concern, and the broad-spectrum bactericidal action of argent is the most known.Silver ion and Ag-containing compound can kill or suppress antibacterial, virus, algae and fungi.Silver has the effect to anti-disease, so the parent's biological metal that is otherwise known as.Silver is harmless to human normal cell.
Appearance along with nanotechnology, nano material is also because of skin effect, small-size effect, quantum size effect and the macro quanta tunnel effect of its uniqueness, show the most special physics and chemical property, the particularly block materials at the aspects such as mechanics, calorifics, magnetics, photoelectricity, electronics Yu homogeneity presents huge difference, causes people to study interest widely.
Along with the development of nanotechnology, silver sterilizing ability under nm regime is made to create qualitative leap.Nanometer silver (Nano Silver) is exactly to utilize forward position nanotechnology by silver nanoparticle, and particle diameter is accomplished nanoscale (0.1～100nm) argent.Few nanometer silver can produce powerful bactericidal action, can kill 650 various bacteria in several minutes.And it is strong and without any drug resistance to have broad-spectrum antiseptic, long acting antibiotic, strong bactericidal, permeability, skin does not finds any irritant reaction yet, and can promote the healing of wound, the growth of cell and the reparation of damaged cell, without the characteristic of any toxic reaction.
Along with bioactivity research more and more deep of nanometer silver, the research about the antiviral activity of nanometer silver also gets more and more.Research finds that nanometer silver all has preferable effect to hepatitis B virus (HBV) and HIV (human immunodeficiency virus) (HIV-1).Nanometer silver is to bird flu (H1N1、H5N1) virus also has killing action.
Nearest research also finds, nanometer silver has obvious inhibited proliferation to the growth of tumor cell.
This just opens wide prospect at the most extensively application nanometer silver for mankind's service.
Three big bottlenecks in nano material preparation technology are the most both at home and abroad: the global problem that high-purity, the industrialization of low cost produce and overcome agglomeration and the applications to nanostructures etc. of nano-powder to become domestic and international Nano-technology Development.
The nano silver preparation technology of prior art, is mostly and elemental metals silver or other Ag-containing compounds is utilized method physically or chemically, make the argent powder of Nano grade.In preparation process, common physical method (such as ball-milling method) is difficult to reach nanoscale.And the preparation of chemical method is puzzled by the highly purified nanometer powder product of acquisition always, especially in industrialization process, the separation of its various " acid groups ", the extremely difficult realization of removing of impurity, it addition, there is also the impact of reducing agent.Thus limit nano silver material in every field especially biology, the application of field of medicaments.
On the other hand, at present in Chinese market, nanometer silver powder is many chemically to be prepared, various particle diameters, shape are mixed deposits, the accuracy of its purity, performance and distribution, stability all difficulties determine, the collection of nanometer powder, deposit, the technical research such as transport waits to strengthen, biological, the safety more Customers ' Legal Right of medicinal application, the standard of medicinal nano silver waits to be formed.
Summary of the invention
It is contemplated that overcome the deficiencies in the prior art, when current medicinal nano silver shortage of standard, select a kind of on the premise of guaranteeing curative effect, it is achieved medicinal nano silver paste of high security and preparation method thereof.
In order to achieve the above object, the technical scheme that the present invention provides is:
Described medicinal nano silver paste is grouped into by the one-tenth of following concentration:
Spherical nano-silver powder 1 2g/L；
Glucose 1 2g/L；
Remaining is water；Described spherical nano-silver powder particle diameter is 0.1 10nm, purity >=99.99% of silver in spherical nano-silver powder.The product that spherical nano-silver powder of the present invention is prepared purchased from optical valley nanosecond science and technology company limited physics mode.
The preparation method of above-mentioned medicinal nano silver paste comprises the steps:
(1) mixing: the spherical nano-silver powder that particle diameter is 0.1 10nm is added to the water, obtains the spherical nano-silver solution that spherical nano-silver powder concentration is 1 2g/L；
(2) dispersion: using ultrasound wave dispersing apparatus to disperse spherical nano-silver solution, ultrasonic frequency (3 band frequency) is 30 40KHZ, and jitter time is 30 60s；
(3) parcel: being added by glucose in the spherical nano-silver solution after step (2) ultrasonic disperse processes, the concentration controlling glucose is 1 2g/L；The most again carrying out ultrasound wave dispersion, ultrasonic frequency (4 band frequency) is 30 54KHZ, and jitter time is 20 30s；Making glucose wrap nanometer silver powder makes it will not assemble agglomerating precipitation；
(4) atomization: being atomized by the spherical nano-silver solution ultrasonic atomization equipment processed through step (3), ultrasonic frequency (2 band frequency) is 20 30KHZ, and the time is 2～15s；
(5) collect: collect step (4) atomization and process the spray of gained, obtain medicinal nano silver paste.
Described medicinal nano silver paste is a kind of semi-transparent clear solution.
Below in conjunction with principle, the invention will be further described:
The spherical nano-silver powder of the present invention is product prepared by optical valley nanometer company physics mode; disperseed by cooled and solidified recycling ultrasound wave after being i.e. full of in the container of protective gas utilize lightning produced by electrion to be vaporized by metal filamentary silver one, then obtained the nanometer silver spherical powder of 0.1 10 nm by demagnetization, air current classifying.Spherical nano-silver powder is added glucose and water, disperseed by ultrasound wave, be atomized, regather and just obtain high purity medical nanometer silver slurry of the present invention.Glucose is as dispersant, and water is then as diluent, it is preferable that make diluent with pure water.
The present invention in institute's selection, reduces the composition kind of a combination thereof thing as far as possible, reduces its consumption, to realize its high security on the premise of meeting medicinal sanitary standard and guaranteeing curative effect:
High intensity: Ag >=99.99% guarantees its high-purity, can be considered elemental silver.High-purity, except having the antibacterial ability of high intensity and disturbing without other mixture, outside safety height, fundamentally limits chemical method and prepares the possibility of nanometer silver powder, thus high-strength with its high-purity guarantee, reduces its consumption.
High effect: the silver granuel footpath of silver powder is the least, its nano effect is such as: skin effect, small-size effect, quantum size effect and macro quanta tunnel effect are the highest, and its activity is the highest, and its unit antimicrobial effect is the highest, the antibacterial efficacy of its homogenous quantities material is the highest, thus reduces its consumption.
High stable: owing to spheroidal particle is the most stable of shape of same volume particle, therefore, use ball shaped nano silver particles, small size particles can be overcome to greatest extent to become reuniting effect that stability causes, make nanometer silver powder obtain the highest stability in the solution, and play its usefulness with the stable granular state of nanometer silver.The most thinning nanometer silver powder wrappage thickness, plays the usefulness of nano silver particles to greatest extent, reduces its consumption simultaneously.
Low concentration: due to the comprehensive function of above-mentioned three-hypers (high intensity, high effect, high stable), a certain amount of nanometer silver usefulness in its slurry is made to become geometrical progression to increase, thus in curative effect one timing, its consumption can be significantly reduced, it is achieved the application of nanometer silver extremely low concentration.
High safety: reduce the application of nanometer silver concentration in curative effect one timing as far as possible, necessarily reach the effect of its high security, even still have fabulous curative effect when concentration 1.25mg/l, the target place of person's pursuit that this is also drug design, thus realize its objective.It addition, the present invention only have selected pharmaceutically acceptable glucose, pure water as its lapping and diluent, reduce compositions kind the most as far as possible, from material, on the other hand guarantee the safety of a combination thereof thing, thus realize its high security.
The inventive method is prepared the difficult point of nanometer silver slurry and is:
Material small size particles to be overcome becomes to stablizing the reuniting effect caused, particle diameter is the least, reuniting effect is the strongest, for this, according to its material behavior, size, selecting a corresponding ultrasonic frequency by dispersed for nanometer silver powder to solution, frequency is the 3rd frequency herein, frequency is 30～40Khz, and the time is 30～60 seconds.
It addition, the present invention makes the following considerations when selecting glucose as nanometer silver wrappage: 1. select to guarantee the material that human body is acceptable and compatible；2. prevent from not reuniting between nano silver particles；3. the wrappage destruction to nano silver particles is prevented；4. prevent nano silver particles from the impact of wrappage causing the harm to human body；5. ensure that nano silver particles can fully discharge that it is high-effect in actual applications, select medical glucose to realize this purpose herein, reach the effect that compatible parcel stably discharges.
In a word, instant invention overcomes existing nanometer silver and be applied to the chaotic situation of biology, drug material, it is provided that one has medicinal nano silver paste and the preparation method of the high security of three high and one low (high intensity, high effect, high stability, low concentration).
Accompanying drawing explanation
Fig. 1 and Fig. 2 is all the detection photograph of slurry of the present invention.
Specific implementation method
Embodiment 1
Select the nanometer silver powder 2g of optical valley nanosecond science and technology company, add the mixing of 996g pure water, use 40KHZ ultrasound wave dispersion 60s, add glucose 2g, using 54khz ultrasound wave dispersion 30S, re-use 30khz ultrasound wave and carry out being atomized 5s, using a glass apparatus to collect steam is the high-purity nano pharmaceutical slurry of silver, nanometer silver concentration is 2000 ppm, and Fig. 1 is shown in by photograph.
Embodiment 2
Select the nanometer silver powder 1g of optical valley nanosecond science and technology company, add the mixing of 998g pure water, use 40KHZ ultrasound wave dispersion 60s, add glucose 1g, using 54khz ultrasound wave dispersion 30S, re-use 30khz ultrasound wave and carry out being atomized 5s, using a glass apparatus to collect steam is the high-purity nano pharmaceutical slurry of silver, nanometer silver concentration is 1000 ppm, and Fig. 2 is shown in by photograph.
Claims (2)
1. a medicinal nano silver paste, it is characterised in that described slurry is grouped into by the one-tenth of following concentration:
Spherical nano-silver powder 1 2g/L；
Glucose 1 2g/L；
Remaining is water；Described spherical nano-silver powder particle diameter is 0.1 10nm, purity >=99.99% of silver in spherical nano-silver powder；
Described medicinal nano silver paste is prepared as follows:
(1) the spherical nano-silver powder that particle diameter is 0.1 10nm is added to the water, obtains the spherical nano-silver solution that spherical nano-silver powder concentration is 1 2g/L；
(2) using ultrasound wave dispersing apparatus to disperse spherical nano-silver solution, ultrasonic frequency is 30 40KHZ, and jitter time is 30 60s；
(3) adding in the spherical nano-silver solution after step (2) ultrasonic disperse processes by glucose, the concentration controlling glucose is 1 2g/L；The most again carrying out ultrasound wave dispersion, ultrasonic frequency is 30 54KHZ, and jitter time is 20 30s；
(4) being atomized by the spherical nano-silver solution ultrasonic atomization equipment processed through step (3), ultrasonic frequency is 20 30KHZ, and the time is 5～15s；
(5) collect step (4) atomization and process the spray of gained, obtain medicinal nano silver paste.
2. the preparation method of medicinal nano silver paste as claimed in claim 1, it is characterised in that described method comprises the steps:
(1) the spherical nano-silver powder that particle diameter is 0.1 10nm is added to the water, obtains the spherical nano-silver solution that spherical nano-silver powder concentration is 1 2g/L；
(2) using ultrasound wave dispersing apparatus to disperse spherical nano-silver solution, ultrasonic frequency is 30 40KHZ, and jitter time is 30 60s；
(3) adding in the spherical nano-silver solution after step (2) ultrasonic disperse processes by glucose, the concentration controlling glucose is 1 2g/L；The most again carrying out ultrasound wave dispersion, ultrasonic frequency is 30 54KHZ, and jitter time is 20 30s；
(4) being atomized by the spherical nano-silver solution ultrasonic atomization equipment processed through step (3), ultrasonic frequency is 20 30KHZ, and the time is 5～15s；
(5) collect step (4) atomization and process the spray of gained, obtain medicinal nano silver paste.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510066287.2A CN104721227B (en) | 2015-02-10 | 2015-02-10 | A kind of medicinal nano silver paste and preparation method thereof |
| PCT/CN2016/000033 WO2016127724A1 (en) | 2015-02-10 | 2016-01-19 | Pharmaceutical nano silver paste and preparation method therefor |
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| CN201510066287.2A CN104721227B (en) | 2015-02-10 | 2015-02-10 | A kind of medicinal nano silver paste and preparation method thereof |
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| CN104721227B true CN104721227B (en) | 2016-10-12 |
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| CN104721227B (en) * | 2015-02-10 | 2016-10-12 | 长沙迪谷纳米生物科技有限公司 | A kind of medicinal nano silver paste and preparation method thereof |
| CN106176810A (en) * | 2016-07-13 | 2016-12-07 | 长沙迪谷纳米生物科技有限公司 | Medicinal nano material compositions DG 5 is for the purposes of antimicrobial agent |
| CN108096277A (en) * | 2018-01-15 | 2018-06-01 | 深圳埃米迦医药生物科技有限公司 | Inhibit Ethylmercurichlorendimide silver parenteral solution of cancer and preparation method thereof, application |
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| CN101633045A (en) * | 2009-08-24 | 2010-01-27 | 北京崇高纳米科技有限公司 | Nanometer silver collosol, preparation method and application thereof |
| WO2011091806A1 (en) * | 2010-01-27 | 2011-08-04 | El Sayed Kamel Morsy Elbaialy | Flame retardant and termite fighting composition and articles coated therewith |
| CN103908473A (en) * | 2014-03-28 | 2014-07-09 | 湖南省轻工投资有限公司 | Nano-sliver anti-cancer composition for treating and preventing female carcinoma of uterine cervix as well as preparation method and application thereof |
| CN103933067A (en) * | 2014-05-09 | 2014-07-23 | 湖南省轻工投资有限公司 | Nano-silver anti-cancer composition for treating lung cancer as well as preparation method and application thereof |
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| US20030185889A1 (en) * | 2002-03-27 | 2003-10-02 | Jixiong Yan | Colloidal nanosilver solution and method for making the same |
| CN101716684B (en) * | 2009-12-18 | 2011-08-17 | 浙江焜之琳生物医药科技股份有限公司 | Highly dispersible spherical nano-silver powder and preparation method thereof |
| CN103083472A (en) * | 2013-01-25 | 2013-05-08 | 北海光谷纳米科技研发中心 | Nano silver anti-inflammatory gel for treating gynecologic inflammation and preparation method thereof |
| CN104721227B (en) * | 2015-02-10 | 2016-10-12 | 长沙迪谷纳米生物科技有限公司 | A kind of medicinal nano silver paste and preparation method thereof |
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Patent Citations (4)
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| CN101633045A (en) * | 2009-08-24 | 2010-01-27 | 北京崇高纳米科技有限公司 | Nanometer silver collosol, preparation method and application thereof |
| WO2011091806A1 (en) * | 2010-01-27 | 2011-08-04 | El Sayed Kamel Morsy Elbaialy | Flame retardant and termite fighting composition and articles coated therewith |
| CN103908473A (en) * | 2014-03-28 | 2014-07-09 | 湖南省轻工投资有限公司 | Nano-sliver anti-cancer composition for treating and preventing female carcinoma of uterine cervix as well as preparation method and application thereof |
| CN103933067A (en) * | 2014-05-09 | 2014-07-23 | 湖南省轻工投资有限公司 | Nano-silver anti-cancer composition for treating lung cancer as well as preparation method and application thereof |
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