CN104720932A - Artificial lens capsule and injection type artificial lens including same - Google Patents
Artificial lens capsule and injection type artificial lens including same Download PDFInfo
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- CN104720932A CN104720932A CN201510104366.8A CN201510104366A CN104720932A CN 104720932 A CN104720932 A CN 104720932A CN 201510104366 A CN201510104366 A CN 201510104366A CN 104720932 A CN104720932 A CN 104720932A
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- utricule
- bladder body
- injection site
- artificial lens
- intraocular lens
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Abstract
The invention provides an artificial lens capsule which consists of a capsule body and an injection position point. The capsule body is of a closed similar-ellipse structure formed by a transparent layered film, and a cavity for accommodating a material is formed inside the capsule body. The injection position point is arranged on the outer surface, close to the equator position, of the capsule body. The artificial lens capsule can be implanted through a surgical incision with the length smaller than 2 mm, a transparent medium is injected into the artificial lens capsule through the injection position point of the capsule body in the applying process to form an artificial lens, and the obtained artificial lens overcomes the defect that an existing artificial lens is easily bonded and scratched or is easily polluted by metabolite in the eye and is poor in autonomic conditioning capacity. In addition, the refraction effect of the artificial lens capsule can be further adjusted through postoperative secondary injection or suction.
Description
Technical field
The present invention relates to intraocular lens, specifically, relate to a kind of intraocular lens's utricule and comprise its injection intraocular lens.
Background technology
Crystalline lens is refractive material (its regulatory mechanism is shown in Fig. 1) important in human eye, and be the lens of biconvex structure, the radius of curvature of its front surface is about 10 millimeters, and the radius of curvature of rear surface is about 6 millimeters, diameter about 9 millimeters, thickness about 4 to 5 millimeters.Natural lens is made up of phacocyst and lens fibers, and phacocyst is transparent membrane, is intactly wrapped in crystalline lens outer surface; Lens fibers is a kind of long prismatic or cylindrical cell, iuntercellular bonds mutually by amorphous ground substance, lens fibers constantly growing in life people, old fiber is extruded into crystalline lens center, form nucleus lentis, its refractive index is 1.406, and peripheral newer fiber is called as cortex of lens, and refractive index is 1.386.With age, nucleus lentis can constantly expand, and follows the string gradually, causes regulating power to decline, occurs presbyopia; Or cause lenticular opacities because of malnutrition, form cataract.
As the most common cause causing blind, cataractous treatment mainly removes muddy crystalline lens by the means such as ECCE or ultrasonic emulsification, then implantable artificial crystalline lens (IOL), mostly is pouch and is implanted into.IOL industry is through the development of over half a century, achieve and achieved comparatively significantly: first, the soft IOL adopting the hydrophilic or material such as hydrophobic acrylate, Silica hydrogel to make can be implanted by less operative incision under folding or rolled state, drastically increase therapeutic effect, shorten post-operative recovery time; The second, adopt the IOL of aspheric design can reduce the optical defects such as spherical aberration, coma, visual field distortion to the full extent, thus improve visual quality; 3rd, in order to provide better vision to patient, have also appeared the novel product such as multifocal IOL, adjustable type IOL, multifocal IOL commonly uses diffraction type, multiple focus meets the long-range and near vision needs of patient respectively, and adjustment type IOL can respond contraction and the diastole of ciliary muscle, makes the opticator of IOL produce displacement on axis oculi direction, simulate the normal regulatory function of human eye with this, realize the focusing to different distance.
Although there is above-mentioned progress, IOL product still comes with some shortcomings, such as: in material, hydrophilic material is easily subject to the pollution of ophthalmic metabolite, causing the complication such as rear capsule muddiness (PCO), easily there is folding line, scuffing in hydrophobic material, etc.; In product design, multifocal IOL comparatively ripe at present cannot realize continuous vari-focus, intermediate range vision is poor, also easily there is the bad phenomenon such as dazzle, following may gradually substitute by the higher adjustment type IOL of bionical degree, but regrettably, the regulation mechanism majority of existing adjustment type IOL product and technology is all rely on the anteroposterior position in-migration of IOL opticator to realize, but not natural lens reaches regulating effect by deformation, the impact causing it to be subject to patient-specific difference is larger, the regulating power that can obtain is also very limited, and application is restricted.
In order to provide more comprehensive to patient, perfect therapeutic effect, the exploitation expectation of following IOL product can concentrate on adjustment type IOL more and more, and need to make breakthroughs in the following aspects: the Material selec-tion 1) more optimized, require material high comprehensive performance, have that the compatibility is good simultaneously, good toughness, not easily to scratch, not by advantages such as ophthalmic metabolite affect.2) better post-operative recovery effect, the progress of super newborn technology makes miniature incision (less than 2 millimeters) perform the operation becomes possibility, requires that IOL implants ophthalmic by less otch, damages to accelerate post-operative recovery further and to reduce art source property.3) obtain more fully vision, require to reach long-range, intermediate range, near vision that IOL product provides good the therapeutic effect identical with healthy natural lens, break away from the postoperative dependence to glasses simultaneously.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of intraocular lens's utricule, it is made up of bladder body and injection site; Described bladder body forms closed nearly ellipsoid structure by transparent layered thin film, the inner cavity formed for holding material; Described injection site is arranged at the outer surface at position, bladder body nearly equator.The injection intraocular lens formed further by it can solve the problem of the autonomous regulating power deficiency of existing intraocular lens, and can obtain better post-operative recovery effect and more fully vision.
The diameter of described bladder body is between 5 ~ 13 millimeters.Preferably, bladder body diameter is 9 ~ 10 millimeters, close to natural lens diameter, thus obtains good rear capsule internal fixtion effect.
Described bladder body is single thin film structure or multi-layer film structure.Preferably, utricule should have two-layer or two-layer above structure, to obtain better mechanics (good flexibility), optics (high refractive index) and biology (compatibility good, Anti cell adhesion) performance.
The material of described bladder body and injection site is selected from: include but not limited to biomacromolecule class or the Silica hydrogel classes etc. such as Parylene (Parylene), polyacrylate, collagen protein; Be preferably silicon fluoride gel or benzene replacement Silica hydrogel, utricule can be avoided swelling by silicone oil, air entrapment can also be made while preventing content leaking material to overflow, in addition, benzene replaces the index of refraction that Silica hydrogel also can improve utricule.Selected all material all must stable performance, aging resistance, to ensure that intraocular lens can resist long-time illumination and invariant color, rotten.
As preferably, described bladder body is double-layer film structure, and internal layer membrane material is Silica hydrogel (index of refraction 1.4), outer membrane material is Parylene (index of refraction 1.6).Silica hydrogel contributes to keeping utricule flexible, and Parylene can improve utricule index of refraction and Anti cell adhesion ability, can improve hardness simultaneously, prevent the outside seepage of inner material and exterior materials to internal contamination.
Described injection site can be single injection or multiple injection design, and single injection site needs to be sealed in site with apparatus upon completion of the injection, and effects on surface does smooth treatment; Multiple injection site adopts self-sealing structure, does not need seal operation after injection, can multiple injection.
Preferably, described injection site is provided with self-sealing otch, inserts and prevent content seepage for syringe needle, and described otch is linear or terraced structure.Be preferably terraced structure, more contribute to strengthening sealing.
Described injection site is one or more.When there being multiple injection site, can inserting simultaneously and carry out injection operation by Multi needle, or carrying out injecting and vacuuming operation simultaneously, this mode of operation is generally used for impurity, the bubble of removing utricule inside, and changes internal matrix.Dyeing process can be carried out, so that location and operation to injection site.
Described injection site near position, equator, thus avoids central optical zone, reserves the optical path that diameter is at least 4.25 millimeters, is preferably 6 millimeters.
Described bladder body under the line near position form projection, can be that square is protruding or other are protruding, in case cellular overgrowth.
The thickness of described bladder body is 5 ~ 100 microns, and index of refraction is at least greater than 1.40; Preferably, Silica hydrogel thylakoid thickness is in 10 to 40 micrometer ranges, and Parylene utricule even can lower than 10 microns, and double-deck or multilamellar utricule gross thickness can in 10 to 50 micrometer ranges; By changing the thickness of different parts layers of material, the adjustment to utricule overall performance can be realized.
The preparation process of described bladder body is: adopt spin coating technique, and two recessed hemispherical die surface coating prepolymer coatings, by coated weight and speed of rotation regulation and control coating layer thickness, matched moulds after tentatively crosslinked, obtains utricule after complete crosslinking curing; For the utricule of multiple structure, need to complete successively from outside to inside the coating of each layer and preliminary crosslinked and then matched moulds, disposablely complete after fixing, obtain utricule.
In practical application, adjust overall performance by the thickness changing layers of material, the thickness such as increasing Parylene can improve hardness; Such as, or use different-thickness at different parts, position increases the thickness of Parylene under the line, obtains larger hardness; Reduce the thickness of Parylene in central optic region, to keep flexible, thus obtain higher regulating power; Utricule rear surface thickness can be greater than front surface, thus prevents utricule from breaking.
The thickness of described injection site is 100 ~ 700 microns, is preferably 150 ~ 350 microns.Ensureing that under the prerequisite that inner material is non-leakage, the thickness of injection site should be as far as possible thin, in order to avoid touch surrounding tissue, causes the complication such as glaucoma, uveitis, hyphema.
The preparation process of described utricule injection site is: the moulding material of injection site is inserted molding in close die, and demoulding post-treatment otch, namely obtains injection site, then injection site is affixed on the outer surface at position, nearly equator of aforementioned bladder body.
Present invention also offers a kind of injection intraocular lens comprising aforementioned utricule.
Described intraocular lens, transparent medium is accommodated in aforementioned utricule inside, described transparent medium selects transparency liquid or the hydrogel of the projecting tissue of index of refraction, preferably with the material that viscosity is lower, convenient injection on the one hand, also contribute to the change that intraocular lens responds muscular movement fast on the other hand, thus obtain better regulatory function.The injection volume of transparent medium is 0.1 to 1 milliliter, is preferably about 0.5 milliliter, is advisable just to prop up whole utricule.Generally, need in transparent medium to add ultraviolet absorber, if necessary, blue-light absorbers can be added simultaneously, to obtain blue light filtering function, thus protection retina.In addition, can also add ingredient, obtained medicament slow release type intraocular lens product, utilizes the multiple injection function of injection site, can carry out repeatedly dosing, thus extends administration time.
Described transparent medium includes but not limited to silicone oil with low viscosity or esters of acrylic acid hydrogel.
During operation, first by less otch, empty pocket body is implanted, then inject appropriate transparent medium wherein via injection site.Because each layer of utricule is different with the index of refraction of interior media, therefore this intraocular lens is gradient-index lens (GRIN).
Concrete implantation process is as follows: after the muddy crystalline lens of super newborn excision, first by minor operation otch implantable artificial crystalline lens utricule, rotates utricule to correct position, locating injection site, inserts syringe, inject appropriate transparent medium.Bubble may be produced in utricule in injection process, the breathability of utricule can make bubble overflow gradually, but preferably in operation process, removal of bubbles is clean, multidigit point can be adopted repeatedly to inject/aspirate, or the apparatus such as the insertion collar carry out the method for driveing etc. and complete aerofluxus.Injection intraocular lens can change the refractive power of intraocular lens's product by two kinds of modes: the shape and the diopter that 1) adjust intraocular lens by changing injection volume; 2) by the transparent medium that injection different proportion is dissimilar, different dioptric effects is obtained.Can the injection site of multiple injection make doctor can in operation process even the dioptric performance of Post operation to intraocular lens adjust.
Described intraocular lens can also be furnished with the accessory such as fixture (button loop or binding agent) and cue mark (as dioptric instruction, intraocular pressure instruction).
The plate-like button loop that fixture can adopt general accommodative intraocular lens to use is fixed, but more preferably, adopts binding agent intraocular lens to be fixed in back room.The kind of binding agent can select temperature sensitive type material NIPA (PNIPAAm), and the Gel-sol transition temperature of this material is a little less than body temperature, and after implant into body, the automatic gelation of meeting, forms good bond.The use of binding agent can strengthen the fixed effect of intraocular lens, reduces the undue growth of endotheliocyte; Intraocular lens is directly chimeric with rear capsule, can obtain better regulatory function, and along with the contraction or lax of ciliary muscle, intraocular lens's diameter reduces or increases, and then its refractive power increases or reduces.
According to actual needs, the cue mark with difference in functionality can be added in intraocular lens's utricule.Label more with practical value comprises: 1) deformation cue mark, indicates the circular tag which of IOL deformation degree by self-deformation, for showing change and the adjustment of intraocular lens's dioptric performance; 2) intraocular pressure cue mark, can respond to the circular tag which of intraocular pressure change, for glaucoma patient; 3) laser is by labelling, can arrange several ring-type or horse-hof shape region on utricule surface, and its thickness is comparatively large, can resist Nd:YAG laser and irradiate, for needing the patient carrying out Fundus laser treatment.
Beneficial effect of the present invention is:
Intraocular lens's utricule provided by the invention is implanted by the operative incision of less than 2 millimeters; The layer structure of utricule and the selection to laminar film material, can prevent the seepage of inner material, then coordinate with self-sealing injection site, both facilitated intraocular lens's injection to transparent medium in utricule in operation process, and in turn enhanced the sealing of utricule.
The advantage that the design that utricule adds transparent medium had both remained hydrophilic material not easily adhesion, not easily scratched, it also avoid the deficiency being subject to ophthalmic metabolite and polluting simultaneously;
After implanting, intraocular lens can respond the motion of ciliary muscle fast, possesses autonomous regulating power preferably; Can in operation even Post operation diopter is regulated; Different types of cue mark can be set, thus possess several functions.Also by postoperative biphasic injection or suction, its dioptric effect is adjusted simultaneously.
Accompanying drawing explanation
Fig. 1 is the crystalline lens regulatory mechanism described in background technology of the present invention; In figure, a is non-regulated state, and b is adjustment state.
Fig. 2 is intraocular lens's utricule structural representation of the present invention; In figure, 1, bladder body, 2, injection site, 3, protruding.
Fig. 3 is injection site notch flank schematic diagram of the present invention; In figure, a is straight slits, and b is step otch.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art obtain under the prerequisite of not making creative work, all belongs to the scope of protection of the invention.
Embodiment 1 intraocular lens utricule
As shown in Figure 2, the intraocular lens's utricule described in the present embodiment is made up of bladder body 1 and injection site 2; Described bladder body 1 forms closed nearly ellipsoid structure by transparent layered thin film, the inner cavity formed for holding material; Described injection site 2 is arranged at the outer surface at the nearly position, equator of bladder body 1.
Described bladder body 1 is double-layer film structure, and internal layer membrane material is silicon fluoride gel, and thickness is 30 microns, and outer membrane material is Parylene, and thickness is 5 microns.The diameter of described bladder body is 10 millimeters, central optical zone diameter 6 millimeters.
Described injection site 2 is provided with self-sealing otch, and notch flank schematic diagram as shown in Figure 3 b, is step otch, and the number of injection site 2 is one.The thickness of described injection site 2 is 200 microns.
Described bladder body 1 under the line neighbouring position forms protruding 3, and shown projection is square.
Embodiment 2 intraocular lens utricule
The present embodiment is compared with embodiment 1, and distinctive points is:
1, the internal layer membrane material of the present embodiment bladder body 1 is that benzene replaces Silica hydrogel.
2, as shown in Figure 3, the self-sealing notch flank schematic diagram of the present embodiment injection site 2 as shown in Figure 3 a, is straight slits.
3, the diameter of described bladder body is 5 millimeters, central optical zone diameter 4.25 millimeters.
Embodiment 3 intraocular lens utricule
The present embodiment is compared with embodiment 1, and distinctive points is: the present embodiment bladder body 1 is single thin film structure, and thin-film material is Parylene, and thickness is 10 microns.
Embodiment 4 intraocular lens utricule
The present embodiment is compared with embodiment 1, and distinctive points is: described bladder body 1 is three-layer thin-film structure, and internal layer membrane material is silicon fluoride gel, and thickness is 20 microns; Middle layer membrane materials is acrylate, and thickness is 20 microns; Outer membrane material is Parylene, and thickness is 5 microns.
Embodiment 5 intraocular lens utricule
The present embodiment is compared with embodiment 1, and distinctive points is: the number of the present embodiment injection site 2 is two.
Embodiment 6 intraocular lens utricule
The present embodiment is compared with embodiment 1, and distinctive points is: the present embodiment bladder body 1 under the line neighbouring position forms protruding 3, and shown projection is that eaves shape is protruding.
Embodiment 7 intraocular lens
Intraocular lens described in the present embodiment obtains for inject transparent medium in intraocular lens's utricule described in embodiment 1 after; Described transparent medium is silicone oil with low viscosity, and injection volume is 0.5 milliliter.
Embodiment 8 intraocular lens
The present embodiment is compared with embodiment 7, and distinctive points is: described transparent medium is esters of acrylic acid hydrogel.
Embodiment 9 intraocular lens
The present embodiment, on the basis of embodiment 7 intraocular lens, is furnished with fixing haptics and dioptric instruction accessory.
Embodiment 10 intraocular lens
The present embodiment, on the basis of embodiment 7 intraocular lens, is furnished with NIPA (PNIPAAm) binding agent and intraocular pressure instruction accessory.
The above; be only the specific embodiment of the present invention, but protection scope of the present invention is not limited thereto, is anyly familiar with those skilled in the art in the technical scope that the present invention discloses; the change that can expect easily or replacement, all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of described claim.
Claims (10)
1. intraocular lens's utricule, is characterized in that, it is made up of bladder body and injection site; Described bladder body forms closed nearly ellipsoid structure by transparent layered thin film, the inner cavity formed for holding material; Described injection site is arranged at the outer surface at position, bladder body nearly equator.
2. utricule according to claim 1, is characterized in that, described bladder body is single thin film structure or multi-layer film structure.
3. utricule according to claim 1 and 2, is characterized in that, the material of described bladder body and injection site is selected from Parylene, polyacrylate, collagen protein class or Silica hydrogel class; Be preferably silicon fluoride gel or benzene replacement Silica hydrogel.
4. utricule according to claim 3, is characterized in that, described bladder body is double-layer film structure, and internal layer membrane material is Silica hydrogel, outer membrane material is Parylene.
5. utricule according to claim 4, is characterized in that, described injection site is provided with self-sealing otch.
6. utricule according to claim 5, is characterized in that, described injection site is one or more.
7. the utricule according to claim 5 or 6, is characterized in that, described bladder body under the line neighbouring position forms projection.
8. utricule according to claim 7, is characterized in that, the thickness of described bladder body is 5 ~ 100 microns; The thickness of described injection site is 100 ~ 700 microns.
9. comprise the injection intraocular lens of utricule described in any one of claim 1-8.
10. intraocular lens according to claim 9, is characterized in that, described utricule inside accommodates transparent medium, and described transparent medium is silicone oil with low viscosity or esters of acrylic acid hydrogel.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510104366.8A CN104720932A (en) | 2015-03-10 | 2015-03-10 | Artificial lens capsule and injection type artificial lens including same |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510104366.8A CN104720932A (en) | 2015-03-10 | 2015-03-10 | Artificial lens capsule and injection type artificial lens including same |
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| CN101090679A (en) * | 2004-12-29 | 2007-12-19 | 博士伦公司 | Small incision intraocular lens with anti-pco feature |
| CN204581595U (en) * | 2015-03-10 | 2015-08-26 | 北京艾克伦医疗科技有限公司 | A kind of intraocular lens's utricule and comprise its injection intraocular lens |
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2015
- 2015-03-10 CN CN201510104366.8A patent/CN104720932A/en active Pending
Patent Citations (6)
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| JPH04132547A (en) * | 1990-09-21 | 1992-05-06 | Terumo Corp | Balloon type internal lens |
| EP0493090A1 (en) * | 1990-12-25 | 1992-07-01 | Menicon Co., Ltd. | Intraocular lens having balloon member |
| CN2626458Y (en) * | 2003-03-13 | 2004-07-21 | 河南宇宙人工晶状体研制有限公司 | Artificial ocular lens for prevention of acquired cataract |
| CN101090679A (en) * | 2004-12-29 | 2007-12-19 | 博士伦公司 | Small incision intraocular lens with anti-pco feature |
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| CN204581595U (en) * | 2015-03-10 | 2015-08-26 | 北京艾克伦医疗科技有限公司 | A kind of intraocular lens's utricule and comprise its injection intraocular lens |
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| 韩建栋，徐爱东: "Parylene涂覆材料及其应用", 《材料与器件》 * |
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Application publication date: 20150624 |