CN104707169A - Medical semi-degraded titanium-magnesium composite microsphere bone filling material - Google Patents
Medical semi-degraded titanium-magnesium composite microsphere bone filling material Download PDFInfo
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- CN104707169A CN104707169A CN201510114428.3A CN201510114428A CN104707169A CN 104707169 A CN104707169 A CN 104707169A CN 201510114428 A CN201510114428 A CN 201510114428A CN 104707169 A CN104707169 A CN 104707169A
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Abstract
The invention discloses a medical semi-degraded titanium-magnesium composite microsphere bone filling material which comprises titanium-magnesium composite microspheres. The titanium-magnesium composite microspheres are woven into porous microspheres by medical titanium or titanium alloy wires, wherein liquid magnesium or magnesium alloy melt liquid is injected into the centers of the porous microspheres; the titanium/magnesium two-phase composite material formed after cooling and solidifying are used for preparing microsphere cores and microsphere surfaces formed by winding type titanium porous layers; spaces for biological activity coating of the surfaces and loading of drug are formed in the surfaces of the microspheres; the magnesium in the titanium/magnesium two-phase composite material is degraded in the biological environment; the degradation rate can be regulated. By virtue of the medical semi-degraded titanium-magnesium composite microsphere bone filling material, the strength and stiffness of the bone filling material are improved; the fatigue life of the biological environment is prolonged; the excellent biocompatibility and osteoconduction are retained; the long-term stability of the implant in the biological environment can be retained by degradation of magnesium and growth of new bone; the space and the possibility of loading drugs and loading bone induction factors are also provided; the material is suitable for orthopedic clinical application for filling, repairing and rebuilding various bones in the minimally-invasive situation.
Description
Technical field
The present invention relates to a kind of medical bone packing material, be specifically related to a kind of half degraded titanium magnesium complex microsphere bone and fill medical material, belong to biomedical engineering technology field.
Background technology
Orthopedic Clinical has a large amount of Cranial defect case, and needing to provide that the bone of sufficient intensity is filled, repair materials, although the autologous bone transplanting of generally acknowledging is the most safe and reliable method, has secondary injury to patient; The problem of the existing rejection of allogenic bone transplantation, the restriction of being originated again; The bone cement of clinical a large amount of use also exists the risk of curing exotherm damage surrounding body tissues, and the bone-cement biological mechanical property after solidification is not seriously mated with natural bone, affects long-time stability.Therefore have outstanding bone conduction, outstanding biomechanical property novel orthopaedics material significant to orthopedics clinic practice.
Patent application (publication number is CN101584880) before applicant provides a kind of material of filling reparation for defect of human body bone, this Cranial defect filling renovation material comprises fiber multihole titanium microsphere and nanometer saamite layer, this fiber multihole titanium microsphere is made up of pure titanium fiber, the POROUS TITANIUM microsphere of fiber and nanometer saamite layer complex repairation Cranial defect, can on the basis keeping original textile porous materials, promote osteoblasticly to stick, breed and break up, more effectively induce the formation of bone.
But due to the restriction of its material structure feature, the strength and stiffness of above-mentioned material are lower, and comprcssive strength is only 15.0-16.0MPa, and elastic modelling quantity is only 0.9-1.2GPa.So fiber multihole titanium microsphere can only be used for the bone lower to strength and stiffness requirement fill reparation occasion, great majority are needed to the Bone Defect Repari of carrying, above-mentioned material is difficult to meet the demands.
Summary of the invention
The object of the invention is to overcome the low deficiency of existing defect of human body bone repair materials strength and stiffness, a kind of titanium tantalum complex microsphere bone is provided to fill medical material, on the basis keeping outstanding bone conductibility, significantly improve strength and stiffness, and by degraded and the new Bone Ingrowth of magnesium in material core part, the long-time stability of structure implant under biotic environment, enough surface porous layer are provided in addition, conveniently carry out follow-up bioactivity coatings, introduce bone-inducing factor, be loaded into strontium element, be loaded into antimicrobial silver ion, be loaded into the various improvement in functionality such as antiinflammatory or antitumor drug, thus there is high strength and rigidity, under biotic environment compared with long-fatigue life and outstanding bone conduction performance.
The technical scheme that the present invention solves its technical problem is:
A kind of half degraded titanium magnesium complex microsphere bone fills medical material, it is characterized in that: it is titanium magnesium complex microsphere that described bone fills medical material, this titanium magnesium complex microsphere comprises employing medical titanium or titanium alloy wire is woven into porous microsphere, and inject liquid magnesium or magnesium alloy liquation at this porous microsphere center, the microsphere heart portion that the titanium formed after cooled and solidified/magnesium two-phase composite material is formed and the microsphere surface that winding-type titanium porous layer is formed, comprise in this microsphere surface promising surface bioactive coating and medicine the space provided is provided, magnesium in described titanium/magnesium two-phase composite material is degraded under biotic environment, its degradation speed can regulate.
As further improvement, the volume ratio that in described microsphere heart portion, compound is biphase is: titanium/magnesium=0.1:0.9 ~ 0.9:0.1.
As further improvement, the porosity of described microsphere surface is 10%-90%.
As further improvement, described medical titanium or the diameter of titanium alloy wire are 0.05mm-1mm.
As further improvement, realize the described different mechanics of titanium magnesium complex microsphere and the coupling of biological conductive performance by regulating the described size in microsphere heart portion and the thickness of microsphere surface.
As further improvement, the compressive strength of described titanium magnesium complex microsphere is in 15 ~ 180MPa scope; Elastic modelling quantity is in 3 ~ 35GPa scope.
As further improvement, the diameter of described titanium magnesium complex microsphere is 1-10mm.
As further improvement, described medicine is loaded into and refers to, is loaded into bone-inducing factor, is loaded into the strontium element of growth promoting effects, is loaded into antimicrobial silver ion and is loaded into antiinflammatory or antitumor drug.
As further improvement, in described titanium/magnesium two-phase composite material, the control method of magnesium degradation speed is, at the corrosion-resistant biological coating of surface-coated in described microsphere heart portion.
As further improvement, in described titanium/magnesium two-phase composite material, the control method of magnesium degradation speed is, adds element Zn, Zr or Ca of reducing magnesium degradation speed in described liquid magnesium or magnesium alloy liquation.
Compared with prior art, microsphere inside of the present invention is injected into liquid magnesium or magnesium alloy liquation, forms the microsphere heart portion of titanium/magnesium two-phase composite material, reaches the high fatigue life under high strength, enough elastic modelling quantity and biotic environment; The winding-type titanium porous layer of microsphere surface makes when injected organism tissue can to grow into microsphere, formed and fix biology, guarantee long-term biological stability, simultaneously for further medicine carrying, loading bone-inducing factor etc. provide enough spaces and probability, and the magnesium matrix of titanium magnesium complex microsphere core can be degraded after the implantation, for growing into of follow-up natural bone provides more space, form the implant of sufficient intensity, and long-term stability can be kept.Invention significantly improves the strength and stiffness of material, maintain outstanding biocompatibility and bone conductibility simultaneously, be applicable to the orthopedics clinic practice that the various bones in Wicresoft's situation are filled, repaired and rebuild.
Accompanying drawing explanation
Fig. 1 is the sectional view of titanium magnesium complex microsphere of the present invention.
Detailed description of the invention
The present invention adopts the thinking of composite, improve the strength and stiffness of titanium porous microsphere, and take into account the outstanding osteoconductive nature of former titanium porous microsphere, retain enough surface porosity inner spaces simultaneously, be used for applying biological activity layer, be loaded into bone-inducing factor, be loaded into the strontium element of growth promoting effects, be loaded into antimicrobial silver ion, be loaded into antiinflammatory or antitumor drug etc., thus obtain the Novel Titanium magnesium complex microsphere bone that mechanical property, biological fatigue behaviour, Biofunctional, disease treatment function etc. be better than former titanium porous microsphere comprehensively and fill medical material.Further, the magnesium matrix of half novel degraded titanium magnesium complex microsphere core can be degraded after the implantation, for growing into of follow-up natural bone provides more space, forms the implant of sufficient intensity, and can keep long-term stability.
Below in conjunction with drawings and Examples, the present invention is elaborated.
Refer to Fig. 1, it is titanium magnesium complex microsphere that bone of the present invention fills medical material, and this titanium magnesium complex microsphere comprises the microsphere heart portion of titanium/magnesium two-phase composite material formation and the microsphere surface of winding-type titanium porous layer formation.
Described microsphere heart portion adopts medical titanium or titanium alloy wire to utilize machine knits to become porous microsphere, and adopt at this porous microsphere center that negative pressure inhales casting, Serum Magnesium invade ooze, the technology such as compression casting injects liquid magnesium or magnesium alloy liquation, formed after cooled and solidified.
Described microsphere heart portion provides the high fatigue life under high strength, enough elastic modelling quantity and biotic environment, and the volume ratio that wherein compound is biphase is: titanium/magnesium=0.1:0.9 ~ 0.9:0.1.The described different mechanics of titanium tantalum complex microsphere and the coupling of biological conductive performance is realized by regulating the described size in microsphere heart portion and the thickness of microsphere surface.Magnesium in described titanium/magnesium two-phase composite material is degraded under biotic environment, and for growing into of follow-up natural bone provides more space, to form the implant of sufficient intensity, and implant can keep long-term stability under biotic environment; The degradation speed of magnesium can regulate, control method has two kinds: at the corrosion-resistant biological coating of surface-coated in described microsphere heart portion, or in described liquid magnesium or magnesium alloy liquation, add the elements such as Zn, Zr or the Ca reducing magnesium degradation speed, enter titanium/magnesium two-phase composite material.
Described microsphere surface provides biological conductive performance, and when injected organism tissue can be grown into microsphere, is formed and fixes biology, guarantee long-term biological stability; The porosity of this microsphere surface is 10%-90%, and inside comprises the coating of promising surface bioactive and medicine is loaded into the sufficient space provided; Medicine is loaded into and refers to, is loaded into bone-inducing factor, is loaded into the strontium element of growth promoting effects, is loaded into antimicrobial silver ion and is loaded into antiinflammatory or antitumor drug.
Medical titanium used or the diameter of titanium alloy wire are 0.05mm-1mm.The diameter of described titanium magnesium complex microsphere is 1-10mm.The compressive strength of described titanium magnesium complex microsphere is in 15 ~ 180MPa scope; Elastic modelling quantity is in 3 ~ 35GPa scope.
Be below embodiments of the invention.
Embodiment 1
The titanium silk of 0.05mm is adopted to be wound in porosity 10%, the POROUS TITANIUM microsphere of diameter 1mm, then the magnesium alloy liquation that with the addition of Zn and Ca element is injected POROUS TITANIUM microsphere, be prepared into the titanium magnesium complex microsphere of diameter 1mm, wherein, compound biphase volume ratio in microsphere heart portion is: titanium/magnesium=0.9:0.1, and microsphere surface thickness is about 0.2mm, porosity is 10%, and surface bioactive coating is carried out in inner space.The compressive strength of titanium magnesium complex microsphere reaches 120MPa; Elastic modelling quantity reaches 15GPa.
Embodiment 2
The titanium silk of 1mm is adopted to be wound in porosity 50%, the POROUS TITANIUM microsphere of diameter 10mm, then the magnesium melt that with the addition of Zr and Ca element is injected POROUS TITANIUM microsphere, be prepared into the titanium magnesium complex microsphere of diameter 10mm, wherein, compound biphase volume ratio in microsphere heart portion is: titanium/magnesium=0.5:0.5, and microsphere surface thickness is about 1.5mm, porosity is 50%, and inner space is loaded into bone-inducing factor and antimicrobial silver ion.The compressive strength of titanium magnesium complex microsphere reaches 116MPa; Elastic modelling quantity reaches 13GPa.
Embodiment 3
The titanium alloy wire of 0.1mm is adopted to be wound in porosity 90%, the POROUS TITANIUM microsphere of diameter 3mm, then magnesium melt is injected POROUS TITANIUM microsphere, be prepared into the titanium magnesium complex microsphere of diameter 3mm, wherein, compound biphase volume ratio in microsphere heart portion is: titanium/magnesium=0.1:0.9, the corrosion-resistant biological coating of surface-coated in microsphere heart portion, microsphere surface thickness is about 0.5mm, and porosity is 90%, and inner space is loaded into strontium element and the anti-inflammation drugs of growth promoting effects.The compressive strength of titanium magnesium complex microsphere reaches 15MPa; Elastic modelling quantity reaches 3GPa.
Embodiment 4
The titanium alloy wire of 0.15mm is adopted to be wound in porosity 35%, the POROUS TITANIUM microsphere of diameter 5mm, then the magnesium alloy liquation that with the addition of Zr element is injected POROUS TITANIUM microsphere, be prepared into the titanium magnesium complex microsphere of diameter 5mm, wherein, compound biphase volume ratio in microsphere heart portion is: titanium/magnesium=0.65:0.35, and microsphere surface thickness is about 0.8mm, porosity is 35%, and inner space is loaded into antitumor drug.The compressive strength of titanium magnesium complex microsphere reaches 180MPa; Elastic modelling quantity reaches 35GPa.
Claims (10)
1. one and half degraded titanium magnesium complex microsphere bones fill medical material, it is characterized in that: it is titanium magnesium complex microsphere that described bone fills medical material, this titanium magnesium complex microsphere comprises employing medical titanium or titanium alloy wire is woven into porous microsphere, and inject liquid magnesium or magnesium alloy liquation at this porous microsphere center, the microsphere heart portion that the titanium formed after cooled and solidified/magnesium two-phase composite material is formed and the microsphere surface that winding-type titanium porous layer is formed, comprise in this microsphere surface promising surface bioactive coating and medicine the space provided is provided, magnesium in described titanium/magnesium two-phase composite material is degraded under biotic environment, its degradation speed can regulate.
2. half degraded titanium magnesium complex microsphere bone according to claim 1 fills medical material, it is characterized in that: the volume ratio that in described microsphere heart portion, compound is biphase is: titanium/magnesium=0.1:0.9 ~ 0.9:0.1.
3. half degraded titanium magnesium complex microsphere bone according to claim 1 and 2 fills medical material, it is characterized in that: the porosity of described microsphere surface is 10%-90%.
4. half degraded titanium magnesium complex microsphere bone according to claim 1 fills medical material, it is characterized in that: described medical titanium or the diameter of titanium alloy wire are 0.05mm-1mm.
5. half degraded titanium magnesium complex microsphere bone according to claim 1 fills medical material, it is characterized in that: realize the described different mechanics of titanium magnesium complex microsphere and the coupling of biological conductive performance by regulating the described size in microsphere heart portion and the thickness of microsphere surface.
6. half degraded titanium magnesium complex microsphere bone fills medical material according to claim 1 or 5, it is characterized in that: the compressive strength of described titanium magnesium complex microsphere is in 15 ~ 180MPa scope; Elastic modelling quantity is in 3 ~ 35GPa scope.
7. half degraded titanium magnesium complex microsphere bone according to claim 1 fills medical material, it is characterized in that: the diameter of described titanium magnesium complex microsphere is 1-10mm.
8. half degraded titanium magnesium complex microsphere bone according to claim 1 fills medical material, it is characterized in that: described medicine is loaded into and refers to, be loaded into bone-inducing factor, be loaded into the strontium element of growth promoting effects, be loaded into antimicrobial silver ion and be loaded into antiinflammatory or antitumor drug.
9. half degraded titanium magnesium complex microsphere bone according to claim 1 fills medical material, it is characterized in that: in described titanium/magnesium two-phase composite material, the control method of magnesium degradation speed is, at the corrosion-resistant biological coating of surface-coated in described microsphere heart portion.
10. half degraded titanium magnesium complex microsphere bone according to claim 1 fills medical material, it is characterized in that: in described titanium/magnesium two-phase composite material, the control method of magnesium degradation speed is, in described liquid magnesium or magnesium alloy liquation, add element Zn, Zr or Ca of reducing magnesium degradation speed.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510114428.3A CN104707169A (en) | 2015-03-16 | 2015-03-16 | Medical semi-degraded titanium-magnesium composite microsphere bone filling material |
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| CN201510114428.3A CN104707169A (en) | 2015-03-16 | 2015-03-16 | Medical semi-degraded titanium-magnesium composite microsphere bone filling material |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106390207A (en) * | 2016-08-29 | 2017-02-15 | 上海交通大学 | Application of porous titanium alloy in medical science as carrier |
| CN110773739A (en) * | 2019-11-01 | 2020-02-11 | 淮阴工学院 | Gradient titanium-magnesium composite material implant for inducing bone growth and forming method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101584880A (en) * | 2009-06-25 | 2009-11-25 | 上海交通大学 | Material for repairing defect of human body bone and preparation method thereof |
| CA2754861A1 (en) * | 2009-03-31 | 2010-10-07 | Enbio Limited | Method for coating metal implants with therapeutic mixtures |
| CN103251984A (en) * | 2013-05-13 | 2013-08-21 | 上海交通大学 | Porous titanium microsphere bone filling material |
| CN103599560A (en) * | 2013-11-05 | 2014-02-26 | 上海交通大学 | Medical titanium/magnesium composite material and preparation method thereof |
| CN104313391A (en) * | 2014-09-26 | 2015-01-28 | 中南大学 | A Ti-Mg alloy material, a preparing method thereof and applications of the alloy material |
-
2015
- 2015-03-16 CN CN201510114428.3A patent/CN104707169A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2754861A1 (en) * | 2009-03-31 | 2010-10-07 | Enbio Limited | Method for coating metal implants with therapeutic mixtures |
| CN101584880A (en) * | 2009-06-25 | 2009-11-25 | 上海交通大学 | Material for repairing defect of human body bone and preparation method thereof |
| CN103251984A (en) * | 2013-05-13 | 2013-08-21 | 上海交通大学 | Porous titanium microsphere bone filling material |
| CN103599560A (en) * | 2013-11-05 | 2014-02-26 | 上海交通大学 | Medical titanium/magnesium composite material and preparation method thereof |
| CN104313391A (en) * | 2014-09-26 | 2015-01-28 | 中南大学 | A Ti-Mg alloy material, a preparing method thereof and applications of the alloy material |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106390207A (en) * | 2016-08-29 | 2017-02-15 | 上海交通大学 | Application of porous titanium alloy in medical science as carrier |
| CN110773739A (en) * | 2019-11-01 | 2020-02-11 | 淮阴工学院 | Gradient titanium-magnesium composite material implant for inducing bone growth and forming method thereof |
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Application publication date: 20150617 |