CN104707108A - Traditional Chinese medicine composition for treating chronic virulent hepatitis b and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic virulent hepatitis b and a preparation method thereof, and belongs to the technical field of Chinese patent medicine for treating hepatitis b. According to the technical scheme, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 55-72 parts of astragalus membranaceus, 58-75 parts of salvia miltiorrhiza, 40-56 parts of glossy privet fruit, 40-58 parts of Chinese wolfberry, 40-58 parts of rhizoma smilacis glabrae, 30-52 parts of radix bupleuri, 32-48 parts of poria cocos, 30-52 parts of schisandra chinensis, 30-58 parts of codonopsis pilosula, 28-56 parts of pinellia ternate, 28-58 parts of Chinese yam, 30-46 parts of isatis roots, 32-48 parts of bighead atractylodes rhizome, 30-46 parts of curcuma aromatica, 32-46 parts of radix paeoniae alba, 30-49 parts of oldenlandia diffusa, 32-49 parts of angelica sinensis, 35-46 parts of pericarpium citri reticulatae, 35-50 parts of honeysuckle, 30-44 parts of polygonatum sibiricum and 25-35 parts of coke hawthorn. The invention further discloses the preparation method for the traditional Chinese medicine composition for treating chronic virulent hepatitis b. The traditional Chinese medicine composition is prepared from traditional Chinese medicinal materials, has no toxic or side effect, and is low in cost. Animal experiments and clinical application studies find that the traditional Chinese medicine composition has good anti-HBV activity.

Description

A kind of Chinese medicine composition for the treatment of chronic type B viral hepatitis and preparation method thereof

Technical field

The invention belongs to the Chinese patent drug technique field for the treatment of hepatitis B, be specifically related to a kind of Chinese medicine composition for the treatment of chronic type B viral hepatitis and preparation method thereof.

Background technology

The past has hepatitis B or HBVsAg to carry history or the acute hepatitis course of disease exceedes half a year, and still has hepatitis symptom, sign and abnormal liver function person to be diagnosed as chronic viral hepatitis B at present.Though date of the onset is not clear or without history of virus hepatitis, iconography, peritoneoscope or Liver biopsy pathological examination meet chronic hepatitis change or comprehensively analyze according to symptom, sign, chemical examination also can make corresponding diagnosis.According to world's disease for digest meeting in 1994 by the development classification of chronic hepatitis B and by stages, and accordingly by the degree calibration of the state of an illness.Slight: the state of an illness is comparatively light, and clinical symptoms is not obvious, just find when just having a medical check-up that ALT raises or the HBsAg positive.Liver biopsy performance G1-2(course inflammatory activity degree), S0-2(fibrosis).Though this type of conditions of patients delay several years, total trend can take a turn for the better gradually so that recovery from illness, only has minority to transfer moderate chronic hepatitis to.Moderate: symptom, sign, lab testing occupy slight and between severe, liver biopsy G3, S2-3.Severe: have obvious or lasting hepatitis symptom, as weak, poor appetite, feel sick, abdominal distention, upper right abdomen dull pain, loose stool etc., other reasons can be got rid of with chronic hepatopathy face, liver palm, typical spider angioma or hepatosplenomegaly and without portal hypertension person.Lab testing Serum ALT repeatedly or continue raise, albumin lower or A/G abnormal proportion, gamma globulin obviously raises.Except aforementioned condition, all albumin≤32g/L, bilirubin are greater than 5 times of upper limits of normal, Prothrombin activity 40%-60%, acetylcholine esterase≤2500U/L, these four detect in 1 reach above-mentioned standard person and can be diagnosed as severe chronic hepatitis B.Liver biopsy G4, S3-4.

The treatment of chronic hepatitis B, mainly based on antiviral therapy, is aided with simultaneously and protects the liver, and immune modulating treatment reaches suppression virus replication, promotes virus sweep; Alleviate inflammation and necrosis, promote that hepatocyte is repaired; Prevention or delay of progression are liver cirrhosis; Reduce the Probability of HBV associated hepatocellular carcinoma; Improve the quality of life of patient, extend the life cycle of patient; Alleviate, alleviate clinical symptoms.Antiviral drugs main is at present interferon and nucleoside analog, and interferon (IFN) has antiviral, cell proliferation and immunoregulation effect.Interferon anti-reflecting virus effect is to show and can combines with the IFN receptor in surface of hepatocytes, by intracellular Information Conduction, brings out the expression of antiviral protein, the synthesis of interference DNA synthesis and virus protein, thus stops virus replication.Because the virus-cell system of different Infection Status is different to the sensitivity of α-IFN, immunne response is active, hepatocyte inflammation easily produces effect time obvious.IFN treats hepatitis B conditional request HBV and is in replication status; ALT exceedes the 2-10 of upper limits of normal doubly; Normal but the hepatic tissue of ALT has obvious inflammation (G2-G4) or has hepatic fibrosis to be formed; The untoward reaction of IFN is modal is flu syndrome, many 2-4 hour after injection, performance heating, shiver with cold, myalgia etc., generally by anti symptom treatment such as acetyl aminophenols, for severe reaction as psychological problem, arrhythmia, bone marrow depression, nephrotic syndrome etc. should be observed in drug withdrawal immediately.This type of medicine of nucleoside analog mainly contains Entecavir, lamivudine, famciclovir, adefovirdipivoxil, Lobucavir, left-handed-fluorine methylurea pyrimidine, cyclohexanedione hydroxyphenylpyruvate dioxygenase carbon deoxyguanosine etc.Lamivudine copies stronger inhibitory action to the viruses such as HBV, HIV, therefore general in clinical middle application.Lamivudine to HBV polymerase and reverse transcriptase inhibited, thus suppress the process of reverse-transcription in viral replication cycle, the synthesis of blocking virus DNA.But can not suppress and remove the superhelix cccDNA of hepatocyte inner virus, therefore virus may copy once again after drug withdrawal, therefore need long-term taking to obtain lasting effects.Lamivudine stops the expressional function of virus protein weak, so HBeAg negative conversion rate is low.Famciclovir is a kind of efficient, low toxicity antiviral drugs.It had both acted on archaeal dna polymerase and viral process of reverse-transcription, suppressed copying of HBVDNA, acted on again the formation of cccDNA simultaneously.Famciclovir treatment also can cause the variation of HBV, has crossing drug resistant with lamivudine.After short term therapy drug withdrawal, relapse rate is also very high.At present clinically in the urgent need to a kind of effective, oneself is confirmed to play by most people has good result and the Chinese medicine of the slight Treatment chronic Hepatitis B of side effect.

Summary of the invention

The present invention overcomes the deficiencies in the prior art to provide a kind of Chinese medicine composition for the treatment of chronic type B viral hepatitis and preparation method thereof.

The present invention adopts following technical scheme for solving the problems of the technologies described above, a kind of Chinese medicine composition for the treatment of chronic type B viral hepatitis, it is characterized in that being prepared from by the raw material of following weight portion: Radix Astragali 55-72 part, Radix Salviae Miltiorrhizae 58-75 part, Fructus Ligustri Lucidi 40-56 part, Fructus Lycii 40-58 part, Rhizoma Smilacis Glabrae 40-58 part, Radix Bupleuri 30-52 part, Poria 32-48 part, Fructus Schisandrae Chinensis 30-52 part, Radix Codonopsis 30-58 part, Rhizoma Pinelliae 28-56 part, Rhizoma Dioscoreae 28-58 part, Radix Isatidis 30-46 part, Rhizoma Atractylodis Macrocephalae 32-48 part, Radix Curcumae 30-46 part, Radix Paeoniae Alba 32-46 part, Herba Hedyotidis Diffusae 30-49 part, Radix Angelicae Sinensis 32-49 part, Pericarpium Citri Reticulatae 35-46 part, Flos Lonicerae 35-50 part, Rhizoma Polygonati 30-44 part and Fructus Crataegi (parched to brown) 25-35 part.

Further preferably, the Chinese medicine composition of described treatment chronic type B viral hepatitis is prepared from by the raw material of following weight portion: the Radix Astragali 65 parts, Radix Salviae Miltiorrhizae 65 parts, Fructus Ligustri Lucidi 50 parts, Fructus Lycii 50 parts, Rhizoma Smilacis Glabrae 50 parts, Radix Bupleuri 40 parts, 40 parts, Poria, Fructus Schisandrae Chinensis 40 parts, Radix Codonopsis 40 parts, the Rhizoma Pinelliae 40 parts, Rhizoma Dioscoreae 40 parts, Radix Isatidis 40 parts, the Rhizoma Atractylodis Macrocephalae 40 parts, Radix Curcumae 40 parts, the Radix Paeoniae Alba 40 parts, Herba Hedyotidis Diffusae 40 parts, Radix Angelicae Sinensis 40 parts, Pericarpium Citri Reticulatae 40 parts, Flos Lonicerae 40 parts, Rhizoma Polygonati 40 parts and Fructus Crataegi (parched to brown) 30 parts.

The dosage form of the Chinese medicine composition for the treatment of chronic type B viral hepatitis of the present invention is granule.

The preparation method of the Chinese medicine composition for the treatment of chronic type B viral hepatitis of the present invention, it is characterized in that comprising the following steps: (1) takes the raw material of following weight portion respectively, Radix Astragali 55-72 part, Radix Salviae Miltiorrhizae 58-75 part, Fructus Ligustri Lucidi 40-56 part, Fructus Lycii 40-58 part, Rhizoma Smilacis Glabrae 40-58 part, Radix Bupleuri 30-52 part, Poria 32-48 part, Fructus Schisandrae Chinensis 30-52 part, Radix Codonopsis 30-58 part, Rhizoma Pinelliae 28-56 part, Rhizoma Dioscoreae 28-58 part, Radix Isatidis 30-46 part, Rhizoma Atractylodis Macrocephalae 32-48 part, Radix Curcumae 30-46 part, Radix Paeoniae Alba 32-46 part, Herba Hedyotidis Diffusae 30-49 part, Radix Angelicae Sinensis 32-49 part, Pericarpium Citri Reticulatae 35-46 part, Flos Lonicerae 35-50 part, Rhizoma Polygonati 30-44 part and Fructus Crataegi (parched to brown) 25-35 part, (2) Radix Astragali will taken, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Fructus Lycii, Rhizoma Smilacis Glabrae, Radix Bupleuri, Poria, Fructus Schisandrae Chinensis, Radix Codonopsis, the Rhizoma Pinelliae, Rhizoma Dioscoreae, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Radix Curcumae, the Radix Paeoniae Alba, Herba Hedyotidis Diffusae, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Flos Lonicerae, twice is decocted with water after Rhizoma Polygonati and Fructus Crataegi (parched to brown) mixing, the weight wherein added water for the first time is 8-12 times of medical material weight, decoct 1-2h, the weight that second time adds water is 6-10 times of medical material weight, decoct 1-2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, adding ethanol makes the percent by volume of alcohol content reach 65%-85%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, concentrated solution spraying dry, pulverize, obtain dry powder, finally add pharmaceutically acceptable excipient and make clinical acceptable granule.

Hepatitis B morbidity is that catching pestilential pathogen, position is mainly liver on the not enough basis of human righteousness.Liver storing blood, the evil of epidemic disease poison invades liver body, must and nutrient blood, poison volt blood system then hematogenous blockage and blood stasis, " blood stasis with the passing of time also can turn to expectorant water " so epidemic disease poison expectorant stasis of blood is cementing mutually, defines the gesture that the touching difficulty of chronic hepatitis B heals.This epidemic disease poison has damp and hot double properties, has humidifying, transconversion into heat and damp and hot difference of all seeing with the different phase of individual variation and disease, and humidifying person then has the wet strong fortune of spleen, resembling of endogenous damp formation, and transconversion into heat person then can impairment of YIN consumption essence (mainly injuring the moon of Liver and kidney).Chronic hepatitis B in a word, positive QI-insufficiency, experiencing epidemic disease poison is its Basic disease cause, and wet, heat, expectorant, the stasis of blood, void are its main pathological changes, and pathological changes, mainly liver, often involves spleen kidney.Clinical treatment should with regulating functional activities of qi, strengthening the body resistance, and nourishing the liver and kidney, Cheongju separates epidemic disease poison, and blood circulation promoting and blood stasis dispelling is main.Radix Bupleuri, Radix Angelicae Sinensis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba soothing liver and strengthening spleen, regulating functional activities of qi in this compound recipe.The Radix Astragali, Rhizoma Polygonati righting QI invigorating.Fructus Lycii, Fructus Ligustri Lucidi, Semen Cuscutae, Fructus Schisandrae Chinensis nourishing the liver and kidney and consolidating, kidney-replenishing of wherein holding concurrently among Fructus Lycii YIN nourishing, embodies the justice of " for nourishing YIN, must in treating YIN within YANG ".Fructus Ligustri Lucidi is gentle, nourishing YIN and not stagnant greasy, is suitable for clothes of a specified duration.Semen Cuscutae is benefit essence relatively, but temperature and not dry, can flat the kidney invigorating gas.The product of nourishing the liver and kidney like this, and do not hinder the wet fraud staying heresy.Chronic hepatitis B is taken for a long time and consolidates, very suitable.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is that damp eliminating is reduced phlegm key medicine, particularly Succus Bambusae, for the expectorant in blood network, has the effect of sliding profit.Poison volt blood system, medication is when making every effort to detoxify into blood.Patient has weakened body resistance, bitter cold removing toxic substances injuring spleen-stomach, therefore the product of the sweet cold removing toxic substances such as multiselect Flos Lonicerae, Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae.Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Curcumae removing heat from blood and promoting blood circulation, in the removing that blood system is scorchingly hot.Liver is kept for blood stasis particularly suitable.Compatibility like this has taken into account the etiology and pathogenesis of hepatitis B complexity.This prescription is antiviral while simultaneously, and the immunologic function of adjustment body be can yet be regarded as and treated the important means of primary disease.In this Chinese medicine compound, Flos Lonicerae, Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra etc. suppress HBV-DNA and DNA-P all to have certain effect.The Radix Astragali, Fructus Lycii, Poria, Fructus Ligustri Lucidi, the Rhizoma Atractylodis Macrocephalae etc. can strengthen the immunologic function of cell, the wherein formation of Poria, Rhizoma Atractylodis Macrocephalae inducing interferon, the formation of Radix Astragali induction beta-interferon, the formation of the Radix Paeoniae Alba, Fructus Schisandrae Chinensis induction gamma interferon.Radix Bupleuri then can favourable raising interleukin active, lymphocyte transformation reaction can also be suppressed by producing prostaglandin.In immunosuppressant drug for invigorating blood circulation and eliminating stasis as: Radix Paeoniae Rubra Radix Salviae Miltiorrhizae shows good efficacy, can suppress humoral immunization, knows that immune complex is formed.In addition, Radix Angelicae Sinensis etc. can suppress liver proliferation of fibrous tissue, reduce fibrocyte active, improve microcirculation in liver, and increase tissue perfusion, this is not only conducive to the recovery of hepatitis, and it also can be prevented to be converted into liver cirrhosis.Therefore, Chinese medicine compound liver stasis of blood soup not only has antivirus action, and can adjust the immune state of body, repairs hepatopathy reason tissue injury, has wholistic therapy meaning.

Formulation of the present invention is reasonable, and compatibility is rigorous, through long-term clinical verification, and determined curative effect.The present invention consists of Chinese crude drug, has no side effect, low price, and found by zoopery and clinical application research, it is active that this Chinese medicine composition has good anti-hepatitis B.

Detailed description of the invention

Be described in further details foregoing of the present invention by the following examples, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

Embodiment

Raw material (gram) is taken respectively according to following proportioning:

1, the Radix Astragali 65, Radix Salviae Miltiorrhizae 65, Fructus Ligustri Lucidi 50, Fructus Lycii 50, Rhizoma Smilacis Glabrae 50, Radix Bupleuri 40, Poria 40, Fructus Schisandrae Chinensis 40, Radix Codonopsis 40, the Rhizoma Pinelliae 40, Rhizoma Dioscoreae 40, Radix Isatidis 40, the Rhizoma Atractylodis Macrocephalae 40, Radix Curcumae 40, the Radix Paeoniae Alba 40, Herba Hedyotidis Diffusae 40, Radix Angelicae Sinensis 40, Pericarpium Citri Reticulatae 40, Flos Lonicerae 40, Rhizoma Polygonati 40 and Fructus Crataegi (parched to brown) 30;

2, the Radix Astragali 55, Radix Salviae Miltiorrhizae 58, Fructus Ligustri Lucidi 40, Fructus Lycii 40, Rhizoma Smilacis Glabrae 40, Radix Bupleuri 30, Poria 32, Fructus Schisandrae Chinensis 30, Radix Codonopsis 30, the Rhizoma Pinelliae 28, Rhizoma Dioscoreae 28, Radix Isatidis 30, the Rhizoma Atractylodis Macrocephalae 32, Radix Curcumae 30, the Radix Paeoniae Alba 32, Herba Hedyotidis Diffusae 30, Radix Angelicae Sinensis 32, Pericarpium Citri Reticulatae 35, Flos Lonicerae 35, Rhizoma Polygonati 30 and Fructus Crataegi (parched to brown) 25;

3, the Radix Astragali 72, Radix Salviae Miltiorrhizae 75, Fructus Ligustri Lucidi 56, Fructus Lycii 58, Rhizoma Smilacis Glabrae 58, Radix Bupleuri 52, Poria 48, Fructus Schisandrae Chinensis 52, Radix Codonopsis 58, the Rhizoma Pinelliae 56, Rhizoma Dioscoreae 58, Radix Isatidis 46, the Rhizoma Atractylodis Macrocephalae 48, Radix Curcumae 46, the Radix Paeoniae Alba 46, Herba Hedyotidis Diffusae 49, Radix Angelicae Sinensis 49, Pericarpium Citri Reticulatae 46, Flos Lonicerae 50, Rhizoma Polygonati 44 and Fructus Crataegi (parched to brown) 35.

Preparation method is:

By the above-mentioned Radix Astragali taken, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Fructus Lycii, Rhizoma Smilacis Glabrae, Radix Bupleuri, Poria, Fructus Schisandrae Chinensis, Radix Codonopsis, the Rhizoma Pinelliae, Rhizoma Dioscoreae, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Radix Curcumae, the Radix Paeoniae Alba, Herba Hedyotidis Diffusae, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Flos Lonicerae, twice is decocted with water after Rhizoma Polygonati and Fructus Crataegi (parched to brown) mixing, the weight wherein added water for the first time is 8-12 times of medical material weight, decoct 1-2h, the weight that second time adds water is 6-10 times of medical material weight, decoct 1-2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, adding ethanol makes the percent by volume of alcohol content reach 65%-85%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, concentrated solution spraying dry, pulverize, obtain dry powder, finally add pharmaceutically acceptable excipient and make clinical acceptable granule.

Using method and result in clinical application:

Above-mentioned obtained granule, every bag of 9g, morning and afternoon takes for 2 times, serve on 5 days, stops 1-2 days.

Western medicine group: potenlin+thymosin: potenlin 100mL intravenous drip, once a day, the next day of changing into after continuous 3 months once.

Chinese medicine matched group: burnt "Three fresh delicacies" soup: each 15 grams of Massa Medicata Fermentata, Fructus Hordei Germinatus, Fructus Crataegi, decocting is to 200ml, and every day 1 dose, a point morning and afternoon takes for 2 times, continuous 5 days, stops 1-2 days, 3 months each courses for the treatment of.

Clinical data: the routine hepatitis B patient of observation group 59, wherein male patient 36 example, female patient 23 example.The median age 34.12 ± 12.68 years old.The routine hepatitis B patient of western medicine group 42, wherein male patient 26 example, female patient 16 example.The median age 32.95 ± 12.03 years old.The routine hepatitis B patient of Chinese medicine matched group 52, wherein male patient 33 example, female patient 19 example.The median age 31.60 ± 13.11 years old.

Diagnostic criteria 1, the standard revised according to 1984 (Nanning) national viral hepatitis meeting, be diagnosed as chronic persistent hepatitis or chronic active hepatitis, still have obvious liver function injury at present and can get rid of other liver patients; 2, the positive > of HBsAg 6 months; 3, HBeAg is positive and/or DNA-P is positive.

Liver function (ALT, AST, TTT) adopts reitman-frankel method, monthly checks 1 time.HBsAg, HBsAb, HBeAg, HBcAb and DNA-P adopt dot blot McCallum McCallum splaques (sxemiquantitative).HBV-M is detected on before and after treatment and all gets paired sera, and a as detecting use in time, another part is stored in cryogenic refrigerator and terminates rear same lot number reagent repetition measurement in treatment.

Comprehensive therapeutic effect evaluation criteria

Short Term Clinical is cured substantially: (1) ALT, AST, TTT full recovery is normal; (2) the Viral replicative marker the moon such as HBeAg, DNA-P, HBV-DNA turn, and HBsAg is still positive.

Effective: (1) liver function recovery is normal or close normal.ALT and AST < 50U, TTT < 8U; (2) HBeAg, DNA-P, HBV-DNA the moon turn or close to cloudy turning [the P/N value < 2.5, HBV-DNA(1-10pg/40ul of HBeAg, DNA-P).

Take a turn for the better: before the every comparatively treatment of (1) liver function, level declines more than 50%; (2) HBeAg, DNA-P, HBV-DNA have a moon to turn or turn close to cloudy.

Invalid: not reach above-mentioned standard person.

Therapeutic outcome: YUGAN soup and potenlin+Effect of Thymus Peptide Therapy chronic hepatitis B all have good therapeutic effect, Chinese medicine YUGAN soup curative effect is significantly better than Western medicine group.3 courses for the treatment of of the routine patient consumes of clinical observation group 59, effective 13 examples, take a turn for the better 25 examples,

Invalid 6 examples, total effective rate is 89.3%.Concrete course for the treatment of and the results are shown in following table:

Short term effect

The relation YUGAN soup of TCM Syndrome Type and comprehensive therapeutic effect is to dampness-heat in the liver and gallbladder, and stagnation of liver-QI with deficiency of the spleen, liver-kidney yin deficiency curative effect is better

	TCM Syndrome Type	Number of cases	Cure	Effective	Take a turn for the better	Invalid	Effective percentage (%)
									Dampness-heat in the liver and gallbladder	14	3	3	7	1	92.9
Observation group	Stagnation of liver-QI with deficiency of the spleen	19	7	5	7	0	100
								n=59	The hepatic and renal YIN deficiency	14	3	2	8	1	92.9
	Deficiency of spleen-YANG and kidneyYANG	6	1	0	2	3	50
									Obstruction of collaterals by blood stasis	6	1	1	3	1	83.3
	Dampness-heat in the liver and gallbladder	8	1	1	4	2	75
									Stagnation of liver-QI with deficiency of the spleen	13	2	2	4	5	61.5
Western medicine group	The hepatic and renal YIN deficiency	10	2	1	3	4	60
								n=42	Deficiency of spleen-YANG and kidneyYANG	7	3	2	2	0	100
	Obstruction of collaterals by blood stasis	4	9	2	1	1	75
									Dampness-heat in the liver and gallbladder	10	0	1	3	6	40
	Stagnation of liver-QI with deficiency of the spleen	16	2	1	2	11	31.3
								JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) group	The hepatic and renal YIN deficiency	11	0	1	1	9	22.2
n=52	Deficiency of spleen-YANG and kidneyYANG	7	0	0	1	6	14.3
									Obstruction of collaterals by blood stasis	8	0	0	2	6	33.3

Change before and after liver function treatment, observation group is significantly better than Western medicine and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) group

Practical application case:

Case 1: Lee, man, 45 years old.Patient has hepatitis B medical history 6 years, the state of an illness once recurrent exerbation 3 times, nearly one month sense poor appetite, stomach institute painful abdominal mass are vexed, yellowish urine, weak, look into the indexs such as HBeAg, HBsAg and be the positive, pain is kowtowed in hepatic region, is diagnosed as hepatitis B, serve on 5 days, stop 1-2 days, after one month, feel sick, poor appetite disappears but still stomach institute painful abdominal mass is vexed sometimes.After three months, foregoing conditions disappears, light red tongue, stringy pulse, and hepatic region oncontacting kowtows pain, the moon such as HBeAg turns, check liver function after two weeks still normal, all check before and after treatment that blood, urine and stool are conventional, blood urea nitrogen, the change without exception such as electrocardiogram, leave hospital with clinical basic healing, within 1 year, check liver function afterwards normal, stable disease.

Above embodiment is only and technological thought of the present invention is described, can not limit protection scope of the present invention with this, and every technological thought proposed according to the present invention, any change that technical scheme basis is done, all falls within scope.

Claims (4)

1. treat the Chinese medicine composition of chronic type B viral hepatitis for one kind, it is characterized in that being prepared from by the raw material of following weight portion: Radix Astragali 55-72 part, Radix Salviae Miltiorrhizae 58-75 part, Fructus Ligustri Lucidi 40-56 part, Fructus Lycii 40-58 part, Rhizoma Smilacis Glabrae 40-58 part, Radix Bupleuri 30-52 part, Poria 32-48 part, Fructus Schisandrae Chinensis 30-52 part, Radix Codonopsis 30-58 part, Rhizoma Pinelliae 28-56 part, Rhizoma Dioscoreae 28-58 part, Radix Isatidis 30-46 part, Rhizoma Atractylodis Macrocephalae 32-48 part, Radix Curcumae 30-46 part, Radix Paeoniae Alba 32-46 part, Herba Hedyotidis Diffusae 30-49 part, Radix Angelicae Sinensis 32-49 part, Pericarpium Citri Reticulatae 35-46 part, Flos Lonicerae 35-50 part, Rhizoma Polygonati 30-44 part and Fructus Crataegi (parched to brown) 25-35 part.

2. the Chinese medicine composition for the treatment of chronic type B viral hepatitis according to claim 1, it is characterized in that being prepared from by the raw material of following weight portion: the Radix Astragali 65 parts, Radix Salviae Miltiorrhizae 65 parts, Fructus Ligustri Lucidi 50 parts, Fructus Lycii 50 parts, Rhizoma Smilacis Glabrae 50 parts, Radix Bupleuri 40 parts, 40 parts, Poria, Fructus Schisandrae Chinensis 40 parts, Radix Codonopsis 40 parts, the Rhizoma Pinelliae 40 parts, Rhizoma Dioscoreae 40 parts, Radix Isatidis 40 parts, the Rhizoma Atractylodis Macrocephalae 40 parts, Radix Curcumae 40 parts, the Radix Paeoniae Alba 40 parts, Herba Hedyotidis Diffusae 40 parts, Radix Angelicae Sinensis 40 parts, Pericarpium Citri Reticulatae 40 parts, Flos Lonicerae 40 parts, Rhizoma Polygonati 40 parts and Fructus Crataegi (parched to brown) 30 parts.

3. the Chinese medicine composition for the treatment of chronic type B viral hepatitis according to claim 1 and 2, is characterized in that: the dosage form of the Chinese medicine composition of this treatment chronic type B viral hepatitis is granule.

4. treat the preparation method of the Chinese medicine composition of chronic type B viral hepatitis for one kind, it is characterized in that comprising the following steps: (1) takes the raw material of following weight portion respectively, Radix Astragali 55-72 part, Radix Salviae Miltiorrhizae 58-75 part, Fructus Ligustri Lucidi 40-56 part, Fructus Lycii 40-58 part, Rhizoma Smilacis Glabrae 40-58 part, Radix Bupleuri 30-52 part, Poria 32-48 part, Fructus Schisandrae Chinensis 30-52 part, Radix Codonopsis 30-58 part, Rhizoma Pinelliae 28-56 part, Rhizoma Dioscoreae 28-58 part, Radix Isatidis 30-46 part, Rhizoma Atractylodis Macrocephalae 32-48 part, Radix Curcumae 30-46 part, Radix Paeoniae Alba 32-46 part, Herba Hedyotidis Diffusae 30-49 part, Radix Angelicae Sinensis 32-49 part, Pericarpium Citri Reticulatae 35-46 part, Flos Lonicerae 35-50 part, Rhizoma Polygonati 30-44 part and Fructus Crataegi (parched to brown) 25-35 part, (2) Radix Astragali will taken, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Fructus Lycii, Rhizoma Smilacis Glabrae, Radix Bupleuri, Poria, Fructus Schisandrae Chinensis, Radix Codonopsis, the Rhizoma Pinelliae, Rhizoma Dioscoreae, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Radix Curcumae, the Radix Paeoniae Alba, Herba Hedyotidis Diffusae, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Flos Lonicerae, twice is decocted with water after Rhizoma Polygonati and Fructus Crataegi (parched to brown) mixing, the weight wherein added water for the first time is 8-12 times of medical material weight, decoct 1-2h, the weight that second time adds water is 6-10 times of medical material weight, decoct 1-2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, adding ethanol makes the percent by volume of alcohol content reach 65%-85%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, concentrated solution spraying dry, pulverize, obtain dry powder, finally add pharmaceutically acceptable excipient and make clinical acceptable granule.