CN104705319A - Sterilization composition containing penconazole and benthiavalicarb-isopropyl, and applications thereof - Google Patents
Sterilization composition containing penconazole and benthiavalicarb-isopropyl, and applications thereof Download PDFInfo
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- CN104705319A CN104705319A CN201310684064.3A CN201310684064A CN104705319A CN 104705319 A CN104705319 A CN 104705319A CN 201310684064 A CN201310684064 A CN 201310684064A CN 104705319 A CN104705319 A CN 104705319A
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- penconazole
- benzene metsulfovax
- bactericidal composition
- isopropyl
- benzene
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Abstract
The present invention discloses a sterilization composition containing penconazole and benthiavalicarb-isopropyl, and applications thereof, wherein the sterilization composition adopts penconazole and benthiavalicarb-isopropyl as main effective components, and a weight ratio of the penconazole to the benthiavalicarb-isopropyl is 1-70:1-50. The sterilization composition of the present invention can be used for preparation of sterilization drugs for prevention and control of fungi plant diseases of cereal, fruit trees and vegetables, provides significant synergy effects on powdery mildew, scab, downy mildew, late blight, rust disease and other fungi plant diseases, has characteristics of pathogenic bacterial drug resistance overcoming and delaying, rapid sterilization, long last period and application cost reducing, and provides the more excellent prevention and control effect compared with the use of the single agent.
Description
Technical field
The present invention relates to a kind of bactericidal composition and uses thereof, especially a kind of be principle active component bactericidal composition and the application thereof of penconazole and benzene metsulfovax.
Background technology
Penconazole (Penconazole), molecular formula: C
13h
15cl
2n
3, chemical name: 1-[2-(2,4-dichlorophenyl) amyl group]-1H-1,2,4-triazole.Structural formula:
Penconazole is the triazole bactericidal agent developed by Syngenta Co., Ltd; Main Function mechanism is sterol demethylation inhibitors; the biosynthesis of the cell membrane important composition composition ergosterol of destruction and prevention germ; cell membrane is caused not formed; make germ dead; owing to having absorption well; therefore can promptly be absorbed by plants; and in conducted inside; there is well protection and therapeutic activity, disease especially can have excellent preventive effect to powdery mildew, scab etc. caused by effectively preventing basidiomycetes and imperfect fungus.
Benzene metsulfovax (Benthiavalicarb-isopropyl), chemical name is: [[(6-fluoro benzothiazole-2-base)-ethylaminocarbonyl]-2-methyl-propyl] carbamic acid isopropyl ester, molecular formula: C
18h
24fN
3o
3s.Structural formula:
Benzene metsulfovax has good bactericidal activity to phytophthora root rot, has good inhibitory action at low concentrations, but do not act on the release of zoospore and the movement of zoospore the sporangial sprouting of its sporangial formation.
The difficulty of prevention and cure of current phytopathogen is increasing, and on the one hand, along with the change of pattern of farming, the economic crops such as melon and fruit, vegetables cultivated area progressively expands, and disease occurrence degree, generation quantity all increase, and in control, difficulty strengthens; On the other hand, the resistance of pathogen rises year by year under the medicament selection pressure continued, and the control efficiency of single dose is had a greatly reduced quality, and control of plant disease is faced with significant challenge.
Summary of the invention
The object of the invention is the plant bactericidal composition containing penconazole and benzene metsulfovax providing a kind of applied widely, cost low, effective for above-mentioned technical problem.
A further object of the invention is to provide the application of this bactericidal composition on the fungal disease germ killing drugs of preparation control Cereal, fruit tree, vegetables.
The object of the invention is to be realized by following measures:
A kind of bactericidal composition, it with penconazole with benzene metsulfovax for principle active component, wherein penconazole and benzene metsulfovax weight ratio are 1 ~ 70:1 ~ 50, preferably 5 ~ 50:10 ~ 50, more preferably 5 ~ 40:10 ~ 30.
In the compositions of the present invention, the weight percentage that both described penconazole and benzene metsulfovax account for composition is 2 ~ 80%, preferably 10 ~ 40%.Wherein in bactericidal composition, effective ingredient is present in composition with enhancing effective amount." % " of the present invention is weight percentage.
Described bactericidal composition, wherein with penconazole and benzene metsulfovax for principle active component, be re-dubbed with known insecticides adjuvant and excipient any one formulation that agricultural chemicals allows.Preferably be processed into missible oil, wetting powder, suspending agent, aqueous emulsion, microemulsion or water dispersion granule.
These known auxiliary agents have dispersant, diffusant, defoamer, wetting agent, disintegrant etc., auxiliary agent specifically can adopt calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, Ben-zylphenol Polyoxyethyl Ether, phenethyl phenol polyethenoxy ether, fatty alcohol-polyoxyethylene ether and similar products thereof, aliphatic amine polyoxyethylene ether, fatty acid ethylene oxide addition product, the rare block compound of polyoxyethylene polyoxy third, castor oil polyoxyethylene ether, polyoxyethylene nonylphenol ether, TWEEN Series, fatty alcohol-polyoxyethylene ether, polyethylene glycol series, Sulfonates, carboxylate, sulphate, phosphate, phosphite, lignosulfonates, xanthans, phenol formaldehyde condensate, ammonium salt, one or more combinations in quaternary etc.Excipient comprises cyclohexanone, dimethylbenzene, various solvent naphtha, water, antifreezing agent (as propane diols), deionized water etc.Above auxiliary agent, excipient and other auxiliary material can be alone or and use.
The application of bactericidal composition of the present invention on the fungal disease germ killing drugs of preparation control Cereal, fruit tree, vegetables, preferably preparing the application prevented and treated on powdery mildew, scab, downy mildew, late blight, rust germ killing drugs, the application most preferably on preparation control wheat powdery mildew germ killing drugs.
Compared with prior art, beneficial effect of the present invention:
(1) compared with single dose, said composition antagonism fungal disease such as the fungal diseases such as powdery mildew, scab, downy mildew, late blight, rust have obvious synergistic function, and overcome and delayed pesticide resistance, sterilization speed is fast, the lasting period is long, expanding prevention is composed, and significantly improves control efficiency; (2) control recruitment, drug cost is reduced; (3) alternative routine and the easy agricultural chemicals producing resistance; (4) consumption of the independent reactive compound of the amount ratio of this bactericidal composition reduces greatly, compared with single dose, produces and use cost reduction; (5) Antifungi is to the drug-fast generation of unitary agent (penconazole and benzene metsulfovax arbitrary), and its successful uses higher than its single dose.
Embodiment
Two kinds of reactive compounds can be processed into any one formulation of permission, with specific embodiment, the preparation that two kinds of active ingredients are processed into are described below, but the preparation that these two kinds of active components can be processed be not limited only to following listed by.
Embodiment 1:
Take 5g penconazole, 10g benzene metsulfovax, 2g detergent LS(to methoxyl group fatty acid amido benzene sulfonic acid sodium salt), 4g dispersing agent NNO (sodium methylene bis-naphthalene sulfonate), 5g white carbon, kaolin adds to 100g, mixture carries out air-flow crushing, and obtained active ingredient weight percentage is 15% penconazole-benzene metsulfovax wetting powder.
Embodiment 2:
Take 3g penconazole, 12g benzene metsulfovax, 3g lauryl sodium sulfate, 4g dispersing agent NNO, 5g white carbon, kaolin adds to 100g, and mixture carries out air-flow crushing, and obtained active ingredient weight percentage is 15% penconazole-benzene metsulfovax wetting powder.
Embodiment 3:
Take 2g penconazole, 14g benzene metsulfovax, 3g lauryl sodium sulfate, 4g dispersing agent NNO, 5g white carbon, kaolin adds to 100g, and mixture carries out air-flow crushing, and obtained active ingredient weight percentage is 16% penconazole-benzene metsulfovax wetting powder.
Embodiment 4:
Take 5g penconazole, 50g benzene metsulfovax, 3g phenethyl phenol polyethenoxy ether phosphate, 2g agriculture breast 33#, 1g alkylphenol polyoxyethylene, 100 ﹟ solvent naphtha 13g, add water to 100g.The method above raw material being prepared routinely aqueous emulsion drops into the mixing of mixing kettle high speed, and making active ingredient weight percentage is 55% penconazole-benzene metsulfovax aqueous emulsion.
Embodiment 5:
Take 2g penconazole, 30g benzene metsulfovax, 6g calcium dodecyl benzene sulfonate, 3g phenethyl phenol polyethenoxy ether phosphate, 2g agriculture breast 33#, 1g alkylphenol polyoxyethylene, 10g isopropyl alcohol, add water to 100g.The method above raw material being prepared routinely microemulsion drops in mixing kettle and mixes, and making active ingredient weight percentage is 32% penconazole-benzene metsulfovax microemulsion.
Embodiment 6:
Take 1g penconazole, 5g benzene metsulfovax, 3g phenethyl phenol polyethenoxy ether phosphate, 2g agriculture breast 33#, 1g alkylphenol polyoxyethylene, 150 ﹟ solvent naphtha 13g, add water to 100g.The method above raw material being prepared routinely aqueous emulsion drops into the mixing of mixing kettle high speed, and making active ingredient weight percentage is 6% penconazole-benzene metsulfovax aqueous emulsion.
Embodiment 7:
Take 50g penconazole, 20g benzene metsulfovax, 5g calcium dodecyl benzene sulfonate, 2g phenethyl phenol polyethenoxy ether, 2g castor oil polyoxyethylene ether, add 150 ﹟ solvent naphthas to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making active ingredient weight percentage is 70% penconazole-benzene metsulfovax missible oil.
Embodiment 8:
Take 2g penconazole, 40g benzene metsulfovax, 8g calcium dodecyl benzene sulfonate, 5g phenethyl phenol polyethenoxy ether, add 150 ﹟ solvent naphthas to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making active ingredient weight percentage is 42% penconazole-benzene metsulfovax missible oil.
Embodiment 9:
Take 5g penconazole, 20g benzene metsulfovax, 6g calcium dodecyl benzene sulfonate, 3g phenethyl phenol polyethenoxy ether phosphate, 2g agriculture breast 33#, 1g alkylphenol polyoxyethylene, 10g isopropyl alcohol, add water to 100g.The method above raw material being prepared routinely microemulsion drops in mixing kettle and mixes, and making active ingredient weight percentage is 25% penconazole-benzene metsulfovax microemulsion.
Embodiment 10:
Take 5g penconazole, 0.5g benzene metsulfovax, 6g calcium dodecyl benzene sulfonate, 7g phenethyl phenol polyethenoxy ether, add 150 ﹟ solvent naphthas to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making active ingredient weight percentage is 5.5% penconazole-benzene metsulfovax missible oil.
Embodiment 11:
Take 5g penconazole, 30g benzene metsulfovax, 4g calcium dodecyl benzene sulfonate, 4g phenethyl phenol polyethenoxy ether, add 150 ﹟ solvent naphthas to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making active ingredient weight percentage is 35% penconazole-benzene metsulfovax missible oil.
Embodiment 12:
Take 10g penconazole, 10g benzene metsulfovax, 2g lignin, 4g polyoxyethylene poly-oxygen propylene aether, 0.15g xanthans, 5g ethylene glycol, 0.10g silica ethane, 0.5g aluminium-magnesium silicate, complement to 100g with water, under the effect of sand mill, make active ingredient weight percentage is 20% penconazole-benzene metsulfovax suspending agent.
Embodiment 13:
Take 30g penconazole, 12g benzene metsulfovax, 2g lignin, 4g polyoxyethylene poly-oxygen propylene aether, 0.15g xanthans, 5g ethylene glycol, 0.10g silica ethane, 0.5g aluminium-magnesium silicate, complement to 100g with water, under the effect of sand mill, make active ingredient weight percentage is 42% penconazole-benzene metsulfovax suspending agent.
Embodiment 14:
Take 2g penconazole, 5g benzene metsulfovax, 8g sodium lignin sulfonate, 2g lauryl sodium sulfate, 5g ammonium sulfate, 5g polyvinyl alcohol, 2g borax, 3g white carbon, add diatomite and complement to 100g, it is 7% penconazole-benzene metsulfovax water dispersion granule that above raw material is made active ingredient weight percentage by water dispersible granular agent method.
Embodiment 15:
Take 4g penconazole, 13g benzene metsulfovax, 8g sodium lignin sulfonate, 2g lauryl sodium sulfate, 5g ammonium sulfate, 5g polyvinyl alcohol, 2g borax, add diatomite and complement to 100g, it is 17% penconazole-benzene metsulfovax water dispersion granule that above raw material is made active ingredient weight percentage by water dispersible granular agent method.
Embodiment 16:
Take 5g penconazole, 15g benzene metsulfovax, 2g lignin, 4g polyoxyethylene poly-oxygen propylene aether, 0.15g xanthans, 5g ethylene glycol, 0.10g silica ethane, 0.5g aluminium-magnesium silicate, complement to 100g with water, under the effect of sand mill, make active ingredient weight percentage is 20% penconazole-benzene metsulfovax suspending agent.
Embodiment 17:
(1) indoor biometrics test:
In indoor employing mycelial growth rate method, measure different agents to the EC of wheat powdery mildew (Erysiphe graminis f.sp.tritici) bacterial strain
50value, adopt co-toxicity coefficient computational methods, calculate the co-toxicity coefficient (CTC) of mixture, determine the building performance of mixture, circular is as follows:
With single dose a certain in mixture for standard agent (selects EC usually
50junior), calculate:
Single dose toxicity index=standard agent EC
50/ certain single dose EC
50× 100
Toxicity index × B single dose proportion in mixture of toxicity index × A single dose proportion+B single dose in mixture of theoretical toxicity index=A single dose
The EC of actual measurement toxicity index=standard single dose
50the EC of value/mixture
50value × 100
Co-toxicity coefficient=actual measurement toxicity index/theoretical toxicity index × 100
When co-toxicity coefficient classification: CTC is greater than 120, mixture has synergetic, and be antagonism when CTC is less than 80, CTC is summation action between 80 ~ 120.
Table 1: penconazole+benzene metsulfovax different ratio is to the indoor biometrics result of wheat powdery mildew bacterial strain
Medicament | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient |
Penconazole EC (A) | Y=1.52X+4.17 | 3.527 | - |
Benzene metsulfovax WP (B) | Y=2.03X+2.93 | 10.478 | - |
A:B=1:1 | Y=1.15X+3.79 | 11.197 | 140.03 |
A:B=1:2 | Y=1.35X+3.55 | 11.842 | 158.64 |
A:B=1:4 | Y=2.37X+2.11 | 16.631 | 134.25 |
Table 1 indoor biometrics result of the test shows, penconazole and benzene metsulfovax composition co-toxicity coefficient are all greater than 120, have obvious synergistic function to wheat powdery mildew.
(2) field control effectiveness test:
With the pesticidal preparations control wheat powdery mildew test that above-described embodiment is obtained.
1), test process: this test medicine consumption establishes three concentration for the treatment of respectively according to the difference of each composition, and contrast medicament is agricultural chemicals single dose 25% penconazole EC and 15% benzene metsulfovax WP and blank clean water experiment respectively.
2), each plot area of test method is 66.7m
2, repeat 3 times; Investigation drug effect method before dispenser after Investigation and Prevention is: random sampling 5 point (often each sampling 2m in test treatment region
2), carry out severity Scaling according to national field trial relevant criterion, calculate preventive effect.
3), result of the test sees the following form:
Table 2: penconazole+benzene metsulfovax different ratio is to the field control effectiveness test result of wheat powdery mildew
Table 2 field efficacy result shows, penconazole and benzene metsulfovax composition are better than 25% penconazole missible oil and 15% benzene metsulfovax wetting powder to wheat powdery mildew control efficiency, sterilization speed is fast, the lasting period is long, and control efficiency is all better than single dose kind, in agricultural application, have using value.
Claims (10)
1. a bactericidal composition, is characterized in that wherein the weight ratio of penconazole and benzene metsulfovax is 1 ~ 70:1 ~ 50 with penconazole and benzene metsulfovax for principle active component.
2. bactericidal composition according to claim 1, is characterized in that the weight ratio of described penconazole and benzene metsulfovax is 5 ~ 50:10 ~ 50.
3. bactericidal composition according to claim 2, is characterized in that the weight ratio of described penconazole and benzene metsulfovax is 5 ~ 40:10 ~ 30.
4. bactericidal composition according to claim 1, is characterized in that the weight percentage that both described penconazole and benzene metsulfovax account for composition is 2 ~ 80%.
5. bactericidal composition according to claim 4, is characterized in that the weight percentage that both described penconazole and benzene metsulfovax account for composition is 10 ~ 40%.
6. bactericidal composition according to claim 1, to is characterized in that with penconazole and benzene metsulfovax, for principle active component, being mixed with known insecticides adjuvant, excipients any one formulation that agricultural chemicals allows.
7. bactericidal composition according to claim 6, is characterized in that described formulation is missible oil, wetting powder, suspending agent, aqueous emulsion, microemulsion or water dispersion granule.
8. the bactericidal composition containing penconazole and benzene metsulfovax according to claim 1 is preparing the application on the fungal disease germ killing drugs preventing and treating Cereal, fruit tree, vegetables.
9. the bactericidal composition containing penconazole and benzene metsulfovax according to claim 8 is preparing the application prevented and treated on the fungal disease germ killing drugs such as powdery mildew, scab, downy mildew, late blight, rust.
10. the bactericidal composition containing penconazole and benzene metsulfovax according to claim 9 is preparing the application on control wheat powdery mildew germ killing drugs.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106417334A (en) * | 2016-12-01 | 2017-02-22 | 佛山市普尔玛农化有限公司 | Bactericide composition containing 2-methylsulfuryl-5-(2, 4-dichlorophenyl)-1, 3, 4-oxadiazole and benthiavalicarb-isopropyl |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN87105156A (en) * | 1986-07-07 | 1988-01-27 | 蒙特爱迪生公司 | Fungicidal mixture |
US20110152079A1 (en) * | 2009-12-23 | 2011-06-23 | Bayer Cropscience Ag | Pesticidal Compound Mixtures |
CN103141493A (en) * | 2013-04-02 | 2013-06-12 | 海利尔药业集团股份有限公司 | Bactericidal composition containing difenoconazole and benthiavalicarb-isopropyl |
-
2013
- 2013-12-12 CN CN201310684064.3A patent/CN104705319A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN87105156A (en) * | 1986-07-07 | 1988-01-27 | 蒙特爱迪生公司 | Fungicidal mixture |
US20110152079A1 (en) * | 2009-12-23 | 2011-06-23 | Bayer Cropscience Ag | Pesticidal Compound Mixtures |
CN103141493A (en) * | 2013-04-02 | 2013-06-12 | 海利尔药业集团股份有限公司 | Bactericidal composition containing difenoconazole and benthiavalicarb-isopropyl |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106417334A (en) * | 2016-12-01 | 2017-02-22 | 佛山市普尔玛农化有限公司 | Bactericide composition containing 2-methylsulfuryl-5-(2, 4-dichlorophenyl)-1, 3, 4-oxadiazole and benthiavalicarb-isopropyl |
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