CN104689804A - Styrene resin adsorbent of new structure for removing AIDS (Acquired Immune Deficiency Syndrome) virus molecules in blood - Google Patents
Styrene resin adsorbent of new structure for removing AIDS (Acquired Immune Deficiency Syndrome) virus molecules in blood Download PDFInfo
- Publication number
- CN104689804A CN104689804A CN201510120605.9A CN201510120605A CN104689804A CN 104689804 A CN104689804 A CN 104689804A CN 201510120605 A CN201510120605 A CN 201510120605A CN 104689804 A CN104689804 A CN 104689804A
- Authority
- CN
- China
- Prior art keywords
- resin
- blood
- adsorbent
- aperture
- valence state
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
- B01J2220/48—Sorbents characterised by the starting material used for their preparation
- B01J2220/4812—Sorbents characterised by the starting material used for their preparation the starting material being of organic character
Abstract
The invention discloses a styrene resin adsorbent of new structure for removing AIDS (Acquired Immune Deficiency Syndrome) virus molecules in blood. A styrene resin of a new structure of which the aperture is 0-200nm comprises no less than 60% of the resin of which the particular size is 100-200nm. When the styrene resin adsorbent is used for a blood perfusion device as an adsorbent, a functional group of a counterpoint valence state and the resin of proper apertures are selected to fill the blood perfusion device according to the valence state property and particle size of the AIDS virus modules absorbed.
Description
Technical field
The present invention relates to the phenylethylene resin series adsorbent for removing AIDS virus molecular substance in blood.
Background technology
Phenylethylene resin series in prior art, comprises styrene-divinylbenzene macroreticular resin etc. as adsorbent, is widely used.
In medical resin adsorbent application, modern medicine is to " virulence factor " systematic achievement in research.And to adopt blood purification therapy to remove " virulence factor " from human peripheral blood be a kind of simple and effective approach.To remove for the purpose of " virulence factor ", development new construction adsorbent material is put on the agenda.
Summary of the invention
The present invention is an embodiment of earlier application patent of invention, and earlier application patent name is " the new construction product of phenylethylene resin series, preparation method and its usage ", application number: 201310347458.X.
The object of the invention is the technical scheme of the phenylethylene resin series adsorbent new construction product proposed for removing AIDS virus molecule in blood.By changing the structure of matter of phenylethylene resin series, make it to have the New function being more suitable as and removing AIDS virus molecular adsorbent in blood.
Content of the present invention: be embed metallic element X in the carbochain of cancellated styrene-divinyl benzene resin skeleton, its structural formula is C-X-C; Wherein C is carbon, and the metallic element X of embedding is ferric iron element or trivalent aluminium element, and its structural formula is C-Fe-C or C-Al-C; Wherein the 3rd price of iron Fe or aluminium Al is avtive spot Y; Strong and weak according to the ripple alive of element, Y site can be element F(fluorine successively) or Elements C l (chlorine) or element B r(bromine) or I(iodine); There is OH-(hydroxyl) time, also can be OH-; Or there is the functional group of contraposition valence state.
The pore diameter range of the polystyrene new construction resin adopted can be 0-200nm, and pore volume and specific area are not limit; The Y site of the trivalent metallic element embedded in its skeleton is by OH-occupy-place and/or by the occupy-place of monose loop chain and/or by the functional group occupy-place with contraposition valence state; Its purposes is used as Medical Adsorbents, for blood perfusion device; Or be used as oral resin sorbent; By Peripheral Circulation system or gi system, adsorption removal AIDS virus molecule wherein.
AIDS, i.e. acquired immunodeficiency syndrome; Human immunodeficiency virus is RNA virus, comprising: human immunodeficiency virus type 1 (HIV-1) and human immunodeficiency virus 2 type (HIV-2).
The rounded particle of electricity Microscopic observation HIV-1, diameter is about 110nm; Adventitia has outer membrane glycoprotein (Env).
HIV-1 viral genome is about 10kb, and respectively there is a RNA sequence being called long end repetition (1ong terminal repeat, LTR) at two ends, are about 634bp.
New construction resin sorbent of the present invention is in HIV-1 virus replication regrouping process, to the virokine in each stage, all there is good suction-operated, can blocks protein virus pass on, the a large amount of progeny virus produced in adsorption removal peripheral blood, stop virus fast-developing, and then remaining virokine is run its course in its life cycle.
Ultra microstructure and the cell tropism of HIV-2 are similar to HIV-1.Resin sorbent of the present invention can infect virus by adsorption removal HIV-2 equally, blocks the inflammatory factor outburst of waterfall type.
Resin aperture of the present invention is prepared when resin polymerization reacts, relevant with the pore-foaming agent material adopted.The inventive method, when participating in insertion reaction with metallic catalyst, has dilating effect to resin aperture.According to the needs that adsorption removal AIDS virus molecule clinical diagnosis wherein proposes, can the new construction product of medical phenylethylene resin series according to its pore diameter range, do following differentiation: the aperture 0-200nm of the polystyrene new construction resin of employing, the resin wherein containing 100-200nm particle diameter is not less than 60%.
When making adsorbent for blood perfusion device and using, can select according to the valence state attribute of the AIDS virus molecule of absorption and particle diameter the resin that there is contraposition valence state functional group and be suitable for aperture, fill blood perfusion device; The mode of filling can be that a kind of resin of pore diameter range loads a tank, and blood perfusion device is according to the material valence state attributive classification in in-built resin aperture and Y site; Or according to the direction arrangement flowed through along blood, the large resin filling in aperture is at upstream position; Be loaded in perfusion device according to the order layering that aperture is descending is mixed, and according to the material valence state delamination classification that the element or functional group that occupy Y point have.
Use for doing oral adsorbent agent, the resin of the different valence state material function that has with Y site group and different pore size is distinguished or hybrid packed in medicinal spansule in proportion.
In such use embodiment of the present invention, the pore diameter range of resin is from " 0 ", and refer to that aperture is " 0 ", namely resin particle does not have hole.But in a perfusion device, the gap between resin particle also can be regarded as in " aperture ", then " aperture " even should cannot measure concrete data, it perhaps can be very large, the aperture that serious offense resin particle can have.
Also any restriction is not done to " pore volume " and " specific area " in such use embodiment.Because for macroporous absorbent resin, the most important condition that restriction adsorbed material enters resin voids is aperture.After aperture is determined, pore volume and specific area are proportional with Adsorbent rate respectively.And adsorption rate and aperture, proportionate relationship between pore volume and specific area are more statistics contents, not there is disruptive technology invention meaning of the present invention.
In a word, the present invention is used in blood perfusion device He in sampler for the phenylethylene resin series adsorbent new construction product removing AIDS virus molecule in blood and makes adsorbent, due to the existence of avtive spot Y point, can with AIDS virus molecular substance in its polarity adsorption function absorption blood; And can be occupied by monose loop chain due to Y point, in AIDS virus molecular substance composition surface have glycan molecule, glycoprotein molecule can because of compatibility docile wound on it.
Resin of the present invention has the viral material comprising AIDS virus molecule well to be removed and suction-operated, effectively can alleviate the sufferer of AIDS patient, improve the quality of life of patient.
Naval stores new construction of the present invention all never sees the report of any open source literature before this, is unprecedented technical innovation in this area, compared with prior art has outstanding substantive distinguishing features.
The new construction product of phenylethylene resin series of the present invention uses as adsorbent in blood perfusion device, and the adsorption effect removing AIDS virus molecule in blood is verified in test, is also do not report at the resin sorbent of prior art; Do not remove the effective ways of AIDS virus molecule in blood in prior art, the present invention has significant progress than prior art.
Claims (5)
1. for removing the phenylethylene resin series adsorbent new construction product of AIDS virus molecule in blood, it is characterized in that: be modified phenylethylene-divinylbenzene macroporous absorbent resin, the carbochain of cancellated styrene-divinyl benzene resin skeleton embeds metallic element X, and its structural formula is C-X-C; Wherein C is carbon; The metallic element X that the carbochain of cancellated styrene-divinyl benzene resin skeleton embeds be ferric iron element or trivalent aluminium element time, its structural formula is C-Fe-C or C-Al-C; Wherein the 3rd price of iron Fe or aluminium Al is avtive spot Y; Strong and weak according to the ripple alive of element, Y site can be element F(fluorine successively) or Elements C l (chlorine) or element B r(bromine) or I(iodine); There is OH-(hydroxyl) time, also can be OH-; Or there is the functional group of contraposition valence state.
2. as claimed in claim 1
for removing the phenylethylene resin series adsorbent new construction product of AIDS virus molecule in blood, it is characterized in that:the aperture 0-200nm of the polystyrene new construction resin adopted, pore volume and specific area are not limit; The Y point of the trivalent metallic element embedded in its carbochain is by OH-occupy-place and/or by the occupy-place of monose loop chain and/or by the functional group occupy-place with contraposition valence state; Its purposes is used as Medical Adsorbents,
for blood perfusion device adsorbent; Or be used as oral resin sorbent; By outwardall circulatory system or the gi system adsorption removal wherein AIDS virus molecular substance of particle diameter in resin pore diameter range.
3. as claimed in claim 2
for removing the phenylethylene resin series adsorbent new construction product of AIDS virus molecule in blood, it is characterized in that: the aperture 0-200nm of the polystyrene new construction resin of employing, the resin wherein containing 100-200nm particle diameter is not less than 60%.
4. as described in claim 2,3
for removing the phenylethylene resin series adsorbent new construction product of AIDS virus molecule in blood, it is characterized in that:when making adsorbent for blood perfusion device and using, can select according to the valence state attribute of AIDS virus molecule of absorption and particle diameter and there is contraposition valence state functional group, and the resin being suitable for aperture is to fill blood perfusion device; The mode of filling can be that a kind of resin of pore diameter range loads a tank, and blood perfusion device is according to the material valence state attributive classification in in-built resin aperture and Y site; Or according to the direction arrangement flowed through along blood, the large resin filling in aperture is at upstream position; Be loaded in perfusion device according to the order layering that aperture is descending is mixed, and according to the material valence state delamination classification that the element or functional group that occupy Y point have.
5. as described in claim 2,3
for removing the phenylethylene resin series adsorbent new construction product of AIDS virus molecule in blood, it is characterized in that:for do oral adsorbent agent use, the resin of the different valence state attribute that different pore size and Y point have, distinguish or hybrid packed in medicinal spansule in proportion.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310347458.XA CN103483487B (en) | 2013-08-01 | 2013-08-12 | Novel structure product, preparation method and use of styrenic resin |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310347458.XA Division CN103483487B (en) | 2013-08-01 | 2013-08-12 | Novel structure product, preparation method and use of styrenic resin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104689804A true CN104689804A (en) | 2015-06-10 |
| CN104689804B CN104689804B (en) | 2016-03-02 |
Family
ID=53744341
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510291587.0A Pending CN104887699A (en) | 2013-08-12 | 2013-08-12 | Medical adsorptive resin for clearing away factors blocking nerve conduction |
| CN201510120761.5A Active CN104667897B (en) | 2013-08-12 | 2013-08-12 | For adsorbing high endotoxic phenylethylene resin series in blood |
| CN201510291602.1A Active CN104941607B (en) | 2013-08-12 | 2013-08-12 | Styrene resin adsorption agent for clearing high beta2 microglobulin in blood |
| CN201510120428.4A Active CN104689803B (en) | 2013-08-12 | 2013-08-12 | For adsorbing the phenylethylene resin series of hepatitis viruse in blood |
| CN201510291617.8A Pending CN104857015A (en) | 2013-08-12 | 2013-08-12 | Styrene type novel-structure adsorption resin for de-addiction and detoxification |
| CN201510291604.0A Active CN104923185B (en) | 2013-08-12 | 2013-08-12 | Medical polymeric adsorbent for removing H N macromoleculars virus |
| CN201510291616.3A Pending CN104887700A (en) | 2013-08-12 | 2013-08-12 | Medical adsorptive resin for eliminating syphilis and sexual disease pathogenic factors |
| CN201510156544.1A Active CN104815628B (en) | 2013-08-12 | 2013-08-12 | A kind of purposes of modified phenylethylene-divinylbenzene macroporous absorbent resin |
| CN201510291618.2A Pending CN104922147A (en) | 2013-08-12 | 2013-08-12 | New structure medical resin for eliminating high cholesterol |
| CN201510120605.9A Active CN104689804B (en) | 2013-08-12 | 2013-08-12 | For adsorbing the phenylethylene resin series of AIDS virus molecule in blood |
Family Applications Before (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510291587.0A Pending CN104887699A (en) | 2013-08-12 | 2013-08-12 | Medical adsorptive resin for clearing away factors blocking nerve conduction |
| CN201510120761.5A Active CN104667897B (en) | 2013-08-12 | 2013-08-12 | For adsorbing high endotoxic phenylethylene resin series in blood |
| CN201510291602.1A Active CN104941607B (en) | 2013-08-12 | 2013-08-12 | Styrene resin adsorption agent for clearing high beta2 microglobulin in blood |
| CN201510120428.4A Active CN104689803B (en) | 2013-08-12 | 2013-08-12 | For adsorbing the phenylethylene resin series of hepatitis viruse in blood |
| CN201510291617.8A Pending CN104857015A (en) | 2013-08-12 | 2013-08-12 | Styrene type novel-structure adsorption resin for de-addiction and detoxification |
| CN201510291604.0A Active CN104923185B (en) | 2013-08-12 | 2013-08-12 | Medical polymeric adsorbent for removing H N macromoleculars virus |
| CN201510291616.3A Pending CN104887700A (en) | 2013-08-12 | 2013-08-12 | Medical adsorptive resin for eliminating syphilis and sexual disease pathogenic factors |
| CN201510156544.1A Active CN104815628B (en) | 2013-08-12 | 2013-08-12 | A kind of purposes of modified phenylethylene-divinylbenzene macroporous absorbent resin |
| CN201510291618.2A Pending CN104922147A (en) | 2013-08-12 | 2013-08-12 | New structure medical resin for eliminating high cholesterol |
Country Status (1)
| Country | Link |
|---|---|
| CN (10) | CN104887699A (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104887699A (en) * | 2013-08-12 | 2015-09-09 | 天津市阳权医疗器械有限公司 | Medical adsorptive resin for clearing away factors blocking nerve conduction |
| WO2017005090A1 (en) * | 2015-07-09 | 2017-01-12 | 于杰 | Micro-nano medical adsorbent resin powder material |
| CN107789691A (en) * | 2016-09-07 | 2018-03-13 | 天津市阳权医疗器械有限公司 | It is exclusively used in treating the disposable blood perfusion device of endotoxemia |
| CN108031454B (en) * | 2017-12-19 | 2021-08-13 | 陈荣胜 | Blood purification adsorbent with physical specificity selectivity and preparation method thereof |
| CN113262762B (en) * | 2021-05-06 | 2023-04-21 | 西安蓝深新材料科技股份有限公司 | Adsorption material for blood perfusion and preparation method thereof |
| CN114085829B (en) * | 2021-11-18 | 2023-08-11 | 军事科学院军事医学研究院环境医学与作业医学研究所 | Efficient enrichment method for viruses in environmental medium |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4383088A (en) * | 1982-02-04 | 1983-05-10 | Combustion Engineering, Inc. | Organic polymer layered dichalcogenides |
| CN101912770A (en) * | 2010-09-03 | 2010-12-15 | 中国科学院长春应用化学研究所 | Polymeric adsorbent and preparation method thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1123393C (en) * | 2001-04-06 | 2003-10-08 | 中国科学院化学研究所 | Solid photocatalyst and its preparing process |
| DE102006010862B4 (en) * | 2005-12-20 | 2010-01-14 | BLüCHER GMBH | Activated carbon with catalytic activity |
| CN100478370C (en) * | 2006-05-12 | 2009-04-15 | 南京大学 | Method for controlloing oxygen containing functional group in surface in synthesizeing adsorptive resin of crosslinked polystyrene |
| CN102335466A (en) * | 2010-07-27 | 2012-02-01 | 天津市阳权医疗器械有限公司 | Blood perfusion device for treating hypertension |
| CN102335465A (en) * | 2010-07-27 | 2012-02-01 | 天津市阳权医疗器械有限公司 | Blood perfusion device for treating uremia |
| CN102268114A (en) * | 2011-05-24 | 2011-12-07 | 南京大学 | Defluorinating resin with compound functions and preparation method thereof |
| CN102847521B (en) * | 2011-06-28 | 2013-07-10 | 于杰 | Macro-porous adsorption resin and its application |
| CN103483487B (en) * | 2013-08-01 | 2015-06-24 | 天津市阳权医疗器械有限公司 | Novel structure product, preparation method and use of styrenic resin |
| CN104887699A (en) * | 2013-08-12 | 2015-09-09 | 天津市阳权医疗器械有限公司 | Medical adsorptive resin for clearing away factors blocking nerve conduction |
-
2013
- 2013-08-12 CN CN201510291587.0A patent/CN104887699A/en active Pending
- 2013-08-12 CN CN201510120761.5A patent/CN104667897B/en active Active
- 2013-08-12 CN CN201510291602.1A patent/CN104941607B/en active Active
- 2013-08-12 CN CN201510120428.4A patent/CN104689803B/en active Active
- 2013-08-12 CN CN201510291617.8A patent/CN104857015A/en active Pending
- 2013-08-12 CN CN201510291604.0A patent/CN104923185B/en active Active
- 2013-08-12 CN CN201510291616.3A patent/CN104887700A/en active Pending
- 2013-08-12 CN CN201510156544.1A patent/CN104815628B/en active Active
- 2013-08-12 CN CN201510291618.2A patent/CN104922147A/en active Pending
- 2013-08-12 CN CN201510120605.9A patent/CN104689804B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4383088A (en) * | 1982-02-04 | 1983-05-10 | Combustion Engineering, Inc. | Organic polymer layered dichalcogenides |
| CN101912770A (en) * | 2010-09-03 | 2010-12-15 | 中国科学院长春应用化学研究所 | Polymeric adsorbent and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104689803A (en) | 2015-06-10 |
| CN104815628A (en) | 2015-08-05 |
| CN104887700A (en) | 2015-09-09 |
| CN104815628B (en) | 2017-08-11 |
| CN104923185A (en) | 2015-09-23 |
| CN104941607B (en) | 2017-02-01 |
| CN104689803B (en) | 2016-03-02 |
| CN104667897A (en) | 2015-06-03 |
| CN104857015A (en) | 2015-08-26 |
| CN104923185B (en) | 2017-10-24 |
| CN104922147A (en) | 2015-09-23 |
| CN104689804B (en) | 2016-03-02 |
| CN104941607A (en) | 2015-09-30 |
| CN104667897B (en) | 2016-03-02 |
| CN104887699A (en) | 2015-09-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104689804A (en) | Styrene resin adsorbent of new structure for removing AIDS (Acquired Immune Deficiency Syndrome) virus molecules in blood | |
| Zhao et al. | Controllable synthesis of porous Cu-BTC@ polymer composite beads for iodine capture | |
| CN103483487B (en) | Novel structure product, preparation method and use of styrenic resin | |
| Agboola et al. | A review on polymer nanocomposites and their effective applications in membranes and adsorbents for water treatment and gas separation | |
| Wang et al. | Macroporous membranes doped with micro-mesoporous β-cyclodextrin polymers for ultrafast removal of organic micropollutants from water | |
| Bu et al. | Magnetic carboxyl-functionalized covalent organic frameworks for adsorption of quinolones with high capacities, fast kinetics and easy regeneration | |
| Alguacil et al. | Organic dyes versus adsorption processing | |
| Ye et al. | Preparation of a GO/PB-modified nanofiltration membrane for removal of radioactive cesium and strontium from water | |
| CN108047361B (en) | A kind of Properties of Magnetic Chelating Resins, preparation method and its application in combined pollution water body purification | |
| Borovik et al. | Platform selection of engineered nanomaterials for water decontamination applications | |
| Rojas et al. | Metal–organic frameworks for the removal of the emerging contaminant atenolol under real conditions | |
| De Pascale et al. | Mixed matrix membranes adsorbers (MMMAs) for the removal of uremic toxins from dialysate | |
| He et al. | Highly-Efficient adsorptive separation of Cs+ from aqueous solutions by porous polyimide membrane containing Dibenzo-18-Crown-6 | |
| Zhao et al. | Surface control approach for growth of cerium oxide on flower-like molybdenum disulfide nanosheets enables superior removal of uremic toxins | |
| Gan et al. | MOFs-alginate/polyacrylic acid/poly (ethylene imine) heparin-mimicking beads as a novel hemoadsorbent for bilirubin removal in vitro and vivo models | |
| CN107569730A (en) | A kind of device applied to haemodialysis | |
| CN104667896A (en) | Styrene-series resin adsorbent new structural product for removing high triglyceride from blood | |
| CN108996597A (en) | A kind of FLUORIDE REMOVAL IN WASTEWATER application of IDS metal chelate adsorbent | |
| EP1679117A2 (en) | Adsorption system for removing viruses and viral components from fluids, in particular from blood and blood plasma | |
| Wu et al. | Blood compatible chitin composite nanofibrous microspheres as efficient adsorbents for removal of blood ammonia in hyperammonemia | |
| CN104418400B (en) | Iron-based nano-alloy and application thereof in adsorption of cesium | |
| CN203139198U (en) | Simple blood purifier | |
| CN103223197A (en) | Combined medical apparatus device for toxemia blood purifying | |
| CN103769052A (en) | Magnetism and temperature double-responded mesoporous carbon material as well as preparation method and application thereof | |
| CN103308658B (en) | Evaluation method for pyrogen removal process in traditional Chinese medicine injection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190809 Address after: 264210 No. 1 Weigao Road, Chucun Town, Weihai Torch High-tech Industrial Development Zone, Shandong Province Patentee after: Weihai Weigaoyangquan Biological Co., Ltd. Address before: 300222 north side of outer ring road, East Mountain Road, Jinnan District, Tianjin Patentee before: Tianjin Yangquan Medical Devices Co., Ltd. |
|
| TR01 | Transfer of patent right |