CN104688654A - Whitening cream and preparation method thereof - Google Patents
Whitening cream and preparation method thereof Download PDFInfo
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- CN104688654A CN104688654A CN201510117682.9A CN201510117682A CN104688654A CN 104688654 A CN104688654 A CN 104688654A CN 201510117682 A CN201510117682 A CN 201510117682A CN 104688654 A CN104688654 A CN 104688654A
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Abstract
The invention relates to the field of cosmetics, and specifically relates to whitening cream and a preparation method thereof. The whitening cream is prepared from the following components: general auxiliary materials of whitening cream, pearl powder, a pearl extract, a glycyrrhiza glabra water solution, hydrolyzed conchiolin protein and a pisum sativum extract; the pearl powder content and the pearl extract are synchronously used; the glycyrrhiza glabra water solution contains 0.5 to 5.0% of a glycyrrhiza glabra extract; the general auxiliary materials of the whitening cream exclude the pearl powder, the pearl extract, glycyrrhiza glabra water solution, hydrolyzed conchiolin protein and the pisum sativum extract. According to the whitening cream, the pearl powder is a nutritional functional ingredient good for human skin; the whitening skin lotion can improve the barrier function of the skin, is able to moisture the skin and increase the degree of hydration of the skin, and has an obvious effect on inhibiting activity of tyrosinase; the study shows that the pearl powder is high in free radical inhibiting and removing capacity.
Description
Technical field
The present invention relates to cosmetic field, be specifically related to a kind of skin whitener and preparation method thereof.
Background technology
The type of the melanin (melanin) that the colour of skin of people, hair color and eye color mainly synthesize with melanocyte (melanocyte), quantity are relevant with distribution.In melanocyte, be subject to the catalytic action of tryrosinase, tyrosine is successively oxidized to DOPA and DOPA quinone, and DOPA quinone changes into dopachrome again further; Under DHI enzyme and dopachrome interconvertible enzyme and the oxidasic catalytic action respectively of DHICA, dopachrome is further converted to 5,6-istain and 5,6-istain-2-carboxylic acid through 5,6-dihydroxy indole and 5,6-dihydroxy indole-2-carboxylic acid; 5,6-istain and 5,6-istain-2-carboxylic acid are finally polymerized formation melanin.Tryrosinase is first step rate-limiting enzyme and the key enzyme of B16 cell.Therefore, all tyrosinase inhibitor is contained in most of whitening agent.
Containing the pigment cell of 4% ~ 5% in the basal layer cell of human epidermal.The color of human skin is not depend on melanocyte quantity, but depends on the quantity of melanosome, size, distribution and melanocyte degree.Therefore, some whitening composition is by affecting formation, the maturation of melanosome and shifting the effect reaching whitening.
Under ultraviolet radiation, keratinocyte can discharge Endothelin, when after the receptors bind on Endothelin and melanocyte film, the propagation of meeting stimulation melanin cell, activate the activity of tryrosinase, accelerate the growth of melanocyte dendritic processes, thus accelerate the migration to keratinocyte of melanic synthesis and melanosome.Therefore, the melanism effect of ultraviolet to skin is effectively suppressed will to block keratinocyte to melanocyte transmission of information.Therefore, endothelin antagonist also becomes the important whitening agent of a class gradually.
The reason formed due to melanin is many-sided, and Beauty of Product white effect be made remarkable, must consider the reason that melanin is formed by Comprehensive, only in this way can design efficient whitening product.But multipath acts on melanic generation and transfer process, the safety of product, stability and outward appearance must be considered.Therefore, select have multi-functional, stable, safety and light-colored whitening raw material, play its collaborative whitening function, have great importance.
Summary of the invention
The present invention has considered the melanic various factors of formation, an object of the present invention is to propose a kind of skin whitener.This skin whitener is main active component with the biological enzymolysis product of multiple natural extract and natural extract, works in coordination with and plays a role, and check melanin generates and moves the effect reaching skin whitening.Another object of the present invention is the preparation method proposing above-mentioned skin whitener.
In order to realize first above-mentioned object, present invention employs following technical scheme:
A kind of skin whitener, said composition comprises following component by mass percentage:
Adjuvant 5 ~ 50% commonly used by skin whitener
Margarita powder 0 ~ 30%
Margarita extract 0 ~ 10%
Glycyrrhiza glabra L. aqueous solution 0.1 ~ 10%
Hydrolysis conchiolin 0.005 ~ 1%
Semen Pisi sativi extract 0.1 ~ 5%;
Be zero when above-mentioned Margarita powder is different with the content of Margarita extract, and the percentage composition of Glycyrrhiza glabra L. extract is 0.5 ~ 5.0% in described Glycyrrhiza glabra L. aqueous solution, above-mentioned skin whitener is commonly used adjuvant and is not comprised Margarita powder, Margarita extract, Glycyrrhiza glabra L. aqueous solution, hydrolysis conchiolin and Semen Pisi sativi extract.
As preferably, said composition comprises following component by mass percentage:
Adjuvant 10 ~ 30% commonly used by skin whitener
Margarita powder 0.5 ~ 20%
Margarita extract 0.5 ~ 5%
Glycyrrhiza glabra L. aqueous solution 0.3 ~ 3%
Hydrolysis conchiolin 0.01 ~ 0.3%
Semen Pisi sativi extract 0.5 ~ 3%.
As preferably, said composition comprises following component by mass percentage:
Adjuvant 10 ~ 30% commonly used by skin whitener
Margarita powder 1.0 ~ 15%
Margarita extract 1.0 ~ 4%
Glycyrrhiza glabra L. aqueous solution 0.5 ~ 3%
Hydrolysis conchiolin 0.05 ~ 0.2%
Semen Pisi sativi extract 1.0 ~ 2.5%.
As preferably, in described Glycyrrhiza glabra L. aqueous solution, the percentage composition of Glycyrrhiza glabra L. extract is 1.0 ~ 3.0%.
As preferably, described Glycyrrhiza glabra L. aqueous solution is scattered in water by Glycyrrhiza glabra L. extract after hydroxypropyl cyclodextrin envelope, and add the solution that 1,2-pentanediol is formed, in Glycyrrhiza glabra L. extract, glabridin mass fraction is greater than 90%.
As preferably, described Margarita powder is that Margarita grinds 1000 ~ 3000 order flours obtained through physical mechanical.
As preferably, the described Margarita extract multiple peptide class that to be Margarita powder obtain through enzymolysis and amino acid whose mixture.
As preferably, the described hydrolysis conchiolin powdered substance that to be hydrobiological conchiolin obtain through the mode of biological enzymolysis, quality purity is greater than 70%.
As preferably, described Semen Pisi sativi extract quality purity is 2 ~ 3%.
As preferably, described skin whitener is commonly used adjuvant and is comprised following component
Magnesiumaluminumsilicate 0 ~ 5%
Phosphoric acid monohexadecyl ester potassium 0 ~ 1%
Nicotiamide 0 ~ 5%
Biological buffer 0 ~ 3%
1,3-PD 0 ~ 20%
Xanthan gum 0 ~ 1%
Cetearyl alcohol 0 ~ 5%
Different hexadecanol 0 ~ 5%
Shea butter 0 ~ 2%
Polydimethylsiloxane 0 ~ 5%
Caprylic/capric triglyceride 0 ~ 10%
Methyl sesquistearate 0 ~ 5%
PEG-20 methyl sesquistearate 0 ~ 5%.
Certainly above-mentioned skin whitener, can also comprise essence 0.01 ~ 0.5%, antiseptic 0.1 ~ 2.0%.
Prepare a method for above-mentioned skin whitener, the method comprises the following steps:
1) Magnesiumaluminumsilicate, Phosphoric acid monohexadecyl ester potassium, nicotiamide, biological buffer and water are added aqueous phase pot, heated and stirred to 75 ~ 80 DEG C, homogenizing 5 minutes is as A phase;
2) using Margarita powder, 1,3-PD and xanthan gum dispersed with stirring evenly as B phase, B is added to A phase, continue heated and stirred to 75 ~ 80 DEG C, dispersed with stirring is even;
3) cetearyl alcohol, different hexadecanol, shea butter, polydimethylsiloxane, caprylic/capric triglyceride, methyl sesquistearate, PEG-20 methyl sesquistearate are added in oil cauldron, heated and stirred to 80 ~ 85 DEG C, be stirred to and melt completely, as C phase;
5) to adding Glycyrrhiza glabra L. aqueous solution, Margarita extract, hydrolysis conchiolin, Semen Pisi sativi extract when 45 ~ 50 DEG C, stirring and dissolving is complete;
6) continue to be stirred to material temperature not higher than after 38 DEG C, stop stirring, terminate.
As preferably, described skin whitener is commonly used adjuvant and is comprised following component:
Glycerol 0 ~ 15%
Lecithin 0 ~ 5%
C12-16 alcohol 0 ~ 5%
Palmic acid 0 ~ 5%
Margarita powder 0 ~ 2%
Butanediol 0 ~ 10%
Polyglutamic acid 0 ~ 0.5%
Cetearyl alcohol 0 ~ 5%
Virgin oil 0 ~ 5%
Shea butter 0 ~ 5%
Polydimethylsiloxane 0 ~ 5%
Caprylic/capric triglyceride 0 ~ 5%
Cetearyl alcohol ethylhexoate 0 ~ 10%.
Prepare a method for above-mentioned skin whitener, the method comprises the following steps:
1) glycerol, lecithin, C12-16 alcohol, Palmic acid and water are added aqueous phase pot, heated and stirred to 75 ~ 80 DEG C, constant temperature stirs 30 minutes as A phase;
2) using Margarita powder, butanediol and polyglutamic acid dispersed with stirring evenly as B phase, B is added to A phase, continue heated and stirred to 75 ~ 80 DEG C, dispersed with stirring is even;
3) add in oil cauldron by cetearyl alcohol, virgin oil, shea butter, polydimethylsiloxane, caprylic/capric triglyceride, cetearyl alcohol ethylhexoate, heated and stirred to 80 ~ 85 DEG C, are stirred to and melt completely, as C phase;
4) by A phase and B phase suction homogenizing reaction pot, open and stir, suction C phase, homogenizing 5 minutes, open cooling circulating water, stir cooling;
5) to adding Margarita extract, Glycyrrhiza glabra L. aqueous solution, hydrolysis conchiolin, Semen Pisi sativi extract, essence and antiseptic when 45 ~ 50 DEG C, stirring and dissolving is complete;
6) continue to be stirred to material temperature not higher than after 38 DEG C, stop stirring, terminate.
Margarita powder in this skin whitener is the good nutritive effect composition of one of human body skin.It can improve the barrier function of skin, can also skin care, increases the degree of hydration of skin, goes out inhibitory action significantly to the activities present of tryrosinase.Further, there are some researches show that Margarita powder has very strong suppression and removes the ability of free radical.
Margarita extract in this skin whitener contains Margarita native polypeptide and multiple necessary aminoacid, Margarita native polypeptide has the effect suppressing Endothelin to activate tryrosinase and suppression Endothelin promotion Differentiation of Melanocytes, and aminoacid can promote that Skin Cell increases, restraint of tyrosinase promotes to generate the multi abilities such as melanin activity, scavenging free radicals.
Active component in Glycyrrhiza glabra L. aqueous solution in this skin whitener is glabridin, glabridin has significant antiinflammatory and whitening effect, in the world glabridin is published as check and approve license, one of the safest, most whitening effect composition, be the whitening gold that industry is generally acknowledged, exist only in the root of Glycyrrhiza glabra L..But find in the application, the low mixture strip of glabridin purity has color and luster, and under temperature high condition color burn, have impact to the color and luster of cosmetics like this.And glabridin content is not less than 90% in the Glycyrrhiza glabra L. extract adopted in the present invention, therefore in use less for cosmetic color impact.In addition, water-soluble formation aqueous solution after this product employing hydroxypropyl cyclodextrin envelope, easy to use.
Hydrolysis conchiolin in this skin whitener is a kind of endothelin antagonist, and endothelin antagonist is a kind of natural whiting additive of extracting and developing and purification from natural product.After the mid-90 skin physiology scholar finder body skin is irradiated by ultraviolet (UVB), epithelial cells discharges Endothelin, the information of this Endothelin is by after the receptor acceptance on melanocyte film, have stimulated the differentiation of melanocyte, propagation activate the activity of tryrosinase, thus melanin sharply increases.Endothelin antagonist can preferentially and the receptors bind of melanocyte film, make Endothelin ineffective, thus suppress the propagation of the melanocyte caused because ultraviolet radiation causes Endothelin to discharge and melanic synthesis, and play whitening function by suppressing keratinocyte release Endothelin, be safety, efficiently whitening agent.
Semen Pisi sativi extract in this skin whitener can suppress the activity of Pmel 17 protein gene, and Pmel 17 is key genes of melanosome maturation.Melanic generation can be reduced from source like this, and there is effect of whitening and light speckle.
Accompanying drawing explanation
Fig. 1 experimenter's face-image example.
Detailed description of the invention
Skin whitening skin whitener provided by the invention be with Margarita powder or Margarita extract, Glycyrrhiza glabra L. aqueous solution, hydrolysis conchiolin, Semen Pisi sativi extract for main component, be aided with cosmetics and commonly use matrix components emulsifying agent, emollient, wetting agent, thickening agent, antiseptic, essence and water and make.The present invention will be described to enumerate a part of specific embodiment below, but do not limit content of the present invention.
Detailed description of the invention
Embodiment 1
The component and the relative content thereof that form above-mentioned skin whitener are:
| Magnesiumaluminumsilicate | 1 |
| Phosphoric acid monohexadecyl ester potassium | 0.3 |
| Nicotiamide | 2 |
| Biological buffer | 1 |
| Margarita powder | 20 |
| 1,3-PD | 10 |
| Xanthan gum | 0.3 |
| Cetearyl alcohol | 3 |
| Different hexadecanol | 2 |
| Shea butter | 1 |
| Polydimethylsiloxane | 2 |
| Caprylic/capric triglyceride | 5 |
| Methyl sesquistearate | 1 |
| PEG-20 methyl sesquistearate | 2 |
| Glycyrrhiza glabra L. aqueous solution | 2 |
| Hydrolysis conchiolin | 0.09 |
| Semen Pisi sativi extract | 2 |
| Essence | 0.2 |
| Antiseptic | 0.8 |
| Water | Surplus |
The preparation method of above-mentioned skin whitener, comprises the following steps: Magnesiumaluminumsilicate, Phosphoric acid monohexadecyl ester potassium, nicotiamide, biological buffer and water to add aqueous phase pot, heated and stirred to 75 ~ 80 DEG C, and homogenizing 5 minutes is as A phase; Using Margarita powder, 1,3-PD and xanthan gum dispersed with stirring evenly as B phase, B is added to A phase, continue heated and stirred to 75 ~ 80 DEG C, dispersed with stirring is even; Cetearyl alcohol, different hexadecanol, shea butter, polydimethylsiloxane, caprylic/capric triglyceride, methyl sesquistearate, PEG-20 methyl sesquistearate are added in oil cauldron, heated and stirred to 80 ~ 85 DEG C, be stirred to and melt completely, as C phase; By in A phase and B phase suction homogenizing reaction pot, open and stir, suction C phase, homogenizing 5 minutes, open cooling circulating water, stir cooling; To adding Glycyrrhiza glabra L. aqueous solution, hydrolysis conchiolin, Semen Pisi sativi extract, essence and antiseptic when 45 ~ 50 DEG C, stirring and dissolving is complete; Continue to be stirred to material temperature not higher than after 38 DEG C, stop stirring, terminate.
Embodiment 2
The component and the relative content thereof that form above-mentioned skin whitener are:
| Magnesiumaluminumsilicate | 1 |
| Phosphoric acid monohexadecyl ester potassium | 0.3 |
| Nicotiamide | 2 |
| Biological buffer | 1 |
| Margarita powder | 15 |
| Margarita extract | 2 |
| 1,3-PD | 10 |
| Xanthan gum | 0.3 |
| Cetearyl alcohol | 3 |
| Different hexadecanol | 2 |
| Shea butter | 1 |
| Polydimethylsiloxane | 2 |
| Caprylic/capric triglyceride | 5 |
| Methyl sesquistearate | 1 |
| PEG-20 methyl sesquistearate | 2 |
| Glycyrrhiza glabra L. aqueous solution | 2 |
| Hydrolysis conchiolin | 0.09 |
| Semen Pisi sativi extract | 2 |
| Essence | 0.2 |
| Antiseptic | 0.8 |
| Water | Surplus |
The preparation method of above-mentioned skin whitener, comprises the following steps: Magnesiumaluminumsilicate, Phosphoric acid monohexadecyl ester potassium, nicotiamide, biological buffer and water to add aqueous phase pot, heated and stirred to 75 ~ 80 DEG C, and homogenizing 5 minutes is as A phase; Using Margarita powder, 1,3-PD and xanthan gum dispersed with stirring evenly as B phase, B is added to A phase, continue heated and stirred to 75 ~ 80 DEG C, dispersed with stirring is even; Cetearyl alcohol, different hexadecanol, shea butter, polydimethylsiloxane, caprylic/capric triglyceride, methyl sesquistearate, PEG-20 methyl sesquistearate are added in oil cauldron, heated and stirred to 80 ~ 85 DEG C, be stirred to and melt completely, as C phase; By in A phase and B phase suction homogenizing reaction pot, open and stir, suction C phase, homogenizing 5 minutes, open cooling circulating water, stir cooling; To adding Margarita extract, Glycyrrhiza glabra L. aqueous solution, hydrolysis conchiolin, Semen Pisi sativi extract, essence and antiseptic when 45 ~ 50 DEG C, stirring and dissolving is complete; Continue to be stirred to material temperature not higher than after 38 DEG C, stop stirring, terminate.
Embodiment 3
The component and the relative content thereof that form above-mentioned skin whitener are:
| Glycerol | 8 |
| Lecithin | 1 |
| C12-16 alcohol | 2 |
| Palmic acid | 1 |
| Margarita powder | 0.5 |
| Butanediol | 5 |
| Polyglutamic acid | 0.05 |
| Cetearyl alcohol | 3 |
| Virgin oil | 2 |
| Shea butter | 1 |
| Polydimethylsiloxane | 3 |
| Caprylic/capric triglyceride | 3 |
| Cetearyl alcohol ethylhexoate | 5 |
| Glycyrrhiza glabra L. aqueous solution | 1 |
| Hydrolysis conchiolin | 0.03 |
| Semen Pisi sativi extract | 2 |
| Essence | 0.2 |
| Antiseptic | 0.8 |
| Water | Surplus |
The preparation method of above-mentioned skin whitener, comprise the following steps: glycerol, lecithin, C12-16 alcohol, Palmic acid and water to add aqueous phase pot, heated and stirred to 75 ~ 80 DEG C, constant temperature stirs 30 minutes as A phase; Using Margarita powder, butanediol and polyglutamic acid dispersed with stirring evenly as B phase, B is added to A phase, continue heated and stirred to 75 ~ 80 DEG C, dispersed with stirring is even; Add in oil cauldron by cetearyl alcohol, virgin oil, shea butter, polydimethylsiloxane, caprylic/capric triglyceride, cetearyl alcohol ethylhexoate, heated and stirred to 80 ~ 85 DEG C, are stirred to and melt completely, as C phase; By in A phase and B phase suction homogenizing reaction pot, open and stir, suction C phase, homogenizing 5 minutes, open cooling circulating water, stir cooling; To adding Glycyrrhiza glabra L. aqueous solution, hydrolysis conchiolin, Semen Pisi sativi extract, essence and antiseptic when 45 ~ 50 DEG C, stirring and dissolving is complete; Continue to be stirred to material temperature not higher than after 38 DEG C, stop stirring, terminate.
Embodiment 4
The component and the relative content thereof that form above-mentioned skin whitener are:
| Glycerol | 8 |
| Lecithin | 1 |
| C12-16 alcohol | 2 |
| Palmic acid | 1 |
| Margarita powder | 0.5 |
| Margarita extract | 5 |
| Butanediol | 5 |
| Polyglutamic acid | 0.05 |
| Cetearyl alcohol | 3 |
| Virgin oil | 2 |
| Shea butter | 1 |
| Polydimethylsiloxane | 3 |
| Caprylic/capric triglyceride | 3 |
| Cetearyl alcohol ethylhexoate | 5 |
| Glycyrrhiza glabra L. aqueous solution | 1 |
| Hydrolysis conchiolin | 0.03 |
| Semen Pisi sativi extract | 2 |
| Essence | 0.2 |
| Antiseptic | 0.8 |
| Water | Surplus |
The preparation method of above-mentioned skin whitener, comprise the following steps: glycerol, lecithin, C12-16 alcohol, Palmic acid and water to add aqueous phase pot, heated and stirred to 75 ~ 80 DEG C, constant temperature stirs 30 minutes as A phase; Using Margarita powder, butanediol and polyglutamic acid dispersed with stirring evenly as B phase, B is added to A phase, continue heated and stirred to 75 ~ 80 DEG C, dispersed with stirring is even; Add in oil cauldron by cetearyl alcohol, virgin oil, shea butter, polydimethylsiloxane, caprylic/capric triglyceride, cetearyl alcohol ethylhexoate, heated and stirred to 80 ~ 85 DEG C, are stirred to and melt completely, as C phase; By in A phase and B phase suction homogenizing reaction pot, open and stir, suction C phase, homogenizing 5 minutes, open cooling circulating water, stir cooling; To adding Margarita extract, Glycyrrhiza glabra L. aqueous solution, hydrolysis conchiolin, Semen Pisi sativi extract, essence and antiseptic when 45 ~ 50 DEG C, stirring and dissolving is complete; Continue to be stirred to material temperature not higher than after 38 DEG C, stop stirring, terminate.
embodiment 5whitening effect is evaluated
The skin whitener provided in this experimental selection embodiment 3 carries out clinical experiment.
This experiment comprises 23 volunteers, and female age is in 23-50 one full year of life, and face has the speckle caused due to Exposure to Sunlight, operating pressure, age etc.Tested material is used and all information by regulation at duration of test.Every day smears skin whitener twice sooner or later, and test period is 4 weeks.Before W0(uses), W2 (using 2 weeks), W4(use 4 weeks) obtain face image data by VISIA-CR, and with the change of the facial particular spots L* value of SSA software analysis, and check its diversity with t.Its result is as follows:
1. L-value change list
Note: * * represents difference highly significant (P<0.01)
Can see from table, can see that use is after two weeks, skin colourity L* value just has increase trend, and the level be obviously greater than before use, difference has statistical significance (p<0.01), illustrate that face uses after skin whitener, skin color shoal gradually and mottle color thin out gradually.
As can see from Figure 1, when W2, blee obviously highlights, and can have a good maintenance effect when W4.Be consistent with the L-value result of face.
2. volunteer's self evaluation
Adopt questionnaire form, the degree that before and after being used by experimenter's self-assessment product, the skin color depth and spot size change judges that product improves degree to skin.Wherein without improvement refer to mottle size unchanged/colour of skin is unchanged; Slight improvement refers to that mottle slightly reduces, thin out/overall colour of skin highlights to some extent; Moderate improvement refers to that mottle obviously reduces, and thin out/overall colour of skin obviously highlights.Use in sample E surrounding, what experimenter thought that blee moderate improves account for 38% of total number of persons, is slightly improved as 54%; And in mottle improvement, what think that moderate improves is 15%, slight improvement account for 77%.
In sum, this whitening product has significant white-skinned face function, namely has the double effects of bright color and desalination mottle.
Claims (10)
1. a skin whitener, is characterized in that this skin whitener comprises following component by mass percentage:
Adjuvant 5 ~ 50% commonly used by skin whitener
Margarita powder 0 ~ 30%
Margarita extract 0 ~ 10%
Glycyrrhiza glabra L. aqueous solution 0.1 ~ 10%
Hydrolysis conchiolin 0.005 ~ 1%
Semen Pisi sativi extract 0.1 ~ 5%;
Be zero when above-mentioned Margarita powder is different with the content of Margarita extract, and in described Glycyrrhiza glabra L. aqueous solution, the percentage composition of Glycyrrhiza glabra L. extract is 0.5 ~ 5.0%.
2. a kind of skin whitener according to claim 1, is characterized in that said composition comprises following component by mass percentage:
Adjuvant 10 ~ 30% commonly used by skin whitener
Margarita powder 0.5 ~ 20%
Margarita extract 0.5 ~ 5%
Glycyrrhiza glabra L. aqueous solution 0.3 ~ 3%
Hydrolysis conchiolin 0.01 ~ 0.3%
Semen Pisi sativi extract 0.5 ~ 3%.
3. a kind of skin whitener according to claim 1, is characterized in that said composition comprises following component by mass percentage:
Adjuvant 10 ~ 30% commonly used by skin whitener
Margarita powder 1.0 ~ 15%
Margarita extract 1.0 ~ 4%
Glycyrrhiza glabra L. aqueous solution 0.5 ~ 3%
Hydrolysis conchiolin 0.05 ~ 0.2%
Semen Pisi sativi extract 1.0 ~ 2.5%.
4. a kind of skin whitener according to claim 1 or 2 or 3, is characterized in that the percentage composition of Glycyrrhiza glabra L. extract in described Glycyrrhiza glabra L. aqueous solution is 1.0 ~ 3.0%; As preferably, described Glycyrrhiza glabra L. aqueous solution is scattered in water by Glycyrrhiza glabra L. extract after hydroxypropyl cyclodextrin envelope, and add the solution that 1,2-pentanediol is formed, in Glycyrrhiza glabra L. extract, glabridin mass fraction is greater than 90%.
5. a kind of skin whitener according to claim 1 or 2 or 3, is characterized in that described Margarita powder is that Margarita grinds 1000 ~ 3000 order flours obtained through physical mechanical; The described Margarita extract multiple peptide class that to be Margarita powder obtain through enzymolysis and amino acid whose mixture.
6. a kind of skin whitener according to claim 1 or 2 or 3, it is characterized in that the described hydrolysis conchiolin powdered substance that to be hydrobiological conchiolin obtain through the mode of biological enzymolysis, quality purity is greater than 70%; Described Semen Pisi sativi extract quality purity is 2 ~ 3%.
7. a kind of skin whitener according to claim 1 or 2 or 3, is characterized in that described skin whitener is commonly used adjuvant and comprised following component:
Magnesiumaluminumsilicate 0 ~ 5%
Phosphoric acid monohexadecyl ester potassium 0 ~ 1%
Nicotiamide 0 ~ 5%
Biological buffer 0 ~ 3%
1,3-PD 0 ~ 20%
Xanthan gum 0 ~ 1%
Cetearyl alcohol 0 ~ 5%
Different hexadecanol 0 ~ 5%
Shea butter 0 ~ 2%
Polydimethylsiloxane 0 ~ 5%
Caprylic/capric triglyceride 0 ~ 10%
Methyl sesquistearate 0 ~ 5%
PEG-20 methyl sesquistearate 0 ~ 5%.
8. prepare a method for skin whitener according to claim 7, it is characterized in that the method comprises the following steps:
1) Magnesiumaluminumsilicate, Phosphoric acid monohexadecyl ester potassium, nicotiamide, biological buffer and water are added aqueous phase pot, heated and stirred to 75 ~ 80 DEG C, homogenizing 5 minutes is as A phase;
2) using Margarita powder, 1,3-PD and xanthan gum dispersed with stirring evenly as B phase, B is added to A phase, continue heated and stirred to 75 ~ 80 DEG C, dispersed with stirring is even;
3) cetearyl alcohol, different hexadecanol, shea butter, polydimethylsiloxane, caprylic/capric triglyceride, methyl sesquistearate, PEG-20 methyl sesquistearate are added in oil cauldron, heated and stirred to 80 ~ 85 DEG C, be stirred to and melt completely, as C phase;
4) by A phase and B phase suction homogenizing reaction pot, open and stir, suction C phase, homogenizing 5 minutes, open cooling circulating water, stir cooling;
5) to adding Glycyrrhiza glabra L. aqueous solution, Margarita extract, hydrolysis conchiolin, Semen Pisi sativi extract when 45 ~ 50 DEG C, stirring and dissolving is complete;
6) continue to be stirred to material temperature not higher than after 38 DEG C, stop stirring, terminate.
9. a kind of skin whitener according to claim 1 or 2 or 3, is characterized in that described skin whitener is commonly used adjuvant and comprised following component:
Glycerol 0 ~ 15%
Lecithin 0 ~ 5%
C12-16 alcohol 0 ~ 5%
Palmic acid 0 ~ 5%
Margarita powder 0 ~ 2%
Butanediol 0 ~ 10%
Polyglutamic acid 0 ~ 0.5%
Cetearyl alcohol 0 ~ 5%
Virgin oil 0 ~ 5%
Shea butter 0 ~ 5%
Polydimethylsiloxane 0 ~ 5%
Caprylic/capric triglyceride 0 ~ 5%
Cetearyl alcohol ethylhexoate 0 ~ 10%.
10. prepare a method for skin whitener according to claim 9, it is characterized in that the method comprises the following steps:
1) glycerol, lecithin, C12-16 alcohol, Palmic acid and water are added aqueous phase pot, heated and stirred to 75 ~ 80 DEG C, constant temperature stirs 30 minutes as A phase;
2) using Margarita powder, butanediol and polyglutamic acid dispersed with stirring evenly as B phase, B is added to A phase, continue heated and stirred to 75 ~ 80 DEG C, dispersed with stirring is even;
3) add in oil cauldron by cetearyl alcohol, virgin oil, shea butter, polydimethylsiloxane, caprylic/capric triglyceride, cetearyl alcohol ethylhexoate, heated and stirred to 80 ~ 85 DEG C, are stirred to and melt completely, as C phase;
4) by A phase and B phase suction homogenizing reaction pot, open and stir, suction C phase, homogenizing 5 minutes, open cooling circulating water, stir cooling;
5) to adding Margarita extract, Glycyrrhiza glabra L. aqueous solution, hydrolysis conchiolin, Semen Pisi sativi extract, essence and antiseptic when 45 ~ 50 DEG C, stirring and dissolving is complete;
6) continue to be stirred to material temperature not higher than after 38 DEG C, stop stirring, terminate.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510117682.9A CN104688654A (en) | 2015-03-17 | 2015-03-17 | Whitening cream and preparation method thereof |
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| CN201510117682.9A CN104688654A (en) | 2015-03-17 | 2015-03-17 | Whitening cream and preparation method thereof |
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| CN104688654A true CN104688654A (en) | 2015-06-10 |
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| CN201510117682.9A Pending CN104688654A (en) | 2015-03-17 | 2015-03-17 | Whitening cream and preparation method thereof |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106474040A (en) * | 2016-12-07 | 2017-03-08 | 广州丽丰化妆品制造有限公司 | Pearl essence face frost and preparation method thereof |
| CN107137327A (en) * | 2017-05-05 | 2017-09-08 | 海南京润珍珠生物技术股份有限公司 | Saturating white elite breast of the naked adornment of pearl and preparation method thereof |
| CN107496316A (en) * | 2016-06-13 | 2017-12-22 | 欧诗漫生物股份有限公司 | A kind of face cream and preparation method thereof |
| CN108618992A (en) * | 2018-06-25 | 2018-10-09 | 亿利耐雀生物科技有限公司 | A kind of glabridin composition and preparation method thereof |
| CN108721196A (en) * | 2018-08-08 | 2018-11-02 | 界首市王集镇顺义家庭农场 | A kind of snake gourd fruit pulp skin whitener and preparation method thereof |
| CN110115705A (en) * | 2019-06-19 | 2019-08-13 | 广东默默化妆品有限公司 | A kind of emulsifying process of maintenance frost |
| CN110522711A (en) * | 2019-05-27 | 2019-12-03 | 广州好蝶化妆品有限公司 | A kind of lady's cream and preparation method |
| CN111000770A (en) * | 2019-12-25 | 2020-04-14 | 浙江长生鸟健康科技股份有限公司 | Whitening cream containing pearl peptide |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| US11110049B2 (en) | 2017-06-23 | 2021-09-07 | The Procter & Gamble Company | Composition and method for improving the appearance of skin |
| CN113440453A (en) * | 2021-08-17 | 2021-09-28 | 蔓之研（上海）生物科技有限公司 | Composite whitening active matter nanoparticles and preparation method and application thereof |
| US11583488B2 (en) | 2020-06-01 | 2023-02-21 | The Procter & Gamble Company | Method of improving penetration of a vitamin B3 compound into skin |
| US11622963B2 (en) | 2018-07-03 | 2023-04-11 | The Procter & Gamble Company | Method of treating a skin condition |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107496316A (en) * | 2016-06-13 | 2017-12-22 | 欧诗漫生物股份有限公司 | A kind of face cream and preparation method thereof |
| CN106474040A (en) * | 2016-12-07 | 2017-03-08 | 广州丽丰化妆品制造有限公司 | Pearl essence face frost and preparation method thereof |
| CN107137327A (en) * | 2017-05-05 | 2017-09-08 | 海南京润珍珠生物技术股份有限公司 | Saturating white elite breast of the naked adornment of pearl and preparation method thereof |
| US11110049B2 (en) | 2017-06-23 | 2021-09-07 | The Procter & Gamble Company | Composition and method for improving the appearance of skin |
| CN108618992A (en) * | 2018-06-25 | 2018-10-09 | 亿利耐雀生物科技有限公司 | A kind of glabridin composition and preparation method thereof |
| US11622963B2 (en) | 2018-07-03 | 2023-04-11 | The Procter & Gamble Company | Method of treating a skin condition |
| CN108721196A (en) * | 2018-08-08 | 2018-11-02 | 界首市王集镇顺义家庭农场 | A kind of snake gourd fruit pulp skin whitener and preparation method thereof |
| CN110522711A (en) * | 2019-05-27 | 2019-12-03 | 广州好蝶化妆品有限公司 | A kind of lady's cream and preparation method |
| CN110115705A (en) * | 2019-06-19 | 2019-08-13 | 广东默默化妆品有限公司 | A kind of emulsifying process of maintenance frost |
| CN111000770A (en) * | 2019-12-25 | 2020-04-14 | 浙江长生鸟健康科技股份有限公司 | Whitening cream containing pearl peptide |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| US11583488B2 (en) | 2020-06-01 | 2023-02-21 | The Procter & Gamble Company | Method of improving penetration of a vitamin B3 compound into skin |
| US11911498B2 (en) | 2020-06-01 | 2024-02-27 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| CN113440453A (en) * | 2021-08-17 | 2021-09-28 | 蔓之研（上海）生物科技有限公司 | Composite whitening active matter nanoparticles and preparation method and application thereof |
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