CN104688388A - 3D (three-dimensional) printing technique-based cartilage repair system and method - Google Patents
3D (three-dimensional) printing technique-based cartilage repair system and method Download PDFInfo
- Publication number
- CN104688388A CN104688388A CN201510143867.7A CN201510143867A CN104688388A CN 104688388 A CN104688388 A CN 104688388A CN 201510143867 A CN201510143867 A CN 201510143867A CN 104688388 A CN104688388 A CN 104688388A
- Authority
- CN
- China
- Prior art keywords
- cartilage
- printing
- release lever
- carriage release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Prostheses (AREA)
Abstract
The invention discloses a 3D (three-dimensional) printing technique-based cartilage repair system and a cartilage repair method using the same and belongs to the field of cartilage repair techniques. The system comprises a 3D printing system and a feeding system. The 3D printing system comprises a multi-DOF (multiple degrees of freedom) printing nozzle and a nozzle shifting rod; a radial rotating structure allowing the printing nozzle to radially rotate around the axis of the nozzle shifting rod at 360 degrees. The invention further discloses the cartilage repair method using the system. The method includes the steps such as: generating a 3D printing model, a generating a printing program, and debugging the program. The 3D printing technique-based cartilage repair system and the cartilage repair method have the advantages that all-directional scanning and printing can be performed for the inside of a focus cavity of the defective cartilage, the focal cartilage defect can be quickly and accurately repaired just under the arthroscopic minimally-invasive condition, wound can be greatly reduced, therapeutic time is shortened, pain is effectively relived for patients, and economic burden is effectively reduced for the patients.
Description
Technical field
The invention belongs to cartilage repair techniques field, be specifically related to a kind of cartilage repair systems based on 3D printing technique and repair of cartilage method thereof.
Background technology
Articular cartilage defect is clinical common, and more than 60% patients with knee arthroscopy is with cartilage defect according to statistics, and wherein 42% is focal hyaline cartilage defect, and namely the degree of depth of defect is no more than calcified cartilage layer, and the area of defect is at 2 ~ 4cm
2between
[1].Because hyaline cartilage does not have blood vessel, nerve and lymphsystem, natural repair ability is low, and diameter almost can not be repaired completely more than the defect of 4mm.If do not treated in time, damage and to increase the weight of continuing and to cause arthritis, occur arthralgia swelling, deformity.
For this type of cartilage defect, traditional therapeutic strategies adopts micro-fracture method that marrow blood is oozed out in art, utilizes the mescenchymal stem cell in blood clot to breed, repair cartilage defect, but final what formed is the poor fibrous cartilage of wearability.Along with the fast development of tissue engineering technique, Autologous Chondrocyte implantation technique is gradually at clinical application, but this technology needs to carry out amplification in vitro to Autologous Chondrocyte, and then second operation is implanted; Because In vitro culture is difficult to simulation in body microenvironment, especially the monitoring of body immune system is lacked, usually there is phenotypic alternation in the chondrocyte implanted, therefore structurally or on composition all there is essential difference with natural cartilage in the final repair tissue formed, and is difficult to the long-term effectiveness guaranteeing that it is treated.
For the problems referred to above, in early stage on the basis of Injectable tissue engineering cartilage research, in conjunction with domestic and international latest Progress, we propose " apply autologous BMSCs compound fabrication of cartilage colloidal sol substrate and build tissue engineering bone/cartilage in 3 D-printing (3DP) mode " New Policy, make it have the interior spatial structure that the dissection profile that matches to defect is similar with natural cartilage, to realizing the bionical and function bionics of the bionic structure of repair tissue, composition.Fabrication of cartilage substrate colloidal sol is identical with natural cartilage matrix components, has good biocompatibility; Autologous BMSCs has stronger multiplication capacity and to Chondrocyte Differentiation potential; The biological technology of beating of 3D can realize tissue engineering bone/cartilage and have natural cartilage characteristics of organizational structure (the dissection profile matched with defect and the distinctive space distribution rule of chondrocyte); Under being fixed on the effect of the BMSCs chemical factors in articular cavity cartilage microenvironment in gel, propagation, differentiating cartilage-forming cell, secretion specificity cartilage extracellular matrix, thus regeneration forms high-quality articular cartilage.
Therefore, be necessary to work out a kind of new cartilage repair systems and repair of cartilage method, only can realize carrying out fast accurate reparation to focal cartilage defect under arthroscope Wicresoft condition, significantly can reduce wound, shorten treatment time, effectively alleviate patient suffering and economic pressures.
Summary of the invention
In view of this, the invention provides the cartilage repair systems based on 3D printing technique and repair of cartilage method thereof, overcome the treatment cycle length of prior art existence and the problem of potential safety hazard.
An object of the present invention is achieved through the following technical solutions:
Based on the cartilage repair systems of 3D printing technique, comprise 3D print system and feeding system,
Described 3D print system comprises and has multivariant printing head and shower nozzle carriage release lever, the radial rotary structure that printing head can be made to rotate around carriage release lever Axial and radial 360 ° is provided with between described printing head and shower nozzle carriage release lever, described radial rotary structure comprises the rotating shaft vertical with shower nozzle carriage release lever and is arranged at the miniature stepping power supply of roller end, described rotating shaft is connected with printing head and shower nozzle carriage release lever respectively, wherein, with printing head for being fixedly connected with, with shower nozzle carriage release lever for being rotatably connected, the exit of described printing head is provided with can carry out the 3D scanner that 360 ° of spaces scan and the photographic head that can carry out real-time tracking to print state to cartilage defect,
Described feeding system comprises provides the supply lines of printed material, the charge box be communicated with feed and pipeline power set, described supply lines is communicated with the type channel of printing head, described pipeline power set comprise the electromagnetic throttle valve controlled the peristaltic pump of printed material generation driving force and air exercise print flow of material for extruding supply lines, are provided with the supercharger that printed material supercharging can be formed spurting in the type channel of described printing head.
Further, also comprise hydraulic system, described hydraulic system comprises the compound motion executive component of the realized printing head multifreedom motion be connected with shower nozzle carriage release lever, the hydraulic oil closed circuit be communicated with compound motion executive component, and provide the hydraulic pump of hydraulic-driven power for compound motion executive component, described compound motion executive component comprises the first hydraulic cylinder driving it to move up and down be fixedly connected with shower nozzle carriage release lever, the second hydraulic cylinder be rotatably connected with the first hydraulic cylinder, the 3rd hydraulic cylinder be rotatably connected with the first hydraulic cylinder and the second hydraulic cylinder respectively and the 4th hydraulic cylinder be rotatably connected with the second hydraulic cylinder.
Further, the external part of described first hydraulic cylinder piston is provided with the piston hole with piston coaxial, be provided with in described piston hole and make shower nozzle carriage release lever do 360 ° of axial-rotation mechanisms rotated around piston axial direction, described axial-rotation mechanism comprises and is arranged on bearing between piston and shower nozzle carriage release lever and is arranged on the miniature stepping power supply that rotary actuation is carried out in shower nozzle carriage release lever end.
Further, described hydraulic oil closed circuit comprises for regulating the automatically controlled flow valve of hydraulic fluid flow rate, the oil sump for stock solution force feed, and described oil sump is communicated with peristaltic pump.
Further, also comprise control system, described control system comprises information receiving system, analysis process system, and the display to print routine or operational order or print state Real-Time Monitoring, described information receiving system is connected with 3D scanner, and described analysis process system is connected with printing head, electromagnetic throttle valve, automatically controlled flow valve, hydraulic oil pump and peristaltic pump.
Further, also comprise for 3D print system, feeding system, hydraulic system, control system provide the power-supply system of driving force.
Further, also comprise the pedestal having and have two chambers at least, described second hydraulic cylinder, the 4th hydraulic cylinder are hinged on pedestal, and described oil sump, power-supply system are deposited in two chambers respectively.
Two of object of the present invention is achieved through the following technical solutions:
Adopt as mentioned above based on the repair of cartilage method of the cartilage repair systems of 3D printing technique, its concrete operation step is:
1) 3D printer model is generated: by compound motion executive component, 3D printing head is moved to defect cartilage focus intracavity from equipment initial point, under the combined effect of compound motion executive component and rotating mechanism, by the 3D scanner be arranged on printing head, comprehensive scanning is carried out to defect cartilage focus inner chamber, and spatial coordinated information is sent to information receiving system generation defect cartilage 3D printer model;
2) generate print routine: the digital information of defect cartilage 3D printer model is sent to analysis process system by information receiving system, processing system denoising generates 3D print routine by analysis;
3) program debugging: 3D print routine is checked and debugs, confirm errorless after assign print command, otherwise, repeat step 2) or 1), 2);
4) print procedure: under the combined effect of compound motion executive component and rotating mechanism, 3D print system, feeding system, hydraulic system perform print routine;
5) print after executing print routine and terminate, each print member gets back to appointment initial point.
Further, step 4) in, also comprise the process of by photographic head, print state being carried out to real-time tracking monitoring.
Further, step 4) in, printing type is that layering prints, and every layer of print thickness is 0.2mm.
The invention has the beneficial effects as follows:
The present invention can carry out comprehensively scanning and printing at defect cartilage focus intracavity by having multivariant scanner and printing head, only Wicresoft's focus surface just can realize the reparation to defect cartilage, and do not need producing and cultivating of chondroconia, significantly can shorten treatment cycle and reduce treatment cost, the slight illness being conducive to alleviating patient torments and economic pressures.
Other advantages of the present invention, target and feature will be set forth to a certain extent in the following description, and to a certain extent, based on will be apparent to those skilled in the art to investigating hereafter, or can be instructed from the practice of the present invention.Target of the present invention and other advantages can be realized by description below and obtain.
Accompanying drawing explanation
In order to make the object, technical solutions and advantages of the present invention clearly, below in conjunction with accompanying drawing, the present invention is described in further detail, wherein:
Fig. 1 is the structural representation of the cartilage repair systems that the present invention is based on 3D printing technique;
Fig. 2 is the partial enlarged drawing of the cartilage repair systems that the present invention is based on 3D printing technique.
Reference numeral: 1-defect cartilage focus chamber; 2-printing head; 3-shower nozzle carriage release lever; 4-radial rotary mechanism; 401-rotating shaft; 402-miniature stepping power supply I; 5-3D scanner; 6-photographic head; 7-supply lines; 8-pipeline power set; 801-peristaltic pump; 802 electromagnetic throttle valves; 9-compound motion executive component; 901-first hydraulic cylinder; 902-second hydraulic cylinder; 903-the 3rd hydraulic cylinder; 904-the 4th hydraulic cylinder; 10-hydraulic oil closed circuit; 11-hydraulic pump; The automatically controlled flow valve of 12-; 13-oil sump; 14-piston hole; 15-axial-rotation mechanism; 151-bearing; 152-miniature stepping power supply II; 16-information receiving system; 17-analysis process system; 18-display; 19-power-supply system; 20-pedestal; 21-charge box; 22-supercharger.
Detailed description of the invention
Hereinafter with reference to accompanying drawing, the preferred embodiments of the present invention are described in detail.Should be appreciated that preferred embodiment only in order to the present invention is described, instead of in order to limit the scope of the invention.
As shown in Figures 1 and 2, the present embodiment is based on the cartilage repair systems of 3D printing technique, comprise 3D print system and feeding system, described 3D print system comprises and has multivariant printing head 1 and shower nozzle carriage release lever 2, the radial rotary structure that printing head can be made to rotate around carriage release lever Axial and radial 360 ° is provided with between described printing head 1 and shower nozzle carriage release lever 2, described radial rotary structure comprises the rotating shaft 3 vertical with shower nozzle carriage release lever 2 and is arranged at the miniature stepping power supply I4 of rotating shaft 3 end, described rotating shaft 3 is connected with printing head 1 and shower nozzle carriage release lever 2 respectively, wherein, with printing head 1 for being fixedly connected with, with shower nozzle carriage release lever 2 for being rotatably connected, the present embodiment is that ball bearing or cylindrical bearing connect, make printing head 1 consistent with the motion of rotating shaft 2, 3 rotations rotated around the shaft can be done relative to shower nozzle carriage release lever 2, the exit of described printing head 1 is provided with can carry out the 3D scanner 5 that 360 ° of spaces scan and the photographic head 6 that can carry out real-time tracking to print state to cartilage defect,
Described feeding system comprises the supply lines 7 providing printed material, the charge box 21 be communicated with feed and pipeline power set 8, the printed material of the present embodiment is stem cell, the type channel of described supply lines 7 and printing head 1 and stem cell channel connection, described pipeline power set 8 comprise the electromagnetic throttle valve 802 controlled the peristaltic pump 801 of printed material generation driving force and air exercise print flow of material for extruding supply lines, the supercharger 22 that printed material supercharging can be formed spurting is provided with in the type channel of described printing head 1, the compactness after printing can be increased, improve the regeneration capacity of stem cell.
The present embodiment can be printed, scan and follow the tracks of level cartilage defect space by radial rotary structure, simultaneously, when shower nozzle carriage release lever moves up and down, drive the 3D scanner on printing head 1 and printing head 1 and photographic head also to move up and down, realize printing the space of differing heights, scan and following the tracks of.
In the present embodiment, also comprise hydraulic system, described hydraulic system comprises the compound motion executive component 9 of the realized printing head multifreedom motion be connected with shower nozzle carriage release lever, the hydraulic oil closed circuit 10 be communicated with compound motion executive component 9, and provide the hydraulic pump 11 of hydraulic-driven power for compound motion executive component 9, described compound motion executive component 9 comprises the first hydraulic cylinder 901 driving it to move up and down be fixedly connected with shower nozzle carriage release lever 2, the second hydraulic cylinder 902 be rotatably connected with the first hydraulic cylinder 901, the 3rd hydraulic cylinder 903 be rotatably connected with the first hydraulic cylinder 901 and the second hydraulic cylinder 902 respectively and the 4th hydraulic cylinder 904 be rotatably connected with the second hydraulic cylinder 902, by compound motion executive component 9, multifreedom motion can be performed to shower nozzle carriage release lever 2, before and after comprising, left and right, upper and lower rectilinear motion and the planar rotational movement around the first hydraulic cylinder 901, make shower nozzle carriage release lever 2 can enter in defect cartilage focus chamber 1 from any direction in space, described hydraulic oil closed circuit 10 comprises the automatically controlled flow valve 12 for regulating hydraulic fluid flow rate, for the oil sump 13 of stock solution force feed, described oil sump 13 is communicated with peristaltic pump 801.
In the present embodiment, the external part of described first hydraulic cylinder 901 piston is provided with the piston hole 14 with piston coaxial, be provided with in described piston hole 14 and make shower nozzle carriage release lever 2 do 360 ° of axial-rotation mechanisms 15 rotated around piston axial direction, described axial-rotation mechanism 16 comprises and is arranged on bearing between piston and shower nozzle carriage release lever 2 151 and is arranged on the miniature stepping power supply II 152 that rotary actuation is carried out in shower nozzle carriage release lever 2 end, by the piston hole 14 coaxially arranged, shower nozzle carriage release lever 2 and piston coaxial can be made, make the shower nozzle carriage release lever 2 that enters in defect cartilage focus chamber 1 less, Ye Shi Wicresoft wound is less, also the volume reducing whole print system is conducive to, alleviate its quality, the rotation of shower nozzle carriage release lever 2 and piston axial direction can be realized by arranging axial-rotation mechanism 15, shower nozzle carriage release lever 2 is made to drive printing head 1 to rotate arbitrarily in level cartilage defect space, make printing, scan and follow the tracks of without dead angle, effect is better.
As the improvement of the present embodiment, also comprise control system, described control system comprises information receiving system 16, analysis process system 17, and the display 18 to print routine or operational order or print state Real-Time Monitoring, described information receiving system 16 is connected with 3D scanner 5, and described analysis process system 17 is connected with printing head 1, electromagnetic throttle valve 802, automatically controlled flow valve 12, hydraulic pump 11 and peristaltic pump 801.And automatization intelligent to the whole process of the real-time tracking scanning process, print procedure and print state can be realized by control system, make cartilaginous repair processes more accurate, controlled, and efficiency be higher.
As the improvement of the present embodiment, also comprise for 3D print system, feeding system, hydraulic system, control system provide the power-supply system 19 of driving force.
As the improvement of the present embodiment, also comprise the pedestal 20 having and have two chambers at least, described second hydraulic cylinder, the 4th hydraulic cylinder are hinged on pedestal 20, described oil sump 13, power-supply system 19 are deposited in two chambers respectively, make that whole system is cleaner and tidier, specification, be conducive to the risk reducing operate miss.
Two of object of the present invention is achieved through the following technical solutions:
Adopt as mentioned above based on the repair of cartilage method of the cartilage repair systems of 3D printing technique, its concrete operation step is:
1) 3D printer model is generated: by compound motion executive component, 3D printing head is moved to defect cartilage focus intracavity from equipment initial point, under the combined effect of compound motion executive component and rotating mechanism, by the 3D scanner be arranged on printing head, comprehensive scanning is carried out to defect cartilage focus inner chamber, compound motion executive component performs composite straight line motion, rotating mechanism rotates, control 3D scanner does straight line and rotary motion at defect cartilage focus inner chamber, thus realize multifreedom motion, to defect cartilage focus inner chamber milli exhaustively panorama scan, make printer model more accurate, and spatial coordinated information is sent to information receiving system generation defect cartilage 3D printer model, put in cartilage focus intracavity just can implement to scan and print due to carriage release lever and printing head only need be printed, only need open an osculum at defect cartilage surface, pass through for printing carriage release lever, even only need original opening, hardly new wound is brought to patient, patient Geng Yi is recovered.
2) generate print routine: the digital information of defect cartilage 3D printer model is sent to analysis process system by information receiving system, processing system denoising generates 3D print routine by analysis;
3) program debugging: 3D print routine is checked and debugs, confirm errorless after assign print command, otherwise, repeat step 2) or 1), 2); When inspection in find that 3D printer model is not right, need again scan defect cartilage, namely will repeat step 1), 2); When only discovery procedure is not right, only repeat step 2).
4) print procedure: under the combined effect of compound motion executive component and rotating mechanism, 3D print system, feeding system, hydraulic system perform print routine;
5) print after executing print routine and terminate, each print member gets back to appointment initial point.
As the improvement of the present embodiment, step 4) in, also comprise the process of by photographic head, print state being carried out to real-time tracking monitoring, can mistake in Timeliness coverage print procedure, and correct in time.
As the improvement of the present embodiment, step 4) in, printing type is that layering prints, every layer of print thickness is 30-200um, and concrete thickness needs to adapt with printing environment, and the present embodiment is preferably 150um, the stem cell of printing is more evenly distributed and densification, regeneration capacity is strengthened.
The present embodiment makes cartilage repair systems have multivariant scanner and printing head by radial rotary structure, axial-rotation structure and compound motion executive component can to carry out comprehensively scanning, printing and real-time tracking at defect cartilage focus intracavity any direction, only Wicresoft's focus surface just can realize the reparation to defect cartilage, and do not need producing and cultivating of chondroconia, significantly can shorten treatment cycle and reduce treatment cost, the slight illness being conducive to alleviating patient torments and economic pressures.
What finally illustrate is, above embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, although with reference to preferred embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that, can modify to technical scheme of the present invention or equivalent replacement, and not departing from aim and the scope of the technical program, it all should be encompassed in the middle of right of the present invention.
Claims (10)
1., based on the cartilage repair systems of 3D printing technique, comprise 3D print system and feeding system, it is characterized in that:
Described 3D print system comprises and has multivariant printing head and shower nozzle carriage release lever, the radial rotary structure that printing head can be made to rotate around carriage release lever Axial and radial 360 ° is provided with between described printing head and shower nozzle carriage release lever, described radial rotary structure comprises the rotating shaft vertical with shower nozzle carriage release lever and is arranged at the miniature stepping power supply of roller end, described rotating shaft is connected with printing head and shower nozzle carriage release lever respectively, wherein, with printing head for being fixedly connected with, with shower nozzle carriage release lever for being rotatably connected, the exit of described printing head is provided with can carry out the 3D scanner that 360 ° of spaces scan and the photographic head that can carry out real-time tracking to print state to cartilage defect,
Described feeding system comprises provides the supply lines of printed material, the charge box be communicated with feed and pipeline power set, described supply lines is communicated with the type channel of printing head, described pipeline power set comprise the electromagnetic throttle valve controlled the peristaltic pump of printed material generation driving force and air exercise print flow of material for extruding supply lines, are provided with the supercharger that printed material supercharging can be formed spurting in the type channel of described printing head.
2. the cartilage repair systems based on 3D printing technique according to claim 1, it is characterized in that: also comprise hydraulic system, described hydraulic system comprises the compound motion executive component of the realized printing head multifreedom motion be connected with shower nozzle carriage release lever, the hydraulic oil closed circuit be communicated with compound motion executive component, and provide the hydraulic pump of hydraulic-driven power for compound motion executive component, described compound motion executive component comprises the first hydraulic cylinder driving it to move up and down be fixedly connected with shower nozzle carriage release lever, the second hydraulic cylinder be rotatably connected with the first hydraulic cylinder, the 3rd hydraulic cylinder be rotatably connected with the first hydraulic cylinder and the second hydraulic cylinder respectively and the 4th hydraulic cylinder be rotatably connected with the second hydraulic cylinder.
3. the cartilage repair systems based on 3D printing technique according to claim 2, it is characterized in that: the external part of described first hydraulic cylinder piston is provided with the piston hole with piston coaxial, be provided with in described piston hole and make shower nozzle carriage release lever do 360 ° of axial-rotation mechanisms rotated around piston axial direction, described axial-rotation mechanism comprises and is arranged on bearing between piston and shower nozzle carriage release lever and is arranged on the miniature stepping power supply that rotary actuation is carried out in shower nozzle carriage release lever end.
4. the cartilage repair systems based on 3D printing technique according to claim 2, is characterized in that: described hydraulic oil closed circuit comprises for regulating the automatically controlled flow valve of hydraulic fluid flow rate, the oil sump for stock solution force feed, and described oil sump is communicated with peristaltic pump.
5. the cartilage repair systems based on 3D printing technique according to claim 4, it is characterized in that: also comprise control system, described control system comprises information receiving system, analysis process system, and the display to print routine or operational order or print state Real-Time Monitoring, described information receiving system is connected with 3D scanner, and described analysis process system is connected with printing head, electromagnetic throttle valve, automatically controlled flow valve, hydraulic oil pump and peristaltic pump.
6. the cartilage repair systems based on 3D printing technique according to claim 1, is characterized in that: also comprise for 3D print system, feeding system, hydraulic system, control system provide the power-supply system of driving force.
7. the cartilage repair systems based on 3D printing technique according to claim 1, it is characterized in that: also comprise the pedestal having and have two chambers at least, described second hydraulic cylinder, the 4th hydraulic cylinder are hinged on pedestal, and described oil sump, power-supply system are deposited in two chambers respectively.
8. adopt as arbitrary in claim 1-7 as described in based on the repair of cartilage method of the cartilage repair systems of 3D printing technique, its concrete operation step is:
1) 3D printer model is generated: by compound motion executive component, 3D printing head is moved to defect cartilage focus intracavity from equipment initial point, under the combined effect of compound motion executive component and rotating mechanism, by the 3D scanner be arranged on printing head, comprehensive scanning is carried out to defect cartilage focus inner chamber, and spatial coordinated information is sent to information receiving system generation defect cartilage 3D printer model;
2) generate print routine: the digital information of defect cartilage 3D printer model is sent to analysis process system by information receiving system, processing system denoising generates 3D print routine by analysis;
3) program debugging: 3D print routine is checked and debugs, confirm errorless after assign print command, otherwise, repeat step 2) or 1), 2);
4) print procedure: under the combined effect of compound motion executive component and rotating mechanism, 3D print system, feeding system, hydraulic system perform print routine;
5) print after executing print routine and terminate, each print member gets back to appointment initial point.
9. repair of cartilage method according to claim 8, is characterized in that: step 4) in, also comprise the process of by photographic head, print state being carried out to real-time tracking monitoring.
10. repair of cartilage method according to claim 8, is characterized in that: step 4) in, printing type is that layering prints, and every layer of print thickness is 30-200um.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510143867.7A CN104688388B (en) | 2015-03-30 | 2015-03-30 | Cartilage repair systems based on 3D printing technique and repair of cartilage method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510143867.7A CN104688388B (en) | 2015-03-30 | 2015-03-30 | Cartilage repair systems based on 3D printing technique and repair of cartilage method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104688388A true CN104688388A (en) | 2015-06-10 |
| CN104688388B CN104688388B (en) | 2016-08-17 |
Family
ID=53336234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510143867.7A Active CN104688388B (en) | 2015-03-30 | 2015-03-30 | Cartilage repair systems based on 3D printing technique and repair of cartilage method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104688388B (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105342726A (en) * | 2015-08-21 | 2016-02-24 | 郭开今 | 3D (three-dimensional) printing micropore inlaying type bone grain |
| CN108788158A (en) * | 2018-08-28 | 2018-11-13 | 铜仁市人民医院 | A kind of hyperbaric oxygen chamber 3D printing equipment |
| CN112976581A (en) * | 2021-04-08 | 2021-06-18 | 重庆大学 | Trajectory planning method based on multi-axis cartilage repair |
| CN113274172A (en) * | 2021-04-29 | 2021-08-20 | 重庆大学 | Multi-view fusion-based cartilage repair operation robot platform system |
| CN113499170A (en) * | 2021-07-09 | 2021-10-15 | 中国人民解放军陆军军医大学第一附属医院 | Articular cavity cartilage 3D printing unit and printing equipment thereof |
| CN113927696A (en) * | 2021-08-30 | 2022-01-14 | 广东电网有限责任公司广州供电局 | Sand table 3D printer |
| CN114505500A (en) * | 2021-12-21 | 2022-05-17 | 江苏靖宁智能制造有限公司 | Multi-gun collaborative material increase device with real-time adjustable distance, posture and height |
| EP4000551A1 (en) | 2017-04-02 | 2022-05-25 | Mazor Robotics Ltd. | Three dimensional robotic bioprinter |
| US11523916B2 (en) | 2019-12-17 | 2022-12-13 | Warsaw Orthopedic, Inc. | In-situ additive implants |
| US11523909B2 (en) | 2019-12-17 | 2022-12-13 | Warsaw Orthopedic, Inc. | In-situ additive implants |
| US11903846B2 (en) | 2019-12-17 | 2024-02-20 | Warsaw Orthopedic, Inc. | In-situ additive expandable implants |
| US11903841B2 (en) | 2020-06-22 | 2024-02-20 | Warsaw Orthopedic, Inc. | In-situ additive channeled implants |
| US11964074B2 (en) | 2019-12-17 | 2024-04-23 | Warsaw Orthopedic, Inc. | Additive-manufactured non-woven fibrous implants, systems, and related methods |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3984501A1 (en) * | 2020-10-14 | 2022-04-20 | Warsaw Orthopedic, Inc. | Additive-manufactured non-woven fibrous implants, systems, and related manufacturing methods |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103302860A (en) * | 2013-06-08 | 2013-09-18 | 王健犀 | Light-curing three-dimensional printer based on digital light processing (DLP) projection |
| CN103331913A (en) * | 2013-07-25 | 2013-10-02 | 陕西恒通智能机器有限公司 | Settling-type 3D (3-dimensional) printing and forming machine |
| US20140031967A1 (en) * | 2012-07-30 | 2014-01-30 | 6598057 Manitoba Ltd. | Method and system for rapid prototyping of complex structures |
| US20140061974A1 (en) * | 2012-08-29 | 2014-03-06 | Kenneth Tyler | Method and apparatus for continuous composite three-dimensional printing |
| CN103948456A (en) * | 2014-04-22 | 2014-07-30 | 上海大学 | Automatic control turntable pneumatic multi-sprayer biological 3D (three dimensional) printing forming system and method |
| KR101430582B1 (en) * | 2014-01-17 | 2014-08-21 | 비즈텍코리아 주식회사 | 3D printer with extruder including multi feeder and rotable multi nozzle and thereof operating method |
| CN203829093U (en) * | 2014-04-18 | 2014-09-17 | 清华大学 | Three-dimensional print forming device for tough tissue structures |
| CN104224405A (en) * | 2014-09-03 | 2014-12-24 | 上海大学 | Composite turntable pneumatic multi-spray-head biological 3D (three-dimensional) printing forming system and method |
| CN204092271U (en) * | 2014-10-28 | 2015-01-14 | 深圳迈普再生医学科技有限公司 | A kind of biological 3D printing equipment |
| CN104401007A (en) * | 2014-10-15 | 2015-03-11 | 合肥海闻自动化设备有限公司 | Three-dimensional color inkjet additive printer |
-
2015
- 2015-03-30 CN CN201510143867.7A patent/CN104688388B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140031967A1 (en) * | 2012-07-30 | 2014-01-30 | 6598057 Manitoba Ltd. | Method and system for rapid prototyping of complex structures |
| US20140061974A1 (en) * | 2012-08-29 | 2014-03-06 | Kenneth Tyler | Method and apparatus for continuous composite three-dimensional printing |
| CN103302860A (en) * | 2013-06-08 | 2013-09-18 | 王健犀 | Light-curing three-dimensional printer based on digital light processing (DLP) projection |
| CN103331913A (en) * | 2013-07-25 | 2013-10-02 | 陕西恒通智能机器有限公司 | Settling-type 3D (3-dimensional) printing and forming machine |
| KR101430582B1 (en) * | 2014-01-17 | 2014-08-21 | 비즈텍코리아 주식회사 | 3D printer with extruder including multi feeder and rotable multi nozzle and thereof operating method |
| CN203829093U (en) * | 2014-04-18 | 2014-09-17 | 清华大学 | Three-dimensional print forming device for tough tissue structures |
| CN103948456A (en) * | 2014-04-22 | 2014-07-30 | 上海大学 | Automatic control turntable pneumatic multi-sprayer biological 3D (three dimensional) printing forming system and method |
| CN104224405A (en) * | 2014-09-03 | 2014-12-24 | 上海大学 | Composite turntable pneumatic multi-spray-head biological 3D (three-dimensional) printing forming system and method |
| CN104401007A (en) * | 2014-10-15 | 2015-03-11 | 合肥海闻自动化设备有限公司 | Three-dimensional color inkjet additive printer |
| CN204092271U (en) * | 2014-10-28 | 2015-01-14 | 深圳迈普再生医学科技有限公司 | A kind of biological 3D printing equipment |
Non-Patent Citations (2)
| Title |
|---|
| 张维杰等: "基于3-D打印技术的软骨修复及软骨下骨重建", 《中国修复重建外科杂志》 * |
| 王镓垠等: "人体器官3D打印的最新进展", 《机械工程学报》 * |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105342726A (en) * | 2015-08-21 | 2016-02-24 | 郭开今 | 3D (three-dimensional) printing micropore inlaying type bone grain |
| US11864795B2 (en) | 2017-04-02 | 2024-01-09 | Mazor Robotics Ltd. | Three dimensional robotic bioprinter |
| EP4000551A1 (en) | 2017-04-02 | 2022-05-25 | Mazor Robotics Ltd. | Three dimensional robotic bioprinter |
| CN108788158A (en) * | 2018-08-28 | 2018-11-13 | 铜仁市人民医院 | A kind of hyperbaric oxygen chamber 3D printing equipment |
| US11964074B2 (en) | 2019-12-17 | 2024-04-23 | Warsaw Orthopedic, Inc. | Additive-manufactured non-woven fibrous implants, systems, and related methods |
| US11903846B2 (en) | 2019-12-17 | 2024-02-20 | Warsaw Orthopedic, Inc. | In-situ additive expandable implants |
| US11523916B2 (en) | 2019-12-17 | 2022-12-13 | Warsaw Orthopedic, Inc. | In-situ additive implants |
| US11523909B2 (en) | 2019-12-17 | 2022-12-13 | Warsaw Orthopedic, Inc. | In-situ additive implants |
| US11903841B2 (en) | 2020-06-22 | 2024-02-20 | Warsaw Orthopedic, Inc. | In-situ additive channeled implants |
| CN112976581A (en) * | 2021-04-08 | 2021-06-18 | 重庆大学 | Trajectory planning method based on multi-axis cartilage repair |
| CN113274172A (en) * | 2021-04-29 | 2021-08-20 | 重庆大学 | Multi-view fusion-based cartilage repair operation robot platform system |
| CN113499170B (en) * | 2021-07-09 | 2023-12-22 | 中国人民解放军陆军军医大学第一附属医院 | Articular cavity cartilage 3D printing unit and printing equipment thereof |
| CN113499170A (en) * | 2021-07-09 | 2021-10-15 | 中国人民解放军陆军军医大学第一附属医院 | Articular cavity cartilage 3D printing unit and printing equipment thereof |
| CN113927696A (en) * | 2021-08-30 | 2022-01-14 | 广东电网有限责任公司广州供电局 | Sand table 3D printer |
| CN114505500A (en) * | 2021-12-21 | 2022-05-17 | 江苏靖宁智能制造有限公司 | Multi-gun collaborative material increase device with real-time adjustable distance, posture and height |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104688388B (en) | 2016-08-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104688388A (en) | 3D (three-dimensional) printing technique-based cartilage repair system and method | |
| Wang et al. | Application of 3D printing in implantable medical devices | |
| CN107823714B (en) | Forming system for preparing tissue engineering osteochondral scaffold and biological 3D printing forming method | |
| CN103919629B (en) | A kind of toughness organizational structure and 3D printing-forming equipment thereof and method | |
| CN107028681B (en) | A kind of 3D printing device and method of tissue engineering bracket | |
| CN107296983B (en) | System and method for constructing three-dimensional micro-nano-scale prefabricated blood vessel network of bone tissue | |
| CN104924614B (en) | Towards the biological 3D printing shower nozzle of rotating switching type and its method of many file printings | |
| CN105997306A (en) | Design method for filling porous grid structure in bone implantation body | |
| GB2504679A (en) | Bone substitute structure and material | |
| CN109966026B (en) | Preparation method of functional gradient artificial bone scaffold based on curve interference | |
| CN102552981A (en) | Method for preparing tissue-engineered bone/cartilage integrated scaffold | |
| CN102846408B (en) | Metallic granular body for bone-grafting filling | |
| CN108404205A (en) | A kind of biological 3 D printing preparation method thereof of the load anti-inflammatory Meniscus scaffold of cartilage cell | |
| CN101332313B (en) | Bracket for regenerating decalcification cortical-bone articular cartilage with vertical drill and preparation method thereof | |
| CN204581601U (en) | Based on the cartilage repair systems of 3D printing technique | |
| CN108201632A (en) | A kind of articular cartilage repaiies scaffold | |
| Dong et al. | Robotic-assisted automated in situ bioprinting | |
| CN109472096B (en) | Implant design method combining macroscopic topology optimization and microscopic topology optimization | |
| CN201154961Y (en) | Bioreactor applying rolling load and sliding load | |
| CN102599989A (en) | Multiple-material-source conveying single-nozzle injection device for three-dimensional controlled cell assembling machine | |
| CN108201634A (en) | A kind of joint repair stent | |
| CN101822851B (en) | Preparation method of tissue engineered bone cartilage frame | |
| Wang et al. | Robotics-driven printing of curved 3D structures for manufacturing cardiac therapeutic devices | |
| CN105067465B (en) | A kind of double acting platform parallel connected bionic hip joint tester and its test method | |
| CN104990864A (en) | Biomaterial physiological load external load simulator and test method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |