CN104684626A - Purified air and methods of making and using the same - Google Patents

Purified air and methods of making and using the same Download PDF

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Publication number
CN104684626A
CN104684626A CN201380049008.0A CN201380049008A CN104684626A CN 104684626 A CN104684626 A CN 104684626A CN 201380049008 A CN201380049008 A CN 201380049008A CN 104684626 A CN104684626 A CN 104684626A
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China
Prior art keywords
air
particle
filter
vitro fertilization
voc
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CN201380049008.0A
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Chinese (zh)
Inventor
凯瑟琳·C·沃里洛
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Lifeaire System Co Ltd
LifeAire系统有限责任公司
LifeAire Systems LLC
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Lifeaire System Co Ltd
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Priority claimed from US13/554,366 external-priority patent/US20120283508A1/en
Application filed by Lifeaire System Co Ltd filed Critical Lifeaire System Co Ltd
Publication of CN104684626A publication Critical patent/CN104684626A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/16—Disinfection, sterilisation or deodorisation of air using physical phenomena
    • A61L9/18—Radiation
    • A61L9/20—Ultraviolet radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/34—Chemical or biological purification of waste gases
    • B01D53/38—Removing components of undefined structure
    • B01D53/44—Organic components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/34—Chemical or biological purification of waste gases
    • B01D53/74—General processes for purification of waste gases; Apparatus or devices specially adapted therefor
    • B01D53/81—Solid phase processes
    • B01D53/82—Solid phase processes with stationary reactants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2251/00—Reactants
    • B01D2251/10—Oxidants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2253/00—Adsorbents used in seperation treatment of gases and vapours
    • B01D2253/10—Inorganic adsorbents
    • B01D2253/102—Carbon
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2257/00—Components to be removed
    • B01D2257/70—Organic compounds not provided for in groups B01D2257/00 - B01D2257/602
    • B01D2257/708—Volatile organic compounds V.O.C.'s
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2257/00—Components to be removed
    • B01D2257/91—Bacteria; Microorganisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2259/00—Type of treatment
    • B01D2259/45—Gas separation or purification devices adapted for specific applications
    • B01D2259/4508—Gas separation or purification devices adapted for specific applications for cleaning air in buildings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2259/00—Type of treatment
    • B01D2259/45—Gas separation or purification devices adapted for specific applications
    • B01D2259/4533—Gas separation or purification devices adapted for specific applications for medical purposes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2259/00—Type of treatment
    • B01D2259/80—Employing electric, magnetic, electromagnetic or wave energy, or particle radiation
    • B01D2259/804—UV light

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental & Geological Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
  • Filtering Materials (AREA)

Abstract

Purified air is provided, having a TVOC content of from less than 5 ppb to about 500 ppb, a Biologicals content of from less than 1 CFU/M3 to 150 CFU/M3 and a Particulate content of from about 1,000 0.3 mum particles per ft3 to about 50,000 0.3 mum particles per ft3, or from about 600 0.5 mum particles per ft3 to about 500,000 0.5 mum particles per ft3.

Description

Purify air and production and preparation method thereof
Specification
Background of the present invention
This PCT application is 13/554 according to U.S.'s bill the 35th volume the 120th article of U.S. Patent Application No. requiring on July 20th, 2012 to submit to, the rights and interests of 366, this U.S. Patent application is the application number submitted on September 26th, 2011 is 13/244, the cip application of the U.S. Patent application of 973, and application number is 13/244, the continuity case of the U.S. Patent application of 973 to be the patent No.s submitted on March 26th, 2010 the be U.S. Patent application of 12/732,246.The priority of the international application no submitted on March 23rd, 2011 to be the application requirement patent No. of PCT/US2011/029567 the be U.S. Patent application of 12/732,246.
2. background technology
(" IVF ") in vitro fertilization is the program that a kind of egg cell is fertilized in laboratory environments, instead of in uterus.If egg cell successful fertilization, then can successfully transfer in the uterus of the patient wishing pregnancy.
Patient for suffering from infertility in vitro fertilization is one and effectively selects, especially when the method failure of other supplementary reproductions.But, in vitro fertilization very expensive, and usually can not enjoy medical insurance.2009, in the U.S., the cost in single cycle in vitro fertilization was approximately 10,000 to 15,000 dollar.For most people, repeatedly their financial resources that allow in vitro fertilization are unable to stand.Therefore, public domain is become to optimize embryo before implantation imperative, so that by successful maximization.
The epochmaking factor affecting the probability of success before Embryonic limb bud cell is the air quality in laboratory in vitro fertilization.The gamete grown in vitro and the impact of embryo on environment extremely sensitive.Human embryos cannot filter environment virus and pathogen and protect oneself.They are subject to controlling of environment completely.A certain proportion of room air is often comprised in human embryonic incubator.Although the pollutant in air has adverse effect to embryo, in past 30 years, seldom emphasize that the laboratory in vitro fertilization of Optimal Experimental room air quality has been widely used in treatment infertile.
Existing filter plant is inadequate for the optimization of the air quality of real acceptable level in vitro fertilization.Such as, only in fact poorer than the air quality of outdoor through the Laboratory air of High Efficiency Particulate Air (" HEPA ") filter process.In addition, some filter can produce byproduct or in fact to the air quality in laboratory in vitro fertilization other pollutants prejudicial.Such as, active carbon filter can produce the carbon dust harmful to extracorporeal fertilization process.But this is not that active carbon filter or High Efficiency Particulate Air filter shall not be applied to the process of the air supply in laboratory in vitro fertilization.On the contrary, active carbon filter or High Efficiency Particulate Air filter or its respective equivalent are included in the filtering medium supplied for Laboratory air in vitro fertilization.The optimization that the space of laboratory or other base closeds realizes air quality of being fertilized in vitro requires correct selection, and in conjunction with the order-checking of various filter medium.
1. technical field
The present invention relates to a kind of equipment of filtering and purifying air and method.Particularly, a kind of purification of the air quality level to the extremely sensitive environment of air pollutants is related to, such as laboratory in vitro fertilization or other medical environments.In addition, the present invention is applicable to the environment of base closed, includes but not limited to family, commercial building, hotel, automobile, public transport, train, aircraft, pleasure-boat, educational alternative, office, government building.The present invention is also applied to, such as national security, national defence, or the industry such as airline.
Summary of the invention
Therefore the present invention provides highly purified air feature and manufacture and uses the method for this air.
An aspect of of the present present invention provides a kind of air, and it is characterized in that the content of TOVC is by being less than 5ppb to about 500ppb, biological content is by being less than 1CFU/M 3to 150CFU/M 3with particle content from every cubic feet about 1,0000.3 μm to 50,0000.3 μm, or from every cubic feet about 6000.5 μm to about 500,0000.5 μm.
Another aspect of the present invention realizes the method that Clinical pregnancy rate in vitro fertilization is at least 50%.The method be included in air characteristics be the content of TOVC from being less than 5ppb to about 500ppb, biological content is by being less than 1CFU/M 3to 150CFU/M 3with particle content from every cubic feet about 1,0000.3 μm to 50,0000.3 μm, or perform repeatedly circulation in vitro fertilization from the laboratory in vitro fertilization of every cubic feet about 6000.5 μm to about 500,0000.5 μm.
Another aspect of the present invention is a kind of method purified air, comprise and provide a kind of air that makes by the inlet air flow path of a housing flow further downstream, by the prefilter filtered air of the oxidation in housing and absorbing volatile organic compound, by the vacuum ultraviolet metre filter air that the prefilter downstream of housing internal oxidition and absorbing volatile organic compound is arranged, with by final particulate filter filtered air that the vacuum ultraviolet filter downstream in housing is arranged.
Accompanying drawing explanation
Describe the present invention below in conjunction with accompanying drawing, wherein identical label represents identical element:
Fig. 1 is the top view according to air purifier of the present invention.
Fig. 2 is the side view according to air purifier of the present invention.
Fig. 3 is the sectional view along the air purifier of hatching A-A in Fig. 1.
Fig. 4 is the sectional view along the air purifier of B-B hatching in Fig. 2.
Detailed description of the invention
Referring now to the details of each figure of air purifier 2 according to the present invention, wherein similar reference number refers to identical parts, as shown in the top view of Fig. 1 and 2 and side view.Air purifier 2 comprises cuboid shell 4, and it has an entrance 6, so that admission of air, also has an outlet 8 and is convenient to discharge air." air " is used for referring to widely gas or the admixture of gas that can be breathed and/or can be used as by laboratory in vitro fertilization source of the gas by animal safety.Shell 4 is that the air flowing in downstream provides a flow path, such as, flows to outlet 8 from entrance 6." shell " refers to any pipeline, chamber and/or enclosing in inlet air flow path, or the multiple pipelines, chamber and/or the enclosing that are coupled with miscellaneous part.Therefore, " shell " comprises, such as, and existing heat supply, heating ventilation and air-conditioning (" HVAC ") system or air conditioner unit (" AHU ").
As illustrated in fig. 1 and 2, although shell 4 preferably cuboid, it is not limited to any special shape.In addition, can also inner curve be comprised, bending and/or other profile, wherein, inlet air flow path by along such curve, bending and/or other profile.But shown in the embodiment of shell 4 as depicted in figs. 1 and 2, preferably, inlet air flow path is straight line substantially.
Preferably, air purifier 2 is suitable for being contained in existing heat supply, ventilating and air conditioning system or air conditioner unit.In an alternative em bodiment, air purifier according to the present invention possesses the function as separate unit, a part for such as non-heat supply, ventilating and air conditioning system or air conditioner unit.Classical shell 4 is actually the about 11 feet long cuboids of 2 feet high of being 4 inches wide.This size makes to be filled the air by the air of air purifier 2 or spread, to provide enough resonance time for the air by each filter medium discussed below.It will be apparent to those skilled in the art that the shape and size parameter in above-described embodiment is only illustrate, it can change, and even substantially depends on environment for use.Such as, in some applications, air purifier 2 may be 6 feet long.
Referring now to Fig. 3, it demonstrates the sectional view along the air purifier 2 shown in Fig. 1 section line A-A.In the diagram, the internal view of the air purifier 2 shown in Fig. 2 section line B-B is illustrated.
In order to obtain the air quality of optimization, such as, be applicable to laboratory in vitro fertilization, the air processed by air purifier 2 should be preconditioning and stable, and such as, temperature and humidity condition is all gentle.It is desirable that the air that air purifier 2 processed should between 68 ℉ to 75 ℉, humidity is between 45%-55%.In addition, the air turnover rate of ventilating air clarifier 2 should be preferably about 250 feet per minute clocks, and lower than 2000CFM.This preferred amount of flow is to have enough resonance time to when flowing through each filtering medium discussed below." filter " refers to one or more airhandling equipment widely herein, such as, attract, delete, stop using and/or destroy consequent pollutant.
In order to provide by enough air turnover rates during air purifier 2, increase a booster fan 10 (always although necessary) in the downstream of entrance 6.Booster fan 10 can be connected with the control system (not shown) measuring air turnover rate, and triggers booster fan 10 when needed, to maintain the air turnover rate of expectation.(not shown) in an optional embodiment, booster fan can not be comprised, and enough air turnover rates provide by additive method and maintain, such as, inside arranges the air blast of the heat supply of air purifier 2, heating ventilation and air-conditioning (" HVAC ") system or air conditioner unit (" AHU ").
Entrance 6 downstream is particle pre-filter 12, is used for capturing the particle in air.In one embodiment, described particle pre-filter 12 is preferably about 2 inchs, comprises left folding particle pre-filter 14 and right folding particle pre-filter 16 in addition.This particle pre-filter 14 and 16, before the air of air purifier 2 discussed below arrives other filtering mediums, absorbs total particulate (such as, dust and mosquito etc.) from outside air.The adaptive filter of particle pre-filter 12 to be that to have U.S.'s heating installation and air-conditioning man IEEE average dust spot efficiency (standard 52.1) be the minimum efficiency report value (" MERV ") of 20%-80% be 5 to 13 filter.The pleated filter of the particularly preferred filter of particle pre-filter 12 to be minimum efficiency report values be 7-8, this pleated filter has the dust spot efficiency of the average 30%-45% that U.S.'s heating installation and air-conditioning man IEEE (standard 52.1) specify.
Suitable particle pre-filtering select should by can not excessive influence to absorb the total particulate needed by the gas flow rate of air purifier 2 be guiding.The type selecting of particle pre-filter depends on the pre-filtered various factors of particle, comprises outside air quality.Preferably, as Fig. 3 and Fig. 4 particle pre-filter 12 is positioned at the upstream near-end of extra filtering medium discussed below.But, alternately (or additionally), particle pre-filter should be positioned at upstream distal end, and such as, air purifier 2 is arranged on heat supply, in the piping upstream of ventilating and air conditioning system or air conditioner unit.
The downstream of particle pre-filter 12 is VOC (" VOC ") prefilters 18.One denier air is by particle pre-filter 12, then the total particle in air can be efficiently removed, otherwise will reduce effect and the service life of VOC prefilter 18.Desirable VOC prefilter comprises absorption medium, such as active carbon, and oxide isolation, such as potassium permanganate (" KMnO 4") or photocatalyst.Particularly preferably the carbon of type is cocoanut shell.In a preferred embodiment, VOC prefilter 18 is mixtures of active carbon and potassium permanganate, such as, with the ratio mixing of 50/50.In certain embodiments, described mixture may comprise other elements, such as natural zeolite.The ratio of described mixture may change according to the type of VOC in air-source and level.It is desirable that air-source is for testing VOC, and, based on test result, mixture can be configured voluntarily to remove VOC substantially under prescribed conditions.In the embodiment of the change of a VOC prefilter (not shown), have employed the filter that (such as, not mixing) separately uses active carbon and potassium permanganate.
The embodiment of the VOC prefilter 18 shown in Fig. 3 and Fig. 4 comprises 20 layers of filtration pallet 20 and 22 altogether, and the left side of its housing 4 arranges ten described pallets 20, and there are ten described pallet 22 direct neighbors on right side.The length of described pallet, such as in one embodiment, the fore-and-aft distance of air flowing, preferably 17 inches, certainly, this size can be longer or shorter.Each pallet 20,22 comprises two kinds in conjunction with carbon and potassium permanganate filter 24, and it is along the V-shaped arrangement of vertical plane (plane such as shown in Fig. 3).The arrangement of this V-type adds the surf zone of air process in filter 24, therefore improves the efficiency of VOC prefilter 18.One denier air have passed through VOC prefilter 18, and content of volatile organic compound wherein effectively reduces.
The downstream of VOC prefilter 18 is particle post-filters 26, to capture the particle in air, and the particle (such as carbon dust) such as produced by VOC prefilter 18.Particle post-filter 26 comprises left folding particle post-filter 28 and right folding particle post-filter 30.The filter filter that may use with particle pre-filter 12 that particle post-filter 26 uses is same or similar, before once discussed.When preferably, the essential features of the not all application of particle post-filter 26 is set in VOC prefilter 18 downstream.Such as, if VOC prefilter is a kind of filter that can not produce DEP driven particle capture, as in conjunction with carbon, particle post-filter is optionally.
The downstream of particle post-filter 26 is the biological pollutants that can destroy in air, in certain embodiments, is ultraviolet (" the UV ") filter 32 reducing chemical pollutant.No matter whether use particle post-filter 26, the air arriving ultraviolet filter 32 all efficiently should eliminate total particle and significantly reduce the level of VOC, not weaken effect of ultraviolet filter 32.
Ultraviolet filter can comprise one or more ultraviolet light source, preferably multiple ultraviolet light source.It is further preferred that these ultraviolet light sources are shortwave sterilizing ultraviolet sources, its UV radiation wavelength that can produce is from 220nm to 288nm.Have most choosing, described shortwave sterilizing ultraviolet source can produce the ultraviolet radiation ripple that wavelength is 260nm, but it is that it is enough for the ultraviolet radiation ripple of 260nm that commercial shortwave sterilizing ultraviolet source can produce wavelength.Its two entirety is incorporated to U.S. Patent number herein is by reference 5,833, in one various embodiments of the patent of 740 (Bu Leisi), ultraviolet filter comprises at least one VUV line source, and it can produce the radiation wavelength ultraviolet that (preferably 185nm) changes from 170nm to 220nm and at least one can produce the shortwave sterilizing ultraviolet source that UV radiation wavelength (preferably 260nm) from 220nm to 288nm changes.In this embodiment, VUV line source has been broken oxygen molecule and has been entered antozone, then reacts with the chemical pollutant be present in air, then is the chemical pollutant that odorlessness and harmless accessory substance reduce in air by continuous oxidation.The residual ozone that the VUV line source that described shortwave sterilizing ultraviolet source enters molecular oxygen by radiation and reduction produces kills the biological pollutant in air.
Ultraviolet filter 32 is as shown in Figure 3 and Figure 4 preferably " the ultraviolet biological wall " that three noxs (Sanuvox) produce.Alternatively, " the biological 30GX " that still produced by three noxs, this is the preferred model of ultraviolet filter.Described ultraviolet filter 32 comprises a pair lamp 34,36, and they have five vitalight lamps 38 (can see for not all five in figure) separately.Described ultraviolet lamp 38 preferably 60 inches long, and extending longitudinally in shell 4, therefore, it is possible to make the air time for exposure under uv irradiation maximize.In one embodiment, described vitalight lamp is shortwave sterilizing ultraviolet source, and it is the ultraviolet produced by the radiation in the ultraviolet wave-length coverage of shortwave sterilizing previously discussed.In a variable embodiment, if U.S. Patent number is 5,833, describe in the application of 740 (Bu Leisi), each lamp 38 is two-way, and it has upstream vacuum ultraviolet source and downstream shortwave sterilizing ultraviolet source.In the embodiment that is variable, the VUV line source of upstream may be, such as one can produce wave-length coverage is the mercury vapor lamp that 170nm arrives the high strength of the ultraviolet radiation of about 220nm, the shortwave sterilizing ultraviolet source in downstream may be, such as one can produce the low intensive mercury vapor lamp of radiation wavelength within the scope of 220nm to about 288nm.The ultraviolet filter 32 of inwall 44 setting-in of shell 4 is highly reflectives, preferably has the reflectance factor of at least 60%, to improve the efficiency of lamp 38.
The killing rate of biological pollutant is the shortwave sterilizing ultraviolet that produces of ultraviolet filter 32 and the radiation function reflected by the inwall of shell 4, just as this pollutant is in the shortwave sterilizing ultraviolet time for exposure.Therefore, the ultraviolet intensity of shortwave sterilizing is larger, and the time for exposure of this pollutant in shortwave sterilizing ultraviolet radiation is longer, and bactericidal level is higher.As the dependence factor of sterilization aspiration level, the space total amount of ultraviolet filter available in shell, and the cost of operation and maintenance ultraviolet filter, the desired value of the shortwave sterilizing ultraviolet output total amount of ultraviolet filter 32 is all transformable.Find in an actual embodiment, the total value of shortwave sterilizing ultraviolet output valve 33,464 μ J/cm 2to about 90,165 μ J/cm 2, the ultraviolet overall average output valve of shortwave sterilizing is about 43,771 μ J/cm 2, which provide desirable bactericidal level, give the actual restriction in cost and space.These total ultraviolet output valves of shortwave sterilizing kill numerous biological pollutants of 100%, include but not limited to, smallpox, influenza, pulmonary tuberculosis, anthrax and H1N1 virus.
Described ultraviolet filter 32 is included in shell 4, during use, is sightless to the user of air purifier 2, because directly ultraviolet exposure is harmful.Therefore whether no matter wait 38 in operation preset time, user can not see (such as, seeing air purifier 2 itself simply).When can not guarantee ultraviolet filter whether true(-)running, can not think that air purifier 2 can destroy the biological and chemical pollutant in air effectively.Therefore, preferably, the present invention includes sensor and monitor (not shown) how long to use and each ultraviolet lamp 38 started in the specific time to detect respectively and to show each ultraviolet lamp 38.Described monitor can comprise, and such as, rolling digital dock, it shows the length of the operating time of each lamp 38.When described sensor and monitor can replace arbitrary lamp 38 by indicating user.
As general item, the moisture in shell 4 can make biological pollutant grow.Correspondingly, preferably, shortwave sterilizing ultraviolet source is comprised at the areas adjacent of moisture generation and gathering.May there be one or more cooling coil (not shown) the upstream of such as particle pre-filter 12 to help the temperature conditions ensureing the air processed by air purifier 2 to be gentle.This cooling coil easily produces moisture.Therefore preferably a shortwave sterilizing ultraviolet source is comprised in the place of contiguous this cooling coil.Similarly, it is suitable that the upstream near-end entering the filter/diffuser (not shown) in base closed space at air comprises a shortwave sterilizing ultraviolet, and such as, one is left the laboratory in vitro fertilization after air purifier 2 or other rooms.
The downstream of ultraviolet filter 32 is VOC post-filters 46, and it is caught, such as, irradiated the VOC byproduct of generation by ultraviolet filter 32.The possible embodiment of VOC post-filter 46 comprise discussed above any one about VOC prefilter 18.VOC post-filter 46 shown in Fig. 3 and Fig. 4 comprises along the horizontal plane the left VOC post-filter 48 of (such as plane shown in Fig. 4) V-type arrangement and right VOC post-filter 50.The same item of VOC post-filter 48 and 50 and its upstream is similar, preferably adopts in conjunction with carbon and potassium permanganate.Although VOC post-filter 46 is preferred version in some applications, it also can not be arranged or omit.
Gamete and human embryos are extremely sensitive to VOC, although its total amount is negligible in other application.Therefore, the removal efficiency entering the VOC carried out in surrounding air in vitro fertilization is very necessary to removing for voc filter device (prefilter 18 and post-filter 46).Correspondingly, preferably, fertilization laboratory arranges one or more sensor (not shown) detecting VOC level in real time in vitro, and is connected to display (not shown) to be shown to the level of the VOC in interior laboratory of fixing time.There is the detection of so indoor VOC, the user of air purifier 2 just knows when go to replace VOC prefilter 18 and post-filter 46, and/or the need of another kind of type or whether merge voc filter device and be more suitable for.When indoor VOC detection is used in particular for laboratory in vitro fertilization, be helpful to any VOC level of environmental requirement.
The downstream of VOC post-filter 46 captures the ultimate particulate filter 52 leaving nearly all remainder particulate in the air of outlet 8.This ultimate particulate filter 52 preferably comprises the filter of one or more fine particle that can catch in air, such as, there is the filter that minimum efficiency report value is 13 or larger than U.S. heating installation and air-conditioning man IEEE average dust spot efficiency (standard 52.1) 80%.It is further preferred that it is 16 or larger than U.S. heating installation and air-conditioning man IEEE average dust spot efficiency (standard 52.1) 95% that this filter has minimum efficiency report value.Most preferably, this filter has minimum efficiency report value to be 17 or to be greater than U.S.'s heating installation and air-conditioning man IEEE average dust spot efficiency (standard 52.1) 99.97%, thus accomplishes High Efficiency Particulate Air (" HEPA ") filter.In addition, ultralow particulate air (" ULPA ") filter is applicable.The filter of final particulate filter is selected to lead by keeping the potential rival demand of best air turnover rate and the efficient particle removed in air.
Final particulate filter 52 shown in Fig. 3 and Fig. 4 comprises the left High Efficiency Particulate Air filter 54 of 12 inchs and right High Efficiency Particulate Air filter 56.Preferably, manometric magnetic spiral (not shown) is arranged on the upstream and downstream of High Efficiency Particulate Air filter 54 and 56, to measure the pressure drop by filter.Pressure drop degree aid identification is changed High Efficiency Particulate Air filter 54 and 56 or other are used for opportune moment of final particulate filter.
The downstream of final particulate filter 52 is atomizing humidifiers 58.The whether necessary or inessential device requirement depending on air purifier 2 of this humidifier 58.If but an atomizer 52 is needs, it must be arranged on the downstream of final particulate filter 52, so that moisture can not affect VOC post-filter 48 and 50, High Efficiency Particulate Air filter 54 and 56 or other performances for final particulate filter.Humidifying air can regulate and the growth of biological pollutant.Correspondingly, if use the extra shortwave sterilizing ultraviolet source (not shown) of humidifier 58 to destroy pollutant.This extra shortwave sterilizing ultraviolet source should be arranged on the downstream of humidifier 58, preferably, should be located at the pipeline of the last point before entering air purifier chamber.
As previously mentioned, high-purity will be produced according to air purifier of the present invention, be applicable to the extremely sensitive environment of air pollutants, the such as air of laboratory in vitro fertilization or other medical environments.This shows, air purifier according to the present invention is not limited in vitro fertilization or other medical applications.He may be applicable to the environment of any base closed, includes but not limited to, house, residential building, Business Building, hotel, automobile, bus, train, aircraft, pleasure boat, educational alternative, office and government building.The present invention also can apply as such as, national security, national defence or aircraft industry.The expectation purity of air changes according to application and environment.According to air purifier of the present invention, such as, describe in detail above, the purity level reaching expectation can be applicable to.The inaccessiable aeroscope of former equipment is provided according to the sequence of air filtering medium in air purifier provided by the invention and type.
Therefore, another aspect of the present invention comprises and purifying air, such as, adopt aforementioned air clarifier to purify air.Ideally, this purifying air has high cleanliness, and it is characterized by three measurement parameters: (a) " VOC ", the total amount of such as VOC, is characterized by unit " ppb " or every parts per billion (ppb); (b) " living beings ", such as, biological pollutant, comprises spore, is measured by the colony forming unit of " CFU/M3 " or every cubic metre; And (c) " particle ", such as, every cubic feet of population comprised, such as nominal size is 0.3 μm or 0.5 micron.
The content of TOVC can be measured, such as, by grey wolf sensing solution, model is: photoionization detector (" PID ") the detection toxic gas of TG-502, sensor uses the lamp of 10.6 electron-volts to calibrate isobutene.The lower limit using TG-502 toxic gas detector monitoring TOVC is 5ppb.
In order to ensure precision, measuring biological content and preferably using two kinds of complementary methods to assess.According to the first method measuring biological content, the vavuum pump of the high volume of extraction per minute 15 liters of normal airs is adopted to carry out draw ambient air (such as, tested air) to the sampling instrument extracting spore.Continue 10 minutes like this, then the air ading up to 150 liters will be extracted by spore sampling pump.Then whether the biological pollutant of some Selective type of qualification is observed with CFU/M by orthoscope 3progression exist.The method that the second measures biological content is, uses the sampler of spore sampling instrument N6 to obtain educable air sample (test environment air) in three kinds of media: m alt extract agar, cellulose agar and DG-18 agar.In the sampling time that this sampler calibrates 5 minutes extraction per minute 28.3 liters in advance with delayed collection.Adopt second method to measure biological content and can determine that in three kinds of dissimilar growth media, any biological content is CFU/M 3unique identification.
Also can carry out particle test, such as, use U.S.'s Handheld laser corpuscular counter that model is TSI AEROTRAK 9306.This corpuscular counter is preferably calibrated by National Institute of Standards and Technology, and its source adopts the classification of Technical Sourcing Internation of the U.S. and the measurement unit of condensation particle counter, and this is particle measurement the recognized standard.Particle concentration in air, with the nominal particle diameter 0.3 μm of every cubic feet, 0.5 μm, 1.0 μm, 3.0 μm, 5.0 μm, is measured for 10.0 μm.
In a preferred embodiment, expect to adopt above-mentioned air purifier to purify air, it is characterized in that: (a) is less than the TOVC content (or by grey wolf sensing solution, lower than Monitoring lower-cut value when the toxic gas detector of TG-502 type photoionization detector or measurement function other Equipment Inspections similar with tolerance) of 5ppb; B () biomass content is less than 1CFU/M 3the Monitoring lower-cut value of aforementioned biological quality detection method or other measuring abilities method similar with tolerance (or lower than); And (c) particle content is containing having an appointment 1,0000.3 μm to about 10, the particle of 5000.3 μm in every cubic foot of air, or containing having an appointment 6000.5 μm to about 1, the particle of 0000.5 μm in about every cubic foot of air.
The acceptable level of TOVC, living beings and particle changes according to application scenario or environment.Such as, in one embodiment, the feature purified air may be: the content of (a) TOVC is less than 5ppb to about 500ppb; B () biomass content is less than 1CFU/M 3to 150CFU/M 3, and (c) particle content is containing having an appointment 1,0000.3 μm to about 50, the particle of 0000.3 μm in every cubic foot of air, or containing having an appointment 6000.5 μm to about 500, the particle of 0000.5 μm in every cubic foot of air.How preferred particle content is containing having an appointment 1,0000.3 μm to about 30, the particle of 0000.3 μm from about every cubic foot of air, or containing having an appointment 6000.5 μm to about 10, the particle of 0000.5 μm in every cubic foot of air.Particularly preferred particle content is containing having an appointment the particle of 1,0000.3 to about 10,5000.3 μm in every cubic foot of air, or containing having an appointment 6000.5 μm to about 1, the particle of 0000.5 μm in every cubic foot of air.
The present invention also comprises on the other hand for laboratory in vitro fertilization provides the air of purification, to improve Clinical pregnancy rate in vitro fertilization and/or implantation rate.Described Clinical pregnancy rate refers to that intrauterine fetal has fetal rhythm.Described implantation rate refers to that single embryo enters uterus and grows for fetus fetal rhythm.A kind of method of the present invention may comprise providing and purifies air, the air that such as preceding feature is following: according to the test of the minimum patient group to 20 patients, for laboratory in vitro fertilization, to perform in laboratory repeatedly circulate in vitro fertilization, and to reach Clinical pregnancy rate be 50% or higher, and/or implantation rate is 35% or higher.In one embodiment, expect that the Clinical pregnancy rate that reaches is 50%-70% and preferably 60%-70%.In another embodiment, the implantation rate of expection is 35%-40%.
Each aspect of the present invention will describe in further detail in following example, but it should be understood that and the invention is not restricted to these examples.
example
The air purifier before described, the average national level of Clinical pregnancy rate is about 38%.Man and wife's test in vitro fertilization of usually having had to repeatedly is just able to pregnancy, because overall success is relatively on the low side.As previously discussed, the cost of single experiment in vitro fertilization is high, and the cost of repeatedly experiment circulation in vitro fertilization simply highly must allow people hang back.Therefore, before about 30 years of appearance in vitro fertilization-with regard to there being strong and long-term needs to go significantly to improve Clinical pregnancy rate in vitro fertilization so as to infertile patient have the ability select in vitro fertilization.
The air purifier of the present invention before described, even if its inventor finds to adopt existing filtration system to filter air, the air quality in laboratory in vitro fertilization is still unfavorable for the successful growth of embryo.The air quality of necessity that other human embryos that can not provide support of existing air filtration are become pregnant, therefore can not obviously improve clinical efficacy in vitro fertilization.In addition, existing air filtering system can not improve the pollutant levels from ambient air source, therefore cannot protect the air in laboratory in vitro fertilization.Such as, if neighbouring road or roof just spread pitch, poisonous chemical substance release also may enter in source air and laboratory in vitro fertilization, therefore have impact on the development of embryo.
Being described air purifier below provides to air the example significantly improved, and it presents unresolved and be the surprised and unexpected result of another people of the problem meeting human demand for a long time.These examples comprise the air purifier in existing air cleaning system, comprise system and Zandair system.Described system and Zandair system are at least the major air filtration systems for laboratory in vitro fertilization in past 10 years.
example 1
One embodiment of air purifier described herein is arranged on laboratory in vitro fertilization test station.Before installation, this laboratory employs two covers system.Often overlap system comprises from upstream successively to downstream: (1) particulate filter; (2) active carbon and potassium permanganate filter; And (3) High Efficiency Particulate Air filter.Before the embodiment adopting above-mentioned air cleaner, the Clinical pregnancy rate in laboratory is 36.4%, and it is close to average national level 38%.Be contained in the embodiment of the described air cleaner in laboratory, comprise successively to downstream from upstream: (1) particulate filter (being positioned at the upstream of air conditioner unit); (2) active carbon and potassium permanganate filter; (3) ultraviolet filter; (4) active carbon and potassium permanganate filter; (5) High Efficiency Particulate Air filter.In the embodiment of this air purifier of assembling, the Clinical pregnancy rate in laboratory reaches 67.4%, and this result is the seminar based on 191 patients, which show clinical efficacy and patient care aspect significantly, result that another people is surprised.
Measure the implantation rate of " before " and " afterwards " in laboratory in vitro fertilization.Before the air purifier of assembling described in previous embodiment, the implantation rate in laboratory is 21% and the average level in the whole nation is 26.1%.After the air purifier of assembling described in previous embodiment, the implantation rate that laboratory in vitro fertilization test station measures is increased to 39%, these data based on 191 patients group-which represent clinical efficacy and patient care aspect is significant and amazing result.Significantly improving of implantation rate allows laboratory to provide less embryo for every patient, and therefore the probability of multifetation reduces (such as, twins, triplet etc.) and improves the overall curative effect of obstetrics.
In a word, the remarkable improvement in Clinical pregnancy rate and implantation rate shows that the air purifier described in previous embodiment compared with prior art can reach beyond thought effect, and can meet the demand be not satisfied for a long time.
example 2
Three forms below provide from independently third party about the test data of the air quality in laboratory in vitro fertilization.These three groups of forms possess following collective term: (1) " source air "-entering the air advancing into laboratory in vitro fertilization of respective filtration system; (2) surrounding air in " IVF laboratory "-laboratory in vitro fertilization; (3) " TVOC "-TOVC, measures with unit " ppb " or parts per billion (ppb); (4) " living beings "-biological pollutant, comprises spore, and measurement unit is " CFU/M 3", or the CFU of every cubic metre; And (5) " particle "-every cubic feet nominal size comprised is the population of 0.3 μm or 0.5 micron.More than measure and use measurement mechanism mentioned above and technology to carry out.
table 1
IVF laboratory
Use two Coda air filtering systems
Table 1 compared for source air and through two the air quality in the laboratory in vitro fertilization of board filtration system process, as described in earlier examples 1.Table 1 shows, and in fact the air in laboratory in vitro fertilization contains more TOVC and biological pollutant (comprising spore) compared with the air of source.Only that the content of particle in laboratory in vitro fertilization declines to some extent than source air.
table 2
IVF laboratory
Use three Zandair air cleaners
Table 2 compared for the air quality in source air and the laboratory in vitro fertilization through the process of three Zandair air cleaners.Each Zandair system comprises from upstream to downstream: (1) active carbon filter; (2) High Efficiency Particulate Air filter; And (3) photochemical catalytic oxidation ultraviolet filter.As shown in table 2, in fact the air in laboratory in vitro fertilization contains more TOVC and biological pollutant (comprising spore) than in the air of source.Comparatively speaking, be only that granule content in laboratory in vitro fertilization decreases than source air.
table 3
IVF laboratory
Use the air purifier of inventor in a previous embodiment
Table 3 compared for the air quality in source air and the laboratory in vitro fertilization through the air purifier process described in an embodiment of the present invention.Air purifier in previous embodiment, is from upstream to downstream and comprises: (1) particulate filter (upstream at air conditioner unit); (2) active carbon/potassium permanganate filter; (3) ultraviolet filter; (4) active carbon/potassium permanganate filter; (5) High Efficiency Particulate Air filter.As shown in Table 3, with table 1 through two board filtration system is different through the result of the air quality of three Zandair systems process with table 2, the process of the air purifier described in single previous embodiment all significantly can improve air quality on three measurement parameters, such as, (1) TOVC; (2) living beings; And (3) particle.
board filtration system and Zandair system are that at least last decade is interior at first for the filtration system in laboratory in vitro fertilization.Table 1, the third party autonomous test data provided in 2 and 3 show, significant air purifier with before at least ten years at first for laboratory in vitro fertilization air filtering system compared with can significantly improve aeroscope.The aeroscope effect produced by described air purifier makes us pleasantly surprised.As aforementioned exemplary 1 be shown in and improve Clinical pregnancy rate and implantation rate aspect Be very effective, thus air purifier as herein described creates purer air.
Generally speaking, example 1 and 2 shows at three parameter-TOVCs, perform in the air ambient of the purification of living beings and particle-sign in vitro fertilization unexpectedly and considerably improve Clinical pregnancy rate in vitro fertilization and implantation rate.In addition, in vitro fertilizationly 30 years have been present in nearly, and system and Zandair system as at least last decade at first for the filtration system in laboratory in vitro fertilization, it is fertilized in vitro and has long-term needs and unsatisfied target in other application.Air purifier of the present invention needs under just in time meeting this.
example 3
The test station in laboratory of being fertilized in vitro assembles the product described in an embodiment of air purifier as herein described.This embodiment, from upstream to downstream direction, comprising: (1) particulate filter (being positioned at the upstream of air conditioner unit); (2) active carbon and potassium permanganate filter; (3) ultraviolet filter; (4) active carbon and potassium permanganate filter; And (5) High Efficiency Particulate Air filter.
The catastrophic burden of VOC is the building dropping into place, laboratory in vitro fertilization.Particularly, contractor on the floor in the room in contiguous laboratory in vitro fertilization in large area bedding floor glue time.This floor glue comprises the dimethylbenzene of 10% and the acetone of 40%.Dimethylbenzene and acetone all have very high embryotoxicity.Member under this air outside laboratory in vitro fertilization there will be the headache of feeling sick with strong, and the air purifier described in previous embodiment can protect the member in embryo and laboratory in vitro fertilization.Although the TOVC test before accident and in its process show in the air outside next-door neighbour laboratory containing more than 6000ppb TOVC-this is that the level of TOVC in a high level-laboratory can not change.
In a word, the remarkable and amazing effect of the air purifier of the applicant as described in example 1,2 and 3 is unexpected and surprising concerning inventor, and this is also pleasantly surprised with beyond thought to one skilled in the art.It is how to meet improving a long-term problem needing also always not to be solved in purification of air that these examples also help to demonstrate applicant's air purifier, and the improvement of this purification of air to Clinical pregnancy rate and implantation rate is very significant.
Be detailed above the present invention and its instantiation, obviously, for a person skilled in the art, variations and modifications can not depart from the scope of the present invention and thought.

Claims (19)

1. the air of purification, is characterized in that:
A. the content of TOVC is less than 5ppb to about 500ppb;
B. biomass content is less than 1 CFU/M 3to 150 CFU/M 3; And
C. particle content is about 1,000 0.3 μm of particle/cubic feet to about 50,000 0.3 μm of particle/cubic feet, or from about 600 0.5 μm of particle/cubic feet to about 500,000 0.5 μm of particle/cubic feet.
2. purify air as claimed in claim 1, it is characterized in that: the content of TOVC is less than 5ppb, biomass content is less than 1 CFU/M 3and particle content is from 1,000 0.3 μm of particle/cubic feet to about 10,500 0.3 μm of particle/cubic feet, or from about 600 0.5 μm of particle/cubic feet to about 1,000 0.5 μm of particle/cubic feet.
3. reach the method for Clinical pregnancy rate at least 50% in vitro fertilization, the method is included in the laboratory in vitro fertilization with air and carries out repeatedly circulation in vitro fertilization, it is characterized in that:
A. the content of TOVC is from being less than 5ppb to about 500ppb;
B. biomass content is from being less than 1 CFU/M 3to 150 CFU/M 3; And
C. the particle content in air from about 1,000 0.3 μm of particle/cubic feet to about 30,000 0.3 μm of particle/cubic feet, or from about 600 0.5 μm of particle/cubic feet to about 10,000 0.5 μm of particle/cubic feet.
4. method as claimed in claim 3, is characterized in that: Clinical pregnancy rate in vitro fertilization is 50% to 70%.
5. method as claimed in claim 3, is characterized in that: Clinical pregnancy rate in vitro fertilization is 50% to 65%.
6. method as claimed in claim 3, is characterized in that: Clinical pregnancy rate in vitro fertilization is 55% to 70%.
7. method as claimed in claim 3, is characterized in that: Clinical pregnancy rate in vitro fertilization is 55% to 65%.
8. reach the method for Clinical pregnancy rate at least 50% in vitro fertilization, the method is included in be had the laboratory in vitro fertilization purified air and carries out repeatedly circulation in vitro fertilization, it is characterized in that:
A. the content of TOVC is less than 5ppb;
B. biomass content is less than 1 CFU/M 3; And
C. particle content is from about 1,000 0.3 μm of particle/cubic feet to about 10,500 0.3 μm of particle/cubic feet, or from about 600 0.5 μm of particle/cubic feet to about 1,000 0.5 μm of particle/cubic feet,
Thus to reach Clinical pregnancy rate in vitro fertilization be at least 50%.
9. method as claimed in claim 8, is characterized in that: Clinical pregnancy rate in vitro fertilization is 50% to 70%.
10. method as claimed in claim 8, is characterized in that: Clinical pregnancy rate in vitro fertilization is 50% to 65%.
11. methods as claimed in claim 8, is characterized in that: Clinical pregnancy rate in vitro fertilization is 55% to 70%.
12. methods as claimed in claim 8, is characterized in that: Clinical pregnancy rate in vitro fertilization is 55% to 65%.
13. 1 kinds of methods purified air, comprise the following steps:
A., a kind of inlet air flow path flowed by shell downstream is provided;
B. the VOC prefilter filtered air of oxidation in shell and absorption is used;
C. by being arranged on the ultraviolet filter filtered air in the VOC prefilter downstream of oxidation and absorption in shell; And
D. by being arranged on the final particulate filter filtered air in ultraviolet filter downstream in shell.
14. methods as claimed in claim 13, also comprise the step of the particle pre-filter filtered air arranged by VOC prefilter upstream in shell.
15. methods as claimed in claim 13, is characterized in that: shown VOC prefilter comprises in conjunction with carbon.
16. methods as claimed in claim 13, also comprise the step of the VOC prefilter filtered air by the oxidation in shell and absorption, this VOC prefilter is between ultraviolet filter downstream and final particulate filter upstream.
17. methods as claimed in claim 13, is characterized in that: VOC prefilter comprises one or more filter comprised in conjunction with carbon and potassium permanganate.
18. methods as claimed in claim 13, also comprise the step of the particle pre-filter filtered air by being arranged on VOC prefilter upstream in shell, and by the VOC prefilter filtered air of ultraviolet filter downstream in shell and the oxidation arranged between final particulate filter upstream and absorption.
19. methods as claimed in claim 18, is characterized in that: VOC prefilter and VOC post-filter comprise one or more filter comprised in conjunction with carbon and potassium permanganate.
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