CN104666557B - A kind of Chinese medicine for treating Raynaud's disease - Google Patents
A kind of Chinese medicine for treating Raynaud's disease Download PDFInfo
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Abstract
The present invention relates to the Chinese medicine for the treatment of Raynaud's disease, can effectively solve the problems, such as the medication of Raynaud's disease, its technical scheme solved is made up of the material medicine of following parts by weight meter：10 20 parts of 5 15 parts of cassia twig, 5 15 parts of Morinda officinalis, 5 15 parts of herba aristolochiae, 10 30 parts of reticulate millettia, 5 20 parts of lycopodium calvatum, 5 20 parts of the root of Chinese clematis, 10 40 parts of cortex acanthopanacis, 10 40 parts of the Radix Astragali, 10 30 parts of Semen Lablab Album, 10 30 parts of arillus longan and jujube, abundant raw material of the present invention, it is cheap, with the positive kidney-nourishing of temperature, tonifying Qi and blood, warming meridians and promoting circulation of qi, it is promoting blood circulation and removing obstruction in channels the effect of, effective for treating Raynaud's disease, good effect, drug safety, it is to treat the innovation on Reynolds medicine.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of Chinese medicine for treating Raynaud's disease.
Background technology
Reynolds (family name) disease is also known as acra arteriospasm disease, when referring to that acra blood circulation is obstructed, one group of syndrome of appearance,
This sick cause of disease is still not clear, and is mainly in cold district, common with 16~40 years old young women, clinically grey with acra color of the leather
In vain, feel cold, send out cool, be numb, shouting pain etc. is cardinal symptom, visible refer to (toe) of severe holds livid purple, ulcer or gangrene.Pierced more with cold
The factor such as sharp, emotional factors and organism endocrine function obstacle, dysimmunity is closely related.Modern medicine typically gives blood vessel expansion
Agent, improve microcirculation to release vasopasm, the methods of reducing the stimulate the reaction of peripheral vessels but therapeutic effect unobvious, often
Easy recurrent exerbation.Traditional medicine thinks that Raynaud's disease belongs to " bi Zheng, cold card " category.Traditional Chinese medicine thinks:YANG QI deficiency, qi and blood lose
Void, cold-evil's invasion is its Etiological.Cold then blood is puckery, deficiency of qi and blood, battalion is not capable smooth, and qi and blood stagnation, obstructed blood vessels are that its is main
The interpretation of the cause, onset and process of an illness.The normal perfusion temperature that limb end loses in qi and blood is supported, so there is the sick duke or princess under an emperor.Though there are many Chinese traditional treatment medicines at present
Thing, but effect is all not ideal enough.Therefore, the problem of improvement on treatment Reynolds medicine and innovation are current urgent need to resolve.
The content of the invention
For the above situation, to solve the defect of prior art, the purpose of the present invention is just to provide one kind and treats Raynaud's disease
Chinese medicine, can effectively solve the problems, such as the medication of Raynaud's disease.
This disease category traditional Chinese medical science " cold limbs ", " cold limbs " category, YANG QI deficiency, deficiency of qi and blood, cold-evil's invasion are its main diseases
Cause.Cold then blood is puckery, deficiency of qi and blood, battalion is not capable smooth, and qi and blood stagnation, obstructed blood vessels are its main pathogenesis.Control when with the positive kidney-nourishing of temperature, benefit
Replenishing qi and blood, warming meridians and promoting circulation of qi, it is promoting blood circulation and removing obstruction in channels based on.Accordingly, the technical scheme that the present invention solves is, by the original of following parts by weight meter
Material medicine is made：Cassia twig 5-15 parts, Morinda officinalis 5-15 parts, herba aristolochiae 5-15 parts, reticulate millettia 10-30 parts, lycopodium calvatum 5-20 parts, prestige
Medicine xiaolingxian 5-20 parts, cortex acanthopanacis 10-40 parts, Radix Astragali 10-40 parts, Semen Lablab Album 10-30 parts, arillus longan 10-30 parts and jujube 10-20
Part, above-mentioned raw materials medicine is mixed, added water to submerge, soaks 30-60min, intense fire is fried boiling, and slow fire decocts 20-30min again,
Filtering, obtains first time filtrate, and the dregs of a decoction add water to submerge, and intense fire is fried boiling, and slow fire decocts 20-30min again, filtering, obtains second of filtrate, closes
And filtrate twice, mix,.
Abundant raw material of the present invention, it is cheap, there is the positive kidney-nourishing of temperature, tonifying Qi and blood, warming meridians and promoting circulation of qi, work(promoting blood circulation and removing obstruction in channels
Effect, good effect, drug safety, it is to treat the innovation on Reynolds medicine effective for treating Raynaud's disease.
Embodiment
The embodiment of the present invention is described in further detail with reference to embodiments.
Embodiment 1
The present invention in the specific implementation, can be made up of the material medicine of following parts by weight meter：5 parts of cassia twig, Morinda officinalis 15
Part, 5 parts of herba aristolochiae, 30 parts of reticulate millettia, 5 parts of lycopodium calvatum, 20 parts of the root of Chinese clematis, 10 parts of cortex acanthopanacis, 40 parts of the Radix Astragali, 10 parts of Semen Lablab Album,
10 parts of 30 parts of arillus longan and jujube, above-mentioned raw materials medicine is mixed, added water to submerge, and soaks 30min, and intense fire is fried boiling, text
Fire decocts 30min again, filtering, obtains first time filtrate, and the dregs of a decoction add water to submerge, and intense fire is fried boiling, and slow fire decocts 30min again, filtering, obtains second
Secondary filtrate, merge filtrate twice, mix,.
Embodiment 2
The present invention in the specific implementation, can also be made up of the material medicine of following parts by weight meter：10 parts of cassia twig, Morinda officinalis
10 parts, 10 parts of herba aristolochiae, 20 parts of reticulate millettia, 12 parts of lycopodium calvatum, 13 parts of the root of Chinese clematis, 25 parts of cortex acanthopanacis, 25 parts of the Radix Astragali, Semen Lablab Album 20
15 parts of part, 20 parts of arillus longan and jujube, above-mentioned raw materials medicine is mixed, added water to submerge, and soaks 45min, and intense fire is fried boiling,
Slow fire decocts 25min again, filtering, obtains first time filtrate, and the dregs of a decoction add water to submerge, and intense fire is fried boiling, and slow fire decocts 25min again, filtering, obtains the
Secondary filtrate, merge filtrate twice, mix,.
Embodiment 3
The present invention in the specific implementation, can also be made up of the material medicine of following parts by weight meter：15 parts of cassia twig, Morinda officinalis
5 parts, 15 parts of herba aristolochiae, 10 parts of reticulate millettia, 20 parts of lycopodium calvatum, 5 parts of the root of Chinese clematis, 40 parts of cortex acanthopanacis, 10 parts of the Radix Astragali, Semen Lablab Album 30
20 parts of part, 10 parts of arillus longan and jujube, above-mentioned raw materials medicine is mixed, added water to submerge, and soaks 60min, and intense fire is fried boiling,
Slow fire decocts 20min again, filtering, obtains first time filtrate, and the dregs of a decoction add water to submerge, and intense fire is fried boiling, and slow fire decocts 20min again, filtering, obtains the
Secondary filtrate, merge filtrate twice, mix,.
The present invention can also be according to being actually needed, and routinely pulvis, tablet, granule, pill, capsule etc. is made in preparation method
Formulation.It is all to use any formulation made of the application prescription, and for treating the medicine of Raynaud's disease, belong to the application protection
Scope.
In instant component：
Cassia twig：Acrid, sweet, warm.The thoughts of returning home, lung, bladder warp.Major function sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi, put down punching
Sending down abnormally ascending.For anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, joint pain, phlegm and retained fluid, oedema, palpitaition, run quickly globefish.
Morinda officinalis：It is sweet, pungent, tepor.Return kidney, Liver Channel.Major function kidney-replenishing, strengthening the bones and muscles, wind-damp dispelling.Lost for impotence
Essence, uterus cold infertile, irregular menstruation, few abdomen crymodynia, arthralgia pain due to rheumatism, muscles and bones impotence.
Herba aristolochiae：Hardship, temperature.Return liver, spleen, kidney channel.Major function：The promoting flow of qi and blood circulation, inducing diuresis for removing edema.For gastral cavity abdomen shouting pain, close
Save numbness pain, cyesedema.
Reticulate millettia：It is bitter, sweet, temperature.Return liver and kidney channel.Major function：Enrich blood, invigorate blood circulation, dredging collateral.For irregular menstruation, the deficiency of blood is withered
Huang, paralysis and numbness, arthralgia pain due to rheumatism.
Lycopodium calvatum:Slight bitter, pungent, temperature.Return liver, spleen, kidney channel.Major function：Dispelling wind and eliminating dampness, relaxing tendons and activating collaterals.For joint acid
Bitterly, joint stuffiness.
The root of Chinese clematis:It is pungent, salty, temperature.Return bladder warp.Major function：Dispelling wind and eliminating dampness, remove obstruction in channels to relieve pain.For arthralgia pain due to rheumatism, limbs
Numbness, muscle arteries and veins contraction, joint stuffiness, bone are choked with sobs larynx.
Cortex acanthopanacis：Pungent, slight bitter, temperature.Returns spleen, kidney, the heart channel of Hang-Shaoyin.Major function：Replenish qi to invigorate the spleen, tonify the kidney to relieve mental strain.For spleen kidney yang
Void, physically weak weak, poor appetite, soreness of waist and knee joint, insomnia and dreamful sleep.
The Radix Astragali:Return lung, the spleen channel.Major function：Invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation.For treatment deficiency of vital energy weak,
Anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult to burst, burst for a long time and does not holds back, the deficiency of blood
Impotence is yellow, Heat Diabetes；Chronic rephrilis protinuria, diabetes.
Semen Lablab Album:It is sweet, tepor.Returns spleen, stomach.Major function：Invigorating the spleen for eliminating dampness, and in relieve summer heat.For weakness of the spleen and the stomach, appetite
It is depressed, diarrhea, leukorrhea, summer-heat and damp vomiting and diarrhoea, abdominal distension uncomfortable in chest.
Arillus longan：It is sweet, temperature.The thoughts of returning home, the spleen channel.Major function：Tonifying heart and spleen, nourishing blood and tranquilization.It is seized with terror for insufficiency of vital energy and blood, palpitaition
It is sad, forgetful insomnia, blood deficiency chlorosis.
Jujube：It is sweet, temperature.Returns spleen, stomach.Major function：Tonifying middle-Jiao and Qi, nourishing blood and tranquilization.For spleen eating less, it is weak just
It is half congealed, hysteria of womam.
Component science of the present invention, reasonable compatibility, support mutually, cassia twig, the positive kidney-nourishing of Morinda officinalis temperature, jujube, arillus longan, slender acanthopanax
Skin, the Radix Astragali, Semen Lablab Album tonifying Qi and blood, lycopodium calvatum, root of Chinese clematis warming meridians and promoting circulation of qi, herba aristolochiae, reticulate millettia are promoting blood circulation and removing obstruction in channels.By clinical real
Trample discovery, the present composition has the effect of unique to Raynaud's disease, and all medicines play the positive kidney-nourishing of temperature altogether, tonifying Qi and blood, warming meridians and promoting circulation of qi,
The effect of promoting blood circulation and removing obstruction in channels, effective for treating Raynaud's disease, good effect, drug safety, and obtain fully proving through clinical trial,
Relevant clinical experimental data is as follows：
1st, clinical data
52 are diagnosed as Reynolds patient and all derive from clinic case, are randomly divided into treatment group and control group.Treatment group 27
Example, women 25, male 2；It is the oldest 50 years old, minimum 16 years old；The course of disease is most long 7 years, most short 3 months.Control group 25, female
Property 23, male 2；It is the oldest 49 years old, minimum 15 years old；The course of disease is most long 8 years, most short 4 months.2 groups of data through statistics at
Reason, difference there are no significant the meaning (P in age, the state of an illness>0.05), there is comparativity.
2nd, diagnostic criteria
With reference to the People's Republic of China (PRC)<New Chinese medicine guideline of clinical investigations》The Reynolds of (second volume, 1995) formulation is comprehensive
The Western medicine diagnostic criteria of simulator sickness.Clinical manifestation mainly has:(l) often because excited or cold stimulation induces；(2) finger when breaking out
Color of the leather turns white, then livid purple, gradually becomes flush, finally recovers normal color, sends out cool with finger, be numb, pain, feeling different
The symptom such as normal, cold exacerbation is met, must warm up, alleviate, mostly both upper extremities are fallen ill, in symmetry；(3) part without necrosis or only has very
Small finger (toe) end cutaneous necrosis；(4) Microcirculation of Nailfold detection has exception；(5) Raynaud's phenomenon caused by other diseases is excluded.
3rd, therapeutic scheme
3.1 medicine for treatment treatment groups:Chinese medicine of the present invention, once in the morning and once at night, warmly take, each 200-300ml.Control group:Salt
Sour benzazoline 25mg, nicotinic acid 50mg, 3 times a day orally, two groups are treated 1 month statistics curative effect.
3.2 criterions of therapeutical effect and observation index
With reference to the People's Republic of China (PRC)《New Chinese medicine guideline of clinical investigations》The Reynolds that (second edition, nineteen ninety-five) formulates
The criterion of the effect of syndrome.
Recovery from illness:Symptom disappears, and has good tolerance to low temperature, and Microcirculation of Nailfold is normal；
It is effective:Cardinal symptom disappears, and has good tolerance to low temperature, and Microcirculation of Nailfold is normal；
Effectively:Cardinal symptom mitigates, and finger low temperature tolerance ability increases, but to the cold after or it is excited when, still have skin
Color change, Microcirculation of Nailfold take a turn for the better earlier above；
It is invalid:Before and after treatment relatively, each side is without improvement.
Observation index：Observe two groups of pretherapy and post-treatment Microcirculation of Nailfold changes.
4th, statistical procedures
Using SPSS13.0 statistical softwares, enumeration data is examined using x2, and ranked data are examined using Ridit, metering money
Material is examined using t.
As can be seen from Table 1, treatment group fully recovers 6, effective 12, effective 6, invalid 3, and total effective rate is
92.59%, compared with control group, effective and total effective rate has notable significant difference；Control group is fully recovered 4, effective 7, is had
Effect 8, invalid 6, total effective rate 76%.
1 two groups of Clinical efficacy comparisons of table
Compared with control group, * P ＜ 0.05, * * P ＜ 0.01
The pretherapy and post-treatment Microcirculation of Nailfold change (example) of 2 two groups of table
Note：* P compared with preceding with group treatment<0.05；**P<0.01；The △ P compared with after control group treatment<0.05
Table 2 shows, after treatment group's treatment, compared with preceding with group treatment, and the various degree aggregations of definition, deformity, red blood cell
And ooze out, the target improvement such as bleeding has notable significant difference (P<0.01)；After treatment group's treatment, compare after being treated with control group
Compared with the index such as each degree aggregation of deformity, red blood cell has obvious significant difference (P<0.05).
5th, conclusion
Component science of the present invention, abundant raw material is cheap, reasonable compatibility, supports mutually, and all medicines play the positive kidney-nourishing of temperature altogether,
Tonifying Qi and blood, warming meridians and promoting circulation of qi, it is promoting blood circulation and removing obstruction in channels the effect of, effective for treating Raynaud's disease, good effect, drug safety is efficient high
Up to more than 92%, it is the big innovation on Chinese medicine, there is actual clinical meaning.
Claims (4)
1. a kind of Chinese medicine for treating Raynaud's disease, it is characterised in that be made up of the material medicine of following parts by weight meter：Cassia twig 5-15
Part, Morinda officinalis 5-15 parts, herba aristolochiae 5-15 parts, reticulate millettia 10-30 parts, lycopodium calvatum 5-20 parts, root of Chinese clematis 5-20 parts, cortex acanthopanacis
10-40 parts, Radix Astragali 10-40 parts, Semen Lablab Album 10-30 parts, arillus longan 10-30 parts and jujube 10-20 parts, above-mentioned raw materials medicine is mixed
It is combined, adds water to submerge, soak 30-60min, intense fire is fried boiling, and slow fire decocts 20-30min again, filtering, obtains first time filtrate, medicine
Slag adds water to submerge, and intense fire is fried boiling, and slow fire decocts 20-30min again, filtering, obtains second of filtrate, merges filtrate twice, mixes, i.e.,
Into.
2. the Chinese medicine for the treatment of Raynaud's disease according to claim 1, it is characterised in that by the bulk drug of following parts by weight meter
Thing is made：5 parts of cassia twig, 15 parts of Morinda officinalis, 5 parts of herba aristolochiae, 30 parts of reticulate millettia, 5 parts of lycopodium calvatum, 20 parts of the root of Chinese clematis, cortex acanthopanacis 10
Part, 40 parts of the Radix Astragali, 10 parts of Semen Lablab Album, 30 parts of arillus longan and 10 parts of jujube, above-mentioned raw materials medicine is mixed, adds water logging
Not yet, 30min is soaked, intense fire is fried boiling, and slow fire decocts 30min again, filtering, obtains first time filtrate, and the dregs of a decoction add water to submerge, and intense fire is fried boiling,
Slow fire decocts 30min again, filtering, obtains second of filtrate, merges filtrate twice, mixes,.
3. the Chinese medicine for the treatment of Raynaud's disease according to claim 1, it is characterised in that by the bulk drug of following parts by weight meter
Thing is made：10 parts of cassia twig, 10 parts of Morinda officinalis, 10 parts of herba aristolochiae, 20 parts of reticulate millettia, 12 parts of lycopodium calvatum, 13 parts of the root of Chinese clematis, cortex acanthopanacis
15 parts of 25 parts, 25 parts of the Radix Astragali, 20 parts of Semen Lablab Album, 20 parts of arillus longan and jujube, above-mentioned raw materials medicine is mixed, adds water logging
Not yet, 45min is soaked, intense fire is fried boiling, and slow fire decocts 25min again, filtering, obtains first time filtrate, and the dregs of a decoction add water to submerge, and intense fire is fried boiling,
Slow fire decocts 25min again, filtering, obtains second of filtrate, merges filtrate twice, mixes,.
4. the Chinese medicine for the treatment of Raynaud's disease according to claim 1, it is characterised in that by the bulk drug of following parts by weight meter
Thing is made：15 parts of cassia twig, 5 parts of Morinda officinalis, 15 parts of herba aristolochiae, 10 parts of reticulate millettia, 20 parts of lycopodium calvatum, 5 parts of the root of Chinese clematis, cortex acanthopanacis 40
Part, 10 parts of the Radix Astragali, 30 parts of Semen Lablab Album, 10 parts of arillus longan and 20 parts of jujube, above-mentioned raw materials medicine is mixed, adds water logging
Not yet, 60min is soaked, intense fire is fried boiling, and slow fire decocts 20min again, filtering, obtains first time filtrate, and the dregs of a decoction add water to submerge, and intense fire is fried boiling,
Slow fire decocts 20min again, filtering, obtains second of filtrate, merges filtrate twice, mixes,.
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Inventor after: Li Xiaobing Inventor after: Li Ruiqin Inventor after: Guo Hongtao Inventor after: Li Ning Inventor after: Cheng Kai Inventor after: Wang Junming Inventor after: Li Zhenzhen Inventor after: Xu Qianlei Inventor after: Liu Xianghua Inventor after: Zhao Xianmin Inventor after: Wang Namei Inventor after: Zhang Huijian Inventor after: Zheng Mingchang Inventor after: Zhan Junping Inventor before: Li Xiaobing Inventor before: Cheng Kai Inventor before: Wang Junming Inventor before: Wang Namei Inventor before: Li Yanfang Inventor before: Zhang Huijian Inventor before: Zheng Mingchang Inventor before: Zhan Junping Inventor before: Li Ruiqin Inventor before: Guo Hongtao Inventor before: Li Ning |
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