CN104664407A - Nutritional agent with noise induced hearing loss resistance - Google Patents
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Abstract
The invention discloses a nutritional agent with noise reduced hearing loss resistance. The nutritional agent is prepared from the following raw materials in parts by weight: 600-1000 parts of N-acetyl-L-cysteine, 1-4 parts of vitamin A, 1-5 parts of vitamin B1, 1-5 parts of vitamin B2, 1-10 parts of vitamin B6, 0.01-0.05 part of vitamin B12, 60-1000 parts of vitamin C, 15-300 parts of vitamin E which is based on alpha-totaxin, 50-400 parts of magnesium and 79-3175 parts of food acceptable accessories. Experiment data displays that the nutritional agent has remarkable effect of preventing and controlling the noise induced hearing loss. The nutritional agent can be used for enhancing the anti-oxidation ability of the organism and lightening the exitotoxicity damage, has the characteristics of being remarkable in curative effect, low in potential toxicity and low in cost, and is suitable for the noise reduced hearing loss protection and daily nutrient supplementation of people who live and work in the environment with continuous exposed high-intensity noise.
Description
Technical field
The present invention relates to a kind of composite nutrient, particularly relate to a kind of for replenishing vitamins, mineral matter, have control noise induced hearing loss effect, the nutritional agents played a role in health care, belongs to composition preparing technical field.
Background technology
Along with the development of modern industry and weaponry, the harm of noise is day by day serious, and is embodied in many aspects, and noise can cause dysfunction and even the pathology damage of the sense of hearing external system such as acoustic trauma and nerve, cardiovascular, digestion or organ.Noise is the ubiquitous hazard factor of army's operating environment, and the noise intensity of my army major part weaponry all exceedes the limit value that related standards specifies.The incidence of exposed personnel acoustic trauma is high, has a strong impact on work efficiency, health and fighting capacity, especially in IT-based warfare, gently then affects work, heavy then bungle the chance of winning a battle.
The main target organ of noise induced damage is hearing organ, noise induced hearing loss main manifestations is that auditory sensitivity declines, the threshold of audibility raises, language accepts and signal distinguishing ability reduces, this process is the process that physiology travels to pathology, causes pathology damage must reach certain noise intensity and (or) time of contact.Noise to the intensity of the harm of auditory system and noise, frequency, open-assembly time and individual sensitivity etc. factor relevant, there is dose-effect relationship between Noise Exposure and hearing loss within the specific limits.Noise causes the mechanism of acoustic trauma to be all by mechanicalness or metaolic damage inner ear sensory hair cell.Noise can cause damage to cochlea most cells, and what wherein stand in the breach most is external hair cell.Think now, the oxidativestress damage that exitotoxicity causes is that Acoustic exposure causes the main trigger mechanism of Hair Cell Death at cellular level.In addition, noise also can hinder human body to the absorption of various vitamin and utilization, and accelerates the excretion of human body to water soluble vitamin, and this also may reduce body normal physiological function further, adds the risk that damage occurs.
The medicine of current treatment sound-induced auditory damage mainly contains blood vessel dilatation class, neurotrophy class, blood dilatation class, Chinese medicine activate blood circulation and disperse blood clots class etc., but effect is all undesirable.Noise induced hearing loss focuses on prevention, and oxidative damage and exitotoxicity play very important effect in the damage of hair cell metabolic, and improves cochlea endogenous anti-oxidative level or external supply antioxidant can alleviate damage of hair cell and hearing loss.Propyloxy phenyl base glycosides (PIA) can improve perilymph GSH-PX activity and SOD level, enhances cochlea oxidation resistance, effectively reduces noise induced hearing loss and wool Se content; Allopurinol, polyethylene glycol, sweet mellow wine, N-acetylcystein, acetyl-L-carnitine, salicylate etc. pass through oxygen radical removing or suppress it to produce, also effectively can prevent and treat noise induced hearing loss, the antioxidants such as lipid peroxidation inhibitor and UTI, alpha-lipoic acid, polysaccharides from ginkgo biloba are also proved effectively.In addition, the calcium ion disbalance that regulation of calcium agent MK801, Nimodipine etc. cause by improving exitotoxicity, and then the effect playing control noise induced hearing loss.
Because most of noise exposure crowd is Occupational Exposure, be namely exposed to the noise circumstance exceeding relevant criterion for a long time, for this type of crowd as adopted chemoprophylaxis, then need Long-term taking medicine, toxic and side effect may be produced to body.People wish while extra-nutrition material, can obtain the multi-effect such as prevention noise induced hearing loss, opposing oxidative damage.Therefore, on the basis of ordinary nutritional agent, strengthening has the active component of anti-exitotoxicity, anti-oxidation function, the nutritional agents that the Long term prophylatic for occupational noise exposure crowd is taken, and expects effect by receiving good control noise induced hearing loss.
Summary of the invention
For the defect that prior art exists, the invention provides a kind of nutritional agents with noise immunity hearing loss, through lot of experiments, choose B B-complex, mineral matter and glutathione precursor material to combine with special ratios, obtain good anti-oxidant, anti-exitotoxicity, improve the effect such as inner ear aerobic metabolism and energy generation.Its reason is glutathione precursor material ACETYLCYSTEINE (NAC) and vitamin A, B race, C, E can work in coordination with performance anti oxidative damage; magnesium then can block the cell Ca2+ influx that exitotoxicity causes, and reduces the damage of hair cell because calcium overload causes.Nutritional agents of the present invention is applicable to long-term life, works in the supplementary of the daily nutrition element of the crowd had in the noise circumstance of potential hazard, to prevent and treat noise induced hearing loss.
In order to solve the problems of the technologies described above, the nutritional agents with noise immunity hearing loss that the present invention proposes, is made up of following raw material: N-acetyl-L-cysteine 600-1000 part, vitamin A 1-4 part, VB11-5 parts, vitamin B2 1-5 part, vitamin B6 1-10 part, vitamin B12 0.01-0.05 part, vitamin C 60-1000 part, vitamin E in alpha-tocopherol 15-300 part, magnesium 50-400 part and food acceptable auxiliary material 79-3175 part by weight.
Preferably: described N-acetyl-L-cysteine 900 parts, vitamin A 3 parts, vitamin B12 .5 part, vitamin B2 2.5 parts, vitamin B6 2 parts, vitamin B12 0.01 part, vitamin C 500 parts, vitamin E in alpha-tocopherol 270 parts, 300 parts, magnesium and the acceptable auxiliary material of food.
ACETYLCYSTEINE (NAC) is the acetyl derivatives of essential amino acid Cys, the free sulfhydryl group of directly having an effect with electrophilic oxide group by an energy (-SH of nucleophilic) and play direct antioxidation.NAC can protect α-1 antitrypsin (elastatinal) from hypochlorous effect inactivation.The molecular structure of NAC makes it be easy to permeate through cell membranes, NAC deacetylate in cell, and form Cys, this is the essential amino acid of a kind of synthesizing glutathion (GSH).GSH is a kind of highly active tripeptides being extensively present in various animal tissue.Glutathione is most important protective agent in cell, to keeping the integrality of cell function and cellular morphology to play a significant role, also can prevent the oxygen radical of cell from inside and outside and the infringement of various cytotoxic substance.NAC is keeping the suitable horizontal important role of GSH, thus contributes to the cytotoxin infringement that Cell protection do not cause because GSH level in body is too low.Research shows, NAC effectively can prevent and treat noise induced hearing loss (.J Am Acad Audiol, 2006, the 17:265 – 278 such as Kramer S.).By being purchased acquisition ACETYLCYSTEINE.
Vitamin A is a kind of liposoluble vitamin playing important physiological function in body.It, except can maintaining the functions such as the Growth and Differentiation of body normal vision and epithelium, can also catch free radical, cancellation single line oxygen (
1o
2), improve the anti-oxidant protection capability of body.VAD incidence is higher, if but a large amount of absorption has overt toxicity to body again, and therefore, the absorption of vitamin A should control at zone of reasonableness.Vitamin A in the present invention can by adding vitamine A acetate and/or Retinol Palmitate acquisition, preferred vitamin A palmitate.
Vitamin B1 participates in the oxidative deamination reaction of 2-ketoacid and the transketolase reaction of pentose phosphate pathway in vivo, plays a significant role in energetic supersession.People's continuous operation 4 hours in the noise of 85-100 decibel intensity, the vitamin B1 in body is by minimizing about 30%.
Vitamin B2 is catalysis oxidation-reduction reaction widely in vivo, also has antioxidation activity, is the important substance promoting energy generation and anti-lipid peroxidation in body.Noise Exposure significantly can reduce the level of body vitamin B2.
Vitamin B6 participates in the main nearly hundred kind enzyme reactions relevant with amino acid metabolism in body, also can affect the stability of vestibular function.Noise Exposure significantly can reduce the level of vitamin B6.
Vitamin B12 and protein synthesize and cell is formed closely related, also relevant with odd numbers of carbon atoms fat metabolic process.Noise Exposure significantly can reduce the level of vitamin B12.
Vitamin C is a kind of electron donor, can carry out reversible oxidation in vivo, can remove multiple free radical as antioxidant, participates in multiple important biosynthetic process as coenzyme.The appropriate vitamin C that supplements is conducive to the higher antioxidant levels of body maintenance.
Vitamin E is high-efficiency antioxidant agent important in non-enzymatic antioxidant system, and Cell protection is from free radical damage in vivo, improves immunologic function, delaying cell aging degenerative process.People's continuous operation 4 hours in the noise of 85-100 decibel intensity, the vitamin C in body is by minimizing about 40%.Vitamin E in the present invention can by adding Vitwas E and/or VE-succinate acquisition, preferred vitamin E acetate.
Magnesium is the dominant cation in human body cell, concentrates in mitochondria, is only second to potassium and phosphorus, and being only second to sodium and calcium occupies the 3rd at extracellular fluid, is the required material of the basic biochemical reaction of various kinds of cell in body.Magnesium can affect the transhipment of potassium ion and calcium ion, the transmission of adjustment signal, participates in the synthesis of energetic supersession, protein and nucleic acid; The regulation and control of the Activation and inhibition of catalyzing enzyme and cell cycle, cell proliferation and Cell Differentiation; Magnesium also participates in anti-body oxidative stress process.Noise Exposure can cause inner ear glutamic acid and NMDA type glutamate receptor abnormal activation thereof, and a large amount of flow of calcium ions causes intracellular calcium overload, causes cellular damage, i.e. exitotoxicity.Magnesium ion calcium channel capable of blocking, alleviates the exitotoxicity damage that intracellular calcium overload causes.In the present invention, content of magnesium can obtain by adding organic magnesium salts, and described organic magnesium salts can be the edible magnesium salts such as magnesium gluconate, magnesium lactate, citric acid U.S., preferred magnesium gluconate.
Nutritional agents of the present invention can adopt the one in following dosage forms: hard shell capsules, soft capsule, ordinary tablet, sugar coated tablet, Film coated tablets, Special-shaped sheet, chewable tablets, effervescent tablet, dispersing tablet, granule, pill, solution, syrup.Be preferably tablet or capsule.
The edible adjuvant of various routine also can be added in the formula of nutritional agents of the present invention, this auxiliary material is determined according to the formulation difference of nutritional agents, the formulation of nutritional agents is tablet, and described edible adjuvant comprises lactose 100 parts, microcrystalline cellulose 80 parts, sodium carboxymethyl starch 40 parts and dolomol 5 parts; The formulation of nutritional agents is effervescent tablet, and described edible adjuvant comprises citric acid 1000 parts, malic acid 500 parts, sodium acid carbonate 1400 parts, Aspartame 35 parts, orange flavor 60 parts, 60 parts, sodium chloride and PEG6000120 part; The formulation of nutritional agents is hard capsule: described edible adjuvant comprises Hydroxypropyl methylcellulose 15 parts, Hydroxypropyl methylcellulose 15 parts, sodium carboxymethyl starch 45 parts and dolomol 4 parts.
The experiment proved that, nutritional agents provided by the invention has the effect of good noise immunity hearing loss.The present invention has the following advantages:
1) according to the different molecular approach that noise induced hearing loss occurs, adopt the reasonable combination of Small molecular amino acid derivativges, vitamin and mineral matter, respectively from anti-oxidant, anti-exitotoxicity, improve the aspect such as inner ear aerobic metabolism and energy generation and intervene, make to have synergistic function between each nutrient, the Be very effective of control noise induced hearing loss strengthens.
2) this nutritional agents comprehensive nutrition, also by its high-efficiency antioxidant efficiency and then improve resisting stress capability, the supplementing of daily nutrition element of the person that is applicable to occupational noise exposure particularly military noise operating personnel.
3) ingredient origin enriches, and toxic and side effect is extremely low, is applicable to professional population long-term taking, safe ready.
Detailed description of the invention
Be described in further detail technical solution of the present invention below in conjunction with subordinate list and specific embodiment, described specific embodiment only explains the present invention, not in order to limit the present invention.
Nutritional agents group component of the present invention is daily dose, and wherein all number dosage is all in milligram, and in addition, daily dose can comprise one or more dosage unit.
Embodiment 1, there is the nutritional agents formula of noise immunity hearing loss.
The present embodiment 1 provides the daily dose of each active component in B B-complex in the present invention, mineral matter, amino acid derivativges nutritional agents, and this dosage can be used as a dosage unit and once takes or multiple dosage unit part vic in a day.
The formula of embodiment 1 nutritional agents is as shown in table 1:
The raw material of table 1 embodiment 1 composite nutrient and each active component formula
| Nutrient title | Raw material | Dosage | Active component content |
| N-acetylcystein | N-acetyl-L-cysteine | 900mg | 900mg |
| Vitamin A | Vitamine A acetate powder | 19.88mg | 3000μgRE |
| Vitamin B1 | Vitamin B1 | 2.5mg | 2.5mg |
| Vitamin B2 | Vitamin B2 | 2.5mg | 2.5mg |
| Vitamin B6 | Vitamin B6 | 2mg | 2mg |
| Vitamin B12 | Vitamin B12 | 10mcg | 10mcg |
| Vitamin C | Vitamin C | 500mg | 500mg |
| Vitamin E | Vitwas E | 540mg | 270mg |
| Magnesium | Magnesium gluconate | 5.2g | 300mg |
In table 1, " RE " refers to retinol equivalent, represents all total amounts (μ g) with retinol active material (comprising established vitamin A and provitamin A).
Embodiment 2, there is the preparation of the nutritional agents sheet of noise immunity hearing loss, raw material and dosage as shown in table 2:
The component of table 2. embodiment 2 nutritional agents sheet and dosage
| Raw material | Dosage |
| N-acetyl-L-cysteine | 900mg |
| Vitamine A acetate powder | 19.88mg |
| Vitamin B1 | 2.5mg |
| Vitamin B2 | 2.5mg |
| Vitamin B6 | 2mg |
| Vitamin B12 | 10mcg |
| Vitamin C | 500mg |
| Vitwas E | 540mg |
| Magnesium gluconate | 5.2g |
| Auxiliary material | Dosage |
| Lactose | 100mg |
| Microcrystalline cellulose | 80mg |
| Sodium carboxymethyl starch | 40mg |
| Dolomol | 5mg |
Preparation method: take raw material by above-mentioned formula dosage, according to the mixing of equal increments method, then with lactose, microcrystalline cellulose, Sodium Hydroxymethyl Stalcs and the acceptable auxiliary materials and mixing of dolomol food, by the mix powder direct tablet compressing of preparation, both.Described tablet can obtain Film coated tablets by dressing further.
Embodiment 3, there is the preparation of the nutritional agents hard shell capsules of noise immunity hearing loss, raw material and dosage as shown in table 3:
The component of table 3. embodiment 3 nutritional agents hard shell capsules and dosage
| Raw material | Dosage |
| N-acetyl-L-cysteine | 900mg |
| Vitamine A acetate powder | 19.88mg |
| Vitamin B1 | 2.5mg |
| Vitamin B2 | 2.5mg |
| Vitamin B6 | 2mg |
| Vitamin B12 | 10mcg |
| Vitamin C | 500mg |
| Vitwas E | 540mg |
| Magnesium gluconate | 5.2g |
| Auxiliary material | Dosage |
| Hydroxypropyl methylcellulose | 15mg |
| Sodium carboxymethyl starch | 45mg |
| Dolomol | 4mg |
Preparation method: take raw material by above-mentioned formula dosage, according to the mixing of equal increments method, then auxiliary materials and mixing acceptable with the food such as sodium carboxymethyl starch and Hydroxypropyl methylcellulose, mixture carries out non-slurry pelletizing, add dolomol, incapsulate, both obtain hard capsule.
Embodiment 4, there is the preparation of the nutritional agents effervescent tablet of noise immunity hearing loss, raw material and dosage as shown in table 4:
The component of table 4. embodiment 4 nutritional agents effervescent tablet and dosage
| Raw material | Dosage |
| N-acetyl-L-cysteine | 900mg |
| Vitamine A acetate powder | 19.88mg |
| Vitamin B1 | 2.5mg |
| Vitamin B2 | 2.5mg |
| Vitamin B6 | 2mg |
| Vitamin B12 | 10mcg |
| Vitamin C | 500mg |
| Vitwas E | 540mg |
| Magnesium gluconate | 5.2g |
| Auxiliary material | Dosage |
| Citric acid | 1000mg |
| Malic acid | 500mg |
| Sodium acid carbonate | 1400mg |
| Aspartame | 35mg |
| Orange flavor | 60mg |
| Sodium chloride | 60mg |
| PEG6000 | 120mg |
Preparation method: take raw material by above-mentioned formula dosage, mix according to equal increments method, again with acceptable auxiliary materials and mixing of food such as citric acid, malic acid, sodium acid carbonate, Aspartame, orange flavor, sodium chloride and PEG6000, mixture carries out direct powder compression under suitable humidity, both obtains effervescent tablet.
Experimental example, nutritional agents of the present invention control noise induced hearing loss Function detection, following invention process is only sketched and is had the experiment content of significance in the present invention.
Animal grouping and process: healthy adult pattern cavy 29 (female 14, male 15), weight 230 ~ 280g, is provided by Hygiene & Environmental Medical Science Inst., Academy of Military Medical Scien's Experimental Animal Center.
Animal is observed 3 days before experiment, is divided into 4 groups at random, wherein:
Experiment contrast group, totally 6 healthy adult pattern cavys, female, male each 3; Experiment contrast group gives deionized water.
Nutritional agents 1 group, totally 8 healthy adult pattern cavys, female, male each 4; Give B B-complex (vitamin a 300 μ gRE/kg/ day+vitaminB10 .25mg/kg/ day+vitamin B2 0.25mg/kg/ day+vitamin B6 0.2mg/kg/ day+vitamin B12 1mcg/kg/ day+vitamin C 50mg/kg/ day+vitamin E2 7mg/kg/ day)+N-acetyl-L-cysteine (400mg/kg/ day).Each component is dissolved in deionized water, is mixed with 500mg/100ml suspension, administration by gavage administration.
Nutritional agents 2 groups, totally 7 healthy adult pattern cavys, female 3, male 4; Give B B-complex (the same)+magnesium (200mg/kg/ day).Each component is dissolved in deionized water, is mixed with 500mg/100ml suspension, administration by gavage administration.
Nutritional agents 3 groups, totally 8 healthy adult pattern cavys, female, male each 4; Give B B-complex (the same)+N-acetyl-L-cysteine (400mg/kg/ day)+magnesium (200mg/kg/ day).Each component is dissolved in deionized water, is mixed with 500mg/100ml suspension, administration by gavage administration.
Expose first three sky until omnidistance administration at the end of experiment in the 7th day after exposing.
Animal used as test Noise Exposure: all tested cavys are placed in wire mesh cage, are put in ground by same radius, overhead suspension speaker.Send white noise by B & K 3560C signal generating system (B & K company, Denmark), be connected in loudspeaker through power amplifier.By B & K2209 type precision sound level meter (B & K company, Denmark) Monitoring and Controlling, the Noise Exposure sound intensity is (110.0 ± 1) dB (SPL), and every day exposes 3h, continuous 2 days.
Tb-ABR detects pure tone audiometry: 0 day, 1 day, 3 days, 7 days threshold of audibility situations of change after Fundamentals of Measurement values and Noise Exposure respectively before Noise Exposure and after Noise Exposure, measuring method: it is subcutaneous 3 needle electrodes to be inserted cavys.Recording electrode inserts in calvarium center position, and reference electrode is placed in picking up the ears mastoid location, and ground wire electrode inserts in mastoid process of picking up the ears subcutaneous, is then placed in electrical shielding iron case.Application Smart-EP Manual Version 3.97 test macro (Zhi Ting company of the U.S.).Adopt short tone burst stimulation (2,4,8,16,32kHz), 1.6ms, the rise/fall time is 2 cycles, and plateau is 1 cycle, selects Blackman window envelope control sidelobe energy.Positive and negative alter polarity stimulates, electrode resistance <5 Ω, and frequency of stimulation is 21.2/s, observes time-histories 12.8ms, filtering bandwidth 100 ~ 500Hz, superposes 512 times, starts to stimulate with 80dBSPL, 10dB successively decreases, and successively decreases with 5dB close to during threshold value, and repeats 2 times.When mensuration 16,32kHz, with high frequency earphone to sound; Measure 2,4,8kHz time, with ER3 earphone to sound.
C-ABR detects the threshold of audibility: stimulus signal is short sound 100ms, frequency of stimulation 11.1/s, filtering bandwidth 100 ~ 3000Hz, superposes 512 times, observes time-histories 12.8ms, adopts TDH-49P earphone to sound during mensuration.All the other are tested with Tb-ABR.
Statistical procedures: data acquisition means standard deviation represents, using SPSS 11.5 software kit to carry out statistical analysis to result, is that difference has statistical significance with P<0.05.
Testing result is as shown in table 5:
Table 5. nutritional agents of the present invention is to the protective effect of noise induced hearing loss
Continued 5
In table 5,0 group is experiment contrast group, and 1 group is nutritional agents 1 group, and 2 groups is nutritional agents 2 groups, and 3 groups is nutritional agents 3 groups; Compared with 0 group, * P<0.05; Compared with 1 group, #P<0.05; Compared with 2 groups, & P<0.05.
Result shows; the exception continuing to give the threshold of audibility that nutritional agents of the present invention significantly can improve caused by noise exposure and pure tone audiometry raises; there is the effect of clear and definite noise immunity hearing loss; wherein; especially best with the protected effect of nutritional agents 3 (i.e. optimization of C/C composites of the present invention), it can reach 19dB to the protective effect of the temporary hearing threshold shift of caused by noise exposure.
Although in conjunction with subordinate list, invention has been described above; but the present invention is not limited to above-mentioned detailed description of the invention; above-mentioned detailed description of the invention is only schematic; instead of it is restrictive; those of ordinary skill in the art is under enlightenment of the present invention; when not departing from present inventive concept, can also make a lot of distortion, these all belong within protection of the present invention.
Claims (8)
1. one kind has the nutritional agents of noise immunity hearing loss, it is characterized in that, be made up of following raw material by weight: N-acetyl-L-cysteine 600-1000 part, vitamin A 1-4 part, vitamin B1 1-5 part, vitamin B2 1-5 part, vitamin B6 1-10 part, vitamin B12 0.01-0.05 part, vitamin C 60-1000 part, vitamin E in alpha-tocopherol 15-300 part, magnesium 50-400 part and food acceptable auxiliary material 79-3175 part.
2. the nutritional agents with noise immunity hearing loss according to claim 1, it is characterized in that, described N-acetyl-L-cysteine 900 parts, vitamin A 3 parts, vitamin B1 2.5 parts, vitamin B2 2.5 parts, vitamin B6 2 parts, vitamin B12 0.01 part, vitamin C 500 parts, vitamin E in alpha-tocopherol 270 parts, 300 parts, magnesium and the acceptable auxiliary material of food 225 parts, wherein, the acceptable auxiliary material of described food comprises: lactose 100 parts, microcrystalline cellulose 80 parts, sodium carboxymethyl starch 40 parts and dolomol 5 parts.
3. the nutritional agents with noise immunity hearing loss according to claim 1, it is characterized in that, described N-acetyl-L-cysteine 900 parts, vitamin A 3 parts, vitamin B1 2.5 parts, vitamin B2 2.5 parts, vitamin B6 2 parts, vitamin B12 0.01 part, vitamin C 500 parts, vitamin E in alpha-tocopherol 270 parts, 300 parts, magnesium and the acceptable auxiliary material of food 79 parts, wherein, the acceptable auxiliary material of described food comprises: Hydroxypropyl methylcellulose 15 parts, Hydroxypropyl methylcellulose 15 parts, sodium carboxymethyl starch 45 parts and dolomol 4 parts.
4. the nutritional agents with noise immunity hearing loss according to claim 1, it is characterized in that, described N-acetyl-L-cysteine 900 parts, 20 parts, vitamine A acetate powder, vitamin B1 2.5 parts, vitamin B2 2.5 parts, vitamin B6 2 parts, vitamin B12 0.01 part, vitamin C 500 parts, Vitwas E 540 parts, magnesium gluconate 5200 parts and the acceptable auxiliary material of food 3175 parts, wherein, the acceptable auxiliary material of described food comprises: citric acid 1000 parts, malic acid 500 parts, sodium acid carbonate 1400 parts, Aspartame 35 parts, orange flavor 60 parts, 60 parts, sodium chloride and PEG6000120 part.
5., according to the described nutritional agents with noise immunity hearing loss arbitrary in Claims 1-4, it is characterized in that, the standard of all raw materials all adopts medicinal standard or food sanitation standard.
6. the nutritional agents with noise immunity hearing loss according to claim 1, is characterized in that, the formulation of described nutritional agents is any one in powder, tablet, granule, capsule and oral fluid agent.
7. the nutritional agents with noise immunity hearing loss according to claim 4, is characterized in that, the formulation of described nutritional agents is the one in hard shell capsules, soft capsule, sugar coated tablet, Film coated tablets, Special-shaped sheet, chewable tablets, effervescent tablet, dispersing tablet, syrup.
8. the nutritional agents with noise immunity hearing loss according to claim 1, is characterized in that, described nutritional agents adds in food as food additives makes functional food.
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