CN104644289B - There is the preparation method of the artificial bone prosthese of dual void - Google Patents
There is the preparation method of the artificial bone prosthese of dual void Download PDFInfo
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- CN104644289B CN104644289B CN201510130395.1A CN201510130395A CN104644289B CN 104644289 B CN104644289 B CN 104644289B CN 201510130395 A CN201510130395 A CN 201510130395A CN 104644289 B CN104644289 B CN 104644289B
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Abstract
nullThe present invention provides the preparation method of a kind of artificial bone prosthese with dual void，Comprise the following steps: utilize medical image data to construct the threedimensional model of original skeleton，Size according to original skeleton threedimensional model and pre-structured diaphysis space determines elementary cell，Shape according to original skeleton threedimensional model、Size builds generation integral unit based on elementary cell，After original skeleton threedimensional model and integral unit are processed by Boolean calculation，Generate the skeleton threedimensional model with diaphysis space，The skeleton threedimensional model with diaphysis space is optimized process，Then，Increasing material manufacturing technology is utilized to print the bone matrix with diaphysis space，On the bone matrix with diaphysis space，Carry out biological coating process，Including adhering to the first coating and the second coating successively on bone matrix，And two coatings have the space of different density degree.The present invention improves the duplication of biocompatibility and the stability of artificial bone prosthese, beneficially cell, grows and repair.
Description
Technical field
The present invention relates to the preparation method of a kind of artificial bone prosthese with dual void, belong to bio-medical false
Body technique field.
Background technology
Vehicle accident, the generation of natural disaster, be easily caused the damage of skeleton, can cause patient time serious
Deformity even loses self care ability, helps bone injury patient's repair deficiency or the sclerous tissues of disappearance, more preferably
It is the problem that medical circle makes great efforts to explore always that ground recovers human body hard tissue function.
Artificial bone prosthese, as solving and repair a kind of technology of autologous skeletal injury, so far, has obtained
To global accreditation.But, in actual use, its biocompatibility is with reliable for artificial bone prosthese
Property aspect still suffer from bigger problem, this is because, bone prosthese is made of metal, itself contain some poison
Property element, rejection and uncomfortable phenomenon easily occur after displacement, in prior art, can be by entering in bone prosthetic surface
Row roughening processes, or nanorize processes, or carrying out the methods such as hydroxyapatite coating layer process improves bone
The biocompatibility of prosthese, but, single surface processes the osteoinductive that can only improve bone prosthetic surface,
The long-term repair of prosthese cannot be promoted, and, coating process there is also coating hold caducous problem, such as,
Chinese patent CN201310122806 and CN201310122725, even if carry out biology outside metal prostheses
Coating processes, but owing to metal is inconsistent with coating bi-material mechanical property, it is easy to ftracture and come off,
Thus reduce the reliability of bone prosthese.
Summary of the invention
In view of the foregoing, it is an object of the invention to provide a kind of artificial bone prosthese with dual void
Preparation method, utilizes the bone prosthese that the method is prepared, not only has good biocompatibility, have simultaneously
There is good stability.
For achieving the above object, the present invention is by the following technical solutions:
The preparation method of a kind of artificial bone prosthese with dual void, comprises the following steps:
S1: utilize medical image data to construct the threedimensional model of original skeleton；
S2: determine elementary cell, foundation according to the size of original skeleton threedimensional model and pre-structured diaphysis space
The shape of original skeleton threedimensional model, size build generation integral unit based on this elementary cell；
S3: after original skeleton threedimensional model and this integral unit being processed by Boolean calculation, is generated and has bone
The skeleton threedimensional model in body space；
S4: the skeleton threedimensional model to generation with diaphysis space is optimized process；
S5: based on the skeleton threedimensional model after optimizing, utilizes increasing material manufacturing technology to print and has diaphysis space
Bone matrix；
S6: on the bone matrix with diaphysis space, carries out biological coating process.
Further,
In described step S6, carry out biological coating process and comprise the following steps:
The coating carrying out ground floor on described bone matrix processes, by bioceramic solution by described skeleton
Diaphysis space on matrix enters inside bone prosthese, forms the first coating of bone matrix, this first coating shape
Become to have lax thick space；
The coating carrying out the second layer on described bone matrix processes, by bioceramic solution by described skeleton
Diaphysis space on matrix enters inside bone prosthese, forms the second coating of bone matrix, this second coating shape
Become to have intensive thin space.
In described step S2, according to the concrete position of bone prosthese, clinical replacement scenario, fixing situation and phase
The biomechanical knowledge closed determines the distribution in pre-structured diaphysis space, density degree etc..
In described step S2, carry out replicating, splicing on horizontal, longitudinal by described elementary cell,
Generate described integral unit.
In described step S3, described original skeleton threedimensional model and integral unit are carried out registration process, so
After carry out Boolean calculation, in the range of described original skeleton threedimensional model, deduct described integral unit, obtain
The described skeleton threedimensional model with diaphysis space, it is empty that this model presents the diaphysis communicated completely from the inside to surface
Gap.
In described step S2, the concrete form of described elementary cell is true according to volume or the thin degree of skeleton
Fixed, the stressing conditions of this elementary cell is consistent with its microcosmic stress form.
The form of described elementary cell can be in HCP, FCC, BCC crystal habit.
In described step S4, to the described skeleton threedimensional model with diaphysis space, carry out virtual emulation and divide
Analysis and optimization, this simulation analysis includes statics Analysis, kinematics analysis, dynamic analysis.
In described step S5, when printing described bone matrix, skeleton threedimensional model entirety is reduced a definite proportion
Example, processes reserved thickness space for follow-up biological coating.
It is an advantage of the current invention that:
The artificial bone prosthese that method under this invention is prepared, has a dual void: metal bone matrix
There is diaphysis space, beneficially bioceramic solution and enter intrinsic silicon through diaphysis space, improve matrix and painting
Combination stability between Ceng, prevents coating shedding；Biological coating has two-layer, and two layers of coatings has thin
The space that density is different, sparse space is conducive to the attachment of cell, grows and repair, and intensive space can
Improve the consistency of bone prosthetic surface, improve wearability and intensity, improve the reliability of bone prosthese.It addition,
The present invention utilizes increasing material manufacturing technology to realize, it is possible to printing speed goes out bone prosthese, and can save material, reduces
Prosthese quality.
Accompanying drawing explanation
Fig. 1 is the method flow schematic diagram of the present invention.
Fig. 2 is the microcosmic schematic diagram in the cross section of the artificial bone prosthese of the present invention.
Fig. 3 is the microstructure schematic diagram of the elementary cell of the present invention one specific embodiment.
Detailed description of the invention
Below in conjunction with drawings and Examples, the present invention is further detailed explanation.
Fig. 1 is the method flow schematic diagram of the present invention, has dual void as it can be seen, disclosed by the invention
The preparation method of artificial bone prosthese, comprise the following steps:
S1: utilize medical image data to construct the threedimensional model of original skeleton；
On the basis of skeleton MRI or CT data, the outline successively extracting skeleton is (available
Mimics software extracts), then the outline overall fit according to each layer generates the three-dimensional mould of original skeleton
Type.
S2: determine elementary cell according to the threedimensional model of original skeleton and the size in pre-structured diaphysis space, depend on
Based on elementary cell, generation integral unit is built according to shape, the size of original skeleton threedimensional model；
First, a kind of form is determined according to the threedimensional model of original skeleton and the size in pre-structured diaphysis space
Elementary cell, and according to the position of bone prosthese, clinical replacement scenario, fixing situation and relevant biomechanics
Knowledge determines the distribution in pre-structured diaphysis space, density degree etc., e.g., the bone prosthese of large volume (as
Long bone), the diaphysis space of structure should more greatly, relatively thin prosthese (such as phalanges), and the diaphysis space of structure should
More intensive；Fixed position and the marginal portion of bone prosthese are difficult to distributed voids, in order to avoid affecting intensity；
Then, according to shape, the size of original skeleton threedimensional model, by elementary cell respectively at horizontal, vertical
Upwards carry out replicating, splicing, generate the entirety substantially adapted with original skeleton threedimensional model shape, size
Unit；
Fig. 3 is the microstructure schematic diagram of the elementary cell of the present invention one specific embodiment, as it can be seen, base
This unit 6 generates lateral cell 7 through laterally replicating, after splicing, lateral cell 7 again through longitudinally replicating,
Integral unit 8 is generated after splicing；Duplication therein, splicing refer to, arrange the duplication of elementary cell
Number and displacement, it is achieved the modeling of multiple base units, and ensure the communicating of diaphysis space, unanimously, with
It is beneficial to the reparation of cell after the making of follow-up coating and displacement.
The concrete form of elementary cell can be designed according to the volume of skeleton or thin degree, design principle
Being to try to make its stressing conditions consistent with microcosmic stress form, the form of elementary cell is referred to common
Crystal structure, such as HCP, FCC, BCC etc..
S3: after original skeleton threedimensional model and integral unit being processed by Boolean calculation, is generated and has diaphysis
The skeleton threedimensional model in space；
Original skeleton threedimensional model and integral unit are carried out registration process, then carries out Boolean calculation, former
Deduct integral unit in the range of beginning skeleton threedimensional model, obtain the skeleton threedimensional model with diaphysis space,
This model presents the diaphysis space communicated completely from the inside to surface.
S4: the skeleton threedimensional model to generation with diaphysis space is optimized process；
To having the skeleton threedimensional model in diaphysis space, carry out simulation analysis and optimization, specifically,
According to biomechanical knowledge, utilize and can realize the software of statics simulation analysis (such as ABAQUS
Software) carry out statics Analysis, to ensure artificial bone borrowed structure reliability in a static condition；Then,
Utilization can realize the software (such as ADAMS software) of Dynamics Simulation Analysis, sets up and artificial bone prosthese phase
Other skeleton models coordinated, and move based on the relevant knowledge in body biomechanics and rehabilitation engineering
Learn emulation to guarantee artificial bone prosthese reliability and stability under moving condition；Finally, utilize
MATLAB software carries out dynamics simulation, further determines that the motion of artificial bone prosthese and the reasonable of stress
Property.In above-mentioned each simulation process, according to simulation result, skeleton threedimensional model is carried out reasonability amendment, so
After again emulate, until simulation result is good.
S5: based on the skeleton threedimensional model after optimizing, utilizes increasing material manufacturing technology to print and has diaphysis space
Bone matrix；
The threedimensional model of skeleton is converted to stl file form, by the input of this stl file to increasing material manufacture
Equipment, to print the bone matrix of titanium alloy material；It is also performed to raw in view of subsequent metal bone prosthese
Thing coating processes, and when printing bone matrix, model entirety is reduced certain proportion so that subsequent bio coating
Bone prosthese after process is suitable with green bone size.
S6: on the bone matrix with diaphysis space, carries out biological coating process.
On the basis of the bone matrix with diaphysis space, the biological pottery of the compositions such as hydroxyapatite will be comprised
Porcelain melts as solution, and under the effect of chemical reaction, bioceramic solution is by the diaphysis space on bone matrix
Enter inside bone prosthese, and be attached on bone matrix, the binding ability of coating and matrix can be improved, anti-
Anti-avulsion falls.
For ensureing that bone prosthese has preferable biocompatibility and wearability, and guarantee biological coating difficult drop-off
And there is good stability, the present invention, when carrying out biological coating and processing, is divided into following two step:
The coating carrying out ground floor on bone matrix processes, i.e. utilize chemical reaction to make bioceramic solution
Enter inside bone prosthese by diaphysis space on bone matrix, form the first coating of bone matrix, the
In the forming process of one coating, by the control to temperature or electric current, the first coating is made to generate the laxest
Thick space, with improve the attachment of cell after the binding ability of bone matrix and coating, beneficially Using prosthesis,
Growth and reparation；
The coating carrying out the second layer on bone matrix processes, i.e. at the skeleton base of above-mentioned attachment the first coating
On the basis of body, chemical reaction is utilized to make bioceramic solution enter bone by the diaphysis space on bone matrix false
Internal portion, forms the second coating of bone matrix, in the forming process of the second coating, by temperature or
It is the control of electric current, makes the second coating generate the most intensive thin space, to improve the densification of bone prosthetic surface
Degree, improves wearability and intensity, increases the reliability of bone prosthese.
As in figure 2 it is shown, the microstructure schematic diagram in the cross section of its bone prosthese that to be method under this invention make,
There is the artificial bone prosthese of dual void, including bone matrix 5, be sequentially attached to the of bone matrix surface
One coating 1 and the second coating 2；Bone matrix 5 has the entrance in diaphysis space 4, beneficially two layers of coatings
With attachment, the first coating 1 has sparse thick space, and the spacing between the most each molecule 3 is relatively big, and second is coated with
Layer 2 has intensive thin space, and each intermolecular spacing is less, the space of whole bone prosthese from inside to outside by
Diminishing greatly, this is similar with the microstructure of skeleton.
The preparation method of the artificial bone prosthese with dual void of the present invention, first builds original skeleton three-dimensional mould
Type, determines elementary cell according to the size in pre-structured diaphysis space, according to original skeleton threedimensional model size,
Shape constructs integral unit based on elementary cell, deducts overall single in original skeleton threedimensional model
Unit, generates the skeleton threedimensional model with diaphysis space, after model optimization processes, utilizes and increases material manufacturing technology
Print the bone matrix with diaphysis space, this bone matrix adheres to the first coating and second successively and is coated with
Layer.Bone matrix has diaphysis space, is conducive to guiding bioceramic solution in diaphysis space enters matrix
Portion, reduces " stress shielding " between bone matrix and biological coating, improves combination therebetween stable
Property, prevent coating shedding；First, second coating has the space that density is different, by temperature or
The control of electric current, the first coating is formed with the thick space that spacing is bigger, can improve the knot of bone matrix and coating
Closing the attachment of cell after performance, beneficially bone Using prosthesis, grow and repair, the second coating is attached to first
In coating, it is formed with the thin space that spacing is less, can improve the consistency of bone prosthetic surface, improves wear-resisting
Property and intensity, improve bone prosthese reliability.
The present invention utilizes the diaphysis space of bone matrix and the gap structure of two layers of coatings, improves artificial bone false
The biocompatibility of body and stability, after displacement bone prosthese, can be realized by the long-term repair of cell, phagocytosis
Osteanagenesis so that bone prosthese gradates and is possibly realized for real skeleton；It addition, the present invention utilizes increasing material
Manufacturing technology, can realize the printing speed of fine structure titanium prosthesis, alleviates prosthese quality, saves material.
The above is presently preferred embodiments of the present invention and the know-why used thereof, for the skill of this area
For art personnel, without departing from the spirit and scope of the present invention, any based on the technology of the present invention side
Equivalent transformation on the basis of case, simple replacement etc. obviously change, belong to scope it
In.
Claims (8)
1. there is the preparation method of the artificial bone prosthese of dual void, it is characterised in that comprise the following steps:
S1: utilize medical image data to construct the threedimensional model of original skeleton；
S2: determine elementary cell, foundation according to the size of original skeleton threedimensional model and pre-structured diaphysis space
The shape of original skeleton threedimensional model, size build generation integral unit based on this elementary cell；
S3: after original skeleton threedimensional model and this integral unit being processed by Boolean calculation, is generated and has bone
The skeleton threedimensional model in body space, and this has the skeleton threedimensional model in diaphysis space, its diaphysis space is from inner
Communicate completely to outer；
S4: the skeleton threedimensional model to generation with diaphysis space is optimized process；
S5: based on the skeleton threedimensional model after optimizing, utilizes increasing material manufacturing technology to print and has diaphysis space
Bone matrix；
S6: on the bone matrix with diaphysis space, carries out biological coating process, and formation is sequentially attached to
The thick space on bone matrix surface and thin space.
There is the preparation method of the artificial bone prosthese of dual void, its feature the most as claimed in claim 1
Be, in described step S2, according to the concrete position of bone prosthese, clinical replacement scenario, fixing situation and
Relevant biomechanical knowledge determines the distribution in pre-structured diaphysis space, density degree.
There is the preparation method of the artificial bone prosthese of dual void, its feature the most as claimed in claim 2
It is, in described step S2, carries out replicating, splicing by described elementary cell on horizontal, longitudinal,
Generate described integral unit.
There is the preparation method of the artificial bone prosthese of dual void, its feature the most as claimed in claim 3
It is, in described step S3, described original skeleton threedimensional model and integral unit is carried out registration process,
Then carry out Boolean calculation, in the range of described original skeleton threedimensional model, deduct described integral unit,
Having the skeleton threedimensional model in diaphysis space described in, it is empty that this model presents the diaphysis communicated completely from the inside to surface
Gap.
There is the preparation method of the artificial bone prosthese of dual void, its feature the most as claimed in claim 1
Being, in described step S2, the concrete form of described elementary cell is according to the volume of skeleton or thin degree
Determining, the stressing conditions of this elementary cell is consistent with its microcosmic stress form.
There is the preparation method of the artificial bone prosthese of dual void, its feature the most as claimed in claim 5
Being, the form of described elementary cell is HCP, FCC, BCC crystal habit.
There is the preparation method of the artificial bone prosthese of dual void, its feature the most as claimed in claim 1
It is, in described step S4, to the described skeleton threedimensional model with diaphysis space, carries out virtual emulation
Analyzing and optimize, this simulation analysis includes statics Analysis, kinematics analysis, dynamic analysis.
There is the preparation method of the artificial bone prosthese of dual void, its feature the most as claimed in claim 1
Being, in described step S5, when printing described bone matrix, the skeleton threedimensional model after optimizing is overall
Reduce certain proportion, process reserved thickness space for follow-up biological coating.
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| CN105574227A (en) * | 2015-10-14 | 2016-05-11 | 深圳市艾科赛龙科技有限公司 | Method for making artificial shoulder blade |
| CN106983551B (en) * | 2017-05-12 | 2019-06-14 | 国家康复辅具研究中心 | The porous complex bone plate and preparation method thereof of rigidity gradient variation |
| CN109228354A (en) * | 2018-09-26 | 2019-01-18 | 东华大学 | A kind of increasing material manufacturing process of the enhancing of geometry containing 3 D weaving composite material |
| CN109938883B (en) * | 2019-01-28 | 2020-12-18 | 国家康复辅具研究中心 | Dodecahedron rod structure unit, bone implant and mass transfer performance evaluation method thereof |
| CN112704582B (en) * | 2021-01-25 | 2022-05-06 | 山东建筑大学 | Preparation method of customizable regenerated porous nano-material 3D printed femoral head |
| CN115414159A (en) * | 2022-09-19 | 2022-12-02 | 中国人民解放军联勤保障部队第九二〇医院 | Artificial scaphoid prosthesis and preparation method and preparation tool thereof |
| CN116029161B (en) * | 2023-03-27 | 2023-09-08 | 北京爱康宜诚医疗器材有限公司 | Prosthesis design method with gradual porosity |
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| WO2003070288A2 (en) * | 2001-10-12 | 2003-08-28 | Inframat Corporation | Coated implants and methods of coating implants |
| CN1493709A (en) * | 2002-10-31 | 2004-05-05 | 刘国献 | Biofunction gradient composite coating layer material |
| US7416564B2 (en) * | 2003-11-26 | 2008-08-26 | Seoul National University Industry Foundation | Porous bioceramics for bone scaffold and method for manufacturing the same |
| US8066770B2 (en) * | 2007-05-31 | 2011-11-29 | Depuy Products, Inc. | Sintered coatings for implantable prostheses |
| CN201154007Y (en) * | 2008-01-22 | 2008-11-26 | 徐宁 | Hip-joint prosthesis with hydroxylapatite coating |
| CN102784014B (en) * | 2012-08-14 | 2014-11-26 | 中国科学院深圳先进技术研究院 | Porotic bone scaffold and preparation method thereof |
| CN103751840B (en) * | 2014-02-12 | 2016-04-27 | 吴志宏 | A kind of have bone defect repair support of the controlled low modulus of porous and preparation method thereof |
| CN103977451B (en) * | 2014-05-19 | 2015-09-02 | 吉林大学 | The 3D of tantalum coating multi-stage porous polyether-ether-ketone artificial bone scaffold prints manufacture method |
| CN104000674B (en) * | 2014-06-10 | 2016-03-09 | 张衣北 | Tool pliability trabecular bone structure Invasive lumbar fusion device |
| CN104173123B (en) * | 2014-08-22 | 2016-06-08 | 国家康复辅具研究中心 | Quickly, reliable artificial bone prosthese preparation method |
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