CN104623538A - Traditional Chinese medicine preparation for treating urinary calculus and application of traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation for treating urinary calculus and application of traditional Chinese medicine preparation Download PDFInfo
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- CN104623538A CN104623538A CN201510021010.8A CN201510021010A CN104623538A CN 104623538 A CN104623538 A CN 104623538A CN 201510021010 A CN201510021010 A CN 201510021010A CN 104623538 A CN104623538 A CN 104623538A
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine preparation for treating urinary calculus and application of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation comprises the following components: christina loosestrife herb, akebiaquinata, liquorice, endothelium corneum gigeriae galli, bamboo leaf, astragalus membranaceus, dianthus superbus, curcuma zedoary, dogwood and caulis perllae. The traditional Chinese medicine preparation is a pure traditional Chinese medicine preparation, is reasonable in composition, is capable of medicating by syndrome differentiation, and has a relatively good curative effect on urinary calculus, especially damp-heat type urinary calculus.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine preparation for the treatment of urinary system calculus and uses thereof.
Background technology
Stranguria caused by urinary stone is accumulate for a long time by damp and hot, decocts urine Cheng Shi, and retardance kidney system is urinary system calculus.This sick sickness rate is high, and easily recur, wherein ureteral calculus is the most common in urinary system calculus.For the treatment of ureteral calculus, current Therapeutic Method comprises ESWL art, URL art, peritoneoscope and open surgery, dissolution therapy and Drug therapy etc., and the clinical method adopting Wicresoft, as ESWL and ureterorenoscope lithotrity etc. more.But the infringement of ESWL to renal function is subject to people's attention gradually, is characterized in the capacity issue solving calculus, not there is direct calculus removing effect.
Use theory of Chinese medical science, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, study effective Treated with Chinese Decoction urinary system calculus and can not only overcome the untoward reaction that Western medicine causes, more can effectively reduce its relapse rate, there is good researching value and practical significance.
Summary of the invention
The invention provides a kind of new Chinese medicine preparation for the treatment of urinary system calculus, overcome the deficiency of Chinese and western medicine preparation in the past, have good curative effect to damp-heat type urinary system calculus, and have no side effect.Described Chinese medicine preparation is obtained by following raw material: Herba Lysimachiae, Caulis Akebiae, Radix Glycyrrhizae, Endothelium Corneum Gigeriae Galli, Folium Bambusae, the Radix Astragali, Herba Dianthi, Rhizoma Curcumae, Fructus Corni, Caulis Perillae.
The technical scheme adopted for solving its technical problem is the Chinese medicine preparation of described treatment urinary system calculus, be made up of the medicine of following weight: Herba Lysimachiae 20-36 part, Caulis Akebiae 10-20 part, Radix Glycyrrhizae 4-8 part, Endothelium Corneum Gigeriae Galli 5-15 part, Folium Bambusae 15-25 part, Radix Astragali 8-16 part, Herba Dianthi 8-16 part, Rhizoma Curcumae 15-25 part, Fructus Corni 15-25 part, Caulis Perillae 10-20 part.
The preferred technical solution of the present invention is, described Chinese medicine preparation of the present invention, is obtained by the raw material of following weight portion: Herba Lysimachiae 28 parts, Caulis Akebiae 15 parts, 6 parts, Radix Glycyrrhizae, Endothelium Corneum Gigeriae Galli 10 parts, 20 parts, Folium Bambusae, the Radix Astragali 12 parts, Herba Dianthi 12 parts, Rhizoma Curcumae 20 parts, Fructus Corni 20 parts, Caulis Perillae 15 parts.
Present invention also offers the preparation method of described Chinese medicine preparation, after specifically comprising the steps: the raw material Herba Lysimachiae of above-mentioned weight portion, Caulis Akebiae, Radix Glycyrrhizae, Endothelium Corneum Gigeriae Galli, Folium Bambusae, the Radix Astragali, Herba Dianthi, Rhizoma Curcumae, Fructus Corni, Caulis Perillae to pulverize respectively, add the water of 10 times amount of medical material gross weight, decoct 3 times, collecting decoction filters, and concentrate filtrate to thick paste, crushed after being dried.
Those skilled in the art directly can be used as medicine on obtained active constituents of medicine basis of the present invention to use or add on pharmaceutics acceptable adjuvant routinely technique be prepared into required preparation.Preferably, Chinese medicine preparation of the present invention conveniently preparation technology be prepared into tablet or capsule.Described tablet, active component pulverize after and microcrystalline Cellulose, hydroxypropyl cellulose mixing, add 2% polyvidone alcoholic solution soft material, cross 20 mesh sieves granulate, drying, add magnesium stearate, 20 mesh sieve granulate, mix, tabletting, to obtain final product.
The present invention also asks to protect above-mentioned Chinese medicine preparation in the purposes of preparation treatment urinary system calculus particularly in preparation treatment damp-heat type urinary system calculus medicine.Known by clinical trial, cure 39 examples in treatment group 50 example, 9 examples that take a turn for the better (wherein, lost to follow-up after 2 routine patients take a turn for the better to some extent, only by the statistics that takes a turn for the better), invalid 2 examples.Cure rate 78%, improvement rate 18%, inefficiency 4%, total effective rate 96%.Treat effective follow-up of patients after 1 year, relapse rate 6.25%.22 examples are cured, 16 examples that take a turn for the better (wherein, lost to follow-up after 4 routine patients take a turn for the better to some extent, only by the statistics that takes a turn for the better), invalid 12 examples in matched group 50 example.Cure rate 44%, improvement rate 32%, inefficiency 24%, total effective rate 76%.Treat effective follow-up of patients after 1 year, relapse rate 20%.In safety evaluatio, in treatment group patient treatment procedure, vital sign steadily and without the untoward reaction such as nausea and vomiting, allergy, clinical treatment outcome is remarkable.
The side of Chinese medicine preparation of the present invention separates as follows: described Herba Lysimachiae, sweet, salty, is slightly cold.Return liver, gallbladder, kidney, urinary bladder channel.Eliminating damp-heat, treating stranguria, detumescence.For pyretic stranguria, Sha Lin, urinates and puckeryly to have a pain, jaundice dark coloured urine, carbuncle furuncle, venom; Liver and bile stone, lithangiuria.
Caulis Akebiae, bitter; Cold in nature.The heart; Spleen; Kidney; Small intestinal; Urinary bladder channel.Clearing away heat and promoting diuresis; Blood circulation and channel invigorating.Main red urine is red; Stranguria with turbid discharge; Edema; Irritable feverish sensation in the chest; Larynx larynx pain; Aphtha of the mouth and tongue; Rheumatic arthralgia; Galactostasis; Amenorrhea; Dysmenorrhea.
Radix Glycyrrhizae, sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Endothelium Corneum Gigeriae Galli, sweet, flat.Return spleen, stomach, small intestinal, urinary bladder channel.Invigorating the stomach and promoting digestion, arresting seminal emission.Do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission.
Folium Bambusae, sweet; Light; Cold.The heart; Lung; Stomach warp.Clearing heat and relieving fidgetness; To promote the production of body fluid diuresis.Main calentura excessive thirst; little Jing Epilepsy; Cough with dyspnea tells nosebleed; Oliguria with reddish urine; Erosion of the oral mucosa tongue boil.
The Radix Astragali, sweet, tepor.Polishing consolidating superficial resistance, holder skin ulcer granulation promoting.Cure mainly the empty spontaneous perspiration of body, chronic diarrhea, proctoptosis, uterine prolapse, chronic nephritis, body is impractical swollen, chronic ulcer, open sore part disunion of a specified duration.
Herba Dianthi is bitter, cold.GUIXIN, small intestine meridian.Inducing diuresis for treating stranguria syndrome, removing blood stasis stimulates the menstrual flow.For pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, urinary obstruction, drenches the puckery pain of drop, menstruation apolipsis.
Rhizoma Curcumae, pungent, bitter, temperature.Return liver, spleen channel.Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.
Fructus Corni, sour, puckery, tepor.Return liver, kidney channel.Liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Interior-heat is quenched one's thirst.
Caulis Perillae, Xin Gan, tepor.Enter spleen, stomach, lung three warp.Regulate the flow of vital energy, Shu Yu, pain relieving, antiabortive.Control the stagnation of QI, dyspepsia, chest and diaphragm painful abdominal mass is vexed, epigastric pain, and nausea is got along well.
Chinese medicine preparation reasonable recipe of the present invention, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, has the effect of clearing away heat-damp and promoting diuresis, calculus dissolving and excreting, consolidating superficial resistance pain relieving, effectively can cure urinary system calculus particularly damp-heat type urinary system calculus disease.Through clinical practice checking, its determined curative effect, mild in medicine property and, do not occur toxic and side effects and untoward reaction, safety coefficient is high, and relapse rate is low, and clinical observation total effective rate reaches more than 95%, can be used as clinical active drug and applies.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
The each raw material of the present invention is taken: Herba Lysimachiae 28 parts, Caulis Akebiae 15 parts, 6 parts, Radix Glycyrrhizae, Endothelium Corneum Gigeriae Galli 10 parts, 20 parts, Folium Bambusae, the Radix Astragali 12 parts, Herba Dianthi 12 parts, Rhizoma Curcumae 20 parts, Fructus Corni 20 parts, Caulis Perillae 15 parts by following weight portion.
Preparation technology is as follows:
After the raw material Herba Lysimachiae of above-mentioned weight portion, Caulis Akebiae, Radix Glycyrrhizae, Endothelium Corneum Gigeriae Galli, Folium Bambusae, the Radix Astragali, Herba Dianthi, Rhizoma Curcumae, Fructus Corni, Caulis Perillae are pulverized respectively, add the water of 10 times amount of medical material gross weight, decoct 3 times, collecting decoction filters, and concentrate filtrate to thick paste, crushed after being dried.Those skilled in the art can mix with microcrystalline Cellulose, hydroxypropyl cellulose on this basis, add 2% polyvidone alcoholic solution soft material, cross 20 mesh sieves and granulate, and dry, add magnesium stearate, 20 mesh sieve granulate, mixing, tabletting, to obtain final product.
When using Chinese medicine preparation of the present invention to treat urinary system calculus disease, take prepared tablet, every sheet, containing crude drug amount 0.2g, every day 3 times, each 4, is taken after meal half an hour.
Embodiment 2
The each raw material of the present invention is taken: Herba Lysimachiae 20 parts, Caulis Akebiae 10 parts, 4 parts, Radix Glycyrrhizae, Endothelium Corneum Gigeriae Galli 5 parts, 15 parts, Folium Bambusae, the Radix Astragali 8 parts, Herba Dianthi 8 parts, Rhizoma Curcumae 15 parts, Fructus Corni 15 parts, Caulis Perillae 10 parts by following weight portion.
Preparation technology is with embodiment 1.
Embodiment 3
The each raw material of the present invention is taken: Herba Lysimachiae 36 parts, Caulis Akebiae 20 parts, 8 parts, Radix Glycyrrhizae, Endothelium Corneum Gigeriae Galli 15 parts, 25 parts, Folium Bambusae, the Radix Astragali 16 parts, Herba Dianthi 16 parts, Rhizoma Curcumae 25 parts, Fructus Corni 25 parts, Caulis Perillae 20 parts by following weight portion.
Preparation technology is with embodiment 1.
Embodiment 4
The each raw material of the present invention is taken: Herba Lysimachiae 20 parts, Caulis Akebiae 10 parts, 8 parts, Radix Glycyrrhizae, Endothelium Corneum Gigeriae Galli 15 parts, 15 parts, Folium Bambusae, the Radix Astragali 8 parts, Herba Dianthi 16 parts, Rhizoma Curcumae 25 parts, Fructus Corni 15 parts, Caulis Perillae 10 parts by following weight portion.
Preparation technology is with embodiment 1.
Embodiment 5
The each raw material of the present invention is taken: Herba Lysimachiae 36 parts, Caulis Akebiae 20 parts, 4 parts, Radix Glycyrrhizae, Endothelium Corneum Gigeriae Galli 5 parts, 25 parts, Folium Bambusae, the Radix Astragali 16 parts, Herba Dianthi 8 parts, Rhizoma Curcumae 15 parts, Fructus Corni 25 parts, Caulis Perillae 20 parts by following weight portion.
Preparation technology is with embodiment 1.
The clinical observation of embodiment 6 Chinese medicine preparation treatment of the present invention urinary system calculus
1, case-data: that selects hospital ward and outpatient clinic meets damp-heat type Patients with Urinary Stone 100 example, according to patient clinical symptom and sign, all patients all make a definite diagnosis through " color ultrasound " inspection or x-ray plain abdominal radiograph or CT.Be divided into treatment group, matched group at random.
Wherein, treatment group: in 50 routine patients, man 30 example, female 20 example; The oldest 60 years old, minimum 21 years old, 45 years old mean age; Proximal ureteral calculus 30 example, ureter stage casing calculus 15 example, distal ureteral calculi 5 example, the course of disease 15 days-3 years.
Treatment group: in 50 routine patients, man 31 example, female 19 example; The oldest 61 years old, minimum 20 years old, 46 years old mean age; Proximal ureteral calculus 29 example, ureter stage casing calculus 14 example, distal ureteral calculi 7 example, the course of disease 20 days-3 years.
2, diagnosis basis:
(1) tcm diagnosis standard:
1) waist angina abdominis during outbreak, pain and external genitalia, pale complexion, cold sweat, nausea and vomiting.Can with fever with chills, difficulty and pain in micturition is frequently anxious, or has interruption of urinating;
2) the visible hematuria of naked eyes, or urine has sandstone to discharge;
3) routine urianlysis has erythrocyte;
4) do the ultrasound diagnosis of kidney system, or x-ray plain abdominal radiograph, pyelography etc. can specify stone location.Make cystoscope retrograde urography if desired.
(2) damp-heat type disease CM syndrome differentiation criterion: waist angina abdominis, difficulty and pain in micturition, is with blood in urine, or interruption of urinating, and during solution, twinge unbearably, constipation with dry stool.Yellowish fur, stringy pulse or number.
3, case standard is included in:
(1) age 20-65 year, male or female;
(2) calculus diameter≤1.0cm, regular shape, smooth surface;
(3) urinary tract is without obviously lopsided, narrow and infection, without hydronephrosis;
(4) diagnostic criteria and the dialectical standard of damp-heat type is met;
(5) clinical observation " Informed Consent Form " is signed.
4, Excluded cases standard:
(1) clinical observation " Informed Consent Form " is not signed;
(2) gestation or women breast-feeding their children;
(3) drug allergy or can not resistance to receptor is used to this research;
(4) psychotic;
(5) age is below 20 years old or over-65s person.
5, case standard is rejected:
(1) rear discovery is included in exclusion standard disease patient;
(2) case of medication is not specified by testing program;
(3) drug administration process data logging is incomplete, cannot judge curative effect person.
6, to come off and termination criteria:
(1) naturally come off and person lost to follow-up in observing;
(2) there is the person that should not continue reception test such as complication or special physiological change in experimenter;
(3) serious adverse reaction occurs person in test, should stop clinical trial in time.
Come off and answer itemized record reason with the case stopped, and the switching of its last curative effect testing result is added up for final result.
7, usage and dosage:
Treatment group: take Chinese medicine preparation of the present invention treatment, tablet prepared by Example 1, every sheet containing crude drug amount 0.2g, every day 3 times, each 4, after meal half an hour warm water delivery service.Eliminate as principle with clinical symptoms after taking medicine, symptom is not eliminated and is taken drug withdrawal after 30 days.
Matched group: Shenshitong ball (the accurate word Z20070043 of traditional Chinese medicines, specification: often wrap 2g) oral medication, each 1 bag, every day 2 times, takes observe the curative effect after 30 days continuously.
8, curative effect determinate standard:
(1) cure: sandstone is discharged, transference cure, x-ray is taken the photograph sheet calculus shade and is disappeared;
(2) take a turn for the better: symptom is improved, x-ray is taken the photograph sheet calculus and to be reduced or position moves down;
(3) do not heal: symptom and x-ray check that calculus is unchanged.
9, therapeutic effect:
Treatment group efficacy result is as follows: cure 39 examples in 50 examples, 9 examples that take a turn for the better (wherein, lost to follow-up after 2 routine patients take a turn for the better to some extent, only by the statistics that takes a turn for the better), invalid 2 examples.Cure rate 78%, improvement rate 18%, inefficiency 4%, total effective rate 96%.Treat effective follow-up of patients after 1 year, relapse rate 6.25%.
Matched group efficacy result is as follows: cure 22 examples in 50 examples, 16 examples that take a turn for the better (wherein, lost to follow-up after 4 routine patients take a turn for the better to some extent, only by the statistics that takes a turn for the better), invalid 12 examples.Cure rate 44%, improvement rate 32%, inefficiency 24%, total effective rate 76%.Treat effective follow-up of patients after 1 year, relapse rate 20%.
In treatment group therapeutic process, vital sign steadily and without serious adverse reactions such as allergy, result shows that the clinical application of we is safely and effectively, and relapse rate is low, is worth studying and applying further.
Claims (6)
1. treat the Chinese medicine preparation of urinary system calculus for one kind, it is characterized in that, its raw material primarily of following weight portion obtains: Herba Lysimachiae 20-36 part, Caulis Akebiae 10-20 part, Radix Glycyrrhizae 4-8 part, Endothelium Corneum Gigeriae Galli 5-15 part, Folium Bambusae 15-25 part, Radix Astragali 8-16 part, Herba Dianthi 8-16 part, Rhizoma Curcumae 15-25 part, Fructus Corni 15-25 part, Caulis Perillae 10-20 part.
2. Chinese medicine preparation as claimed in claim 1, is characterized in that, its raw material primarily of following weight portion obtains: Herba Lysimachiae 28 parts, Caulis Akebiae 15 parts, 6 parts, Radix Glycyrrhizae, Endothelium Corneum Gigeriae Galli 10 parts, 20 parts, Folium Bambusae, the Radix Astragali 12 parts, Herba Dianthi 12 parts, Rhizoma Curcumae 20 parts, Fructus Corni 20 parts, Caulis Perillae 15 parts.
3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, described Chinese medicine preparation is oral formulations.
4. Chinese medicine preparation as claimed in claim 3, it is characterized in that, described oral formulations is tablet or capsule.
5. Chinese medicine preparation as claimed in claim 4, it is characterized in that, described tablet is obtained by following steps:
After the raw material Herba Lysimachiae of weight portion described in claim 1, Caulis Akebiae, Radix Glycyrrhizae, Endothelium Corneum Gigeriae Galli, Folium Bambusae, the Radix Astragali, Herba Dianthi, Rhizoma Curcumae, Fructus Corni, Caulis Perillae are pulverized respectively, add the water of 10 times amount of medical material gross weight, decoct 3 times, collecting decoction filters, and by filtrate reduced in volume thick paste, crushed after being dried; Those skilled in the art can mix with microcrystalline Cellulose, hydroxypropyl cellulose on obtained this active constituents of medicine basis, add 2% polyvidone alcoholic solution soft material, cross 20 mesh sieves and granulate, drying, adds magnesium stearate, 20 mesh sieve granulate, mixing, tabletting, to obtain final product.
6. the purposes of Chinese medicine preparation as claimed in claim 1 or 2 in preparation treatment damp-heat type urinary system calculus medicine.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1554413A (en) * | 2003-12-26 | 2004-12-15 | 喻建平 | Chinese medicine for treating urolithiasis and its preparing method |
| CN101810833A (en) * | 2010-05-25 | 2010-08-25 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating edema and preparation method thereof |
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- 2015-01-16 CN CN201510021010.8A patent/CN104623538A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1554413A (en) * | 2003-12-26 | 2004-12-15 | 喻建平 | Chinese medicine for treating urolithiasis and its preparing method |
| CN101810833A (en) * | 2010-05-25 | 2010-08-25 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating edema and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 董秀文 等主编: "《当代心脑肾肝胆病医方集成》", 30 September 2003 * |
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Application publication date: 20150520 |