CN104622518A - Cervical cell sampling device - Google Patents

Cervical cell sampling device Download PDF

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Publication number
CN104622518A
CN104622518A CN201510100081.7A CN201510100081A CN104622518A CN 104622518 A CN104622518 A CN 104622518A CN 201510100081 A CN201510100081 A CN 201510100081A CN 104622518 A CN104622518 A CN 104622518A
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CN
China
Prior art keywords
sampler
localizer
cervix uteri
generating unit
force generating
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Granted
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CN201510100081.7A
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Chinese (zh)
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CN104622518B (en
Inventor
胡妙申
俞宏
朱金良
崔德宝
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Hangzhou Dian Biotechnology Co Ltd
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Hangzhou Dian Biotechnology Co Ltd
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Priority to CN201510100081.7A priority Critical patent/CN104622518B/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B10/0291Instruments for taking cell samples or for biopsy for uterus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045Devices for taking samples of body liquids
    • A61B2010/0074Vaginal or cervical secretions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention discloses a cervical cell sampling device which comprises a sampler master pipe, a power generator, a uterine neck locator and a sampler, wherein the uterine neck locator can be movably arranged in the sampler master pipe under the drive of the power generator; the sampler is movably arranged in the uterine neck locator under the drive of the power generator; the head of the sampler is defined in the uterine neck locator in an initial state; and the head of the sampler extends out of the uterine neck locator under the drive of the power generator in the sampling process.

Description

Cervical cells sampling device
Technical field
The present invention relates to medical instruments field, particularly a kind of under the guidance of doctor or individual read illustrate after can the cervical cells sampling device of independent collection cervical exfoliated cell.
Background technology
Cervical cancer is that cervical epithelial cells is subject to human papillomavirus HPV and infects and cause, especially high-risk HPV persistent infection, and women's cervical cancer of bibliographical information more than 97% is all that HPV infects and causes.HPV infects and causes the abnormal growth of cervical epithelial cells, and especially in cervical canal and cervix uteri oral thermometer chrotoplast, the non-Timeliness coverage of persistent infection gives treatment and develops into cervical exfoliated cell pathological changes, infects developing into pernicious cervical cancer through in a few years.Therefore carry out cytology to detect and HPV-DNA detects and becomes the Main Means of cervical carcinoma screening by gathering cervical exfoliated cell, main detection method is cell smear method, ThinPrep cytologic test, HPV-DNA detection.At present, cervical exfoliated cell is sampled, and is all at hospital of medical and health organization, MEC process chamber, under the help of doctor, insert vagina by vaginal dilator and expand, exposing cervix uteri and use scraping blade or Uterine neck bush to gather cervix uteri exfoliation cell/secretions.
Current cervical carcinoma screening has been the important test item of women's health health check-up, and several amount detection of ten million is huge every year.Above-mentioned detection method without exception all must at hospital or inspection center's process chamber, in professional person's collected specimens such as doctors, working doctor amount is large and complete that to detect sampling patient limited every day, causes Physical Check-Ups patient to block up, seriously hinders cervical carcinoma screening.Along with doctors and nurses's sampling work amount increases, standard for manual sampling has deviation unavoidably.
Aforementioned cervix sampling method has a lot of not enough place therefore to need to design and develop the autonomous sampling apparatus of a kind of cervical exfoliated cell and the method for sampling.
Summary of the invention
Goal of the invention: technical problem to be solved by this invention is for the deficiencies in the prior art, provides a kind of cervical exfoliated cell sampling apparatus.
In order to solve the problems of the technologies described above, the invention discloses a kind of cervical cells sampling device, comprising:
One sampler supervisor;
One dynamic force generating unit;
One cervix uteri localizer, what it can be moved under the driving of dynamic force generating unit is arranged in sampler supervisor;
One sampler, it is movably arranged in cervix uteri localizer under dynamic force generating unit drives, during original state, the sampler head of sampler is limited in cervix uteri localizer, during sampling, stretches out cervix uteri localizer at the sampler head of the driving down-sampler of dynamic force generating unit.
In the present invention, comprise a signal indicator, after sampling terminates, under the driving of dynamic force generating unit, drive singal indicator is out of shape.
In the present invention, described signal indicator and described dynamic force generating unit or sampler are provided with hasp structure in mobilizable first between being responsible for, the nested instruction spring of the part of sampler between signal indicator and cervix uteri localizer, signal indicator and cervix uteri localizer close to each other time compression instruction spring, when the power indicating spring to be applied to signal indicator is greater than the pre set force of hasp structure in first, instruction spring promotes hasp structure in first and breaks off relations, make signal indicator depart from dynamic force generating unit or sampler supervisor, thus deform.
In the present invention, after sampling, recall in supervisor at the sampler head of the driving down-sampler of dynamic force generating unit.
In the present invention, the sampler head of sampler is removable structure, after sampling, signal indicator drive and cervix uteri localizer restriction under, sampler head removes from sampler.
In the present invention, be provided with between sampler and cervix uteri localizer can break off relations second in hasp structure, the thrust be subject to when sampler exceeds the pre set force of hasp structure in second, then sampler stretches out cervix uteri localizer.
In the present invention, be threaded between dynamic force generating unit with cervix uteri localizer and realize power transmission, control the movement of cervix uteri localizer in sampler supervisor by rotary power generator.
In the present invention, one end shape adaptation of described signal indicator one end and sampler, and after both combine, form the fixing integrative-structure of relative position, control sampler by rotawink indicator during sampling and rotate.
In the present invention, be provided with sampling spring between described signal indicator and sampler, the power being applied to sampler when sampling spring is greater than the pre set force of hasp structure in second, and sampling spring promotes hasp structure in second and breaks off relations, and makes sampler stretch out cervix uteri localizer.
In the present invention, in described first, the separation pre set force of hasp structure is greater than the separation pre set force of hasp in described second.
Cervical exfoliated cell sampling apparatus of the present invention under the guidance of doctor or individual read illustrate after can independent collection cervical exfoliated cell, for the sampling one automaton of cervical carcinoma screening and diagnosis.
Beneficial effect: advantage of the present invention comprises:
One: user can effectively use this device, gather cervical exfoliated cell in hospital or family according to operating instruction self-developed standardization.
Two: the present invention can accurately navigate to position between cervix uteri mouth and cervical canal by sampler for cervix, collects cervical exfoliated cell accurately;
Three: apparatus of the present invention can specify the collection of specification cervical exfoliated cell, standardization movements design reduces the generation of human error.
Accompanying drawing explanation
To do the present invention below in conjunction with the drawings and specific embodiments and further illustrate, above-mentioned and/or otherwise advantage of the present invention will become apparent.
Fig. 1 is external structure schematic diagram of the present invention.
Fig. 2 is profile of the present invention.
Fig. 3 a is that outside schematic diagram is responsible for by sampler.
Fig. 3 b is sampler supervisor sectional view.
Fig. 3 c is sampler supervisor end view.
Fig. 4 a is the outside schematic diagram of cervix uteri localizer.
Fig. 4 b is cervix uteri localizer sectional view.
Fig. 4 c is cervix uteri localizer end view.
Fig. 5 a is dynamic force generating unit sectional view.
Fig. 5 b is the outside schematic diagram of dynamic force generating unit.
Fig. 5 c is dynamic force generating unit upper grooves structural representation.
Fig. 5 d is pawl schematic diagram in dynamic force generating unit
Fig. 6 a is the outside schematic diagram of signal indicator.
Fig. 6 b is signal indicator sectional view.
Fig. 6 c is the convex leg structure schematic diagram of signal indicator.
Fig. 6 d is signal indicator bottom square orifice structural representation.
Fig. 7 is sampler structure schematic diagram.
Detailed description of the invention
Embodiment 1
As shown in Figure 1, the present invention includes the autonomous sampling apparatus 1 of a kind of cervical exfoliated cell, comprise the combination of sampler supervisor 2, cervix uteri localizer 3, dynamic force generating unit 4, sampler 6, signal indicator 5, object realizes user independently to gather cervical exfoliated cell.
As shown in Fig. 1, Fig. 3 a ~ Fig. 3 c, sampler supervisor 2 comprises: insertion tube 7, degree of depth indicatrix 9, control valve 8, sampler supervisor is 2 for inserting vagina inside, and user holds control valve 8 and controls insertion tube 7 and insert intravaginal progress and strength, avoids injuring user.
Insertion tube 7, for inserting vagina inside, vaginal dilation, carries cervix uteri localizer 3 and touches user's cervix uteri mouth place.Insertion tube 7 inside has three straight lines thin by protruding 11, and protrusion direction is consistent with insertion tube y direction, and projection is mated with cervix uteri localizer 3 outer surface groove 15, plays auxiliary power generator 4 transmission and guide effect.
Control valve 8 external diameter is slightly larger than insertion tube 7, and having protruding between control valve 8 and insertion tube 7 is degree of depth indicatrix 9.
As shown in Fig. 3 a ~ Fig. 3 c, control valve 8 afterbody has outer eaves 10, the clockwise pawl 25 in outer eaves top, and outer eaves bottom has one week outer lug combined integrated with dynamic force generating unit 4, clockwise inverted tooth-like effect uses dynamic force generating unit 4 to turn clockwise, and cannot be rotated counterclockwise.
Degree of depth indicatrix 9 is positioned in the middle part of sampler supervisor 2, and user can touch or perceive indicatrix, is used to indicate the degree of depth that sampler supervisor 2 inserts vagina.
As shown in figures 4 a and 4b, cervix uteri localizer 3 comprises: front end is the combination of hollow round table body 12, middle part hollow tubule 13, afterbody dynamic connector 14 3 parts.
Cervix uteri localizer 3 front end hollow round table body 12, connects middle part hollow tubule 13.The frustum cone structure of hollow round table body 12 end is convenient to cervical exfoliated cell sampling apparatus and is inserted intravaginal, can vaginal dilation slowly.Rotary-table hollow is used for hiding sampler for cervix head 33, and as shown in Fig. 3 c and Fig. 4 c, Rotary-table surface has three grooves 15 and insertion tube internal projection 11 to match, and as shown in Figure 2, plays auxiliary power generator 4 gearing.
As shown in Figure 2, dynamic connector 14 design surface screw thread 16 and dynamic force generating unit female thread 20 combine, when sampling apparatus starts, dynamic force generating unit 4 is turned clockwise and to be combined by screw thread 20, Rotary-table surface groove, insertion tube internal projection 11, drives cervix uteri localizer 3 to retract sampler supervisor 2.
Dynamic connector 14 inner hollow design the inside is placed with spring 37.
Spring is between dynamic connector 14 and signal indicator hollow pipe 24.
As shown in figures 4 a and 4b, cervix uteri localizer 3 hollow tubule 13 designs inner four salient points 17, and circular salient point 17 is crossing with sampler mobile jib outer lug 31, as shown in Figure 2, localizer hollow tubule salient point 17 is positioned at bottom, and in the middle part of sampler mobile jib, protruding 31 are positioned at top, i.e. hasp structure in second.
As shown in figures 4 a and 4b, dynamic connector hollow tubule has screw thread 36 below salient point 17, and sampler mobile jib projection 31 can be prolonged screw thread and be slided, the speed that minimizing sampler 6 moves down under spring 27 acts on and impulse force.
As shown in figure 5 a and 5b, dynamic force generating unit 4 is made up of hollow transmission tube 19 and power-booster 18, and dynamic force generating unit female thread 20 mates with dynamic connector external screw thread 16, starting power gearing.
Power-booster 18 outer surface erects type striped, plays power-booster 18 and rotates assosting effect.Lower recess 21 mates combined integrated with the outer eaves 10 of control valve, as shown in Figure 2.Upper grooves 23 is combined integrated with signal indicator convex foot 28.
As shown in Fig. 6 a ~ Fig. 6 d, signal indicator 5 comprises: hollow pipe 24, spring 27 and nut 26 combine.
Hollow pipe top has convex foot 28 to mate with dynamic force generating unit upper grooves 23, as shown in Figure 5 c, combined integrated with dynamic force generating unit 4, and dynamic force generating unit 4 turns clockwise and drives signal indicator 5 to rotate together.
Hollow pipe middle part surface one week protruding 29 intersects with dynamic force generating unit internal protrusion 22 and be engaged, and as shown in Figure 2, i.e. hasp structure in first, plays and hinder sampler 6 because stressed sampler of returning is responsible for 2 and is acted on.
As Fig. 2, spring 27 is positioned at hollow tube, between nut 26 and sampler collet 32.Spring 27 compresses and produces elastic force, and elastic force breaks through hasp structure resistance in second, and promote sampler 6 and move, sampler afterbody collet 32 cross empennage is engaged with signal indicator 5 bottom square orifice 35, as shown in fig 6d.
Signal indicator 5 bottom is square aperture 35, and bottom sampler, 32 when being mutually engaged, and can drive sampler 6 rotating acquisition cervical exfoliated cell.
As shown in Figure 7, sampler is made up of mobile jib 30 and sampler head 33.
Be have cross empennage to connect round collet 32 mobile jib head 34 to design with projection bottom sampler mobile jib 30, be convenient to connect sampler head 33 and prevent from coming off.
Circular protrusions design 31 in one week is had, object one: circular protrusions 31 is crossing with localizer hollow tube circular protrusions point 17, hasp structure in being formed, as shown in Figure 2 in the middle part of mobile jib.Object two: in the middle part of mobile jib, protruding 31 slide along the screw thread 36 in localizer hollow pipe, the speed that minimizing sampler 6 moves down under spring 27 acts on and impulse force.Sampler head 33 is mountain font cervix uteri brush or circular cervix uteri brush, can disassembly and assembly on sampler mobile jib, for gathering cervical exfoliated cell.The present invention is not limited to above-mentioned shape, comprise likely modified model.
The present embodiment using method is as follows:
1, user holds control valve 8 and sampler supervisor 2 is slowly inserted vagina.When the touching of user's vaginal orifice or when perceiving degree of depth indicatrix 9, or when cervix uteri mouth perceives the contact of cervix uteri localizer 3, stop inserting sampler supervisor 2.
2, user's handheld power generator 4 turns clockwise, and cervix uteri localizer 3 is retraction insertion tube 7 slowly.
(illustrate: drive at dynamic force generating unit 4, dynamic force generating unit drives dynamic connector 14 by screw thread, in insertion tube fine rule protruding 11 and the outer groove 15 of cervix uteri localizer auxiliary under, cervix uteri localizer 3 moves to sampler supervisor 2.)
3, dynamic force generating unit 4 continues to rotate, and sampler 6 skids off sampler supervisor 2, contact cervix uteri mouth.
(illustrate: dynamic force generating unit 4 continues to rotate, and move in cervix uteri localizer 3 continues, dynamic connector 14 carries spring and moves up, in second hasp effect under, sampler 6 moves up, and sampler collet 32 Compress Spring 27 breaks through hasp structure resistance in second, and sampler 6 ejects.)
4, dynamic force generating unit 4 continues to rotate, and drives sampler 6 to rotate, gathers cervical exfoliated cell.
(illustrate: spring 27 is in compressive state, lasting thrust makes sampler afterbody 32 and signal indicator bottom square aperture 35 in interlocking pattern, and sampler 6 rotates.)
5, dynamic force generating unit 4 continues to rotate, and signal indicator 5 is ejected dynamic force generating unit 4, and prompting sampling terminates.
(illustrate: move in cervix uteri localizer 3 continues, spring 37 compression elasticity breaks through hasp structure resistance in first, and signal indicator 5 is ejected dynamic force generating unit 4, and prompting sampling terminates.)
6, user holds sampler control valve 8 and sampling apparatus is slowly extracted vagina.Insertion tube 7 aims at cervical exfoliated cell save set bottleneck, and pull signal indicator 5 sampler head 33 falls in cell save set.
7, cervical exfoliated cell has independently been sampled, and cervical exfoliated cell sampler 6 is discarded.
Conclusion:
Above result shows: the present embodiment effectively can gather cervical exfoliated cell, and user can realize autonomous sampling after reading operation instruction, reduces the workload of doctor and the patient pressure of medical institutions, realizes standard acquisition cervical exfoliated cell.
The invention provides cervical cells sampling device; the method and access of this technical scheme of specific implementation is a lot; the above is only the preferred embodiment of the present invention; should be understood that; for those skilled in the art; under the premise without departing from the principles of the invention, can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.The all available prior art of each ingredient not clear and definite in the present embodiment is realized.

Claims (10)

1. cervical cells sampling device, is characterized in that, comprising:
One sampler supervisor;
One dynamic force generating unit;
One cervix uteri localizer, what it can be moved under the driving of dynamic force generating unit is arranged in sampler supervisor;
One sampler, it is movably arranged in cervix uteri localizer under dynamic force generating unit drives, during original state, the sampler head of sampler is limited in cervix uteri localizer, during sampling, stretches out cervix uteri localizer at the sampler head of the driving down-sampler of dynamic force generating unit.
2. cervical cells sampling device according to claim 1, is characterized in that, comprises a signal indicator, and after sampling terminates, under the driving of dynamic force generating unit, drive singal indicator is out of shape.
3. cervical cells sampling device according to claim 2, it is characterized in that, described signal indicator and described dynamic force generating unit or sampler are provided with hasp structure in mobilizable first between being responsible for, the nested instruction spring of the part of sampler between signal indicator and cervix uteri localizer, signal indicator and cervix uteri localizer close to each other time compression instruction spring, when the power indicating spring to be applied to signal indicator is greater than the pre set force of hasp structure in first, instruction spring promotes hasp structure in first and breaks off relations, signal indicator is made to depart from dynamic force generating unit or sampler supervisor, thus deform.
4. cervical cells sampling device according to claim 1, is characterized in that, after sampling, recalls sampler supervisor at the sampler head of the driving down-sampler of dynamic force generating unit.
5. the cervical cells sampling device according to claim 1 or 4, is characterized in that, the sampler head of sampler is removable structure, and after sampling, under the restriction of signal indicator and cervix uteri localizer, sampler head removes from sampler.
6. cervical cells sampling device according to claim 3, it is characterized in that, be provided with between sampler and cervix uteri localizer can break off relations second in hasp structure, the thrust be subject to when sampler exceeds the pre set force of hasp structure in second, then sampler stretches out cervix uteri localizer.
7. cervical cells sampling device according to claim 1, is characterized in that, being threaded between dynamic force generating unit with cervix uteri localizer realizes power transmission, controls the movement of cervix uteri localizer in sampler supervisor by rotary power generator.
8. cervical cells sampling device according to claim 2, it is characterized in that, one end shape adaptation of described signal indicator one end and sampler, and after both combine, form the fixing integrative-structure of relative position, control sampler by rotawink indicator during sampling and rotate.
9. cervical cells sampling device according to claim 6, it is characterized in that, sampling spring is provided with between described signal indicator and sampler, the power being applied to sampler when sampling spring is greater than the pre set force of hasp structure in second, sampling spring promotes hasp structure in second and breaks off relations, and makes sampler stretch out cervix uteri localizer.
10. cervical cells sampling device according to claim 6, is characterized in that, in described first, the separation pre set force of hasp structure is greater than the separation pre set force of hasp in described second.
CN201510100081.7A 2015-03-06 2015-03-06 Cervical cells sampling device Active CN104622518B (en)

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107811657A (en) * 2017-11-23 2018-03-20 北京海普威生物技术有限公司 One cervical cell sample-taking brush
WO2018055564A1 (en) * 2016-09-23 2018-03-29 Universidad Industrial De Santander Device for collecting biological samples
CN108852271A (en) * 2018-08-02 2018-11-23 康涛 A kind of cervical lesions explorer and its method for surveying
CN110200664A (en) * 2019-06-27 2019-09-06 郑州华之源医学检验实验室有限公司 Sampler, preservation container, sampling component and the method that cervical cell samples certainly
WO2020028143A1 (en) 2018-07-28 2020-02-06 Smart Pap, Inc. Methods and systems for collecting cells and biological samples for screening
CN113081066A (en) * 2021-05-06 2021-07-09 成都市双流区第一人民医院 Vaginal secretion sampling and storing device
EP3928716A4 (en) * 2019-02-21 2022-10-19 Biodyne Co., Ltd. Exfoliative cell collection device for uterus examination
USD1021130S1 (en) 2022-06-13 2024-04-02 Teal Health, Inc. Sample collection device
CN107811657B (en) * 2017-11-23 2024-06-04 北京海普威生物技术有限公司 Cervical cell sampling brush

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CN103153200A (en) * 2009-08-21 2013-06-12 罗微斯控股公司 Sampling device and method for preparing the same
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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018055564A1 (en) * 2016-09-23 2018-03-29 Universidad Industrial De Santander Device for collecting biological samples
US11406366B2 (en) 2016-09-23 2022-08-09 Universidad Industrial De Santander Device for collecting biological samples
CN107811657A (en) * 2017-11-23 2018-03-20 北京海普威生物技术有限公司 One cervical cell sample-taking brush
CN107811657B (en) * 2017-11-23 2024-06-04 北京海普威生物技术有限公司 Cervical cell sampling brush
WO2020028143A1 (en) 2018-07-28 2020-02-06 Smart Pap, Inc. Methods and systems for collecting cells and biological samples for screening
EP3829451A4 (en) * 2018-07-28 2022-04-20 Teal Health, Inc. Methods and systems for collecting cells and biological samples for screening
CN108852271A (en) * 2018-08-02 2018-11-23 康涛 A kind of cervical lesions explorer and its method for surveying
EP3928716A4 (en) * 2019-02-21 2022-10-19 Biodyne Co., Ltd. Exfoliative cell collection device for uterus examination
CN110200664A (en) * 2019-06-27 2019-09-06 郑州华之源医学检验实验室有限公司 Sampler, preservation container, sampling component and the method that cervical cell samples certainly
CN113081066A (en) * 2021-05-06 2021-07-09 成都市双流区第一人民医院 Vaginal secretion sampling and storing device
USD1021130S1 (en) 2022-06-13 2024-04-02 Teal Health, Inc. Sample collection device

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