CN1046200C - Inflammation diminishing and pain easing plaster and making of same - Google Patents
Inflammation diminishing and pain easing plaster and making of same Download PDFInfo
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- CN1046200C CN1046200C CN92114296A CN92114296A CN1046200C CN 1046200 C CN1046200 C CN 1046200C CN 92114296 A CN92114296 A CN 92114296A CN 92114296 A CN92114296 A CN 92114296A CN 1046200 C CN1046200 C CN 1046200C
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Abstract
The present invention relates to an inflammation relieving and pain diminishing plaster prepared from at least one kind of non-steroid anti-inflammatory analgesic (a) selected from ketoprofen, flurbiprofen, cyclopentanone methylhydrocinnamic acid, etc., an ester derivative thereof, or a salt, solvent (b) of a rosin ester derivative and 1-menthol, styrene-isoprene-styrene block copolymer (c) used as polymer of raw material, a softening agent (d) and polyester supporting material (e). The plaster of the present invention can enhance percutaneous absorption and medicine release and can lighten maculopapular eruption of the skin. When the present invention is used in treatment, the use is simple and convenient.
Description
The present invention relates to a kind of manufacture method of inflammation diminishing and pain easing plaster.
People just are contained in adhesive tape agent in the butyrous adhesive agent, so-called in extensive experimentation with non-steroid class anti-inflammatory analgesic and are used for the treatment of.For example, the spy opens clear 59-227819 communique and discloses and a kind ofly make non-steroid class anti-inflammatory analgesic be contained in pressure-sensitive adhesive agent of acrylic acid series on non-woven fabrics and the thin film composite support material and the test that is used for the treatment of.The spy opens and then discloses the test that the polyisobutylene/paraffin wax/composite adhesive agent of Abietyl modified glyceride that will contain ketoprofen absorbs through skin on the clear 60-139615 communique.The spy opens then to disclose on the clear 63-227524 communique puts flurbiprofen to the test of Oily preparation administration.The spy opens clear 64-40420 communique and discloses the non-steroid class anti-inflammatory analgesic that will the contain carboxyl test via the Oily preparation medication.EP0285181 discloses a kind of manufacture method that contains according to tolfenamic acid (a kind of non-steroidal anti-inflammatory analgesics) adhesive tape, described method is 150 ℃ of heating with compositions such as styrene isoprene styrene block copolymer (SIS), adhered resin, liquid rubber, softening agents, after the cooling, add, mix anti-inflammatory analgesic, mixture is coated on the processing release paper, is overlying on the supporting material to form.
Yet, no matter above-mentioned which kind of situation, the release of medicine, all insufficient through the skin absorbent properties, people expect a kind of appearance of more outstanding preparation.
Analgesic agent of the present invention, its purpose be following some:
1. improve the Percutaneously absorbable (improving non-steroid class anti-inflammatory analgesic dissolubility and release property in the preparation) of medicine
2. improve the release property (selecting not adsorb the supporting material of non-steroid class anti-inflammatory analgesic) of medicine
3. alleviate when sticking repeatedly the side effect that produces skin macule etc. (pursue adhesiveness, rather than depend on preparation safe in utilization and make the cohesive of its proportioning)
4. (the tool retractility makes to adhere to crooked position) easy to use in treatment
Present inventors are for reaching above-mentioned purpose, done painstakingly research with regard to ketoprofen, flurbiprofen, Ketocyclopentane methylbenzene propanoic acid, ketorolac (ketorolac) and the ester derivant thereof or the salt that belong to carboxylic acids in the non-steroid class anti-inflammatory analgesic, its result has finished being characterised in that with following compositions (a)-(e) and being the anti-inflammatory analgesic adhesive patch of the present invention of necessary composition.That is:
(a) a kind of non-steroid class anti-inflammatory analgesic can be selected from least a of ketoprofen, flurbiprofen, Ketocyclopentane methylbenzene propanoic acid, ketorolac and ester derivant or salt;
(b) a kind of lytic agent is mixed by rosin ester derivative and 1-menthol;
(c) can use styrene isoprene styrene block copolymer (SIS) as raw polymer;
(d) softening agent;
(e) supporting material of forming by mylar.
Supporting material is selected from does not influence the mylar that non-steroid class anti-inflammatory analgesic discharges, and wherein with PET (polyethylene terephthalate), or the cloth that PBT (polybutylene terephthalate (PBT)) makes is for desirable.In order to improve the release property of non-steroid class anti-inflammatory analgesic, necessary condition is: supporting material and non-steroid class anti-inflammatory analgesic should not had an effect mutually, promptly should not adsorb medicine, present inventors have done research with regard to the supporting material of various compositions, find that the component of polymer of supporting material is the best with PET or PBT.The supporting material that use is formed by PET or PBT shows that medicine-releasing performance is good, and is not adsorbed in supporting material.
In the present invention, characteristics are, when adhered resin is prepared with the 1-menthol by a certain percentage with rosin ester derivative, find surprisingly, they have played the effect of the solvent of non-steroid class anti-inflammatory analgesic, also find the release that has improved non-steroid class anti-inflammatory analgesic by a larger margin.Non-steroid class anti-inflammatory analgesic dissolves in order to make, release performance is good, and the ratio of non-steroid class anti-inflammatory analgesic/rosin ester derivative/1-menthol shows that non-steroid class anti-inflammatory analgesic has good dissolving and release performance in 1.0/3.0～11.0/1.0～4.0 scopes.
So-called rosin ester derivative is that the kind of ester has with various rosin esterifications, hydrogenation or refining forming: methyl ester, and glyceride, pentaerythritol esters etc. particularly, have, oleoresin adhesive A, AA-G, H, HP (waste river chemistry produces); Ha リ エ ス -L, S, P (broadcast mill and change into product); Super ester A-75 (waste river chemistry produces), KE-311 (waste river chemistry produces), Ha-コ リ Application D (Ha-キ コ リ-ズ produces), Off オ-ラ Le 85,105 (Ha-キ コ リ-ズ produces) etc.
Secondly,, consider that medicine releasability can suitably be selected for use the adhesiveness of skin etc. from existing polymer to skin safety as raw polymer of the present invention.But consider the release characteristics of non-steroid class anti-inflammatory analgesic, preferably select the low especially styrene isoprene styrene block copolymer (SIS) of polarity for use.Concrete kind has, power リ Off レ Star Network ス TR-1107, TR-1111, TR-1112, TR-1117 (the shell chemistry produces), ソ Le プ レ Application 428 (Philips oil product) etc.
Softening agent can be with the styrene isoprene styrene block copolymer (SIS) of plasticization, softening raw polymer, to keep skin is had the adhesiveness of appropriateness, as almond oil, olive oil, Camellia oil, basswood oil, Oleum Arachidis hypogaeae semen, oleic acid, paraffin wax wet goods.Its match ratio is preferably 100 parts of styrene isoprene styrene block copolymer (SIS): above-mentioned oily 150-350 part.
The consumption proportion of non-steroid class anti-inflammatory analgesic does not have special restriction, but from release, the utilization rate viewpoint of the effective dose that helps to treat, is preferably 100 μ g～430 μ g/cm
2
In addition, can mix known inorganic filler in case of necessity, antioxidant, UV absorbent, antihistamine medicament, antibacterial, spice etc.Much less, this is not subjected to any restriction in the present invention yet.
Inflammation diminishing and pain easing plaster of the present invention, can use the mixer of kneading machine, blender etc., under 120 ℃～160 ℃, heating benzene mixed ethylene one isoprene-styrene block copolymer and softening agent and rosin ester derivative, then, add and mix non-steroid class anti-inflammatory analgesic and 1-menthol, directly sprawl in polyester weave cotton cloth or non-woven fabrics on, perhaps, on paper that the demoulding (typing) is in addition handled or thin film, fill out medicament after, cover required supporting material immediately, duplicate as extrusion.
The as above inflammation diminishing and pain easing plaster of the present invention of gained as described in the following examples and test example, has following characteristics concurrently:
1. improved endermic absorbability;
2. improved medicine releasability;
3. alleviate the side effect such as skin macule that repeat to stick generation;
The ideal inflammation diminishing and pain easing plaster of (the tool retractility makes to adhere to crooked position) 4. easy to use in treatment, industrial is of great use.
Embodiment
Below exemplify embodiment and test example, illustrate in greater detail the present invention.And " part " in all embodiment, comparative example and reference example expression weight portion.Embodiment 1
25.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power リ Off レ ッ Network ス TR-1107)
68.0 parts of petrolatums
5.0 parts of rosin ester derivatives
(trade name: oleoresin adhesive AA-G)
1.5 parts of 1-menthols
0.5 part of ketoprofen
After making finished product according to the above-mentioned method for making side of Clicking here, be cut into required size and promptly can be used as and stick agent.Embodiment 2
20.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name: power リ Off レ Star Network ス TR-1107)
43.5 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
28.5 parts of rosin ester derivatives
(trade name KE-311)
3.0 parts of 1-menthols
After 3.0 parts of ketoprofens are made finished product according to above-mentioned manufacture method by this prescription, be cut into required size and promptly can be used as and stick agent.Embodiment 3
21.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power リ Off レ ッ Network ス TR-1107)
63.0 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
8.0 parts of rosin ester derivatives
(trade name KE-311)
4.0 parts of 1-menthols
2.0 parts of ketoprofens
After root is made finished product according to above-mentioned manufacture method, be cut into required size herein as sticking agent.Embodiment 4
30.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power リ Off レ ッ Network ス TR-1111)
57.0 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
7.0 parts of rosin ester derivatives
(trade name oleoresin adhesive H)
3.0 parts of 1-menthols
1.0 parts of ketoprofens
After root is made finished product according to above-mentioned manufacture method, be cut into required size herein as sticking agent.Embodiment 5
15.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power リ Off レ ッ Network ス TR-1111)
5.0 parts of polyisobutylene (エ Network ソ Application chemistry produces)
23.0 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
40.0 parts of rosin ester derivatives
(trade name oleoresin adhesive H)
10.0 parts of 1-menthols
5.0 parts of ketoprofens
After root is made finished product according to above-mentioned manufacture method, be cut into required size herein as sticking agent.Embodiment 6
18.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power リ Off レ ッ Network ス TR-1111)
54.5 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
16.5 parts of rosin ester derivatives
(trade name Off オ-テ Le 105)
6.0 parts of 1-menthols
3.0 parts of ALRHEUMUN ETHYL ESTER
After root is made finished product according to above-mentioned manufacture method, be cut into required size herein as sticking agent.
Embodiment 7
28.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name ソ Le プ Application 418)
5.0 parts of polybutene
61.7 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
3.0 parts of rosin ester derivatives
(trade name KE-311)
1.8 parts of 1-menthols
0.5 part of flurbiprofen
After root is made finished product according to above-mentioned manufacture method, be cut into required size herein as sticking agent.Embodiment 8
21.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power リ Off レ ッ Network ス TR-1107)
66.8 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
8.0 parts of rosin ester derivatives
(trade name KE-311)
1.2 parts of 1-menthols
1.0 parts of flurbiprofens
After root is made finished product according to above-mentioned manufacture method, be cut into required size herein as sticking agent.Embodiment 9
11.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power リ Off レ Star Network ス TR-1111)
45.0 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
20.0 parts of rosin ester derivatives
(trade name oleoresin adhesive H)
7.0 parts of 1-menthols
5.0 parts of flurbiprofens
After root is made finished product according to above-mentioned manufacture method, be cut into required size herein as sticking agent.Embodiment 10
30.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power リ Off レ ッ Network ス TR-1111)
56.0 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
8.0 parts of rosin ester derivatives
(trade name KE-311)
3.0 parts of 1-menthols
1.0 parts of Ketocyclopentane methylbenzene propanoic acid
After root is made finished product according to above-mentioned manufacture method, be cut into required size herein as sticking agent.Embodiment 11
12.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power Le Off レ ッ Network ス TR-1111)
26.0 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
40.0 parts of rosin ester derivatives
(trade name oleoresin adhesive H)
12.0 parts of 1-menthols
8.0 parts of Ketocyclopentane methylbenzene propanoic acid
After root is made finished product according to above-mentioned manufacture method, be cut into required size herein as sticking agent.Embodiment 12
21.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power リ Off レ ッ Network ス TR-1112)
50.0 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
20.5 parts of rosin ester derivatives
(trade name oleoresin adhesive H)
3.5 parts of 1-menthols
3.0 parts of Ketocyclopentane methylbenzene propanoic acid
After root is made finished product according to above-mentioned manufacture method, be cut into required size herein as sticking agent.Embodiment 13
5.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power リ Off レ ッ Network ス TR-1111)
11.0 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
65.0 parts of rosin ester derivatives
(trade name KE-311)
10.0 parts of 1-menthols
7.0 parts of Ketocyclopentane methylbenzene propanoic acid
After root was made finished product according to above-mentioned manufacture method herein, being cut into needed size as sticking agent.Embodiment 14
20.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power リ Off レ ッ Network ス TR-1107)
45.0 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
21.0 parts of rosin ester derivatives
(trade name oleoresin adhesive H)
9.0 parts of 1-menthols
3.0 parts of Ketocyclopentane methylbenzene sodium propionate
After root is made finished product according to above-mentioned manufacture method, be cut into required size herein as sticking agent.Embodiment 15
22.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power リ Off レ ッ Network ス TR-1107)
5.0 parts of polyisobutylene (Exxon Japan chemical company produces)
54.0 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
10.0 parts of rosin ester derivatives
(trade name Ha-コ リ Application D)
7.0 parts of 1-menthols
2.0 parts of Ketocyclopentane methylbenzene propanoic acid
After root is made finished product according to above-mentioned manufacture method, be cut into required size herein as sticking agent.Embodiment 16
20.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power リ Off レ Star Network ス TR-1112)
38.0 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
28.0 parts of rosin ester derivatives
(trade name KE-311)
8.0 parts of 1-menthols
4.0 parts of Ketorolac
After root is made finished product according to above-mentioned manufacture method, be cut into required size herein as sticking agent.Embodiment 17
28.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power リ Off レ ッ Network ス ス TR-1107)
57.5 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
9.0 parts of rosin ester derivatives
(trade name oleoresin adhesive H)
2.5 parts of 1-menthols
1.0 parts of Ketorolac
After root is made finished product according to above-mentioned manufacture method, be cut into required size herein as sticking agent.Embodiment 18
21.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power リ Off レ ッ Network ス TR-1112)
59.0 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
10.0 parts of rosin ester derivatives
(trade name oleoresin adhesive H)
6.0 parts of 1-menthols
2.0 parts of Ketorolac
After root is made finished product according to above-mentioned manufacture method, be cut into required size herein as sticking agent.Embodiment 19
33.0 parts of styrene isoprene styrene block copolymer (SIS)
(trade name power リ Off レ Star Network ス TR-1111)
58.0 parts of petrolatums
2.0 parts of butylated hydroxytoluenes
5.0 parts of rosin ester derivatives
(trade name Off オ-ラ リ Le 105)
1.5 parts of 1-menthols
(Network ト ロ ラ Star Network Ketorolac) 0.5 part
After root is made finished product according to above-mentioned manufacture method, be cut into required size herein as sticking agent.Comparative example 1
Except that without the rosin ester derivative (oleoresin adhesive H), the same method of all the other and this embodiment makes and sticks agent in embodiment 4.Comparative example 2
Except that without the 1-menthol, the same method of all the other and this embodiment makes and sticks agent in embodiment 4.Comparative example 3
Except that without the rosin ester derivative (KE-311), the same method of all the other and this embodiment makes and sticks agent in embodiment 8.Comparative example 4
Except that without the 1-menthol, the same method of all the other and this embodiment makes and sticks agent in embodiment 8.Comparative example 5
Except that without the rosin ester derivative (KE-311), the same method of all the other and this embodiment makes and sticks agent in embodiment 10.Comparative example 6
Except that without the 1-menthol, the same method of all the other these embodiment makes and sticks agent in embodiment 10.Comparative example 7
Except that without the rosin ester derivative (oleoresin adhesive H), the same method of all the other and this embodiment makes and sticks agent in embodiment 17.Comparative example 8
Except that without the 1-menthol, the same method of all the other and this embodiment makes and sticks agent in embodiment 17.Comparative example 9
In embodiment 4, change supporting material into polyurethane cloth by mylar (PET cloth), the same method of all the other and this embodiment makes and sticks agent.Comparative example 10
In embodiment 8, change supporting material into polyurethane cloth by polyester city (PET cloth), the same method of all the other and this embodiment makes and sticks agent.Comparative example 11
In embodiment 10, change supporting material into polyurethane cloth by mylar (PET cloth), the same method of all the other and this embodiment makes and sticks agent.Comparative example 12
In embodiment 17, change supporting material into polyurethane cloth by mylar (PET cloth), the same method of all the other and this embodiment makes and sticks agent.Comparative example 13
In embodiment 4, change supporting material into polrvinyl chloride (PVC) thin film by mylar (PET cloth), the same method of all the other and this embodiment makes and sticks agent.Comparative example 14
In embodiment 8, change supporting material into polrvinyl chloride (PVC) thin film by mylar (PET cloth), the same method of all the other and this embodiment makes and sticks agent.Comparative example 15
In embodiment 10, change supporting material into polrvinyl chloride (PVC) thin film by mylar (PET cloth), the same method of all the other and this embodiment makes and sticks agent.Comparative example 16
In embodiment 17, change supporting material into polrvinyl chloride (PVC) thin film by mylar (PET cloth), the same method of all the other and this embodiment makes and sticks agent.Reference example 1
To 96 parts of acrylic acid series bonding agent " day meets PE-300 " (Japanese carbide industry is produced) solid constituents, add to mix 4 parts of ketoprofens, sprawl on having made the mylar that the demoulding handles after, do crimping with mylar and shift (duplicating) again, then, be cut into required size as sticking agent.Reference example 2
In reference example 1, change ketoprofen into fluorine biphenyl benzenpropanoic acid, the same method of all the other and this example makes and sticks agent.Reference example 3
In reference example 1, change ketoprofen into Ketocyclopentane methylbenzene propanoic acid (loxopro-fen), the same method of all the other and this example makes and sticks agent.Reference example 4
In reference example 1, change ketoprofen into Ketorolac, then, stick agent to make with the same method of this example.Test example 1 (steady dissolution test)
With embodiment 4,8,10,17 and comparative example 1-8, make 5 ℃ of stability tests of preserving one month down.Its result as shown in Table 1.
Table one
Test example 2 (drug release test 1)
| 5 ℃ 1 month | State | |
| Embodiment 4 | ◎ | No abnormal |
| Embodiment 8 | ◎ | No |
| Embodiment | ||
| 10 | ◎ | No abnormal |
| Embodiment 17 | ◎ | No abnormal |
| Comparative example 1 | × | Crystallization |
| Comparative example 2 | × | Crystallization |
| Comparative example 3 | × | Crystallization |
| Comparative example 4 | × | Crystallization |
| Comparative example 5 | × | Crystallization |
| Comparative example 6 | × | Crystallization |
| Comparative example 7 | × | Crystallization |
| Comparative example 8 | × | Crystallization |
With embodiment 4,8,10,17 and comparative example 1-8, make the release test of medicine in water, try to achieve the release rate that sticks the agent Chinese medicine.It the results are shown in Table two.
Table two
| Drug release rate after 4 hours (%) | |
| Embodiment 4 | 53.10±2.89 |
| Embodiment 8 | 46.77±3.14 |
| | 48.82±2.55 |
| Embodiment 17 | 40.92±3.66 |
| Comparative example 1 | 21.60±1.07 |
| Comparative example 2 | 27.72±2.32 |
| Comparative example 3 | 24.13±1.98 |
| Comparative example 4 | 26.95±1.91 |
| Comparative example 5 | 19.97±1.84 |
| Comparative example 6 | 25.98±2.83 |
| Comparative example 7 | 20.12±2.80 |
| Comparative example 8 | 19.92±2.66 |
Test example 1,2 and clearly show, in the present invention, must while adapted rosin ester derivative and 1-menthol.Test example 3 (drug release test 2)
With embodiment 4,8,10,17 and comparative example 9,10,11,12, do and the same release test of medicine in water of test example, try to achieve the drug release rate that sticks agent.Its result as shown in Table 3.
Table three
| Drug release rate after 4 hours (%) | |
| Embodiment 4 | 53.10±2.89 |
| Embodiment 8 | 46.77±3.14 |
| | 48.82±2.55 |
| Embodiment 17 | 40.92±3.66 |
| Comparative example 9 | 15.21±2.00 |
| Comparative example 10 | 13.19±0.98 |
| Comparative example 11 | 13.57±1.69 |
| Comparative example 12 | 19.26±2.94 |
Use mylar (PET cloth) when making supporting material as can be known by test example 3, obviously medicine-releasing performance is good.And the result same with polyester arranged also when using PBT cloth.Test example 4 (skin of hairless mouse sees through test)
With embodiment 4,8,10,17 and reference example 1,2,3,4, the skin of making hairless mouse sees through test.As shown in Figure 1, embodiment 4,8,10,17 compares with reference example 1,2,3,4, and obviously its drug release rate and utilization rate (skin transmitance) are more excellent.Test example 5 (sticking the agent test)
With embodiment 4 and comparative example 13, stick in the ancon of 30 healthy males and reach 8 hours.It the results are shown in table four.
Table four
| Adhesiveness | Docile sense | |
| Embodiment 4 | ◎ | ◎ |
| Comparative example 13 | × | × |
◎: good *: bad
Promptly using embodiment 8,10,17 and comparative example 14,15,16 to test, also is equifinality.Test example 6 (cutaneous safety test)
With embodiment 2,4, comparative example 10, reference example 1 and day office's rubber plaster pasted continuous 7 days 8 hours in one day to the back portion of 30 NAMs.It the results are shown in table five.And evaluation criteria is as follows:
±: rubescent slightly,
+: obviously rubescent,
++: serious macule.
Table five
| Evaluation (people) | Positive rate (%) | ||||
| ++ | + | ± | + more than | ± more than | |
| Embodiment 2 | 0 | 0 | 1 | 0 | 3.3 |
| Embodiment 4 | 0 | 0 | 2 | 0 | 6.7 |
| Comparative example 10 | 0 | 2 | 3 | 6.7 | 16.7 |
| Reference example 1 | 1 | 3 | 6 | 13.3 | 33.3 |
| Day the office rubber plaster | 2 | 4 | 6 | 20.0 | 40.0 |
By test example 5,6 as seen, anti-inflammatory analgesic adhesive patch of the present invention has remarkable simplicity of operation, and is the very safe agent that sticks.
As mentioned above, owing to improved the dissolubility and the release property of non-steroid class anti-inflammatory analgesic, inflammation diminishing and pain easing plaster of the present invention just has the high possibility of the drug effect of demonstration, and significantly reduces the skin macule, be to use simultaneously easy inflammation diminishing and pain easing plaster again, industrial be of great use.
The skin that Figure 1 shows that hairless mouse sees through test.
Claims (4)
1. the manufacture method of an inflammation diminishing and pain easing plaster, described inflammation diminishing and pain easing plaster is with styrene isoprene styrene block copolymer (SIS), softening agent and rosin ester derivative heating, after the mixing, adding the non-steroid class anti-inflammatory analgesic of mixing again forms, it is characterized in that, will be as the styrene isoprene styrene block copolymer (SIS) of raw material, softening agent and rosin ester derivative are 120 ℃～160 ℃ heating down, after the mixing, add again, mix non-steroid class anti-inflammatory analgesic and 1-menthol, described rosin ester derivative, the adding proportion of non-steroid class anti-inflammatory analgesic and 1-menthol is 1.0: 3.0～11.0: 1.0～4.0, then, this medicament is sprawled on the supporting material of being made up of mylar.
2. the manufacture method of inflammation diminishing and pain easing plaster as claimed in claim 1 is characterized in that, described non-steroid class anti-inflammatory analgesic is selected from ketoprofen, flurbiprofen, Ketocyclopentane methylbenzene propanoic acid, ketorolac and ester derivant or the salt at least a.
3. the manufacture method of an inflammation diminishing and pain easing plaster, described inflammation diminishing and pain easing plaster is with styrene isoprene styrene block copolymer (SIS), softening agent and rosin ester derivative heating, after the mixing, adding the non-steroid class anti-inflammatory analgesic of mixing again forms, it is characterized in that, will be as the styrene isoprene styrene block copolymer (SIS) of raw material, softening agent and rosin ester derivative are 120 ℃～160 ℃ heating down, after the mixing, add again, mix non-steroid class anti-inflammatory analgesic and 1-menthol, described rosin ester derivative, the adding proportion of non-steroid class anti-inflammatory analgesic and 1-menthol is 1.0: 3.0～11.0: 1.0～4.0, then, after sprawling this medicament on the paper of doing demoulding processing or thin film, required supporting material is covered thereon, duplicate as extrusion.
4. the manufacture method of inflammation diminishing and pain easing plaster as claimed in claim 3 is characterized in that, described non-steroid class anti-inflammatory analgesic is selected from ketoprofen, flurbiprofen, Ketocyclopentane methylbenzene propanoic acid, ketorolac and ester derivant or the salt at least a.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92114296A CN1046200C (en) | 1992-12-03 | 1992-12-03 | Inflammation diminishing and pain easing plaster and making of same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92114296A CN1046200C (en) | 1992-12-03 | 1992-12-03 | Inflammation diminishing and pain easing plaster and making of same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1087515A CN1087515A (en) | 1994-06-08 |
| CN1046200C true CN1046200C (en) | 1999-11-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN92114296A Expired - Lifetime CN1046200C (en) | 1992-12-03 | 1992-12-03 | Inflammation diminishing and pain easing plaster and making of same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1046200C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4199485B2 (en) * | 2002-06-07 | 2008-12-17 | 久光製薬株式会社 | Patch |
| CN102936475B (en) * | 2011-08-15 | 2014-10-15 | 中国石油化工集团公司 | Carrier adhesive for plasters and patches and preparation method thereof |
| CN106692110B (en) * | 2015-08-19 | 2019-12-17 | 天津市山佳医药科技有限公司 | aryl propionic acid non-steroidal anti-inflammatory drug patch and preparation method thereof |
| CN106692111A (en) * | 2015-11-13 | 2017-05-24 | 北京泰德制药股份有限公司 | External skin patch containing ketoprofen and preparation method of external skin patch |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0285181A2 (en) * | 1987-04-02 | 1988-10-05 | Teikoku Seiyaku Kabushiki Kaisha | Etofenamate-containing adhesive tape |
-
1992
- 1992-12-03 CN CN92114296A patent/CN1046200C/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0285181A2 (en) * | 1987-04-02 | 1988-10-05 | Teikoku Seiyaku Kabushiki Kaisha | Etofenamate-containing adhesive tape |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1087515A (en) | 1994-06-08 |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
| OR01 | Other related matters | ||
| C17 | Cessation of patent right | ||
| CX01 | Expiry of patent term |
Expiration termination date: 20121203 Granted publication date: 19991110 |