CN104606712A - Bionic bioceramic with through-hole structure and preparation method and application thereof - Google Patents
Bionic bioceramic with through-hole structure and preparation method and application thereof Download PDFInfo
- Publication number
- CN104606712A CN104606712A CN201410853889.8A CN201410853889A CN104606712A CN 104606712 A CN104606712 A CN 104606712A CN 201410853889 A CN201410853889 A CN 201410853889A CN 104606712 A CN104606712 A CN 104606712A
- Authority
- CN
- China
- Prior art keywords
- filament
- bioceramic
- base plate
- preparation
- hole structure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention belongs to the technical field of bionic bioceramics, and discloses a bionic bioceramic with a through-hole structure and a preparation method and application thereof. The method for preparing the bionic bioceramic with the through-hole structure comprises the following steps: firstly, preparing a mold with a through filament, feeding organic plastic granules into the mold to prepare a plastic porous scaffold, loading ceramic powder and a binder into the pores of the plastic porous scaffold, removing the through filament and the plastic porous scaffold, sintering at a certain temperature to obtain the bionic bioceramic with the through-hole structure. According to the invention, the shape, size and density of the through hole of the bionic bioceramic can be controlled well through the shape, size and distribution of the through filament, and the bionic bioceramic with the through-hole structure has an obvious advantage when being used for the repair and replacement of cancellous bone or a scaffold for tissue engineering.
Description
Technical field
The invention belongs to bionical bioceramic technical field, be specifically related to a kind of bionical bioceramic with through hole structure and its preparation method and application.
Background technology
The Cranial defect that fracture, osteopathia and bone cyst etc. cause is one of difficult problem of field of orthopaedics always.Bone renovating material is mainly autologous bone, allograph bone and artificial bone, and multiporous biological active ceramic artificial bone becomes desirable osseous tissue with its good biocompatibility and degradability and substitutes and repair materials.
For porous bio-ceramic, existing multiple preparation method and application:
Patent CN 101690828 A discloses a kind of preparation method of gradient porous bioceramic scaffold, by manufacturing three-dimensional shells, cast bioceramic slurry, lyophilization and sintering step, prepare the porous bioceramic scaffold that outside is relatively fine and close, inside has the layered porous structure of oriented alignment.But the connectedness between the Kong Yukong of the bioceramic scaffold described in this invention is indefinite, so the whole burn off of the binding agent such as dextrin, polyvinyl alcohol can not be ensured.
Patent CN 101524555 A discloses a kind of preparation method of combined porous biological ceramics bracket, by manufacturing the spherical granule of bioceramic, manufacturing the step such as three-dimensional shells, assembling, produce the gradient-porosity porous bioceramic scaffold with outside densification, loose and porous inner surface relatively.
Patent CN 101011602 A discloses a kind of preparation method of porous bioceramic scaffold, adopt polyvinyl alcohol water solution make binding agent, mix homogeneously with bioceramic powder body, through orifice plate extruding, cut off and round as a ball, manufacture spheroidal particle; Get polyvinyl alcohol water solution again and above-mentioned granule mixes, compression molding in a mold, put into sintering furnace sintering.
Patent CN 101352583 A discloses a kind of stephanoporate calcium polyphosphate biological ceramic, CPP powder is added water and xanthan gum is made into slurry, and it is dry to gypsum mold then to add chitosan microball, and finally sintering obtains stephanoporate calcium polyphosphate biological ceramic.
Patent CN 1927769 A discloses a kind of preparation method of nano porous biologic ceramics and device: the slurry gained thick paste after centrifugalize being characterized in synthesis to have nanostructured adds foaming agent and becomes porous just idiosome, through 300 ~ 800 DEG C of plastic removals; First idiosome is carried out microwave sintering, obtains the bioceramic product with nanostructured.
Patent CN 102515849 A discloses a kind of surface layer by the porous bio-ceramic of calcium phosphate nano bar construction and constructive method thereof.The method is the porous bio-ceramic adopting hydro-thermal method formation surface layer to have calcium phosphate nano rod, and this calcium phosphate nano rod is formed in the calcium phosphate porous ceramic bases surface extensionality growth with same or analogous chemical composition.
Patent CN 1793057 A discloses a kind of preparation method and application thereof of layered porous calcium phosphate biological ceramic, and adopt supercritical ultrasonics technology to obtain the compound colloidal solution of bovine serum albumin and calcium phosphate, then placement, ageing, obtain starchiness precipitate; Starchiness precipitate is inserted molding in container, after freezing, carries out the presoma that lyophilization obtains having layer structure; Last 600 ~ 1000 DEG C of roastings 1 hour, remove albumin mold plate, and form porous calcium phosphate biological ceramic.
Patent CN 102276291 A discloses a kind of method preparing porous calcium phosphate bioceramic material, to be added in die casting before hydroxyapatite, compacting also keeps certain hour, idiosome is warmed up to 200 ~ 500 DEG C to sinter, be incubated 0.5 ~ 2.0h at such a temperature, then the temperature undergone phase transition mutually before can guaranteeing hydroxyapatite is heated to, reach this temperature can guaranteeing to undergo phase transition and namely stop heating, allow idiosome naturally cool to room temperature in agglomerating plant, namely obtain porous calcium phosphate bioceramic material.
Patent CN 101766843 A discloses the artificial bone of a kind of porous laminated structure and passage, by dense layer and the molding of porous layer alternative stacked of calcium orthophosphate base bioceramic material, and becoming the passage direction of set angle being provided with and carrying cell, body fluid with lamination.Be the obtained slurry of medium mixing with deionized water by the powder such as hydroxyapatite, beta-calcium phosphate.Adopt three dimensional gel laminated forming system, prepare the ceramic idiosome be made up of dense layer, porous layer and passage, then through high temperature sintering, prepare artificial bone.Although this application is mentioned becoming the passage direction of set angle being provided with and carrying cell, body fluid with lamination, its porous part adopts foaming agent fabrication techniques, and porous connectedness is uncontrollable.
Patent CN 102512267 A discloses a kind of bone restoration body with composite porous structure and preparation method thereof, direct metal rapid shaping technique combines with Freeze Drying Technique by described preparation method, first by structural design and direct metal rapid shaping technique manufacture place porous metals support, again the polymer of mix homogeneously/bioceramic mixed solution is poured in porous metals support, and carry out freezing processing, thus obtain bone restoration body with composite porous structure.
Patent CN 103182099 A discloses a kind of porous active artificial bone, with calcium orthophosphate base bioceramic material for matrix, comprises aperture, dense portion and directional hole passage, and chelating diphosphonate.Although this application mentions the concept in directed duct, the connectedness with directed duct between hole can not be accomplished.
Patent CN 1850293 A discloses a kind of medical reinforced porous biological ceramic, preparation method and application thereof.This bioceramic contains porous and tight section, and tight section mainly plays increases mechanical strength effect, and porous part mainly makes biological cells and tissues grow among pottery, makes the newborn corresponding function of organization formation.
Patent CN 103113129 A discloses a kind of multi-stage porous bioactive ceramics and preparation method thereof and application.The present invention, by binding agent, plasticizer, pore creating material and solvent being mixed, obtains pore creating material viscous solution; Again bioactive powder is joined in pore creating material viscous solution mixing, obtain high plasticity walk; Walk is used for extrusion molding, after sintering, obtains cellular multi-stage porous bioactive ceramics.
M.Descamps etc. (M.Descamps et.al. is at Synthesis of macroporous β-tricalcium phosphate with controlled porous architectural) together become support as porogen by hot melt adhesive by PMMA granule, again bioceramic granule is made into serosity and injects support, sinter porous bio-ceramic into.Although the porous ceramics porous that the method obtains is good, the connectivity of the too complicated lack of materials inside of interior material structure.Also there is scholar to adopt fascial flap to wrap up this bioceramic at present, improve its blood for problem, but stem cell still in periphery enrichment and growth, can only can not be distributed in ceramic body, greatly have impact on repairing effect.
Mostly there is inside and be connected uncontrollable, that ditch passband is low or connectivity is poor problem in above patent and the porous ceramics obtained in document, because bioactive ceramics is as et al. Ke material, the connectedness between Kong Yukong and ditch passband are creeped for cell, the degraded of material and angiogenesis significant; Bioceramic internal run-through is poor, causes bone marrow stem cell in the enrichment of material periphery, can not distribute at inner homogeneous, particularly for nonweight-bearing Cranial defect position, and pulp cavity congestion effects repairing effect.Especially for bioceramic prepared by the porogen that need add bio-incompatibility, ceramic inside needs to be communicated with guarantee porogen in sintering process completely and discharges completely outside ceramic embryo.
Summary of the invention
In order to solve the shortcoming and defect part of prior art, primary and foremost purpose of the present invention is to provide a kind of preparation method with the bionical bioceramic of through hole structure.
Another object of the present invention is to provide a kind of bionical bioceramic with through hole structure prepared by above-mentioned preparation method.
Another object of the present invention is to provide the above-mentioned application with the bionical bioceramic of through hole structure.
The object of the invention is achieved through the following technical solutions:
There is a preparation method for the bionical bioceramic of through hole structure, comprise following operating procedure:
(1) preparation of mould: choose length, wide or diameter range is 5mm ~ 40mm, height is the hollow mould main body of 9mm ~ 80mm upper and lower side opening, die main body upper and lower side opening part arranges top cover and base plate respectively, the material of preparing of die main body is zirconia ceramics or aluminium oxide ceramics, the material of preparing of top cover and base plate is gasifiable material at 300 DEG C, die main body, top cover and base plate three surround mold cavity, die main body and base plate can realize being tightly connected, diameter is selected to be the through filament of hard of 300 ~ 500 μm, through filament one end is fixed on base plate, the other end extends to top cover in mold cavity, through filament is spaced 700 μm ~ 1mm,
(2) preparation of plastics porous support: by diameter be the organic plastics granule of 100 μm ~ 500 μm be filled into from die main body upper end open be provided with through filament mold cavity in, adding organic solvent or heating makes organic plastics particle surface dissolve or fusing, realize the mutual bonding between organic plastics granule, then the organic plastics granule mutually bondd is taken out from mold cavity together with base plate and through filament, with distilled water flushing cooling, after drying, be fixed the plastics porous support on base plate and through filament;
(3) bioceramic molding: plastics porous support is reloaded in mold cavity together with base plate and through filament, then place it on reciprocating sieve, biological ceramic powder particle diameter being less than 5 μm adds on plastics porous support from die main body upper end open, biological ceramic powder is made to be full of the hole of plastics porous support by reciprocating sieve vibration, then centrifugal 5 minutes are placed on centrifuge, add the mold integral that binding agent obtains containing ceramic idiosome for centrifugal 1 minute again, mold integral containing ceramic idiosome is put into drying baker dry 24 hours, then remove through filament and put it in sintering furnace and be warming up to 300 DEG C of burn off plastics porous supports, top cover and base plate, be warming up to 900 ~ 1200 DEG C of sintering 12 hours again, remove the bionical bioceramic that die main body obtains having through hole structure.
Described die main body is also arranged horizontal through filament to be connected with through filament fixing on base plate, form three-dimensional netted communicating structure.
The cross section of described die main body is circular, square, rectangle or triangle.
Described through filament is aciculiform or S shape, and the cross section of through filament is circular, square, rectangle or triangle.
Described through filament with the fixed form of base plate is: base plate is distributed with and through filament shape of cross section and the identical aperture of size, and through filament is fixed by inserting aperture.
At described 300 DEG C, gasifiable material is polyethylene, polypropylene or makrolon material.
Described organic plastics granule is the one in polyformaldehyde granule, ABS plastic granule, polyethylene terephthalate granule and polycarbonate pellets.
Described organic solvent is acetic acid, Hexafluoro acetone or acetone.
Described biological ceramic powder is at least one in hydroxylapatite powder, type alpha tricalcium phosphate (α-TCP) powder, bata-tricalcium phosphate (β-TCP) powder, polyphosphoric acid calcium powder and tetracalcium phosphate powder.
Described binding agent is Polyethylene Glycol, polyvinyl alcohol or acrylate copolymer.
The material of preparing of described through filament is metal material, and in step (3), the mode of the through filament of removing is that machinery is extracted.
Described through filament prepare material also can with mould top cover or base plate to prepare material identical, in step (3) the through filament of removing mode for put into sintering furnace 300 DEG C with plastics porous support, top cover burn off together with base plate.
A kind of bionical bioceramic with through hole structure prepared by above-mentioned preparation method.The bionical bioceramic that gained has a through hole structure, by the shape of through filament or distribution, prepares the through hole of different structure.
Above-mentioned there is bionical bioceramic spongy bone in medical domain or veterinary applications of through hole structure alternative reparation or tissue engineering bracket in application.
Had the following advantages and beneficial effect by preparation method of the present invention and the product tool that obtains:
(1) the present invention is by the design of through hole in bioceramic body, can realize the quick reparation to Cranial defect.When being greater than 0.1mm for the stable internal fixtion of employing and Cranial defect gap, bone marrow stem cell is topmost repair cell.Although dissimilar Bone Defect Repari adopts different biological cells and tissues, but the synthesis of final bone is still formed, so the working cell of Bone Defect Repari engineering is osteoblast by mesenchyme osteoblast and/or surperficial osteoblast and braided substrate and/or stratiform substrate.Assuming that in the Cranial defect of certain case-specific, a composition osteocyte is certain for the action effect of Bone Defect Repari, then the repairing effect of Cranial defect depends on the osteoblastic how many and distribution acting on this reparation district.Osteoblasticly how much depend on that bone renovating material is for the adhesive attraction of bone marrow stem cell and differentiation, material internal structure is depended in osteoblastic distribution.Through hole in the present invention be designed with the adhesion and bone marrow stem cell being uniformly distributed in whole bionical bioceramic that are beneficial to bone marrow stem cell, promote transport and the cellular metabolism of nutrient substance simultaneously.
(2) the bionical bioceramic with through hole structure of the present invention can be used for the alternative reparation of spongy bone.The spongy bone of human body is between 30% to 90%.There is contradiction between bioceramic porosity and mechanical strength, then mechanical strength is lower for bioceramic porosity height, and the low then mechanical strength of bioceramic porosity is higher.Because the nonweight-bearing position of human body does not need very large mechanical strength to support, so the present invention produces porosity at the bioceramic of 60% to 90% from bionical angle by the diameter and density controlling through hole, can be used to mate different Cranial defect positions.
(3) the bionical bioceramic with through hole structure of the present invention can be used as good tissue engineering bracket.Because bionical bioceramic structure of the present invention has good connectivity, blood fortune can arrive each position of ceramic material, and the bone marrow stem cell making to be attached to each position on ceramic material all can normal growth, there will not be inner downright bad situation.
(4) the ceramic idiosome that it is porogen that production technology of the present invention adopts vibration and centrifugal step just can obtain with plastics porous support, by being mixed with the slurry filling of ceramic powder and water to the method in porous support materials compared to existing technology, this technique can avoid the pollution of the dispersant medium trace element of water and serosity, greatly save the cost of preparation and detection purified water simultaneously, and can large-scale production have been realized by the optimization of technological parameter.
(5) prior art is prepared in the technique of bioceramic, in the process of porogen gasification, easily causes ceramic idiosome to bend and fractures; This technique substantially increases conforming product rate by the effect of contraction of die main body to ceramic idiosome, in burn off simultaneously in sintering furnace and sintering process, pottery idiosome can shrink and die main body size is constant, certain gap can be produced between pottery idiosome and die main body, thus ensure that porogen can be gasified totally.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited thereto.
Embodiment 1
A kind of preparation method with the bionical bioceramic of through hole structure of the present embodiment, comprises following operating procedure:
(1) preparation of mould: select internal diameter to be 20 millimeters, height is the cylinder mold main body of 80 millimeters and associated top cover and base plate, the material of preparing of die main body is zirconia ceramics, the material of preparing of top cover and base plate is polyethylene, die main body, top cover and base plate three surround mold cavity, on base plate, fixed diameter is 500 microns, spacing distance is the aciculiform cylindrical metal silk of 1 millimeter, and tinsel extends to top cover in mold cavity;
(2) preparation of plastics porous support: be that the ABS plastic granule of 300 μm ~ 400 μm is filled in mold cavity from die main body upper end open by diameter, put into 180 DEG C, baking oven heating 30 minutes, ABS plastic particle surface is made to melt bonding mutually, then cooled from taking-up distilled water in die cavity together with base plate and tinsel by the ABS plastic granule mutually bondd, then drying is fixed the plastics porous support on base plate and tinsel;
(3) bioceramic molding: plastics porous support is reloaded in mold cavity together with base plate and tinsel, then place it on reciprocating sieve, β-TCP powder 78g particle diameter being less than 5 μm adds on plastics porous support from mould upper end open, α-TCP powder is made to be full of the hole of plastics porous support by reciprocating sieve vibration, then centrifugal 5 minutes are placed on centrifuge, add 3.2g Polyethylene Glycol binding agent again, within centrifugal 1 minute, obtain the mold integral containing ceramic idiosome, mold integral containing ceramic idiosome is put into drying baker dry 24 hours, then extract through filament and put it in sintering furnace and be warmed up to 300 DEG C of burn off plastics porous supports with 1 DEG C/min speed, top cover and base plate, then 1200 DEG C of sintering 12 hours are warmed up to 5 DEG C/min, remove the bionical bioceramic that die main body obtains having through hole structure.
Embodiment 2
A kind of preparation method with the bionical bioceramic of through hole structure of the present embodiment, comprises following operating procedure:
(1) preparation of mould: select length to be 31.4 millimeters, wide to be 10 millimeters high the be cuboid die main body of 18 millimeters and associated top cover and base plate, the material of preparing of die main body is zirconia ceramics, the material of preparing of top cover and base plate is polypropylene, die main body, top cover and base plate three surround mold cavity, on base plate, fixed diameter is 300 microns, spacing distance is the aciculiform cylindric polyethylene hard silk of 700 microns, and hard silk extends to top cover in mold cavity.
(2) preparation of plastics porous support: be that the ABS plastic granule of 200 μm ~ 300 μm is filled in mold cavity by diameter, add acetone, ABS plastic particle surface is made to dissolve bonding mutually, fall acetone with distilled water flushing, then the ABS plastic granule mutually bondd is taken out drying together with base plate and polyethylene hard silk in die cavity and be fixed the plastics porous support in base plate and polyethylene hard silk.
(3) bioceramic molding: plastics porous support is reloaded in mold cavity together with base plate and polyethylene hard silk, then place it on reciprocating sieve, β-TCP powder 4.4g particle diameter being less than 5 μm adds on plastics porous support from mould upper end open, β-TCP powder is made to be full of the hole of plastics porous support by reciprocating sieve vibration, then centrifugal 5 minutes are placed on centrifuge, add 0.2g polyvinyl alcohol adhesive again, the mold integral containing ceramic idiosome is obtained after centrifugal 1 minute, mold integral containing ceramic idiosome is put into drying baker dry 24 hours, then put it in sintering furnace and be warmed up to 300 DEG C of burn off plastics porous supports with 1 DEG C/min speed, top cover, base plate and hard silk, then 1150 DEG C of sintering 12 hours are warmed up to 5 DEG C/min, remove the bionical bioceramic that die main body obtains having through hole structure.
Embodiment 3
A kind of preparation method with the bionical bioceramic of through hole structure of the present embodiment, comprises following operating procedure:
(1) preparation of mould: select the length of side to be the square die main body of 24 millimeters and associated top cover and base plate, the material of preparing of die main body is aluminium oxide ceramics, the material of preparing of top cover and base plate is polypropylene, die main body, top cover and base plate three surround mold cavity, on base plate, fixed diameter is 500 microns, spacing distance is the S shape cylindric polypropylene hard silk of 1 millimeter, and hard silk extends to top cover in mold cavity.
(2) preparation of plastics porous support: be that the polycarbonate pellets of 400 μm ~ 500 μm is filled in mold cavity by diameter, add acetone, polycarbonate pellets surface dissolution is bondd mutually, fall acetone with distilled water flushing, then the polycarbonate pellets mutually bondd is taken out drying together with base plate and polypropylene hard silk in die cavity and be fixed the plastics porous support in base plate and polypropylene hard silk.
(3) bioceramic molding: plastics porous support is reloaded in mold cavity together with base plate and polypropylene hard silk, then place it on reciprocating sieve, polyphosphoric acid calcium powder 11g particle diameter being less than 5 μm adds on plastics porous support from mould upper end open, polyphosphoric acid calcium powder is made to be full of the hole of plastics porous support by reciprocating sieve vibration, then centrifugal 5 minutes are placed on centrifuge, add 0.5g acrylate copolymer binding agent again, after centrifugal 1 minute, top cover obtains the mold integral containing ceramic idiosome, mold integral containing ceramic idiosome is put into drying baker dry 24 hours, then put it in sintering furnace and be warmed up to 300 DEG C of burn off plastics porous supports with 1 DEG C/min speed, top cover, base plate and hard silk, then 900 DEG C of sintering 12 hours are warmed up to 5 DEG C/min, remove the bionical bioceramic that die main body obtains having through hole structure.
Above-described embodiment is the present invention's preferably embodiment; but embodiments of the present invention are not restricted to the described embodiments; change, the modification done under other any does not deviate from spirit of the present invention and principle, substitute, combine, simplify; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (10)
1. there is a preparation method for the bionical bioceramic of through hole structure, it is characterized in that: comprise following operating procedure:
(1) preparation of mould: choose length, wide or diameter range is 5mm ~ 40mm, height is the hollow mould main body of 9mm ~ 80mm upper and lower side opening, die main body upper and lower side opening part arranges top cover and base plate respectively, the material of preparing of die main body is zirconia ceramics or aluminium oxide ceramics, the material of preparing of top cover and base plate is gasifiable material at 300 DEG C, die main body, top cover and base plate three surround mold cavity, die main body and base plate can realize being tightly connected, diameter is selected to be the through filament of hard of 300 ~ 500 μm, through filament one end is fixed on base plate, the other end extends to top cover in mold cavity, through filament is spaced 700 μm ~ 1mm,
(2) preparation of plastics porous support: by diameter be the organic plastics granule of 100 μm ~ 500 μm be filled into from die main body upper end open be provided with through filament mold cavity in, adding organic solvent or heating makes organic plastics particle surface dissolve or fusing, realize the mutual bonding between organic plastics granule, then the organic plastics granule mutually bondd is taken out from mold cavity together with base plate and through filament, with distilled water flushing cooling, after drying, be fixed the plastics porous support on base plate and through filament;
(3) bioceramic molding: plastics porous support is reloaded in mold cavity together with base plate and through filament, then place it on reciprocating sieve, biological ceramic powder particle diameter being less than 5 μm adds on plastics porous support from die main body upper end open, biological ceramic powder is made to be full of the hole of plastics porous support by reciprocating sieve vibration, then centrifugal 5 minutes are placed on centrifuge, add the mold integral that binding agent obtains containing ceramic idiosome for centrifugal 1 minute again, mold integral containing ceramic idiosome is put into drying baker dry 24 hours, then remove through filament and put it in sintering furnace and be warming up to 300 DEG C of burn off plastics porous supports, top cover and base plate, be warming up to 900 ~ 1200 DEG C of sintering 12 hours again, remove the bionical bioceramic that die main body obtains having through hole structure.
2. a kind of preparation method with the bionical bioceramic of through hole structure according to claim 1, it is characterized in that: described die main body is also arranged horizontal through filament and be connected with through filament fixing on base plate, form three-dimensional netted communicating structure.
3. a kind of preparation method with the bionical bioceramic of through hole structure according to claim 1 and 2, is characterized in that: the cross section of described die main body is circular, square, rectangle or triangle; Described through filament is aciculiform or S shape, and the cross section of through filament is circular, square, rectangle or triangle.
4. a kind of preparation method with the bionical bioceramic of through hole structure according to claim 1 and 2, it is characterized in that: described through filament with the fixed form of base plate is: base plate is distributed with and through filament shape of cross section and the identical aperture of size, through filament is fixed by inserting aperture.
5. a kind of preparation method with the bionical bioceramic of through hole structure according to claim 1 and 2, is characterized in that: at described 300 DEG C, gasifiable material is polyethylene, polypropylene or makrolon material; Described organic plastics granule is polyformaldehyde granule, ABS plastic granule, polyethylene terephthalate granule or polycarbonate pellets; Described organic solvent is acetic acid, Hexafluoro acetone or acetone.
6. a kind of preparation method with the bionical bioceramic of through hole structure according to claim 1 and 2, is characterized in that: described biological ceramic powder is at least one in hydroxylapatite powder, type alpha tricalcium phosphate powder, bata-tricalcium phosphate powder, polyphosphoric acid calcium powder and tetracalcium phosphate powder; Described binding agent is Polyethylene Glycol, polyvinyl alcohol or acrylate copolymer.
7. a kind of preparation method with the bionical bioceramic of through hole structure according to claim 1 and 2, it is characterized in that: the material of preparing of described through filament is metal material, in step (3), the mode of the through filament of removing is that machinery is extracted.
8. a kind of preparation method with the bionical bioceramic of through hole structure according to claim 1 and 2, it is characterized in that: described through filament prepare material and mould top cover or base plate to prepare material identical, in step (3) the through filament of removing mode for put into sintering furnace be warming up to 300 DEG C with plastics porous support, top cover burn off together with base plate.
9. there is a bionical bioceramic for through hole structure, it is characterized in that: prepared by the preparation method described in any one of claim 1 ~ 8.
10. according to claim 9 a kind of there is bionical bioceramic spongy bone in medical domain or veterinary applications of through hole structure alternative reparation or tissue engineering bracket in application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410853889.8A CN104606712B (en) | 2014-12-31 | 2014-12-31 | A kind of bionical bioceramic with through hole structure and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410853889.8A CN104606712B (en) | 2014-12-31 | 2014-12-31 | A kind of bionical bioceramic with through hole structure and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104606712A true CN104606712A (en) | 2015-05-13 |
| CN104606712B CN104606712B (en) | 2016-08-17 |
Family
ID=53141532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410853889.8A Active CN104606712B (en) | 2014-12-31 | 2014-12-31 | A kind of bionical bioceramic with through hole structure and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104606712B (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106348785A (en) * | 2015-07-21 | 2017-01-25 | 浙江大学 | Bioactive porous ceramic tubular bar material as well as preparation method and application thereof |
| CN107089840A (en) * | 2017-06-05 | 2017-08-25 | 安徽省亚欧陶瓷有限责任公司 | A kind of Ceramic Tiles of high-strength bionic culm structure and preparation method thereof |
| CN107190571A (en) * | 2017-04-27 | 2017-09-22 | 舒尔环保科技（合肥）有限公司 | A kind of new ceramics fiber air scavenging material and preparation method |
| CN107324764A (en) * | 2017-06-30 | 2017-11-07 | 周远华 | It is a kind of to be used to absorb infrared biological cerimic composite and its application |
| CN108310461A (en) * | 2018-02-09 | 2018-07-24 | 武汉纺织大学 | Porous fibroin spinal cord rack with targeted release function and preparation method thereof prepares mold and application |
| CN108452385A (en) * | 2017-02-17 | 2018-08-28 | 重庆润泽医药有限公司 | A kind of porous material |
| CN108452384A (en) * | 2017-02-17 | 2018-08-28 | 重庆润泽医药有限公司 | A kind of porous material |
| CN108452386A (en) * | 2017-02-17 | 2018-08-28 | 重庆润泽医药有限公司 | A kind of porous material |
| CN108452387A (en) * | 2017-02-17 | 2018-08-28 | 重庆润泽医药有限公司 | A kind of porous metals |
| CN108686269A (en) * | 2018-06-06 | 2018-10-23 | 扬州大学 | The preparation method of hydroxyapatite/ABS composite material tooth-implanting |
| CN112094131A (en) * | 2020-09-22 | 2020-12-18 | 广东工业大学 | Double-layer thick film ceramic containing micro-channel and preparation method thereof |
| CN113213962A (en) * | 2021-03-16 | 2021-08-06 | 南京航空航天大学 | Porous ceramic with through holes and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070072009A1 (en) * | 2003-10-27 | 2007-03-29 | Pentax Corporation | Porous calcium phosphate ceramic and method for producing same |
| CN101920043A (en) * | 2010-08-17 | 2010-12-22 | 复旦大学 | Porous bracket with micro grooves on pore walls and preparation method thereof |
| CN102423272A (en) * | 2011-09-20 | 2012-04-25 | 复旦大学 | Porous stent with network passage and preparation method of porous stent |
-
2014
- 2014-12-31 CN CN201410853889.8A patent/CN104606712B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070072009A1 (en) * | 2003-10-27 | 2007-03-29 | Pentax Corporation | Porous calcium phosphate ceramic and method for producing same |
| CN101920043A (en) * | 2010-08-17 | 2010-12-22 | 复旦大学 | Porous bracket with micro grooves on pore walls and preparation method thereof |
| CN102423272A (en) * | 2011-09-20 | 2012-04-25 | 复旦大学 | Porous stent with network passage and preparation method of porous stent |
Non-Patent Citations (3)
| Title |
|---|
| JUAN VIVANCO等: ""Mechanical characterization of injection-molded macro porous bioceramic bone scaffolds"", 《JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS》 * |
| M. DESCAMPS等: ""Synthesis of macroporous b-tricalcium phosphate with controlled porous architectural"", 《CERAMICS INTERNATIONAL》 * |
| 赵娜如等: ""原位凝固成型法制备可控孔隙结构的多孔β-磷酸三钙陶瓷"", 《硅酸盐学报》 * |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106348785B (en) * | 2015-07-21 | 2019-04-02 | 浙江大学 | A kind of bioactivity, porous ceramic tubular bar, preparation method and applications |
| CN106348785A (en) * | 2015-07-21 | 2017-01-25 | 浙江大学 | Bioactive porous ceramic tubular bar material as well as preparation method and application thereof |
| CN108452385B (en) * | 2017-02-17 | 2020-07-03 | 重庆润泽医药有限公司 | Porous material |
| CN108452387B (en) * | 2017-02-17 | 2020-06-09 | 重庆润泽医药有限公司 | Porous metal |
| CN108452385A (en) * | 2017-02-17 | 2018-08-28 | 重庆润泽医药有限公司 | A kind of porous material |
| CN108452384A (en) * | 2017-02-17 | 2018-08-28 | 重庆润泽医药有限公司 | A kind of porous material |
| CN108452386A (en) * | 2017-02-17 | 2018-08-28 | 重庆润泽医药有限公司 | A kind of porous material |
| CN108452387A (en) * | 2017-02-17 | 2018-08-28 | 重庆润泽医药有限公司 | A kind of porous metals |
| CN107190571A (en) * | 2017-04-27 | 2017-09-22 | 舒尔环保科技（合肥）有限公司 | A kind of new ceramics fiber air scavenging material and preparation method |
| CN107089840A (en) * | 2017-06-05 | 2017-08-25 | 安徽省亚欧陶瓷有限责任公司 | A kind of Ceramic Tiles of high-strength bionic culm structure and preparation method thereof |
| CN107324764A (en) * | 2017-06-30 | 2017-11-07 | 周远华 | It is a kind of to be used to absorb infrared biological cerimic composite and its application |
| CN108310461A (en) * | 2018-02-09 | 2018-07-24 | 武汉纺织大学 | Porous fibroin spinal cord rack with targeted release function and preparation method thereof prepares mold and application |
| CN108310461B (en) * | 2018-02-09 | 2021-07-06 | 武汉纺织大学 | Porous silk fibroin spinal cord stent with directional release function, and preparation method, preparation mold and application thereof |
| CN108686269A (en) * | 2018-06-06 | 2018-10-23 | 扬州大学 | The preparation method of hydroxyapatite/ABS composite material tooth-implanting |
| CN112094131A (en) * | 2020-09-22 | 2020-12-18 | 广东工业大学 | Double-layer thick film ceramic containing micro-channel and preparation method thereof |
| CN113213962A (en) * | 2021-03-16 | 2021-08-06 | 南京航空航天大学 | Porous ceramic with through holes and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104606712B (en) | 2016-08-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104606712A (en) | Bionic bioceramic with through-hole structure and preparation method and application thereof | |
| Gmeiner et al. | Additive manufacturing of bioactive glasses and silicate bioceramics | |
| Huang et al. | Porous and strong bioactive glass (13–93) scaffolds fabricated by freeze extrusion technique | |
| Tarafder et al. | Microwave‐sintered 3D printed tricalcium phosphate scaffolds for bone tissue engineering | |
| CN106178124B (en) | A kind of degradable macromolecule network/calcium phosphate bone cement composite bone repairing material and the preparation method and application thereof | |
| Chevalier et al. | Fabrication of porous substrates: a review of processes using pore forming agents in the biomaterial field | |
| CN108478879A (en) | A kind of porous calcium phosphate/natural polymer compound rest and the preparation method and application thereof | |
| CN101690828B (en) | Preparation method of gradient porous bioceramic scaffold | |
| Liu et al. | Selective laser sintering of a hydroxyapatite-silica scaffold on cultured MG63 osteoblasts in vitro | |
| KR101908287B1 (en) | Porous bone substitutes and method for producing thereof | |
| Huang et al. | Microsphere based scaffolds for bone regenerative applications | |
| CN100536938C (en) | Process for preparing porous biological ceramics supporting frame | |
| CN104220102B (en) | A kind of porous hydroxyapatite bioceramic and preparation method thereof | |
| CN102512267A (en) | Bone restoration body with composite porous structure and preparation method thereof | |
| CN103467104B (en) | Method for improving ceramic sintering performance by adding a small amount of polylactic acid in artificial bone prepared by laser | |
| WO2007128192A1 (en) | A medical strengthened-type porous bioceramics, its preparation method and application | |
| CN107823712A (en) | A kind of method for preparing imitative artificial bone of coral with cuttlebone and products thereof | |
| CN111803715A (en) | Degradable artificial bone particle with core-shell structure and preparation method thereof | |
| CN104368040A (en) | Composite 3D printing porous metal support for demineralized bone matrix and preparation method of metal support | |
| Li et al. | Design and fabrication of CAP scaffolds by indirect solid free form fabrication | |
| Miri et al. | Review on the strategies to improve the mechanical strength of highly porous bone bioceramic scaffolds | |
| CN104441668A (en) | Nanometer artificial bone scaffold with structure similar to that of natural bone and preparation method thereof | |
| CN103602844A (en) | Preparation method of porous biomedical metal, ceramic or metal/ceramic composite material | |
| CN109157677B (en) | Personalized calcium phosphate bionic bone tissue scaffold and preparation method and application thereof | |
| CN104984401B (en) | A kind of preparation method of temperature-sensitive hydrogel/tricalcium phosphate material |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |