CN104605897A - Mechanism capable of marking tumor boundary used for biopsy needle - Google Patents
Mechanism capable of marking tumor boundary used for biopsy needle Download PDFInfo
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- CN104605897A CN104605897A CN201510001373.5A CN201510001373A CN104605897A CN 104605897 A CN104605897 A CN 104605897A CN 201510001373 A CN201510001373 A CN 201510001373A CN 104605897 A CN104605897 A CN 104605897A
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- biopsy needle
- label
- sample reception
- tumor
- ejection capsule
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Abstract
The invention discloses a mechanism capable of marking a tumor boundary used for a biopsy needle. The biopsy needle comprises a biopsy needle tube and a sample receiving member movably arranged in the biopsy needle tube. The sample receiving member is provided with a sampling receiving concave opening. The mechanism is arranged in the sampling receiving concave opening. The mechanism comprises an ejection chamber and a marker arranged in the ejection chamber. When the ejection chamber extends out of the front end of the biopsy needle tube along with the sampling receiving concave opening, the marker is ejected from the ejection chamber. The mechanism capable of marking the tumor boundary used for the biopsy needle has the advantages that the structure is simple, the mechanism is convenient to install into an existing biopsy needle, former operation methods and processes are not needed to be changed when using the mechanism, the implantation of the marker is completed while sampling, and no additional operation is needed. By arranging the marker, a tumor positioning and tracking process is easier, the mechanism is beneficial to conducting tumor data sampling and researching during a therapeutic process, and is applicable to various kinds of tumors which can be sampled through puncture such as a breast tumor, a liver tumor and a lung tumor.
Description
Technical field
The present invention relates to a kind of medical surgical instrument, be specifically related to a kind of can the mechanism on marked tumor border on biopsy needle.
Background technology
Biopsy needle is a kind of preoperative conventional apparatus, and can be used for the living tissue sampling, cell absorption etc. of entity tumor, is a kind of important tool of pathological diagnosis clinically.
Enclosed mass is organized for some, as mammary gland tumor, can aspiration biopsy be carried out carrying out operation consent, specify pathological diagnosis.Aspiration biopsy destroys few to tumor tissues, can not contact tumor mass during operation, avoids tumor cell to come off the residual of local, also shortens operating time.If preoperative puncture needle biopsy malignant change, be not only further treatment and provide foundation, and be conducive to the mode that doctor and patient discuss operative treatment jointly, as whether taked the operation etc. of Remainded mamma.
After biopsy, for dissimilar tumor, what have can Direct Surgery, have then need Drug therapy (as chemotherapy) a period of time after determine whether perform the operation according to the size variation of tumor again.Some tumors are after the preoperative therapy such as Drug therapy, and obvious change can occur character, and in order to provide reliable foundation to follow-up therapeutic scheme, doctor needs the information such as the size to tumor before and after Drug therapy, position to have accurate control.
Current Problems existing is, the tumor of Drug therapy carried out for aspiration biopsy, cannot locate efficiently and accurately in follow-up therapeutic process, Partial tumors position, size change, even likely disappear, but these data cannot quantize easily, be unfavorable for the treatment to tumor and research work.
Summary of the invention
For above-mentioned problems of the prior art, the object of the invention is to, a kind of mechanism that can be applied in for marked tumor border on all kinds of biopsy needle is provided, while puncture sampling, leaves label at the boundary of tumor, be convenient to the tracking to tumor and follow-up Therapy study.
In order to realize above-mentioned task, the present invention by the following technical solutions:
A kind of can the mechanism on marked tumor border on biopsy needle, described biopsy needle comprises biopsy needle tubing and the movable sample reception component be arranged in biopsy needle tubing, sample reception recess is provided with in sample reception component, described organization establishes is in sample reception recess, this mechanism comprises ejection capsule and is arranged on the label in ejection capsule, ejection capsule along with sample reception recess stretch out from biopsy needle tubing front end time, label ejects from ejection capsule.
Further, be provided with catapult-launching gear in described ejection capsule, label is arranged in ejection capsule in the mode of compression, and when sample reception component is arranged in biopsy needle tubing, upper end, the lower end of label are limited by the inwall of biopsy needle tubing, catapult-launching gear respectively.
Further, the inwall of described biopsy needle tubing is axially provided with the chute adapted with label upper end profile along it.
Further, described ejection capsule is arranged on the end of sample reception recess, comprises the cylinder that one section of diameter is less than sample reception component internal diameter, cylindrical side offers container cavity, install described label in container cavity.
Further, described ejection capsule can sliding axially along sample reception component.
Further, the contrast agent that described label comprises an airtight cavity and is arranged in cavity.
Further, described label is capsule shape, and the two ends of label are blunt round or taper.
Further, described catapult-launching gear is be arranged on shell fragment bottom ejection capsule or Compress Spring.
Further, described shell fragment arranges a pair, and one of them shell fragment is longer and another shell fragment is shorter.
The present invention has following technical characterstic:
1. structure is simple, can be installed at easily in existing biopsy needle, without the need to changing original operation technique and operating process during use, namely completes the implantation of label while sampling, and without other operation bidirectionals;
2. highly versatile, for dissimilar and biopsy needle that is structure, all can be arranged easily;
3. label has feature special and eye-catching in iconography, after label is implanted, gets final product positioning tumor by the relatively simple measuring means such as B ultrasonic, color ultrasound;
4. convenient and swift when label is installed, do not affect the original function of biopsy needle after installing;
5. by the setting of this label, the location tracking process of tumor is more prone to, is conducive to taking and studying to tumor data in therapeutic process, and be applicable to all kinds of tumor by puncture sampling, as mammary gland, liver, lung tumors etc.
Accompanying drawing explanation
Fig. 1 is overall structure schematic diagram of the present invention;
Fig. 2 is the structural representation of one embodiment of the invention;
Fig. 3 is the schematic diagram of label when launching;
Fig. 4 is the structural representation of ejection capsule;
Fig. 5 is ejection capsule internal structure schematic diagram;
Fig. 6 is the enlarged diagram of label when launching;
Number in the figure represents: 1-biopsy needle tubing, 2-label, 21-contrast agent; 3-ejection capsule, 31-cylinder, 32-container cavity, 33-shell fragment, 4-sample reception recess, 5-sample reception component;
Detailed description of the invention
Biopsy device mainly comprises biopsy needle and the cell taking gun for coordinating biopsy needle to use, ejection system is provided with in cell taking gun, when biopsy needle is arranged on after on cell taking gun, under the guiding of image documentation equipment, borderline tumor is delivered at the needle point position of biopsy needle, then the ejection system in cell taking gun is utilized, sample reception component 5 in biopsy needle is launched vertically from biopsy needle tubing 1, sample reception component 5 is while cutting tumor tissues, the tissue samples cut down is filled in the sample reception recess 4 of sample reception component 5, after launching, sample reception component 5 is multiple gets back to again in biopsy needle tubing 1, then whole biopsy needle is exited, again sample reception component 5 is released from needle tubing outward at patient body, take out the sample in recess, complete sampling process.
Biopsy is a kind of Wicresoft, fast sampling process, and the cutting-edge structure so just determining puncture instrument must be trickle and exquisite as much as possible.The diameter of in fact general biopsy needle end is only several millimeters, and after puncture, wound healing is also very fast.One end that biopsy needle enters sampling in body mainly contains the sharp portion for stinging out tissue and skin, makes needle tip potential energy arrive borderline tumor smoothly.
As depicted in figs. 1 and 2 be two kinds of existing conventional puncture needle structures.No matter be any structure, its common feature is that principle is substantially identical, is all utilize the start of sample reception component 5 quick-expansion with cutting and extract sample, and is provided with sample reception component 5 and sample reception recess 4.In general, sample reception component 5 is a front end is spiny hollow stem, and hollow stem carries out cutting along the axis of bar, and by the partial removal of cutting, this section exposing hollow stem inside is sample reception recess 4.During biopsy sampling, this section of sample reception component 5 at sample reception recess 4 place stretches out the front end of biopsy needle tubing 1 completely with collecting sample in sampling process.
The inventor team of this programme finds in long-term work research, if while puncture to tumor in be implanted in the label 2 having obvious characteristic in iconography equipment, so in later stage tracing process, be very beneficial for tumor-localizing; Labelling is clearly under iconography equipment for label 2, significant difference (be embodied in color of image, brightness, form are first-class) is had with human body remaining tissue, when implanting according to it periphery shape of tumor and again check time shape of tumor contrast, can know the data that tumor changes quantitatively, this medical scheme to the later stage is formulated and is studied equal important in inhibiting.The label 2 implanted, after the later stage, medical scheme was formed, can take out easily in operation process.
The principle of this programme is, by arranging ejection capsule 3 in sample reception component 5, launches in tissue while sampling by label 2, does not affect normal sampling process, is applicable to all kinds of biopsy needle apparatus with sample reception recess 4 simultaneously.The scheme that the present invention adopts is:
A kind of can the mechanism on marked tumor border on biopsy needle, described biopsy needle comprises biopsy needle tubing 1 and the movable sample reception component 5 be arranged in biopsy needle tubing 1, sample reception recess 4 is provided with in sample reception component 5, described organization establishes is in sample reception recess 4, the label 2 that this mechanism comprises ejection capsule 3 and is arranged in ejection capsule 3, ejection capsule 3 along with sample reception recess 4 stretch out from biopsy needle tubing 1 front end time, label 2 ejects from ejection capsule 3.
In aforesaid biopsy needle work process, mention when the sample reception component 5 of biopsy needle works, stretch out fast from the front end of biopsy needle tubing 1, carry out cutting and the collection of tissue samples, in this process, sample reception recess 4 entirety is stretched out biopsy needle tubing 1 front end completely within the time period that certain is very short.So, the structure of this period of time and biopsy needle tubing 1 self just can be utilized to arrange one when sample reception recess 4 stretches out completely, the mechanism of implantable marker thing 2.
This organization establishes, in sample reception recess 4, when sample reception recess 4 stretches into biopsy needle tubing 1 front end, to be hit by a bullet out label 2 from the ejection capsule 3 of mechanism, makes label 2 enter into tumor on the upside of sample reception recess 4.Do not affect the normal sampling of biopsy needle in this process, in the process of sampling, namely additionally carry out the implantation of label 2.
Concrete ejection capsule 3 can be arranged like this:
Be provided with catapult-launching gear in ejection capsule 3, label 2 is arranged in ejection capsule 3 in the mode of compression, and when sample reception component 5 is arranged in biopsy needle tubing 1, upper end, the lower end of label 2 are limited by the inwall of biopsy needle tubing 1, catapult-launching gear respectively.
The mode of above-mentioned compression refers to that the catapult-launching gear in ejection capsule 3 is a kind of accumulating mechanism, and when label 2 is arranged in ejection capsule 3, catapult-launching gear is in energy accumulating state, is namely compressed; And when the restriction of label 2 is removed, label 2 can be launched out ejection capsule 3 by catapult-launching gear.
Mechanism for limit markers thing 2 position is biopsy needle tubing 1.Utilize biopsy needle tubing 1 structure originally, when not sampling, sample reception component 5 and sample reception recess 4 entirety are in biopsy needle tubing 1, and label 2 is compressed in ejection capsule 3, the upper end of label 2 suppress by the inwall of biopsy needle tubing 1, make catapult-launching gear accumulation of energy; And in sampling process, along with sample reception recess 4 entirety is stretched out from biopsy needle tubing 1 front end, the upper end restriction of label 2 is removed, then catapult-launching gear can be sprung into when label 2 exposes biopsy needle tubing 1 front end in the middle of the tissue of surrounding at once.
In order to make wall energy in biopsy needle tubing 1 suppress label 2 better, the inwall of biopsy needle tubing 1 is axially provided with the chute adapted with label 2 upper end profile along it.
Chute is axially arranged along biopsy needle tubing 1 inwall, until the front end of biopsy needle tubing 1, and this chute profile is in order to mating mark thing 2 upper end, if label 2 upper end is semicircle, semicircle chute can be set to, make label 2 entirety position in along with sample reception component 5 motor process more stable, be also convenient to exert pressure.
The sample collected is loaded in order to not affect sample reception recess 4, ejection capsule 3 is arranged on the end of sample reception recess 4, comprise the cylinder 31 that one section of diameter is less than sample reception component 5 internal diameter, side offers container cavity 32 to cylinder 31, installs described label 2 in container cavity 32.
Here end refers to the one end near cell taking gun.Sample reception component 5 is when collected specimens, and sample direction from front to back enters into sample reception recess 4.So ejection capsule 3 is arranged on the end of sample reception recess 4, does not then affect the accommodation of sample in the recess of front end.Ejection capsule 3 overall structure is less, and as shown in Figures 4 to 6, be one section of cylinder 31, its lower end can be cemented in sample reception recess 4.Cylinder 31 side offers container cavity 32 to cylinder 31 inside, makes cylinder 31 Inner Constitution hollow structure.
For some biopsy needle, the push rod for being released forward from sample reception component 5 by sample after sampling also is provided with in cell taking gun, in order to not make the setting of ejection capsule 3 have influence on this structure, being so set to by ejection capsule 3 can along the structure in axial sliding of sample reception component 5.
This structure is easier to realize, and the mode such as coordinated by draw-in groove is arranged in recess by launching, and makes ejection capsule 3 can moving axially along sample reception component 5, but can not deviate from from recess.During push rod driven forward below, ejection capsule 3 also can slide to release sample in recess.
Label 2 in this programme, comprises airtight cavity and is arranged on the contrast agent 21 in cavity.
Contrast agent 21 is the normal a kind of reagent used in iconography, under iconography equipment (CT, magnetic resonance, B ultrasonic etc.), have obvious difference with surrounding tissue.Contrast agent 21 is contained in an airtight cavity, serves as label 2.This cavity can be spherical, cylindricality, rule body or irregular body, and material can adopt rustless steel, titanium, titanium alloy or other medical macromolecular materials.
In an example of this programme, as shown in Figure 4, Figure 5, label 2 is capsule shape, and the two ends of label 2 are blunt round or taper.
Label 2 is convenient to be arranged in ejection capsule 3 for capsule shape.Be more prone to the end of label 2 is arranged to taper or other more sharp-pointed shapes, label 2 can be penetrated in tumor tissues in the process ejected, do not affect sampling process.
The effective catapult-launching gear of a kind of simple structure as shown in Figure 5, comprises and is arranged on shell fragment 33 bottom ejection capsule 3 or Compress Spring.
Require that catapult-launching gear has higher coefficient of elasticity, label 2 can be embedded in surrounding tissue.About the requirement embedded, label 2 tip can be arranged sharp keen and improve coefficient of elasticity dual mode and guarantee.When label 2 is in ejection capsule 3, shell fragment 33 or Compress Spring accumulation of energy, when after the restriction cancellation of label 2 upper end, shell fragment 33 or Compress Spring are ejected.Certainly, except these the two kinds of catapult-launching gears listed, the ejection structure of other routines can also be adopted.
More excellent a kind of scheme is that shell fragment 33 arranges a pair, and one of them shell fragment 33 is longer and another shell fragment 33 is shorter.
This asymmetric structure is set, when making label 2 be ejected ejection capsule 3, not vertically upward but eject with the direction at oblique angle, even if such structure makes, label 2 is unsuccessful to be penetrated in surrounding tissue, also can rest on puncture position, face, needle tubing front, and piercing process can not be affected; In addition, in the process that sample reception component stretches out forward, cut tumor sample to be filled in recess, having hindered to returning bounce-back even if label is subject to tumor, owing to being filled in recess, also can not enter in recess the recovery blocking sample reception component; And label edge is smooth, be difficult to have influence on sample reception component, therefore this device is a kind of mechanism of essential safety, can not have influence on the normal use of puncture needle completely.
Certainly, in order to make label can mark position better, catapult-launching gear should have larger coefficient of elasticity.Sample reception component, when sampling, stretches out forward from needle tubing, punctures tumor and after sampling, then to be retracted in needle tubing.And sample reception component is in the outside process of stretching out of needle tubing, label loses constraint sometime, outwards ejects, timing from this time, and the recess to sample reception component is all retracted in needle tubing, is designated as t during this period of time.
Tumor has certain elasticity, label touches tumor after ejection capsule launches out to start to do retarded motion, now start timing, label touches tumor and makes tumor generation deformation (or puncture enter in tumor), until stop timing when the speed of label reduces to 0, be designated as t1 during this period of time, if t1>t, so just show that label is with the process of tumor contact, sampling work completes, even if label rebounds, also only can fall in the passage formed after sampling, and the recovery of sample reception component can not be affected completely.Actual when using, suitable coefficient of elasticity can be set according to above-mentioned principle, ensure sampling, labeling process safe, smooth.
The two ends of label can be set to tip shape, as taper, or blunt rounded, as hemispherical.When being arranged to tip shape, be more prone to label can be punctured and penetrate in tumor, this label be adapted at preoperative through iconography equipment observed tumor larger time, the label of sharp-pointed shape is adopted in piercing process, and make as far as possible puncturing in tumor foremost of puncture needle, label is thrust in tumor as far as possible, to follow the trail of shape of tumor.And the label of two ends blunt round, structure as shown in Figure 5, then can be used as generally labeling, and puncturing property not as aforementioned structure, but also can play good labelling effect for small sized tumor, and its contour structures is smooth, is not easy free original position, and safety is stronger.
After mechanism sets, in use, first the sample reception component 5 of biopsy needle is released from biopsy needle tubing 1 front end, just expose ejection capsule 3 position, then apparatus is used, as tweezers gripping label 2 is pressed in ejection capsule 3, while pressing label 2, sample reception component 5 is pushed to position originally to biopsy needle tubing 1 inside, label 2 is limited, now biopsy needle is identical with usual use procedure, be arranged on after on cell taking gun and can start sampling work of puncturing, and implant label 2 simultaneously.Primary sample after implanting label 2, replaceable common biopsy needle is also changed position and is carried out secondary sample process.
Application experiment:
In the present embodiment, the sheathing material of label adopts nonbiodegradable biological medical polymer material (polyacrylate, aromatic polyester).Feature: maintain a long-term stability in biotic environment, do not degrade, be cross-linked or physical abrasion, and have good mechanical property, contrast agent adopts common medical contrast medium, as barium sulfate, Operand etc.
1. background:
There being breast tumor need carry out in the patient of Puncture Biopsy under Ultrasound Guidance, in the process to its mass puncture biopsy, do the contrast labeled of corresponding knub position.
2. method:
The biopsy needle that mechanism described in this programme is equipped with in application carries out aspiration biopsy to suffering from Breast Tumor Patients.Follow the tracks of after puncture and follow up a case by regular visits to patient to tumor resection of performing the operation, and check the tumor specimen that patient excises, determine that whether its contrast label object location is correct, with or without breakage, and patient carries in label process and has no adverse reaction.
3. result:
Accept all successful implantable marker thing of 55 patient's piercing process of biopsy, label all launches successfully and does not impact the normal use of biopsy needle.In 55 patients of implantable marker thing, have 49 to carry label patient without any untoward reaction, cut open after ocal resection and can find that label is intact, position is still in inside tumor; Have 6 patients accept new adjuvant chemotherapy due to preoperative and make tumor disappearance, cannot judge mark thing whether in the original position of tumor.
4. conclusion:
The effective marked tumor position of biopsy needle energy of label is housed, can't impacts patient, have good directive function to clinical tumor excision.
Claims (9)
1. one kind can the mechanism on marked tumor border on biopsy needle, it is characterized in that, described biopsy needle comprises biopsy needle tubing (1) and the movable sample reception component (5) be arranged in biopsy needle tubing (1), sample reception recess (4) is provided with in sample reception component (5), described organization establishes is in sample reception recess (4), this mechanism comprises ejection capsule (3) and is arranged on the label (2) in ejection capsule (3), ejection capsule (3) along with sample reception recess (4) stretch out from biopsy needle tubing (1) front end time, label (2) ejects from ejection capsule (3).
2. as claimed in claim 1 can the mechanism on marked tumor border on biopsy needle, it is characterized in that, catapult-launching gear is provided with in described ejection capsule (3), label (2) is arranged in ejection capsule (3) in the mode compressed, when sample reception component (5) is arranged in biopsy needle tubing (1), upper end, the lower end of label (2) are limited by the inwall of biopsy needle tubing (1), catapult-launching gear respectively.
3. as claimed in claim 1 or 2 can the mechanism on marked tumor border on biopsy needle, it is characterized in that, the inwall of described biopsy needle tubing (1) is axially provided with the chute adapted with label (2) upper end profile along it.
4. as claimed in claim 1 or 2 can the mechanism on marked tumor border on biopsy needle, it is characterized in that, described ejection capsule (3) is arranged on the end of sample reception recess (4), ejection capsule (3) comprises the cylinder (31) that one section of diameter is less than sample reception component (5) internal diameter, cylinder (31) side offers container cavity (32), the label (2) described in installing in container cavity (32).
5. as claimed in claim 4 described can the mechanism on marked tumor border on biopsy needle, it is characterized in that, described ejection capsule (3) can sliding axially along sample reception component (5).
6. as claimed in claim 1 can the mechanism on marked tumor border on biopsy needle, it is characterized in that, the contrast agent (21) that described label (2) comprises an airtight cavity and is arranged in cavity.
7. as claimed in claim 6 can the mechanism on marked tumor border on biopsy needle, it is characterized in that, described label (2) is capsule shape, and the two ends of label (2) are blunt round or taper.
8. as claimed in claim 2 can the mechanism on marked tumor border on biopsy needle, it is characterized in that, described catapult-launching gear is for being arranged on shell fragment (33) or the Compress Spring of ejection capsule (3) bottom.
9. as claimed in claim 8 can the mechanism on marked tumor border on biopsy needle, it is characterized in that, described shell fragment (33) arranges a pair, and one of them shell fragment (33) is longer and another shell fragment (33) is shorter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510001373.5A CN104605897B (en) | 2015-01-04 | 2015-01-04 | Mechanism capable of marking tumor boundary used for biopsy needle |
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| CN201510001373.5A CN104605897B (en) | 2015-01-04 | 2015-01-04 | Mechanism capable of marking tumor boundary used for biopsy needle |
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| CN104605897A true CN104605897A (en) | 2015-05-13 |
| CN104605897B CN104605897B (en) | 2017-02-22 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112568869A (en) * | 2020-12-04 | 2021-03-30 | 山东大学齐鲁医院 | Device for diagnosing and marking tumor |
| CN116407168A (en) * | 2023-05-16 | 2023-07-11 | 杭州丽康医学科技有限公司 | Biopsy device with focus marker imbedding function and application method |
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| CN204364028U (en) * | 2015-01-04 | 2015-06-03 | 中国人民解放军第四军医大学 | A kind of can the mechanism on marked tumor border on biopsy needle |
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2015
- 2015-01-04 CN CN201510001373.5A patent/CN104605897B/en not_active Expired - Fee Related
Patent Citations (6)
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| US6056700A (en) * | 1998-10-13 | 2000-05-02 | Emx, Inc. | Biopsy marker assembly and method of use |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112568869A (en) * | 2020-12-04 | 2021-03-30 | 山东大学齐鲁医院 | Device for diagnosing and marking tumor |
| CN112568869B (en) * | 2020-12-04 | 2024-01-26 | 山东大学齐鲁医院 | Device for tumor diagnosis and marking |
| CN116407168A (en) * | 2023-05-16 | 2023-07-11 | 杭州丽康医学科技有限公司 | Biopsy device with focus marker imbedding function and application method |
| CN116407168B (en) * | 2023-05-16 | 2023-10-03 | 杭州丽康医学科技有限公司 | Biopsy device with focus marker is put into function |
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| CN104605897B (en) | 2017-02-22 |
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