CN104547923A - Traditional Chinese medicine composition for treating gouty nephropathy and application thereof - Google Patents
Traditional Chinese medicine composition for treating gouty nephropathy and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating gouty nephropathy and application thereof. The traditional Chinese medicine composition is prepared from the following raw medicines in parts by weight: 40 to 50 parts of astragali radix, 10 to 30 parts of sealwort, 9 to 15 parts of rhizoma cibotii, 9 to 15 parts of angelica sinensis, 10 to 20 parts of polygonum cuspidatum, 6 to 10 parts of safflower carthamus, 25 to 35 parts of caulis spatholobi, 10 to 20 parts of curcuma zedoary and 12 to 18 parts of cordyceps sobolifera, or 40 to 50 parts of astragali radix, 10 to 30 parts of sealwort, 9 to 15 parts of rhizoma cibotii, 9 to 15 parts of angelica sinensis, 10 to 20 parts of polygonum cuspidatum, 10 to 20 parts of tenodera aridifolia stoll, and 10 to 20 parts of curcuma zedoary. The traditional Chinese medicine composition has the effects of tonifying kidney and spleen, and dissipating dampness for diuresis, has an obvious effect on treating a patient suffering from chronic renal failure with hyperuricemia or renal function damage caused by hyperuricemia, and is capable of effectively decreasing serum creatinine and blood uric acid as well as improving the renal function; in addition, few medicines are used, the preparation is convenient, and the cost is low; the traditional Chinese medicine composition is prepared from pure traditional Chinese medicines and free of toxic and side effects.
Description
[technical field]
The present invention relates to a kind of Chinese medicine composition and application thereof for the treatment of gouty nephropathy, specifically, be a kind of take Chinese herbal medicine as Chinese patent medicine prepared by raw material.
[background technology]
Gouty nephropathy refers to that uric acid produces too much or excretion reduces formation hyperuricemia, and the nephropathy that urate deposition causes in kidney, belong to the category such as Chinese medicine " arthromyodynia ", " lumbago ", its etiology and pathogenesis is comparatively complicated.
Chinese periodical " journal of shanghai Chinese medicine ", November the 39th in 2005 volume, the paper the published experience of gouty nephropathy " Chen Yi-ping treatment ", describes the experience of Chen Yi-ping Experience in Treating gouty nephropathy.Chen Shi thinks that the primary disease cause of disease is that natural endowment is not enough, kidney qi virtual loss and diet delicious food, incoordination of seven emotions, overstrain are the main causes of bringing out gouty nephropathy.Chen Shi, according to the etiology and pathogenesis of gouty nephropathy, thinks that its disease take asthenia of both the spleen and kidney as this, stop as mark, therefore strengthening spleen, tonifying kidney, dissipating stasis and purging turbidity is the basic rule for the treatment of of primary disease in turbid silt.Top capping kidney can make kidney storing essence, main water function normal, and cereal nutrient is retained, and the heresy of turbid damp is drained; The transporting the lucid yang sending up function of spleen invigorating then spleen is normal, water paddyization spermatogenesis liquid, and the heresy of turbid damp is difficult to generation; Let out turbid dredging collateral, blood circulation promoting and blood stasis dispelling, eliminate pathological product, make passages through which vital energy circulates unobstructed, the heresy of turbid damp congestion can not be detained and be caused harm.At acute attack stage, patient shows as osteoarthrosis red and swollen heat pain more, edema that lower limb are slight, and routine urinalysis occults blood (+) to (++), blood, urinate acid higher, red tongue, yellow, greasy and thin fur, the diseases such as wiry and frequent pulse.This performance of old Shi Yiwei belongs to damp-heat arthralgia resistance (thermogravimetric is in wet), and control suitable clearing away heat-damp and promoting diuresis, arthralgia aggravated by cold of invigorating blood circulation is main.At stable phase, patient shows as slight edema more, spiritlessness and weakness, soreness of the waist and knees, or with indigestion and loss of appetite, nauseating, mouth has dirty taste, the diseases such as nocturia increases, renal hypofunction, belongs to spleen deficiency of kidney-QI, water-damp not being transformed, accumulate in turbid damp, control and should train spleen reinforcing kidney, invigorating spleen for diuresis, the kidney warming QI invigorating, invigorating blood circulation, it is turbid to let out.
Chinese periodical " world's Chinese medicine ", volume the 6th phase November the 7th in 2012, the paper " experience utilization---the attached 35 routine clinical reports of Chen Yi-ping treatment gouty nephropathy " published, observes Chen Yi-ping professor Empirical formula---and vital energy benefiting and the kidney invigorating dampness removing lets out the curative effect of turbid side treatment gouty nephropathy.Method: adopt method that is random, parallel, contrast selected case to be divided into treatment group 35 example, matched group 20 example, in Primary Care, the oral allopurinol tablet of matched group, treatment group oral allopurinol tablet associating Chen Shi Empirical formula---vital energy benefiting and the kidney invigorating dampness removing lets out turbid side; The course for the treatment of is 6 months, observes the change of index of correlation.Result: after 2 groups of patient treatments, UA obviously declines before all comparatively treating, treatment group UA reduces amplitude and is better than matched group; Obviously reduce after the treatment of SCr treatment group, matched group is then without significant change.Conclusion: vital energy benefiting and the kidney invigorating dampness removing is let out and turbidly significantly can be reduced UA, SCr, and improve renal function, this effect is better than alone allopurinol.This vital energy benefiting and the kidney invigorating dampness removing lets out turbid side with the Radix Astragali, Rhizoma Polygonati, Radix Dipsaci, Rhizoma Cibotii, Radix Angelicae Sinensis, Rhizoma Polygoni Cuspidati for substantially square, and add taste again according to symptom, tongue arteries and veins, damp and hot Sheng person adds Rhizoma Smilacis Glabrae, Rhizoma Dioscoreae Septemlobae, Cortex Fraxini; Constipation person adds Radix Et Rhizoma Rhei (system), Semen Persicae; Merge renal calculus person and add Endothelium Corneum Gigeriae Galli, Folium Pyrrosiae; Arthralgia very adds Cortex Phellodendri, Radix Clematidis, Semen Coicis; Pathogen usually intruding into collateral in protracted disease adds Semen Persicae, Flos Carthami, Caulis Spatholobi; Insufficiency of kidney-YANG adds Herba Epimedii, Radix Morindae Officinalis.
But, in order to treat gouty nephropathy better, being convenient to applying of Chinese medicine, researching and developing new Chinese prescription evident in efficacy and remaining very necessary.
[summary of the invention]
The object of the invention is for deficiency of the prior art, a kind of Chinese medicine composition for the treatment of gouty nephropathy is provided.
Of the present invention again one object be that the purposes of described Chinese medicine composition is provided.
For realizing above-mentioned first object, a kind of technical scheme that the present invention takes is: a kind of Chinese medicine composition for the treatment of gouty nephropathy, and it comprises the crude drug of following weight portion: Radix Astragali 40-50 part, Rhizoma Polygonati 10-30 part, Rhizoma Cibotii 9-15 part, Radix Angelicae Sinensis 9-15 part, Rhizoma Polygoni Cuspidati 10-20 part, Flos Carthami 6-10 part, Caulis Spatholobi 25-35 part, Rhizoma Curcumae 10-20 part, Periostracum cicadae 12-18 part.
Described Chinese medicine composition comprises the crude drug of following weight portion: Radix Astragali 42-48 part, Rhizoma Polygonati 15-25 part, Rhizoma Cibotii 10-14 part, Radix Angelicae Sinensis 10-14 part, Rhizoma Polygoni Cuspidati 12-18 part, Flos Carthami 8-10 part, Caulis Spatholobi 28-32 part, Rhizoma Curcumae 12-18 part, Periostracum cicadae 14-16 part.
Described Chinese medicine composition comprises the crude drug of following weight portion: Radix Astragali 45 parts, Rhizoma Polygonati 20 parts, Rhizoma Cibotii 12 parts, Radix Angelicae Sinensis 12 parts, Rhizoma Polygoni Cuspidati 15 parts, 9 parts, Flos Carthami, Caulis Spatholobi 30 parts, Rhizoma Curcumae 15 parts, Periostracum cicadae 15 parts.
The another kind of technical scheme that the present invention takes is: a kind of Chinese medicine composition for the treatment of gouty nephropathy, and it comprises the crude drug of following weight portion: Radix Astragali 40-50 part, Rhizoma Polygonati 10-30 part, Rhizoma Cibotii 9-15 part, Radix Angelicae Sinensis 9-15 part, Rhizoma Polygoni Cuspidati 10-20 part, Ootheca Mantidis 10-20 part, Rhizoma Curcumae 10-20 part.
Described Chinese medicine composition comprises the crude drug of following weight portion: Radix Astragali 42-48 part, Rhizoma Polygonati 15-25 part, Rhizoma Cibotii 10-14 part, Radix Angelicae Sinensis 10-14 part, Rhizoma Polygoni Cuspidati 12-18 part, Ootheca Mantidis 12-18 part, Rhizoma Curcumae 12-18 part.
Described Chinese medicine composition comprises the crude drug of following weight portion: Radix Astragali 45 parts, Rhizoma Polygonati 20 parts, Rhizoma Cibotii 12 parts, Radix Angelicae Sinensis 12 parts, Rhizoma Polygoni Cuspidati 15 parts, Ootheca Mantidis 15 parts, Rhizoma Curcumae 15 parts.
As above the dosage form of arbitrary described Chinese medicine composition can be decoction, capsule, granule, tablet or mixture.
For realizing above-mentioned second object, the technical scheme that the present invention takes is:
As above the application of arbitrary described Chinese medicine composition in the medicine of preparation treatment gouty nephropathy.
The invention has the advantages that:
1, Chinese medicine composition one of the present invention and Chinese medicine composition two have Yishen Jianpi, removing dampness lets out turbid effect, treatment chronic renal failure companion hyperuricemia person, or the renal function injury Be very effective caused by hyperuricemia, can effectively reduce serum creatinine and blood uric acid, improve renal function;
2, flavour of a drug number is few, and be convenient to preparation, cost is low, is suitable for promoting;
3, be made up of pure Chinese medicine, have no side effect, be easy to be accepted by patient.
[detailed description of the invention]
Below detailed description of the invention provided by the invention is elaborated.
Herein, described conventional method decoction is the manufacture method of Chinese medicine decoction routine, decocts with water into decoction by described crude drug.
The preparation (one) of embodiment 1 Chinese medicine composition one of the present invention
Radix Astragali 45 parts, Rhizoma Polygonati 20 parts, Rhizoma Cibotii 12 parts, Radix Angelicae Sinensis 12 parts, Rhizoma Polygoni Cuspidati 15 parts, 9 parts, Flos Carthami, Caulis Spatholobi 30 parts, Rhizoma Curcumae 15 parts, Periostracum cicadae 15 parts, conventional method decocts.
The preparation (two) of embodiment 2 Chinese medicine composition one of the present invention
Radix Astragali 40 parts, Rhizoma Polygonati 30 parts, Rhizoma Cibotii 9 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Polygoni Cuspidati 10 parts, 10 parts, Flos Carthami, Caulis Spatholobi 25 parts, Rhizoma Curcumae 20 parts, Periostracum cicadae 12 parts, conventional method decocts.
The preparation (three) of embodiment 3 Chinese medicine composition one of the present invention
Radix Astragali 50 parts, Rhizoma Polygonati 10 parts, Rhizoma Cibotii 15 parts, Radix Angelicae Sinensis 9 parts, Rhizoma Polygoni Cuspidati 20 parts, 6 parts, Flos Carthami, Caulis Spatholobi 35 parts, Rhizoma Curcumae 10 parts, Periostracum cicadae 18 parts, conventional method decocts.
The preparation (four) of embodiment 4 Chinese medicine composition one of the present invention
Radix Astragali 50 parts, Rhizoma Polygonati 30 parts, Rhizoma Cibotii 9 parts, Radix Angelicae Sinensis 9 parts, Rhizoma Polygoni Cuspidati 20 parts, 10 parts, Flos Carthami, Caulis Spatholobi 25 parts, Rhizoma Curcumae 10 parts, Periostracum cicadae 18 parts, conventional method decocts.
The preparation (five) of embodiment 5 Chinese medicine composition one of the present invention
Radix Astragali 40 parts, Rhizoma Polygonati 10 parts, Rhizoma Cibotii 15 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Polygoni Cuspidati 10 parts, 6 parts, Flos Carthami, Caulis Spatholobi 35 parts, Rhizoma Curcumae 20 parts, Periostracum cicadae 12 parts, conventional method decocts.
The preparation (six) of embodiment 6 Chinese medicine composition one of the present invention
Radix Astragali 50 parts, Rhizoma Polygonati 10 parts, Rhizoma Cibotii 15 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Polygoni Cuspidati 10 parts, 10 parts, Flos Carthami, Caulis Spatholobi 35 parts, Rhizoma Curcumae 10 parts, Periostracum cicadae 18 parts, conventional method decocts.
The preparation (seven) of embodiment 7 Chinese medicine composition one of the present invention
Radix Astragali 40 parts, Rhizoma Polygonati 30 parts, Rhizoma Cibotii 9 parts, Radix Angelicae Sinensis 9 parts, Rhizoma Polygoni Cuspidati 20 parts, 6 parts, Flos Carthami, Caulis Spatholobi 25 parts, Rhizoma Curcumae 20 parts, Periostracum cicadae 12 parts, conventional method decocts.
The preparation (eight) of embodiment 8 Chinese medicine composition one of the present invention
Radix Astragali 42 parts, Rhizoma Polygonati 25 parts, Rhizoma Cibotii 10 parts, Radix Angelicae Sinensis 14 parts, Rhizoma Polygoni Cuspidati 12 parts, 10 parts, Flos Carthami, Caulis Spatholobi 28 parts, Rhizoma Curcumae 18 parts, Periostracum cicadae 14 parts, conventional method decocts.
The preparation (nine) of embodiment 9 Chinese medicine composition one of the present invention
Radix Astragali 48 parts, Rhizoma Polygonati 15 parts, Rhizoma Cibotii 14 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Polygoni Cuspidati 18 parts, 8 parts, Flos Carthami, Caulis Spatholobi 32 parts, Rhizoma Curcumae 12 parts, Periostracum cicadae 16 parts, conventional method decocts.
The preparation (ten) of embodiment 10 Chinese medicine composition one of the present invention
Radix Astragali 50 parts, Rhizoma Polygonati 30 parts, Rhizoma Cibotii 15 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Polygoni Cuspidati 10 parts, 6 parts, Flos Carthami, Caulis Spatholobi 35 parts, Rhizoma Curcumae 10 parts, Periostracum cicadae 18 parts, conventional method decocts.
The preparation (one) of embodiment 11 Chinese medicine composition two of the present invention
Radix Astragali 45 parts, Rhizoma Polygonati 20 parts, Rhizoma Cibotii 12 parts, Radix Angelicae Sinensis 12 parts, Rhizoma Polygoni Cuspidati 15 parts, Ootheca Mantidis 15 parts, Rhizoma Curcumae 15 parts, conventional method decocts.
The preparation (two) of embodiment 12 Chinese medicine composition two of the present invention
Radix Astragali 50 parts, Rhizoma Polygonati 10 parts, Rhizoma Cibotii 15 parts, Radix Angelicae Sinensis 9 parts, Rhizoma Polygoni Cuspidati 20 parts, Ootheca Mantidis 10 parts, Rhizoma Curcumae 20 parts, conventional method decocts.
The preparation (three) of embodiment 13 Chinese medicine composition two of the present invention
Radix Astragali 40 parts, Rhizoma Polygonati 30 parts, Rhizoma Cibotii 9 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Polygoni Cuspidati 10 parts, Ootheca Mantidis 20 parts, Rhizoma Curcumae 10 parts, conventional method decocts.
The preparation (four) of embodiment 14 Chinese medicine composition two of the present invention
Radix Astragali 50 parts, Rhizoma Polygonati 30 parts, Rhizoma Cibotii 9 parts, Radix Angelicae Sinensis 9 parts, Rhizoma Polygoni Cuspidati 20 parts, Ootheca Mantidis 20 parts, Rhizoma Curcumae 10 parts, conventional method decocts.
The preparation (five) of embodiment 15 Chinese medicine composition two of the present invention
Radix Astragali 40 parts, Rhizoma Polygonati 10 parts, Rhizoma Cibotii 15 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Polygoni Cuspidati 10 parts, Ootheca Mantidis 10 parts, Rhizoma Curcumae 20 parts, conventional method decocts.
The preparation (six) of embodiment 16 Chinese medicine composition two of the present invention
Radix Astragali 40 parts, Rhizoma Polygonati 10 parts, Rhizoma Cibotii 9 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Polygoni Cuspidati 20 parts, Ootheca Mantidis 20 parts, Rhizoma Curcumae 10 parts, conventional method decocts.
The preparation (seven) of embodiment 17 Chinese medicine composition two of the present invention
Radix Astragali 50 parts, Rhizoma Polygonati 10 parts, Rhizoma Cibotii 15 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Polygoni Cuspidati 20 parts, Ootheca Mantidis 20 parts, Rhizoma Curcumae 10 parts, conventional method decocts.
The preparation (eight) of embodiment 18 Chinese medicine composition two of the present invention
Radix Astragali 48 parts, Rhizoma Polygonati 15 parts, Rhizoma Cibotii 14 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Polygoni Cuspidati 18 parts, Ootheca Mantidis 12 parts, Rhizoma Curcumae 18 parts, conventional method decocts.
The preparation (nine) of embodiment 19 Chinese medicine composition two of the present invention
Radix Astragali 42 parts, Rhizoma Polygonati 25 parts, Rhizoma Cibotii 10 parts, Radix Angelicae Sinensis 14 parts, Rhizoma Polygoni Cuspidati 12 parts, Ootheca Mantidis 18 parts, Rhizoma Curcumae 12 parts, conventional method decocts.
The preparation (ten) of embodiment 20 Chinese medicine composition two of the present invention
Radix Astragali 42 parts, Rhizoma Polygonati 25 parts, Rhizoma Cibotii 10 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Polygoni Cuspidati 20 parts, Ootheca Mantidis 20 parts, Rhizoma Curcumae 10 parts, conventional method decocts.
The preparation of embodiment 21 Chinese medicine composition tablet/capsule of the present invention
The arbitrary described Chinese herb of Example 1-20, adds 8-12 times of water gaging, decocts 1-3 hour, leach medicine juice.Add 10 times of water gagings again, decoct 1.5-2.5 hour, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add concentrated solution 2.5 times amount ethanol, stir precipitates overnight.Get supernatant, be concentrated into thick extractum; Add pharmaceutical aids, vacuum drying, pulverize and granulate, be pressed into tablet or fill encapsulated.
The preparation of embodiment 22 Chinese medicinal composition granules of the present invention
The arbitrary described Chinese herb of Example 1-20, adds 8-10 times of water gaging, decocts 2.5-3.5 hour, leach medicine juice.Add 10 times of water gagings again, decoct 2 hours, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add concentrated solution 2 times amount ethanol, stir precipitates overnight.Get supernatant, be concentrated into thick extractum; Add suitable pharmaceutical aids, granulate, dry, granulate, obtains 20g granule, subpackage 10g/ bag.
The preparation of embodiment 23 Chinese medicine composition mixture of the present invention
The arbitrary described Chinese herb of Example 1-20, adds 8-10 times of water gaging, decocts 3 hours, leach medicine juice.Add 8 times of water gagings again, decoct 2 hours, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add concentrated solution 2 times amount ethanol, stir precipitates overnight.Get supernatant, be concentrated into thick extractum; Add suitable pharmaceutical aids, make mixture.
The clinical trial of embodiment 24 Chinese medicine composition of the present invention
1 data and method
1.1 physical data
Select my institute gouty nephropathy patient 125 example in year August in March, 2011 to 2011, be divided into three groups at random.One group 35, Chinese medicine of the present invention example, wherein male 29 example, women 6 example, 29 ~ 81 years old age, average (61.35 ± 11.32) year, the course of disease 3 ~ 14 years, average (7.69 ± 5.81) year.Two group 35, Chinese medicine of the present invention example, wherein male 31 example, women 4 example, 25 ~ 82 years old age, average (62.58 ± 10.07) year, the course of disease 2 ~ 15 years, average (8.12 ± 6.49) year.Vital energy benefiting and the kidney invigorating dampness removing lets out turbid side's group 35 example, wherein male 32 example, women 3 example, 21 ~ 86 years old age, average (60.03 ± 15.49) year, the course of disease 3 ~ 15 years, average (8.41 ± 7.50) year.Matched group 20 example, wherein male 17 example, women 3 example, 45 ~ 80 years old age, average (63.85 ± 8.59) year, the course of disease 2 ~ 16 years, average (7.84 ± 6.52) year.Above-mentioned four groups of data compare not statistically significant (P > 0.05), have comparability.
1.2 diagnostic criteria
Adopt the diagnostic criteria that American Rheumatism Association formulates for 1977: hyperuricemia is with gouty arthritis and nephropathy, comprise the Primary Nephrosis of urine examination exception and/or renal function injury, except other a variety of causes secondary hyperuricemia (Chinese Medical Association. clinical diagnosis guide rheumatism fascicle [M]. Beijing: People's Health Publisher, 2005:123.).
1.3 Therapeutic Method
Each group of patient all gives low purine diet, drinks more water, and take Sodium Bicarbonate Tablets 3 ~ 6g according to urine pH value, other anti symptom treatment are identical.
Matched group gives allopurinol every day 2 times, each 0.1g.
Vital energy benefiting and the kidney invigorating dampness removing let out turbid side give allopurinol every day or the next day 1 time, each 0.1g, Empirical formula-vital energy benefiting and the kidney invigorating the dampness removing simultaneously added with Chen Shi lets out turbid side, the Radix Astragali, Rhizoma Polygonati, Radix Dipsaci, Rhizoma Cibotii, Radix Angelicae Sinensis, Rhizoma Polygoni Cuspidati, this is substantially square (proportioning is the Radix Astragali 45 parts, Rhizoma Polygonati 20 parts, Radix Dipsaci 12 parts, Rhizoma Cibotii 12 parts, Radix Angelicae Sinensis 12 parts, Rhizoma Polygoni Cuspidati 15 parts), add taste again according to symptom, tongue arteries and veins, damp and hot Sheng person adds Rhizoma Smilacis Glabrae, Rhizoma Dioscoreae Septemlobae, Cortex Fraxini; Constipation person adds Radix Et Rhizoma Rhei (system), Semen Persicae; Merge renal calculus person and add Endothelium Corneum Gigeriae Galli, Folium Pyrrosiae; Arthralgia very adds Cortex Phellodendri, Radix Clematidis, Semen Coicis; Pathogen usually intruding into collateral in protracted disease adds Semen Persicae, Flos Carthami, Caulis Spatholobi; Insufficiency of kidney-YANG adds Herba Epimedii, Radix Morindae Officinalis.Decoct according to a conventional method as decoction, one day potion, potion 100ml, containing crude drug amount 0.25g/mL.
One group, Chinese medicine of the present invention give allopurinol every day or the next day 1 time, each 0.1g, add the decoction of Chinese medicine composition prepared by embodiment 1, one day potion, potion 100ml, containing crude drug amount 0.25g/mL simultaneously.
Two groups, Chinese medicine of the present invention give allopurinol every day or the next day 1 time, each 0.1g, add the decoction of Chinese medicine composition prepared by embodiment 11, one day potion, potion 100ml, containing crude drug amount 0.25g/mL simultaneously.
Three groups of courses for the treatment of are half a year, observe the change of index of correlation.
1.4 observation index
Serum creatinine (SCr), blood uric acid (UA) is checked respectively at giving before treatment and after treatment.
1.5 statistical method
Measurement data is with mean ± standard deviation
represent, compare the t inspection adopting independent sample between group, before and after group internal therapy, compare employing paired t-test.
2 results
Before and after each group for the treatment of, SCr, UA compare in table 1.The SCr that one group, Chinese medicine of the present invention, two groups, Chinese medicine of the present invention and vital energy benefiting and the kidney invigorating dampness removing are let out before and after the treatment of turbid side's group more all has statistical significance (P < 0.01), and matched group is then without significant change (P > 0.05).One group, Chinese medicine of the present invention, Chinese medicine of the present invention two groups of SCr reduction amplitudes are let out turbid side's group with vital energy benefiting and the kidney invigorating dampness removing and are compared respectively, are all better than vital energy benefiting and the kidney invigorating dampness removing and let out turbid side's group (P < 0.05).After each group of patient treatment, UA declines all statistical significance (P < 0.05).It is the most obvious that Chinese medicine of the present invention one group of UA reduces amplitude, be better than matched group (P < 0.01), and be better than vital energy benefiting and the kidney invigorating dampness removing and let out turbid side's group (P < 0.05), not statistically significant (P > 0.05) compared with reducing amplitude with Chinese medicine of the present invention two groups of UA.Vital energy benefiting and the kidney invigorating dampness removing is let out turbid side group UA reduction amplitude and is better than matched group (P < 0.05).Above result shows that Chinese medicine composition one of the present invention and Chinese medicine composition two can effectively reduce serum creatinine and blood uric acid, improves renal function, achieves unforeseeable technique effect.
The comparison of SCr, UA respectively organized by table 1 before and after treating
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the inventive method; can also make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.
Claims (8)
1. treat the Chinese medicine composition of gouty nephropathy for one kind, it is characterized in that, it comprises the crude drug of following weight portion: Radix Astragali 40-50 part, Rhizoma Polygonati 10-30 part, Rhizoma Cibotii 9-15 part, Radix Angelicae Sinensis 9-15 part, Rhizoma Polygoni Cuspidati 10-20 part, Flos Carthami 6-10 part, Caulis Spatholobi 25-35 part, Rhizoma Curcumae 10-20 part, Periostracum cicadae 12-18 part.
2. Chinese medicine composition according to claim 1, it is characterized in that, it comprises the crude drug of following weight portion: Radix Astragali 42-48 part, Rhizoma Polygonati 15-25 part, Rhizoma Cibotii 10-14 part, Radix Angelicae Sinensis 10-14 part, Rhizoma Polygoni Cuspidati 12-18 part, Flos Carthami 8-10 part, Caulis Spatholobi 28-32 part, Rhizoma Curcumae 12-18 part, Periostracum cicadae 14-16 part.
3. Chinese medicine composition according to claim 2, it is characterized in that, it comprises the crude drug of following weight portion: Radix Astragali 45 parts, Rhizoma Polygonati 20 parts, Rhizoma Cibotii 12 parts, Radix Angelicae Sinensis 12 parts, Rhizoma Polygoni Cuspidati 15 parts, 9 parts, Flos Carthami, Caulis Spatholobi 30 parts, Rhizoma Curcumae 15 parts, Periostracum cicadae 15 parts.
4. treat the Chinese medicine composition of gouty nephropathy for one kind, it is characterized in that, it comprises the crude drug of following weight portion: Radix Astragali 40-50 part, Rhizoma Polygonati 10-30 part, Rhizoma Cibotii 9-15 part, Radix Angelicae Sinensis 9-15 part, Rhizoma Polygoni Cuspidati 10-20 part, Ootheca Mantidis 10-20 part, Rhizoma Curcumae 10-20 part.
5. Chinese medicine composition according to claim 4, it is characterized in that, it comprises the crude drug of following weight portion: Radix Astragali 42-48 part, Rhizoma Polygonati 15-25 part, Rhizoma Cibotii 10-14 part, Radix Angelicae Sinensis 10-14 part, Rhizoma Polygoni Cuspidati 12-18 part, Ootheca Mantidis 12-18 part, Rhizoma Curcumae 12-18 part.
6. Chinese medicine composition according to claim 5, is characterized in that, it comprises the crude drug of following weight portion: Radix Astragali 45 parts, Rhizoma Polygonati 20 parts, Rhizoma Cibotii 12 parts, Radix Angelicae Sinensis 12 parts, Rhizoma Polygoni Cuspidati 15 parts, Ootheca Mantidis 15 parts, Rhizoma Curcumae 15 parts.
7., according to the arbitrary described Chinese medicine composition of claim 1-6, it is characterized in that, the dosage form of described Chinese medicine composition is decoction, capsule, granule, tablet or mixture.
8. the application of the arbitrary described Chinese medicine composition of claim 1-6 in the medicine of preparation treatment gouty nephropathy.
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2015
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111773264A (en) * | 2020-08-17 | 2020-10-16 | 张博 | A pharmaceutical composition for treating nephropathy, and its preparation method |
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| Publication number | Publication date |
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| CN104547923B (en) | 2018-03-13 |
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