CN104546552A - Scar gel composition - Google Patents
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- CN104546552A CN104546552A CN201310467117.6A CN201310467117A CN104546552A CN 104546552 A CN104546552 A CN 104546552A CN 201310467117 A CN201310467117 A CN 201310467117A CN 104546552 A CN104546552 A CN 104546552A
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Abstract
The invention relates to a scar gel composition containing a siloxane fluid, a volatile diluent, a sedimentation type silicon powder and a polishing powder, wherein the siloxane fluid and the volatile diluent are miscible with each other, and the sedimentation type silicon powder and the polishing powder are evenly dispersed in the silicone fluid and the volatile diluent. The scar gel composition can maintain a homogeneous phase for a long time, does not easily generate oil phase layering, and can provide more perfect usage experience.
Description
Technical field
The invention relates to a kind of compositions, and relate to a kind of compositions of cicatrix gel especially.
Background technology
For skin histology, cicatrix is that the normal knot that the traumas such as health wound healing wound, inflammation or burn produce forms fibrous tissue.But in some cases, the differentiation of cicatrix is unsatisfactory and produce the problem such as depression, outstanding, fertile thick, red and swollen or pigementation, and part cicatrix even can develop into proliferative cicatrix or scar tumor, has a strong impact on attractive in appearance.Wherein, affect outward appearance with hypertrophic cicatrix (hypertrophic scar) and keloid (keloids) again the most serious, and it also easily produces the sensation of red and swollen pain of itching in agglutination.For this kind of abnormal scars, clinical experiment has confirmed there is significant curative effect containing Silica hydrogel to it.Be applied on wound by silicon materials, newly-generated epithelial tissue can be avoided to cause too much percutaneous moisture loss because of not yet normalization, so just can suppress fibroblast paraplasm and produce too much collagen protein, and then produce and significantly swell cicatrix.Therefore, as United States Patent (USP) (US8021683, US5741509) the cicatrix gel products that discloses, composition roughly contains viscosity thousands of polysiloxane fluid (silicone fluid) do not waited to tens thousand of centipoise (cP) and cicatrix moisture-keeping efficacy is provided; The volatile siloxane solvent of low viscosity (silicone solvent) provides the effect using upper rapid-curing cutback; And smoked silicon (fumed silica) is conveniently smeared to make overall cicatrix gel as thickening agent.But use smoked silicon easily causing oil phase layering as the cicatrix gel products of thickening agent after putting for a long time, when therefore extruding on using, transparent low viscous siloxane solvent will first be extruded but not homogeneous cicatrix gel, cause and use perception not good.In addition, the procedure for producing of smoked silicon is loaded down with trivial details, and the equipment energy cost expended needed for its production still has too high doubt.Moreover cicatrix gel products is in use procedure on the market, still easily produce that white lead is separated out and to be easy to discover impact attractive in appearance.Therefore, a kind of cost is lower, has the cicatrix gel combination of not easily phase laminate property and polishing function simultaneously, is still one of doctor art designing industry emphasis direction needing exploitation badly.
Summary of the invention
The invention provides a kind of cicatrix gel combination, it uses sedimentation type silicon powder (precipitated silica) to replace smoked silicon as thickening agent, and therefore cost is lower.In addition still having polishing powder body makes it close with the colour of skin, thus in use not easily for other people discover, also has the character of not easily oil phase layering, can maintain homogeneous phase for a long time, to provide more perfect experience.
The present invention proposes a kind of compositions of cicatrix gel, comprises siloxanes fluids (silicone fluid), volatile thinner (volatile diluent), sedimentation type silicon powder (precipitated silica powder) and polishing powder body.Wherein siloxanes fluids and volatile thinner dissolve each other, and sedimentation type silicon powder is dispersed in siloxanes fluids and volatile thinner with polishing powder body.
In one embodiment of the present invention, above-mentioned polishing powder body comprises the combination of ferrum oxide, manganese oxide, chromium oxide or these metal-oxides.
In one embodiment of the present invention, the percentage by weight of above-mentioned siloxanes fluids is in fact 60 ~ 74%, the percentage by weight of volatile thinner is in fact 16 ~ 28%, the percentage by weight of sedimentation type silicon powder is in fact 3 ~ 23%, and the percentage by weight of polishing powder body is in fact 0.1 ~ 2%.
In one embodiment of the present invention, the pH value of above-mentioned sedimentation type silicon powder is in fact 6 ~ 8.
In one embodiment of the present invention, the compositions of cicatrix gel comprises photic damage protection composition further, and the percentage by weight of photic damage protection composition is in fact 0.1 ~ 10%.
In one embodiment of the present invention, above-mentioned this photic damage protection composition inclusion rationality photic damage protection composition, chemical photic damage protection composition or both combinations.
In one embodiment of the present invention, above-mentioned physical property photic damage protection composition comprises titanium dioxide, zinc oxide, zirconium oxide, this chemical photic damage protection composition comprises pungent-salicylic acid (Salicylic acid), avobenzone (Avobezone), N-(carboethoxyphenyl)-N'-methyl-N'-phenyl formamidine (Benzoate-4), cinoxate (Cinoxate), benzophenone series compound (Dioxybenzone, Oxy-Molybdate-40, Oxybezone), homosaligenin (Homosalate), barley green rather filters ring (Mexoryl SX), Methyl anthranilate (Methyl Anthranilate), octocrilene (Octocrylene), Salicylate (OctylSalicylate), octyl methoxycinnamate (Octyl methoxycinnamate), pentyl diformazan para-amino benzoic acid (Octyl Dimethy PABA), padimate O (Padimate-O), para-aminobenzoic acid (Para Amino Benzoic Acid), Phenylbenzimidazolesulfonic acid (pheny benzimidazole sulfonic acid), roxadimate (Roxadimate), UVNUL MS-40 (sulisobenzone), trolamine salicylate (Trolamine Salicylate).
In one embodiment of the present invention, the compositions of above-mentioned cicatrix gel, comprises inorganic salts powder body further, and the percentage by weight of inorganic salts powder body is in fact 0.1 ~ 5%.
In one embodiment of the present invention, above-mentioned inorganic salts powder body comprises barium sulfate, strontium sulfate, magnesium sulfate, hydrated ferric oxide., calcium hydroxide, sodium chloride, potassium chloride, ammonium chloride, ETHANOLAMINE HYDROCHLORIDE, diethanolamine chloride, sodium sulfate, sodium phosphate, disodium hydrogen phosphate and sodium triphosphate, Magnesiumaluminumsilicate, silicon dioxide, sodium magnesium silicate, sodium silicate, hydrated SiO 2, montorillonite clay, Lithium metasilicate magnesium sodium, hectorite, stearic ammonium montorillonite clay, stearic ammonium hectorite, quaternary ammonium salt-90 montorillonite clay, quaternary ammonium salt-18 montorillonite clay, quaternary ammonium salt-18 hectorite etc.
In one embodiment of the present invention, above-mentioned siloxanes fluids comprises the mixture of polydimethylsiloxane (polydimethylsiloxane) and dimethyl siloxane (dimethylsiloxane), and above-mentioned volatile thinner comprises volatile siloxanes (siloxane) that is linear or ring-type.
The invention has the advantages that: the present invention uses sedimentation type silicon powder to replace smoked silicon as thickening agent, really makes the compositions of cicatrix gel of the present invention have the even phase maintenance more excellent compared with prior art, can provide better experience, and cost is lower; Also having polishing powder body in the compositions of cicatrix gel of the present invention in addition makes it close with the colour of skin, thus in use not easily for other people discover.
Detailed description of the invention
In order to make describing of this disclosure more detailed and complete, hereafter have been directed to enforcement aspect of the present invention and detailed description of the invention proposes illustrative description; But this not implements or uses the unique forms of the specific embodiment of the invention.Each embodiment disclosed below, can mutually combine or replace, also can add other embodiment in one embodiment, and needn't further record or illustrate useful when.In the following description, following embodiment is fully understood describing many specific detail in detail to enable reader.But, can when putting into practice embodiments of the present invention without when these specific detail.
In the compositions of cicatrix gel of the present invention, comprise siloxanes fluids (silicone fluid), volatile thinner (volatile diluent), sedimentation type silicon powder (precipitated silica powder) and polishing powder body.Siloxanes fluids can be described as again the macromolecule organic silicon compound, the advantage such as have clear, colorless, inertia, avirulence, closure (occlusive) is good, poisture-penetrability is low, is therefore widely used in aesthetic medicine Related product.In one embodiment of the present invention, siloxanes fluids comprises the liquid mixture that polysiloxanes (polysiloxane) and siloxanes (siloxane) mix with proper proportion, wherein polysiloxanes and siloxanes are because of possessing different molecular weight and viscosity, therefore the actual demand to product properties such as viscosity in visual application, adjustment mixed proportion between the two.Polysiloxanes can be such as cyclic methyl siloxane (cyclic methyl siloxane), PSI (poly methyl phenyl siloxane), polydimethylsiloxane (poly dimethyl siloxane), two octadecane oxygen base dimethyl polysiloxane (bis-octadecyloxy dimethyl polysiloxane), polysiloxane polyether copolymer (polyether siloxane copolymer) or polydimethylsiloxane (poly dimethylsiloxane) and a series of derivant thereof.In cosmetics, use polysiloxanes to increase lubricity, the protecting film that one deck evenly has water proofing property can be formed after coating skin, and not there is any sticky sense.In one embodiment of the present invention, siloxanes fluids comprises the mixture of polydimethylsiloxane (poly (dimethylsiloxane), PDMS) and dimethyl siloxane (dimethylsiloxane).Dimethyl siloxane time liquid is thick liquid, and also known as making silicone oil (silicone oil), be a kind of polyorganosiloxane mixture with different polymerization degree chain structure, its end group and side base are alkyl (as methyl, ethyl, phenyl etc.) entirely.General silicone oil is colourless, tasteless, nontoxic, not volatile liquid.
Volatile thinner refers to type siloxane and the derivant thereof of molecular weight, has low viscosity, volatile character, to provide the convenience of cicatrix gel rapid-curing cutback on using.Volatile thinner can be such as molecular weight, there is volatile cyclic methyl siloxane (cyclic methyl siloxane), PSI (poly methyl phenyl siloxane), polydimethylsiloxane (poly dimethyl siloxane), two octadecane oxygen base dimethyl polysiloxane (bis-octadecyloxy dimethyl polysiloxane), polysiloxane polyether copolymer (polyether siloxane copolymer) or polydimethylsiloxane (poly dimethylsiloxane) and derivant thereof.In one embodiment of the present invention, volatile thinner comprises volatile siloxanes (siloxane) that is linear or ring-type.Comprehensive speech, in the compositions of cicatrix gel of the present invention, the polymer that siloxanes fluids and volatile thinner can comprise identical or different siloxanyl monomers and form.Siloxanes fluids can be the polyorganosiloxane mixture with different polymerization degree, and it is the higher and not volatile liquid of molecular weight and viscosity, mainly provides the healings such as cicatrix height closure and low-moisture permeability auxiliary; Volatile thinner can be then linear or the volatile siloxanes (siloxane) of ring-type, and it is low viscosity, volatile liquid, mainly provides the convenience of cicatrix gel rapid-curing cutback on using.Because both Main Ingredients and Appearances are type siloxane, therefore both can dissolve each other completely, and form the bulk composition of the compositions of cicatrix gel of the present invention.
It should be noted that, sedimentation type silicon powder is also comprised in the compositions of cicatrix gel of the present invention, its role is to the siloxanes fluids that makes to dissolve each other and volatile thinner mixture, produce thickening effect and form gel, smear in order to user and reduce sticky sense.As previously mentioned, not only procedure for producing is loaded down with trivial details for the smoked silicon (fumed silica) adopted in prior art, and the equipment energy cost expended is also high; It is simple and easy that the sedimentation type silicon powder that the present invention adopts then has production, advantage with low cost.Sedimentation type silicon powder can be such as by after metso (sodium silicate) and sulfuric acid reaction, through filtering and making after dry classification, but is not limited in this way.In addition, sedimentation type silicon powder is completely different because of the mode prepared from smoked silicon, make sedimentation type silicon powder have porous (porosity) not available for smoked silicon, thus the surface area of sedimentation type silicon powder unit volume is large compared with the surface area of smoked silicon unit volume.Generally speaking, the surface area per unit volume of smoked silicon is about 6400 ~ 25600m
2/ L, in each embodiment of the present invention, the surface area per unit volume of sedimentation type silicon powder is in fact 9600 ~ 57600m
2/ L.Sedimentation type silicon powder, because of its special porous, has the surface area per unit volume that comparatively smoked silicon is larger, and then adds in siloxanes fluids and volatile thinner mixture, the siloxanes compatibility each other of different polymerization degree.Accordingly, at the cicatrix gel products using smoked silicon as thickening agent in prior art, the problem of oil phase layering is easily being caused after putting for a long time, sedimentation type silicon powder in the compositions of cicatrix gel of the present invention, more can provide in siloxanes fluids and volatile thinner mixture, the siloxanes of different polymerization degree fully mixes and more long-acting evenly to maintain mutually, when therefore extruding on using, can not occur as in prior art, what be first extruded is transparent low viscous siloxane solvent but not even phase cicatrix gel, causes the problem using perception not good.But, sedimentation type silicon powder granule is also large compared with smoked silicon grain, use and may have granular sensation or skin is whitened, produce white scales, the mode such as therefore sedimentation type silicon powder can be ground further or shatter forms less granule, reduces it and is applied in the problems such as granular sensation on skin and white scales.In addition, the pH value that smoked silicon has is 3.0 ~ 4.2, and its chemical reaction formula prepared of sedimentation type silicon powder adjustable be made as soda acid neutrality, the zest of cicatrix gel to skin can be reduced further accordingly.In one embodiment of the present invention, the pH value of sedimentation type silicon powder is in fact 6 ~ 8.
It should be noted that in addition in the compositions of cicatrix gel of the present invention and still comprise polishing powder body, its role is to make the compositions of cicatrix gel close with the colour of skin, thus in use having improved aesthetic appearance also not easily for other people discover.Polishing powder body such as can comprise ferrum oxide (Iron oxide), manganese oxide (Manganese oxide), chromium oxide (Chromium oxide) or these oxide-metal combinations, but not as limit.Polishing powder body of the present invention anyly can have color and not affect powder pigment of the organic or inorganic that cicatrix is repaired and composition thereof, and can according to the demand of the different colour of skin depth, and adjustment uses suitable material and mixed proportion.Comprehensive speech, in the compositions of cicatrix gel of the present invention, siloxanes fluids and volatile thinner dissolve each other, and sedimentation type silicon powder is dispersed in siloxanes fluids and volatile thinner with polishing powder body.
In an embodiment of the compositions of cicatrix gel of the present invention, the percentage by weight of siloxanes fluids is in fact 60 ~ 74%, the percentage by weight of volatile thinner is in fact 16 ~ 28%, the percentage by weight of sedimentation type silicon powder is in fact 3 ~ 23%, and the percentage by weight of polishing powder body is in fact 0.1 ~ 2%.
In addition, in another embodiment of the present invention, the compositions of cicatrix gel comprises photic damage protection composition further, and the percentage by weight of photic damage protection composition is in fact 0.1 ~ 10%.Photic damage protection composition meaning can provide the material of anti-solarization function, makes the compositions of cicatrix gel of the present invention provide sun-proof effect further, avoids producing melanin deposition in cicatrix repair process.Photic damage protection composition such as the photic damage of inclusion rationality can protect composition, chemical photic damage protection composition or both combinations, but not as limit.Wherein, physical property photic damage protection composition such as can comprise titanium dioxide (Titanium dioxide), zinc oxide (Zinc oxide), zirconium oxide (Zirconia), and chemical photic damage protection composition such as can comprise pungent-salicylic acid (Salicylic acid), avobenzone (Avobezone), N-(carboethoxyphenyl)-N'-methyl-N'-phenyl formamidine (Benzoate-4), cinoxate (Cinoxate), benzophenone series compound (Dioxybenzone, Oxy-Molybdate-40, Oxybezone), homosaligenin (Homosalate), barley green rather filters ring (Mexoryl SX), Methyl anthranilate (Methyl Anthranilate), octocrilene (Octocrylene), Salicylate (Octyl Salicylate), octyl methoxycinnamate (Octyl methoxycinnamate), pentyl diformazan para-amino benzoic acid (Octyl Dimethy PABA), padimate O (Padimate-O), para-aminobenzoic acid (Para Amino Benzoic Acid), Phenylbenzimidazolesulfonic acid (pheny benzimidazole sulfonic acid), roxadimate (Roxadimate), UVNUL MS-40 (sulisobenzone), trolamine salicylate (Trolamine Salicylate), but be not limited with these materials.
Moreover, in another embodiment of the invention, the further inorganic salts powder body of compositions of cicatrix gel, and the percentage by weight of inorganic salts powder body is in fact 0.1 ~ 5%.Inorganic salts powder body has and promotes further the compatibility of sedimentation type silicon powder for siloxanes fluids and volatile thinner, the siloxanes of different polymerization degree more fully can be mixed and more long-acting evenly to maintain mutually, therefore the problem using perception not good in prior art more not easily occurs.Inorganic salts powder body such as can comprise barium sulfate (Barium sulfate), strontium sulfate (Strontium sulfate), magnesium sulfate (Magnesium sulfate), hydrated ferric oxide. (Ferric hydroxide), calcium hydroxide (Calcium hydroxide), sodium chloride (Sodium chloride), potassium chloride (Potassium chloride), ammonium chloride (Ammonium chloride), ETHANOLAMINE HYDROCHLORIDE (Monoethanolamine), diethanolamine chloride (Diethanolamine chloride), sodium sulfate (Sodium sulfate), sodium phosphate (Sodium phosphate), sodium hydrogen phosphate (Disodium hydrogen phosphate), sodium triphosphate (Sodium tripolyphosphate), Magnesiumaluminumsilicate (Magnesium silicate), silicon dioxide (Silicon dioxide), sodium magnesium silicate (Sodium magnesium silicate), sodium silicate (Sodium silicate), hydrated SiO 2 (Hydrated silica), montorillonite clay (Montmorillonite), Lithium metasilicate magnesium sodium (Lithium magnesium sodium silicate), hectorite (Hectorite), stearic ammonium montorillonite clay (Stearyl ammonium montmorillonite), stearic ammonium hectorite (Stearyl ammonium hectorite), quaternary ammonium salt-90 montorillonite clay (Quaternary ammonium montmorillonite90), quaternary ammonium salt-18 montorillonite clay (Quaternary ammonium montmorillonite18), quaternary ammonium salt-18 hectorite (Quaternary ammonium hectorite18) or these combination, but not as limit.
For further illustrating the compositions of cicatrix gel of the present invention, at the long-acting even special efficacy maintained mutually in detail, experimentation and the result of various embodiments of the present invention and comparative example is below described in detail:
Comparative example 1
Get smoked silicon
n20, purchased from Wacker Chemie AG) mix with ferrum oxide, titanium dioxide, barium sulfate, and carry out grinding 6 hours with planetary ball mill with rotating speed 360rpm, after completing, then add siloxanes fluids (DOW to
dIMETHICONOL BLEND20) and volatile thinner (DOW
cyclopentasiloxane, D5) mix homogeneously in mixed liquor.Wherein smoked silicon accounts for that overall percentage by weight is in fact 9wt%, siloxanes fluids accounts for that overall percentage by weight is in fact 60wt%, volatile thinner accounts for that overall percentage by weight is in fact 20wt%, ferrum oxide accounts for that overall percentage by weight is in fact 1wt%, titanium dioxide accounts for that overall percentage by weight is in fact 8wt%, to account for overall percentage by weight be in fact 2wt% to barium sulfate.
Comparative example 2
Production method and aforementioned comparative example 1 similar, difference is that smoked silicon accounts for that overall percentage by weight is in fact 5wt%, to account for overall percentage by weight be in fact 64wt% to siloxanes fluids.
Comparative example 3
Production method and aforementioned comparative example 1 similar, difference is that comparative example 3 does not add barium sulfate, and smoked silicon accounts for that overall percentage by weight is in fact 5wt%, siloxanes fluids accounts for that overall percentage by weight is in fact 64wt%, to account for overall percentage by weight be in fact 22wt% to volatile thinner.
Embodiment 1
Sedimentation type silicon powder purchased from
(model 22LS), carries out grinding 6 hour with planetary ball mill with rotating speed 360rpm by sedimentation type silicon powder and ferrum oxide, titanium dioxide, barium sulfate, after completing, then adds siloxanes fluids (DOW to
dIMETHICONOL BLEND20) and volatile thinner (DOW
cyclopentasiloxane, D5) mix homogeneously in mixed liquor.Wherein sedimentation type silicon powder accounts for that overall percentage by weight is in fact 3wt%, siloxanes fluids accounts for that overall percentage by weight is in fact 66wt%, volatile thinner accounts for that overall percentage by weight is in fact 20wt%, ferrum oxide accounts for that overall percentage by weight is in fact 1wt%, titanium dioxide accounts for that overall percentage by weight is in fact 8wt%, to account for overall percentage by weight be in fact 2wt% to barium sulfate.
Embodiment 2
Production method and previous embodiment 1 similar, difference is to account for overall percentage by weight by sedimentation type silicon powder, and to be promoted to be in fact 5wt%, to account for that overall percentage by weight drops to be in fact 64wt% to siloxanes fluids.
Embodiment 3
Production method and previous embodiment 1 similar, difference is to account for overall percentage by weight by sedimentation type silicon powder, and to be promoted to be in fact 8wt%, to account for that overall percentage by weight drops to be in fact 61wt% to siloxanes fluids.
Embodiment 4
Production method and previous embodiment 1 similar, difference is to account for overall percentage by weight by sedimentation type silicon powder, and to be promoted to be in fact 10wt%, to account for that overall percentage by weight drops to be in fact 59wt% to siloxanes fluids.
Embodiment 5
Production method and previous embodiment 1 similar, difference is to account for overall percentage by weight by sedimentation type silicon powder, and to be promoted to be in fact 12wt%, to account for that overall percentage by weight drops to be in fact 57wt% to siloxanes fluids.
Embodiment 6
Production method and previous embodiment 1 similar, difference is to account for overall percentage by weight by sedimentation type silicon powder, and to be promoted to be in fact 15wt%, to account for that overall percentage by weight drops to be in fact 54wt% to siloxanes fluids.
Embodiment 7
Production method and previous embodiment 1 similar, difference is that embodiment 7 does not add barium sulfate, and sedimentation type silicon powder accounts for that overall percentage by weight is in fact 5wt%, siloxanes fluids accounts for that overall percentage by weight is in fact 64wt%, volatile thinner accounts for that overall percentage by weight is in fact 22wt%, ferrum oxide accounts for that overall percentage by weight is in fact 1wt%, to account for overall percentage by weight be in fact 8wt% to titanium dioxide.
Embodiment 8
Production method and previous embodiment 7 similar, difference is to add a little barium sulfate in embodiment 8, and it is in fact 1wt% that barium sulfate accounts for that overall percentage by weight is promoted to, and volatile thinner accounts for that overall percentage by weight is reduced to is in fact 21wt%.
Embodiment 9
Production method and previous embodiment 7 similar, difference is to add a little barium sulfate in embodiment 9, and it is in fact 3wt% that barium sulfate accounts for that overall percentage by weight is promoted to, and volatile thinner accounts for that overall percentage by weight is reduced to is in fact 19wt%.
Above-mentioned comparative example 1 ~ 3 and embodiment 1 ~ 9 are respectively got 15g and are fills up to 3 LDPE flexible pipes respectively, and by total 36 (each comparative example or embodiment each 3 to average) LDPE flexible pipe puts into 75 DEG C of baking ovens and carries out aging observation.Finally all LDPE flexible pipes are left standstill the different time length such as 3 days, 6 days, 9 days and 12 days, will extrude and calculate upper strata oil pump capacity by material in flexible pipe.Interpretation is as shown in following table 1,2:
Table 1: comparative example 1 ~ 3 and embodiment 1 ~ 3 upper strata oil pump capacity meansigma methods under different time of repose
| Oil pump capacity (g) | Comparative example 1 | Comparative example 2 | Comparative example 3 | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| 3 days | 0.03 | 0.02 | 0.03 | 0.00 | 0.00 | 0.00 |
| 6 days | 0.15 | 0.09 | 0.09 | 0.00 | 0.00 | 0.00 |
| 9 days | 0.20 | 0.16 | 0.15 | 0.02 | 0.02 | 0.01 |
| 12 days | 0.29 | 0.26 | 0.24 | 0.10 | 0.02 | 0.01 |
Table 2: the upper strata oil pump capacity meansigma methods of embodiment 4 ~ 9 under different time of repose
| Oil pump capacity (g) | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 |
| 3 days | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| 6 days | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 |
| 9 days | 0.01 | 0.01 | 0.00 | 0.07 | 0.03 | 0.01 |
| 12 days | 0.02 | 0.02 | 0.01 | 0.13 | 0.04 | 0.01 |
From the experimental result of table 1 and table 2, use the comparative example 1 ~ 3 of smoked silicon in leaving standstill 3 days when, namely have obvious upper strata oil pump capacity to produce, and use the various embodiments of the present invention 1 ~ 9 of sedimentation type silicon powder, then can maintain even phase and produce obvious upper strata oil pump capacity to leaving standstill 9 old name for the Arabian countries in the Middle Easts.Wherein, the percentage by weight accounting for the compositions of overall cicatrix gel when sedimentation type silicon powder is higher, even the time of repose maintaining even phase can be extended to 12 days (such as embodiment 2 ~ 6).Can demonstrate,prove thus, the really comparatively smoked silicon of sedimentation type silicon powder has better dispersibility, and make in the compositions of cicatrix gel of the present invention, the siloxanes of the different polymerization degree of siloxanes fluids and volatile thinner mixture can fully mix and the even phase of long-time maintenance.Accordingly, the compositions of cicatrix gel of the present invention has the even phase maintenance more excellent compared with prior art really, can provide better experience.In addition, from embodiment 4 and embodiment 7-9 experimental result also, the interpolation of inorganic salts (barium sulfate) also has low oil pump capacity and the special efficacy of the even phase of long-acting maintenance system.As without the experimental result display of embodiment 7 adding barium sulfate, namely there is obvious oil pump capacity at the 9th day, review and there is the embodiment 4 of barium sulfate and the result of embodiment 8-9, all effectively extend that the compositions of cicatrix gel is even holds time mutually.
Finally be stressed that, the compositions of cicatrix gel provided by the present invention, it uses sedimentation type silicon powder (precipitated silica) to replace smoked silicon as thickening agent, not only there is the effect simplifying processing procedure, reduce production cost, still there is more long-acting homogeneous special nature, there is the character of not easily oil phase layering, more perfect experience can be provided.And the interpolation of polishing powder body makes it close with the colour of skin, having improved aesthetic appearance in use procedure and not easily for other people discover.In addition, still optionally add inorganic salts and extend overall maintenance homogeneous phase further; Or add photic damage protection composition provide cicatrix repair needed for sun-proof, avoid wound melanin deposition.
Although the present invention discloses as above with embodiment; so itself and be not used to limit the present invention; anyly have the knack of this those skilled in the art; without departing from the spirit and scope of the present invention; when being used for a variety of modifications and variations, the scope that therefore protection scope of the present invention ought define depending on accompanying claims is as the criterion.
Claims (10)
1. a compositions for cicatrix gel, comprises:
Siloxanes fluids;
Volatile thinner;
Sedimentation type silicon powder, and
Polishing powder body,
Wherein, described siloxanes fluids and described volatile thinner dissolve each other, and described sedimentation type silicon powder and described polishing powder body are dispersed in described siloxanes fluids and described volatile thinner.
2. the compositions of cicatrix gel as claimed in claim 1, wherein said polishing powder body is the combination of ferrum oxide, manganese oxide, chromium oxide or these metal-oxides.
3. the compositions of cicatrix gel as claimed in claim 1, the percentage by weight of wherein said siloxanes fluids is in fact 60 ~ 74%, the percentage by weight of described volatile thinner is in fact 16 ~ 28%, the percentage by weight of described sedimentation type silicon powder is in fact 3 ~ 23%, and the percentage by weight of described polishing powder body is in fact 0.1 ~ 2%.
4. the compositions of cicatrix gel as claimed in claim 1, the pH value of wherein said sedimentation type silicon powder is in fact 6 ~ 8.
5. the compositions of cicatrix gel as claimed in claim 1, comprises photic damage protection composition further, and the percentage by weight of described photic damage protection composition is in fact 0.1 ~ 10%.
6. the compositions of cicatrix gel as claimed in claim 5, wherein said photic damage protection composition is physical property photic damage protection composition, chemical photic damage protection composition or both combinations.
7. the compositions of cicatrix gel as claimed in claim 6, wherein said physical property photic damage protection composition is titanium dioxide, zinc oxide, zirconium oxide, described chemical photic damage protection composition comprises pungent-salicylic acid, avobenzone, N-(carboethoxyphenyl)-N'-methyl-N'-phenyl formamidine, cinoxate, benzophenone, homosaligenin, barley green rather filters ring, Methyl anthranilate, octocrilene, Salicylate, octyl methoxycinnamate, pentyl diformazan para-amino benzoic acid, padimate O, para-aminobenzoic acid, Phenylbenzimidazolesulfonic acid, roxadimate, UVNUL MS-40, trolamine salicylate.
8. the compositions of cicatrix gel as claimed in claim 1, comprise inorganic salts powder body further, the percentage by weight of described inorganic salts powder body is in fact 0.1 ~ 5%.
9. the compositions of cicatrix gel as claimed in claim 8, described inorganic salts powder body is barium sulfate, strontium sulfate, magnesium sulfate, hydrated ferric oxide., calcium hydroxide, sodium chloride, potassium chloride, ammonium chloride, ETHANOLAMINE HYDROCHLORIDE, diethanolamine chloride, sodium sulfate, sodium phosphate, disodium hydrogen phosphate, sodium triphosphate, Magnesiumaluminumsilicate, silicon dioxide, sodium magnesium silicate, sodium silicate, hydrated SiO 2, montorillonite clay, Lithium metasilicate magnesium sodium, hectorite, stearic ammonium montorillonite clay, stearic ammonium hectorite, quaternary ammonium salt-90 montorillonite clay, quaternary ammonium salt-18 montorillonite clay, quaternary ammonium salt-18 hectorite, or the combination of these compounds.
10. the compositions of cicatrix gel as claimed in claim 1, wherein said siloxanes fluids is the mixture of polydimethylsiloxane and dimethyl siloxane, and described volatile thinner is linear or the volatile siloxanes of ring-type.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983585A (en) * | 2015-06-18 | 2015-10-21 | 天津嘉氏堂科技有限公司 | Sunscreen silica gel for scars and preparation method thereof |
| CN104983585B (en) * | 2015-06-18 | 2018-09-25 | 天津嘉氏堂科技有限公司 | A kind of scar sun-proof Silica hydrogel and preparation method |
| CN105168045A (en) * | 2015-09-07 | 2015-12-23 | 天津嘉氏堂科技有限公司 | Scar sun-screening and repairing silicon gel and preparation method thereof |
| CN105168045B (en) * | 2015-09-07 | 2018-07-17 | 天津嘉氏堂科技有限公司 | A kind of sun-proof reparation Silica hydrogel of scar and preparation method |
| CN109589302A (en) * | 2018-12-11 | 2019-04-09 | 苏州乐泰医疗科技有限公司 | Silicone scar gel and preparation method thereof |
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