CN104542475A - Breeding method for experimental macaque - Google Patents
Breeding method for experimental macaque Download PDFInfo
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- CN104542475A CN104542475A CN201510000700.5A CN201510000700A CN104542475A CN 104542475 A CN104542475 A CN 104542475A CN 201510000700 A CN201510000700 A CN 201510000700A CN 104542475 A CN104542475 A CN 104542475A
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/02—Breeding vertebrates
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- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Housing For Livestock And Birds (AREA)
- Fodder In General (AREA)
Abstract
The invention relates to the technical field of animal breeding, in particular to a breeding method for an experimental macaque. Main feed containing vitamin E is fed to the macaque in at least one of a suckling period, a growth period and an adult period; cefotaxime or ceftriaxone sodium or ceftazidime is added into the feed continuously for 5-7 days every 1-2 months in at least one of the growth period and the adult period; a young macaque is independently fed in the suckling period, feeding quality is further improved, the health condition of the macaque can be timely discovered and managed, the survival rate of the young macaque is improved, and the young macaque is normal in growth and development, flexible in limbs and physically strong. Moreover, the probability and the risk of bacterial dysentery infection of the macaque are reduced, and common health of the macaque and workers is ensured. A normalized experimental animal breeding standard is provided, and the breeding method is easy to popularize and use.
Description
Technical field
The present invention relates to animal-breeding technical field, particularly relate to a kind of raising method of testing with macaque.
Background technology
Macaque (Macaca mulatta) belongs to Primates (Primates) monkey section (Eereopithecidae) Macaca (Macaca) animal, is " CITS (CITES) " appendix II species.
Macaque is as the species the most close with mankind's affiliation, non-human primates (Nonhuman Primates, NHP) autoploidy of more than 95% is had with the genetic material of the mankind, and it is highly approximate with the mankind in institutional framework, immunity, physiology and metabolism etc., thus in biological medicine research, there are obvious comparative advantages, become and solved human health and the basic research of disease problems and the ideal animals model of preclinical study.China SFDA and U.S. FDA explicitly call for the new drug of more than two classes before entering clinical testing, must obtain the zooperal authentic data of NHP.China also specifies: " after NHP zoopery, must can enter clinical trial through approval to neural class, mental, anesthesia class, biological products class, family planning class medicine utensil etc." current, along with the foundation of the NHP disease model of the long-standing problem mankind persistent ailments such as acquired immune deficiency syndrome (AIDS), Parkinson, tumour, injury of lungs, hepatic injury, and related drugs studies particularly pre-clinical assessment, and the application of NHP is the bank do not walked around.NHP has some idea of for the importance of new drug particularly protide biological products new drug development.
Macaque, as China national second class protection animal, the population quantity being applied to Animal Experimental Study increases recent years year by year, but due at present in the world mainly to cultivate machin, raising for macaque is just in the starting stage, mainly still derive from wild, carrying out experiment with wild monkey does not have clearly genetic background, clear and definite microbe condition and stable biological property because of it on the one hand, makes the reliability of experimental result open to suspicion; On the other hand, the exhaustion of wild resource will inevitably be caused the excessive seizure of wild monkey, do not conform to the development pole of human civilization.
China pays much attention to equally to laboratory primates Animal resources, and experiment macaque has listed " country's " 12 " laboratory animal platform construction " project in, for the development of national strategy new industry provides support condition.The Department of Science and Technology has formulated " primate laboratory animal feeding and management specification and quality standard thereof ", has set up " primate laboratory animal industrial strategy union ".Huge applications just because of experiment macaque is worth, and western developed country (comprising China) is classified as policy of scientific research resource.Even have scholarly forecast, the competition of medicinal career in the future may be exactly the competition of laboratory primates Animal resources.
Therefore the hereditary difference between the genetic background of experiment macaque and colony is understood, by existing hereditary archive management system, to testing, macaque adjusts, hereditary information management, set up the detailed individual archives of laboratory animal macaque and pedigree system, set up effectively, accurately and reliably, the monitoring of fast and simple genetic background, simultaneously Erecting and improving raising, breed normalizing operation flow process, epidemic prevention system and control and prevention of disease scheme, cultivating for experiment Macaca mulatta population provides technical support particularly important.
According to statistics in 2009, the breeding stock more than 210,000 of Laboratory monkey, wherein nearly 30,000 of macaque.And according to statistical data display in 2011, within nearly ten years, international market was to testing the demand of macaque every year with the speed increment more than 20%.2010, the global demand amount of experiment macaque was close to 200,000, and the breeding amount of the macaque of whole world experiment then is only only more than 130,000, and market demand breach is fairly obvious.According to another correlation predictive display, the coming five years (2012-2016), global medical experimental macaque market demand will keep strong growth, will reach 25-30 ten thousand to 2016 annual requirements.
With regard to China demand, along with improving constantly of Chinese science and technology level, and the comparative advantages of various cost, research and development centre is proceeded to China by pharmacy corporation large in the world and research institution one after another, research and development task of being maybe correlated with outsourcing.This is the affirmative to Chinese laboratory animal, is also the affirmative to global zoopery development space.To effectively promote the usage amount of domestic experimental monkey groups and model animal, in foreseeable time range, have the trend constantly risen.
It is reported, the whole world only reaches more than 100,000 for the Macaque of Macaca of scientific research every year, and China also needs thousands of every year.Although some developed countries throw huge fund and successively establish some monkey fields, still need from a large amount of rhesus macaquies of macaque country of origin import such as China, Vietnam at present.
Although raising scale and the demand of Laboratory monkey expand gradually; but due to the management of long-term lacking specification; the series of problems such as cause disorderly competition between industry, in violation of rules and regulations illegal, development to fall behind and Animal performance is low; not only cause huge hidden danger to protection of resources, also compromise the international fame of China.
The macaque of major part experiment is within Chinese territory raised comparatively simply extensive at present, just macaque is carried out stable breeding feeding feed, does not have standardization, causes certain influence to the raising quality of experiment macaque, is unsuitable for promoting the use.
In the feeding process of experiment macaque, applicant finds, the probability of macaque bacterial infection dysentery is very high, and the incidence of disease can up to 100%, and lethality reaches more than 60%.This not only have impact on the production capacity of whole monkey group, has also had a strong impact on the quality of experiment macaque.Research shows, Shigella is the Main Pathogenic Bacteria in macaque enteron aisle, and the serotype complexity of Shigella is easy to change, and drug resistance, in continuous enhancing, brings larger difficulty to clinical treatment.
Shigella is the microorganism that a class has hyperinfection, and artificial liver support shows, few can cause adult onset to 10 bacteriums.People is after the ight soil of contact dysentery macaque or edible food containing Shigella and drinking-water, some bacteriums survive in stomach sour environment, colon is arrived through after small intestine, invade mucous membrane of colon and cause acute necrotizing coloproctitis, acutely clinically show as unexpected diarrhoea, water sample, yellow, pink glue peptone shape, with high heat, useless food, lassitude, row's mucous bloody stool, some appearance whole body toxemia synptoms, severe patient can have infectious shock and (or) toxic encephalopathy, and protracted inflammation does not more become chronic or can recurrent exerbation.
If have a kind of scientific and normal, be easy to the macaque raising method promoted, significantly will improve the quality of raising macaque, ensure the health of keeper simultaneously, it will be very favourable for cultivating for expansion macaque, this provides a large amount of qualified experiment macaques also will to international scientific research institution, promotes Chinese great new drug development, for strategy in China new industry provides base support; Take macaque as carrier, Promoting Experiment macaque animal husbandry diversified development, realizes organic docking of upper, middle and lower trip industrial chain, the high added value of improving product and synthesized competitiveness, promotes the development that macaque industry is good and fast, serve local economic construction better; Abundant job is provided, effectively alleviates the employment pressure of local farmers, promote that local society harmony is stable.
Summary of the invention
The present invention is directed to above-mentioned background technology, provide a kind of raising method of testing with macaque, improve experiment macaque growth, healthy, breeding quality, and adopt scientific and normal feeding and management method, achieve the standardization of artificial feeding animal for research.
For realizing the object of the invention, the technical solution used in the present invention is as follows:
The invention provides a kind of raising method of testing with macaque, comprise a. lactation, b. weaning period, the c. growth stage, the d. manhood, it is characterized in that: feed at least one period containing the main feed of vitamin E in lactation, growth stage, manhood; In growth stage, manhood at least one period, at interval of 1 ~ 2 month, continue in feed, within 5 ~ 7 days, add cefotaxime or ceftriaxone or cefotaxime.
Further, be at interval of 2 ~ March within lactation, continue within 5 ~ 7 days, to feed containing the main feed of vitamin E; Be at interval of 3 ~ 5 weeks within growth stage, manhood, continue to feed containing the main feed of vitamin E for 5 ~ 7 days.
Further, the described experiment raising method of macaque, specifically comprises the following steps:
A. lactation: after young monkey birth, young monkey and female monkey thereof concentrate in lactation cage house and raise, the public monkey that grows up is raised in group support cage house, and grow up in each group support cage house public monkey 1 ~ 2;
B. weaning period: young monkey was weaned after 8 ~ 9 months, young monkey is moved to monoculture cage house in raise, by female monkey through detection qualified after move to group support cage house in raising; Be provided with monoculture monkey cage in monoculture cage house, in each monoculture monkey cage, raise 1 ~ 2 young monkey;
C. the growth stage: young monkey detected after 1 years old, move to after qualified in group support cage house and raise;
D. the manhood: macaque is raised in group support cage house, adopt public many matrixs to distribute, 1 male monkey is with 6 ~ 10 female monkeys;
Further, described group support cage is given up at least one face wall, and be provided with multiple protruding part for macaque climbing, protruding part is provided with 1 ~ 10 on every square metre of metope; In group support cage house, be provided with the hollow pipe that diameter is more than or equal to 40cm, hollow pipe distance ground 0 ~ 1m, hollow pipe two ends enter for macaque.
Further, described lactation cage house or monoculture cage house, be provided with heating, feed pipe, sewer, protect window; Monoculture cage house room temperature in winter controls at 13 ~ 19 DEG C, and summer, room temperature was less than or equal to 30 DEG C, and summer, relative moisture was 65% ~ 75%; Lactation cage house room temperature in winter controls at 18 ~ 22 DEG C, and summer, room temperature was less than or equal to 30 DEG C, and summer, relative moisture was 65% ~ 75%; Described lactation cage house or monoculture cage house, long 35 ~ 45m, wide 5 ~ 10m, be provided with 24 ~ 48 monoculture monkey cages, single cage long 60 ~ 80cm, wide 60 ~ 80cm, high 80 ~ 100cm, distance ground 40 ~ 80cm at the bottom of cage.
Monoculture cage house can see applicant's earlier application, and application number is 2014206760780.
Further, be provided with between multiple raising in described group support cage house, and the totally-enclosed corridor passed through for macaque and for drainage facility under water; Be made up of indoor and outdoor two parts place between described raising, covered court area 6 ~ 10 ㎡ between raising, outdoor sports area 10 ~ 14 ㎡ between raising; Between described raising, covered court is provided with heating installation, illumination, habitation support, drinking bowl, crib, sewer; Between raising, outdoor sports is provided with habitation support, swing, sewer, drinking bowl.
Further, between described raising, covered court room temperature in winter controls at 13 ~ 19 DEG C, and between summer feeding, outdoor sports temperature controls at 23 ~ 29 DEG C, between summer feeding covered court and raise between outdoor sports humid control 60% ~ 80%.
Further, described monoculture cage house or group support cage house, carry out 1 ~ 2 every day and clean, and carries out weekly 1 ~ 2 regularly sterilization; The sterilization Peracetic acid of employing 0.1 ~ 0.2% or 1:(75 ~ 85) liquor natrii hypochloritis or 0.01 ~ 0.02% hundred poisoning carry out, or above-mentioned three kinds of thimerosals are used alternatingly; Disinfection way is aerosol spray and sprinkling; During winter, quicklime is also adopted to carry out disinfection.
Further, in described feeding period, in every day 8:30 ~ 9:00 to throw something and feed corn or loin chop, 11:30 ~ 12:00 and 17:30 ~ 18:00 throws something and feeds main feed, and 15:00 ~ 15:30 throws something and feeds green fodder; After the wean of children monkey, each supplementary milk powder of feeding sooner or later; Described main feed adult rhesus is 130 ~ 160g/ day; Green fodder is vegetables in season or fruit or both matched combined, and adult rhesus is 220 ~ 270g/ day; Vegetables in season or fruit first clean before feeding, then adopt the liquor potassic permanganate of 0.05 ~ 0.1% to soak, dry; The milk powder of young monkey after wean of feeding is 8 ~ 12g/ day, adopt milk powder boil molten after feed.
Further, in described feeding period, every year 4 ~ 5 tuberculosis inspections are carried out to macaque, carry out 1 ~ 2 microorganism and parasitology inspection half a year, check out that positive processes in time.
The present invention is at interval of 3 ~ 5 week with macaque containing the main feed of vitamin E by administering transgenic, continue within 5 ~ 7 days, to feed containing the main feed of vitamin E, can effectively promote macaque property function, increase pregnancy rate, prevent miscarriage, and fertility and promotion health can be improved to grow up effect.
Add vitamin E in experiment with in macaque feed, can promote the secretion of macaque pituitary gonadotropic hormone, promote generation and the activity of sperm, increase ovarian function, ovarian follicle increases, lutein cell increase etc.Because the affiliation of macaque and people is nearer, the experiment of comparing the over E that is deficient in vitamin in macaque feed, easily cause macaque muscular dystrophy, and the performance of vitamin e deficiency is many-sided, but be mainly manifested in reproduction, muscle, cardiovascular and hemopoietic system each side, the Skeletal Muscles Damage caused because of TD obviously also sees the experiment of artificial feeding with macaque, although heart is got involved lighter usually, more rare, but cardiac damage can merge ECG Change sometimes, pathological change, even in heart failure.
And applicant finds, in feed, vitamin E is added by interval is regularly appropriate, effectively can strengthen the reproductive frequency of macaque, compare traditions of the past class feed, experiment macaque feed provided by the invention, macaque is after long-term eating, and the annual August in oestrus fixed by the past is to February next year, increase the probability for all there being breeding of necessarily oestrusing in all the other months, thus significantly improve the breeding amount of the macaque whole year.Female macaque, at pregnancy edible this experiment macaque feed afterwards, effectively antiabortively can be set the mind at rest, reduces abortion rate, thus improve reproduction rate.
The invention provides a kind of new method of raising macaque, by within lactation, young monkey and female monkey thereof are concentrated and raises, isolate the mode of adult public monkey, effectively prevent monkey group to fight problem, young monkey weaning period inherent monoculture monkey cage is raised, improves further and raise quality, can Timeliness coverage manage the health status of macaque.Also combined by whole synthesis feeding and management of the present invention and enrich rational feeding facility, significantly improve health and quality that macaque is used in experiment.As shown in Fig. 1, Fig. 2 in Figure of description, the macaque growth rate adopting the inventive method to raise is stablized, and body weight grows steadily.
Applicant finds, for raising macaque, variation of ambient temperature is crossed conference and had a negative impact to it, and the rate of heat dissipation of monkey body can decline with humidity and rise.It is generally acknowledged that temperature is at 20 ~ 26 DEG C, relative moisture, in 40% ~ 60% scope, to the growth of macaque with to breed be favourable, can have a negative impact to monkey group if exceed this scope, therefore, supporting region to breeding monkey group feeding, to carry out temperature and humidity monitor and forecast be necessary.
The present invention gives up at least one face wall at group support cage, be provided with multiple protruding part for macaque climbing, macaque can carry out climbing by protruding part at metope and play, and in group support cage house, be provided with the hollow pipe that diameter is more than or equal to 40cm, hollow pipe distance ground 0 ~ 1m, hollow pipe two ends can enter for macaque hides, wall limit is also provided with and perches platform, simulate macaque growing environment in the wild, the young macaque meeting more than 1 years old likes the habit located in narrow dark of hiding, and further enhances physique and the mental status of macaque.
The present invention is young monkey after wean raised by employing collective lactation cage house and single cage, female monkey and young monkey all can carry out microorganism detection and quarantine before being transferred to group support cage house, prevent transmission of disease between monkey group further, be more conducive to staff and ill macaque is carried out isolated controlling.
For the shigella infection problem that experiment uses macaque general in feeding process, found by applicant, Shigella Cefotaxime is the most responsive, takes second place to ceftriaxone, cefotaxime, strong to antibiotic resistances such as polymyxin B, Carbenicillin, benzyl azoles XiLin elements.And tentatively determine that experiment raises mass contagion Shigella ubiquity with macaque, and then the possibility causing diarrhoea, dysentery comparatively greatly, cefotaxime etc. are most sensitive medicaments.
Applicant is by raising method of the present invention, 1 ~ 2 month, interval, the mode of lasting cefotaxime of adulterating in feed for 5 ~ 7 days, detection statistics display macaque monkey virus Positive rate obviously successively decreases, TB detects and is all negative, BV virus reduces to 5% from 11%, positive rate decreases 6 percentage points, STLV positive rate reduces to 1.24% from 5.36%, positive rate have dropped 4.12%, SIV Viral diagnosis is all negative, SRV positive rate reduces to 2.0% from 3.87, positive rate declines 1.87 percentage points, statistical data shows that macaque monkey virus positive rate reduces year by year, Quality of Experimental Animals is in annual rising, maintain the common health of macaque and staff.And cefotaxime or ceftriaxone or cefotaxime are quantitatively added in comparatively long-term interval, can't affect the healthy quality of experiment with macaque, the pesticide resistance in body can not cause obvious change.
Beneficial effect of the present invention shows:
One, invention increases experiment macaque health, growth, breeding quality, ensure that the standard quality of experiment with macaque.
Two, invention increases the survival rate of macaque children monkey, young monkey grows, grow normally, pliable legs, physically fit.
Three, the present invention effectively reduces transmission of disease between monkey group, is more conducive to macaque Disease epizootic, isolation.
Four, the present invention effectively promotes macaque property function, increases pregnancy rate, prevents miscarriage, and can improve fertility and promotion health and to grow up effect.
Five, present invention reduces probability and the risk of macaque bacterial infection dysentery, ensure that the common health of macaque and staff.
Six, the invention provides the feeding standard of a kind of laboratory animal of standardizing, be easy to promote the use of.
Accompanying drawing explanation
Fig. 1 adopts a kind of raising method macaque age in days growth body examination Line Chart of testing with macaque provided by the invention.
Fig. 2 adopts a kind of raising method macaque age in days growth body weight Line Chart of testing with macaque provided by the invention.
Embodiment
By the following example, implementation process of the present invention and outstanding advantages can be set forth further, but the present invention is not limited to the following example.
A. after young monkey birth, young monkey and female monkey thereof concentrate in lactation cage house and raise, and the public monkey that grows up is raised in group support cage house.
B. young monkey was weaned after 8 months, young monkey is moved to monoculture cage house in raise, by female monkey through detection qualified after move to group support cage house in raising; Be provided with monoculture monkey cage in monoculture cage house, in each monoculture monkey cage, raise 1 ~ 2 young monkey;
Described group support cage is given up at least one face wall, and be provided with multiple confession macaque and climb the protruding part of playing, protruding part is provided with 3 on every square metre of metope; In group support cage house, be provided with the cement hollow pipe that diameter is 50cm, cement hollow pipe support is located on clump, distance ground 40cm, and hollow pipe two ends enter to hide for macaque and play;
Described lactation cage house and monoculture cage house, be provided with heating, feed pipe, sewer, protect window; Monoculture cage house room temperature in winter controls at 15 ~ 18 DEG C, and summer, room temperature was less than or equal to 30 DEG C, and summer, relative moisture was 70%; Lactation cage house room temperature in winter controls at about 20 DEG C, and summer, room temperature was less than or equal to 30 DEG C, and summer, relative moisture was 70%;
Described lactation cage house and monoculture cage house, long 40m, wide 5m, be provided with 30 monoculture monkey cages, the long 60cm of single cage, wide 60cm, high 80cm, distance ground 60cm at the bottom of cage; Monoculture cage house can see applicant's earlier application, and application number is 2014206760780;
Be provided with between multiple raising in described group support cage house, and the totally-enclosed corridor passed through for macaque and for drainage facility under water; Be made up of indoor and outdoor two parts place between described raising, covered court area 8 ㎡ between raising, outdoor sports area 12 ㎡ between raising.Between raising, covered court is provided with heating installation, illumination, habitation support, drinking bowl, crib, sewer; Between raising, outdoor sports is provided with habitation support, swing, sewer, drinking bowl; Between raising, covered court room temperature in winter controls at 15 ~ 18 DEG C, and between summer feeding, outdoor sports temperature controls at 23 ~ 26 DEG C, between summer feeding covered court and raise between outdoor sports humid control 60%.
C. the growth stage: young monkey detected after 1 years old, move to after qualified in group support cage house and raise;
Above-mentioned monoculture cage house or group support cage house, carry out 2 every day and clean, and carries out weekly 2 regularly sterilizations; The Peracetic acid of sterilization employing 0.1%, the liquor natrii hypochloritis of 1:80, the above-mentioned three kinds of thimerosals of 0.016% hundred poisoning are used alternatingly; Disinfection way is aerosol spray and sprinkling; During winter, quicklime is also adopted to carry out disinfection;
In every day 8:30 to throw something and feed corn or loin chop, 11:30 and 17:30 throws something and feeds main feed, and 15:00 throws something and feeds green fodder; After the wean of children monkey, each supplementary milk powder of feeding sooner or later; Described main feed adult rhesus is 150g/ day; Green fodder is vegetables in season or fruit or both matched combined, and adult rhesus is 250g/ day; Vegetables in season or fruit first clean before feeding, then adopt the liquor potassic permanganate of 0.1% to soak, dry; The milk powder of young monkey after wean of feeding is 10g/ day, adopt milk powder boil molten after feed;
In above-mentioned feeding period, every year 4 tuberculosis inspections are carried out to macaque, carry out 1 microorganism and parasitology inspection half a year, check out that positive processes in time; In a. lactation, the c. growth stage, interim at interval of 1 month when three in the d. manhood, continue within 7 days, to feed containing the main feed of vitamin E; In the c. growth stage, in the d. manhood at least one period, at interval of 2 months, continue in feed, to add cefotaxime in 5 days.
Applicant carried out test to embodiment of the present invention and improves between 2009 to 2013, and significantly improve experiment and use macaque quality, the healthy level of raising macaque improves year by year, and quality testing sees the following form:
Claims (10)
1. test the raising method with macaque, comprise a. lactation, b. weaning period, the c. growth stage, the d. manhood, it is characterized in that: feed at least one period containing the main feed of vitamin E in lactation, growth stage, manhood; In growth stage, manhood at least one period, at interval of 1 ~ 2 month, continue in feed, within 5 ~ 7 days, add cefotaxime or ceftriaxone or cefotaxime.
2. a kind of raising method of testing with macaque according to claim 1, is characterized in that: be at interval of 2 ~ March within lactation, continues within 5 ~ 7 days, to feed containing the main feed of vitamin E; Be at interval of 3 ~ 5 weeks within growth stage, manhood, continue to feed containing the main feed of vitamin E for 5 ~ 7 days.
3. a kind of raising method of testing with macaque according to claim 1, is characterized in that: specifically comprise the following steps:
A. lactation: after young monkey birth, young monkey and female monkey thereof concentrate in lactation cage house and raise, the public monkey that grows up is raised in group support cage house, and grow up in each group support cage house public monkey 1 ~ 2;
B. weaning period: young monkey was weaned after 8 ~ 9 months, young monkey is moved to monoculture cage house in raise, by female monkey through detection qualified after move to group support cage house in raising; Be provided with monoculture monkey cage in monoculture cage house, in each monoculture monkey cage, raise 1 ~ 2 young monkey;
C. the growth stage: young monkey detected after 1 years old, move to after qualified in group support cage house and raise;
D. the manhood: macaque is raised in group support cage house, adopt public many matrixs to distribute, 1 male monkey is with 6 ~ 10 female monkeys.
4. a kind of raising method of testing with macaque according to claim 3, is characterized in that: described group support cage is given up at least one face wall, and be provided with multiple protruding part for macaque climbing, protruding part is provided with 1 ~ 10 on every square metre of metope; In group support cage house, be provided with the hollow pipe that diameter is more than or equal to 40cm, hollow pipe distance ground 0 ~ 1m, hollow pipe two ends enter for macaque.
5. a kind of raising method of testing with macaque according to claim 3, is characterized in that: described lactation cage house and/or monoculture cage house, be provided with heating, feed pipe, sewer, protect window; Monoculture cage house room temperature in winter controls at 13 ~ 19 DEG C, and summer, room temperature was less than or equal to 30 DEG C, and summer, relative moisture was 65% ~ 75%; Lactation cage house room temperature in winter controls at 18 ~ 22 DEG C, and summer, room temperature was less than or equal to 30 DEG C, and summer, relative moisture was 65% ~ 75%; Described monoculture cage house, long 35 ~ 45m, wide 5 ~ 10m, be provided with 24 ~ 48 monoculture monkey cages, single cage long 60 ~ 80cm, wide 60 ~ 80cm, high 80 ~ 100cm, distance ground 40 ~ 80cm at the bottom of cage.
6. a kind of raising method of testing with macaque according to claim 3, is characterized in that: be provided with between multiple raising in described group support cage house, and the totally-enclosed corridor passed through for macaque and for drainage facility under water; Be made up of indoor and outdoor two parts place between described raising, covered court area 6 ~ 10 ㎡ between raising, outdoor sports area 10 ~ 14 ㎡ between raising; Between described raising, covered court is provided with heating installation, illumination, habitation support, drinking bowl, crib, sewer; Between raising, outdoor sports is provided with habitation support, swing, sewer, drinking bowl.
7. a kind of raising method of testing with macaque according to claim 6, it is characterized in that: between described raising, covered court room temperature in winter controls at 13 ~ 19 DEG C, between summer feeding, outdoor sports temperature controls at 23 ~ 29 DEG C, between summer feeding covered court and raise between outdoor sports humid control 60% ~ 80%.
8. a kind of raising method of testing with macaque according to claim 4, is characterized in that: described monoculture cage house or group support cage house, carries out 1 ~ 2 every day and cleans, and carries out weekly 1 ~ 2 regularly sterilization; The sterilization Peracetic acid of employing 0.1 ~ 0.2% or 1:(75 ~ 85) liquor natrii hypochloritis or 0.01 ~ 0.02% hundred poisoning carry out, or above-mentioned three kinds of thimerosals are used alternatingly; Disinfection way is aerosol spray and sprinkling; During winter, quicklime is also adopted to carry out disinfection.
9. a kind of raising method of testing with macaque according to claim 4, it is characterized in that: in described feeding period, in every day 8:30 ~ 9:00 to throw something and feed corn or loin chop, 11:30 ~ 12:00 and 17:30 ~ 18:00 throws something and feeds main feed, and 15:00 ~ 15:30 throws something and feeds green fodder; After the wean of children monkey, each supplementary milk powder of feeding sooner or later; Described main feed adult rhesus is 130 ~ 160g/ day; Green fodder is vegetables in season or fruit or both matched combined, and adult rhesus is 220 ~ 270g/ day; Vegetables in season and/or fruit first clean before feeding, then adopt the liquor potassic permanganate of 0.05 ~ 0.1% to soak, dry; The milk powder of young monkey after wean of feeding is 8 ~ 12g/ day, adopt milk powder boil molten after feed.
10. a kind of raising method of testing with macaque according to claim 4, is characterized in that: in described feeding period, carries out 4 ~ 5 tuberculosis inspections every year to macaque, carry out 1 ~ 2 microorganism and parasitology inspection half a year, check out that positive processes in time.
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