CN104540530A - 放射性药物络合物 - Google Patents

放射性药物络合物 Download PDF

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Publication number
CN104540530A
CN104540530A CN201380036905.8A CN201380036905A CN104540530A CN 104540530 A CN104540530 A CN 104540530A CN 201380036905 A CN201380036905 A CN 201380036905A CN 104540530 A CN104540530 A CN 104540530A
Authority
CN
China
Prior art keywords
complex
hopo
moiety
thorium
octadentate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380036905.8A
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English (en)
Chinese (zh)
Inventor
汉内·特蕾泽·本格-汉森
奥拉夫·本杰明·瑞安
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Algeta ASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Algeta ASA filed Critical Algeta ASA
Publication of CN104540530A publication Critical patent/CN104540530A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
CN201380036905.8A 2012-05-11 2013-05-13 放射性药物络合物 Pending CN104540530A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201208309A GB201208309D0 (en) 2012-05-11 2012-05-11 Complexes
GB1208309.3 2012-05-11
PCT/EP2013/059841 WO2013167756A1 (en) 2012-05-11 2013-05-13 Radio-pharmaceutical complexes

Publications (1)

Publication Number Publication Date
CN104540530A true CN104540530A (zh) 2015-04-22

Family

ID=46458687

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201380035189.1A Pending CN104602716A (zh) 2012-05-11 2013-05-13 放射性药物络合物
CN201380036807.4A Pending CN104619355A (zh) 2012-05-11 2013-05-13 放射性药物络合物
CN201380036905.8A Pending CN104540530A (zh) 2012-05-11 2013-05-13 放射性药物络合物

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CN201380035189.1A Pending CN104602716A (zh) 2012-05-11 2013-05-13 放射性药物络合物
CN201380036807.4A Pending CN104619355A (zh) 2012-05-11 2013-05-13 放射性药物络合物

Country Status (9)

Country Link
US (3) US20150147272A1 (enExample)
EP (3) EP2846843A1 (enExample)
JP (3) JP6211066B2 (enExample)
KR (3) KR20150092701A (enExample)
CN (3) CN104602716A (enExample)
CA (3) CA2873144C (enExample)
GB (1) GB201208309D0 (enExample)
HK (3) HK1206982A1 (enExample)
WO (3) WO2013167755A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108601991A (zh) * 2016-01-05 2018-09-28 拜耳公司 提纯方法
CN108778347A (zh) * 2016-03-24 2018-11-09 拜耳制药股份公司 放射性药物配合物
CN115916731A (zh) * 2020-01-23 2023-04-04 瑞德兰有限责任公司 用于制备定制的放射性同位素溶液的系统和方法

Families Citing this family (20)

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CA2659251C (en) 2006-07-10 2016-06-14 The Regents Of The University Of California Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides
US9273059B2 (en) 2009-08-24 2016-03-01 Lumiphore, Inc. Macrocyclic HOPO chelators
GB201002508D0 (en) 2010-02-12 2010-03-31 Algeta As Product
GB201208309D0 (en) 2012-05-11 2012-06-27 Algeta As Complexes
US11453652B2 (en) 2013-03-15 2022-09-27 Lumiphore, Inc. Di-macrocycles
MA41176A (fr) * 2014-12-17 2017-10-24 Bayer As Complexes radio-pharmaceutiques
WO2017105565A2 (en) * 2015-09-10 2017-06-22 Memorial Sloan Kettering Cancer Center Compositions for therapeutics, targeted pet imaging and methods of their use
GB201600154D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope preparation method
CR20180581A (es) 2016-06-10 2019-02-11 Bayer Pharma AG Complejos radio-farmacéuticos
US20200016283A1 (en) * 2017-02-24 2020-01-16 Bayer As Combination therapy comprising a radiopharmaceutical and a dna-repair inhibitor
EA202092044A1 (ru) * 2018-03-14 2021-03-03 Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез Химерные рецепторы антигена против cd33 и их применения
WO2020043617A1 (en) 2018-08-28 2020-03-05 Bayer As Combination of pi3k-inhibitors and targeted thorium conjugates
CA3119467A1 (en) * 2018-11-20 2020-05-28 Cornell University Macrocyclic complexes of radionuclides and their use in radiotherapy of cancer
USD885822S1 (en) 2018-12-14 2020-06-02 Whirlpool Corporation Food grinder
CA3130747A1 (en) 2019-02-21 2020-08-27 Bayer Aktiengesellschaft Combination of pd-1/pd-l1 inhibitors and targeted thorium conjugates
WO2020169538A1 (en) 2019-02-22 2020-08-27 Bayer Aktiengesellschaft Combination of ar antagonists and targeted thorium conjugates
AR119479A1 (es) 2019-07-25 2021-12-22 Bayer As Radiofármacos dirigidos para diagnóstico y tratamiento de cáncer
AU2021206242A1 (en) * 2020-01-10 2022-08-25 Fusion Pharmaceuticals Inc. Macrocyclic chelates and uses thereof
US20240000838A1 (en) * 2020-11-30 2024-01-04 Simcere Innovation, Inc. Universal chimeric antigen receptor-expressing immune cells for allogeneic cell therapy
CA3208778A1 (en) 2021-01-22 2022-07-28 Bayer Aktiengesellschaft Lrrc15 antibodies and conjugates thereof

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2008085064A2 (en) * 2007-01-11 2008-07-17 Ge Healthcare As Hydroxypyridinone chelating agents, their metal complexes and their use as mri contrast agents
WO2011098611A2 (en) * 2010-02-12 2011-08-18 Algeta As Alpha-emitting complexes

Family Cites Families (13)

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US4698431A (en) * 1985-11-12 1987-10-06 The United States Of America As Represented By The United States Department Of Energy Hydroxypyridonate chelating agents
US5624901A (en) 1994-04-15 1997-04-29 The Regents Of The University Of California 3-hydroxy-2(1H)-pyridinone chelating agents
US8383081B2 (en) * 1999-05-10 2013-02-26 Immunomedics, Inc. Anti-CD74 immunoconjugates and methods of use
NO312708B1 (no) 2000-02-21 2002-06-24 Anticancer Therapeutic Inv Sa Radioaktive liposomer til terapi
NO313180B1 (no) 2000-07-04 2002-08-26 Anticancer Therapeutic Inv Sa Bensökende alfapartikkel emitterende radiofarmasöytika
GB0308731D0 (en) 2003-04-15 2003-05-21 Anticancer Therapeutic Inv Sa Method of radiotherapy
US7794691B2 (en) * 2004-06-25 2010-09-14 The European Community, Represented By The European Commission Radionuclides for medical use
EP2497501B1 (en) 2004-06-25 2019-05-01 The European Union, represented by the European Commission Radionuclides for medical use
EP2051968B1 (en) 2006-08-15 2020-04-29 The Regents of the University of California Luminescent macrocyclic lanthanide complexes
IN2012DN00551A (enExample) * 2009-07-22 2015-06-12 Actinium Pharmaceuticals Inc
US20110189088A1 (en) * 2009-12-24 2011-08-04 Lumiphore, Inc. Radiopharmaceutical complexes
ES2496991T3 (es) * 2010-02-12 2014-09-22 Evonik Degussa Gmbh Composición cosmética que contiene éster parcial de poliglicerol
GB201208309D0 (en) 2012-05-11 2012-06-27 Algeta As Complexes

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2008085064A2 (en) * 2007-01-11 2008-07-17 Ge Healthcare As Hydroxypyridinone chelating agents, their metal complexes and their use as mri contrast agents
WO2011098611A2 (en) * 2010-02-12 2011-08-18 Algeta As Alpha-emitting complexes

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108601991A (zh) * 2016-01-05 2018-09-28 拜耳公司 提纯方法
CN108778347A (zh) * 2016-03-24 2018-11-09 拜耳制药股份公司 放射性药物配合物
CN115916731A (zh) * 2020-01-23 2023-04-04 瑞德兰有限责任公司 用于制备定制的放射性同位素溶液的系统和方法

Also Published As

Publication number Publication date
EP2846843A1 (en) 2015-03-18
CN104602716A (zh) 2015-05-06
CA2873144C (en) 2021-03-16
JP6211066B2 (ja) 2017-10-11
KR20150092701A (ko) 2015-08-13
WO2013167756A1 (en) 2013-11-14
JP6219372B2 (ja) 2017-10-25
EP2846844B1 (en) 2020-04-01
WO2013167754A1 (en) 2013-11-14
CA2873142A1 (en) 2013-11-14
US20150147272A1 (en) 2015-05-28
EP2846844A1 (en) 2015-03-18
US20150104385A1 (en) 2015-04-16
JP2015517482A (ja) 2015-06-22
HK1206982A1 (en) 2016-01-22
CA2873144A1 (en) 2013-11-14
US9827336B2 (en) 2017-11-28
WO2013167755A1 (en) 2013-11-14
CN104619355A (zh) 2015-05-13
JP2015517483A (ja) 2015-06-22
CA2873143A1 (en) 2013-11-14
JP2015523326A (ja) 2015-08-13
KR20150092702A (ko) 2015-08-13
US20150110817A1 (en) 2015-04-23
HK1207307A1 (zh) 2016-01-29
HK1206981A1 (en) 2016-01-22
KR20150092700A (ko) 2015-08-13
GB201208309D0 (en) 2012-06-27
EP2846842A1 (en) 2015-03-18

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