CN104529700A - Purification method for beta-phenylethyl alcohol prepared by bio-fermentation - Google Patents
Purification method for beta-phenylethyl alcohol prepared by bio-fermentation Download PDFInfo
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- CN104529700A CN104529700A CN201410738051.4A CN201410738051A CN104529700A CN 104529700 A CN104529700 A CN 104529700A CN 201410738051 A CN201410738051 A CN 201410738051A CN 104529700 A CN104529700 A CN 104529700A
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- phenethyl alcohol
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
- C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
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Abstract
The invention relates to a purification method for beta-phenylethyl alcohol prepared by bio-fermentation. The method comprises the steps of: 1) pretreatment of a beta-phenylethyl alcohol crude product: taking the beta-phenylethyl alcohol crude product prepared by bio-fermentation as the raw material, removing macromolecular impurities remaining in beta-phenylethyl alcohol through an ultrafiltration device, and collecting permeate liquid; and 2) vacuum precise rectification purification: adding the permeate liquid into a precise rectification tower, conducting vacuum precise rectification to remove low-boiling point impurities and high-boiling point impurities respectively, thus finally obtaining the beta-phenylethyl alcohol product with purity higher than 99.9%. Compared with the prior art, the method provided by the invention adopts the way of filtering the crude product by an ultrafiltration assembly and then performing rectification, is especially suitable for purification of the beta-phenylethyl alcohol product prepared by bio-fermentation, and the obtained product has high purity, which reaches more than 99.9%.
Description
Technical field
The present invention relates to a kind of purification process of bata-phenethyl alcohol, be related specifically to the purification process of bata-phenethyl alcohol prepared by biological fermentation process.
Background technology
Bata-phenethyl alcohol is a kind of aromatic alcohol with pure and fresh simple and elegant fine and smooth rose scent, is widely used in the household chemicals field such as washing composition, makeup and food applications field.Bata-phenethyl alcohol, can also by yeast self-assembling formation during the fermentation except by except plant-scale chemosynthesis.During the fermentation, most of yeast can produce potato spirit, and bata-phenethyl alcohol is the important component part of potato spirit, also be the key factor determining leavened food quality, such as, in pure mellow wine, bata-phenethyl alcohol concentration is 20 ~ 70mg/L, higher than 100mg/L in yellow rice wine.Yeast cell can start anew to synthesize, and also can transform L-Phe by amino acid catabolic pathway and generate bata-phenethyl alcohol.Raising along with people's living standard and the concern to health, human consumer more and more payes attention to the security of food, foodstuff production is more and more inclined to use natural additive for foodstuff, in Europe and the U.S., the spices indicating " natural " must adopt Physical, enzyme process or microbial method process natural resources to produce.At present, natural bata-phenethyl alcohol is mainly produced with microbial transformation L-Phe method, and mainly concentrate on the developed countries such as France, Germany, Japan, the production that China's biological fermentation process produces natural bata-phenethyl alcohol is at the early-stage.
Usually, what fragrance component existence was micro-affects its former aromatic impurity, and its value of the product also can significantly reduce, therefore very high to the purification requirements of spices.Report the bata-phenethyl alcohol adopting the method purifying chemical synthesis of extractive distillation to prepare in patent CN 1170797C, comprise the process using extraction solvent to carry out extractive distillation to bata-phenethyl alcohol crude product and use another solvent to extract the extraction solvent that extractive distillation process uses.Patent CN101583584B reports the method for the bata-phenethyl alcohol adopting the mode purifying chemical synthesis of side take-off to prepare, need the thick product of bata-phenethyl alcohol carrying out purifying after heavy separating step, alkali cleaning step, extractive distillation method are separated the impurity that gently boils, carry out distillation operation, bata-phenethyl alcohol product takes out from the middle part of rectifying tower.The purification process of the two kinds of bata-phenethyl alcohols reported in prior art is mainly to the bata-phenethyl alcohol exploitation that chemical synthesis prepares, purge process is mainly for impurity such as the phenylacetic aldehyde that may generate in chemical reaction process, vinylbenzene, purge process all adopts the unit operation of extractive distillation and liquid-liquid extraction, there is the hidden danger introducing new impurity in raw material.
Comprehensive above documents and materials are known, and along with the raising of people's living standard, natural bata-phenethyl alcohol will be more and more extensive in the application of field of food.Usually, though fragrance component exist trace affect its former aromatic impurity, its value of the product also can significantly reduce, and therefore the purification process of fragrance component is particularly important.But, in prior art, do not have the purification process of the natural perfume bata-phenethyl alcohol prepared about biological fermentation process.
Summary of the invention
Object of the present invention be exactly provide to overcome defect that above-mentioned prior art exists a kind of purity higher than 99.9% the purification process of bata-phenethyl alcohol prepared of biological fermentation process.
Object of the present invention can be achieved through the following technical solutions: the purification process of bata-phenethyl alcohol prepared by a kind of biological fermentation process, is characterized in that, comprise the following steps:
1) pre-treatment of the thick product of bata-phenethyl alcohol: the thick product of the bata-phenethyl alcohol prepared with biological fermentation process is raw material, by macromole impurity residual in ultra-filtration equipment removing bata-phenethyl alcohol, collects permeate;
2) vacuum precision rectification and purification: permeate joined in precise rectification tower, removes lower-boiling impurity, high-boiling-point impurity respectively through vacuum precision rectifying, finally obtain purity higher than 99.9% bata-phenethyl alcohol product.
The ultra-filtration membrane that described ultra-filtration equipment adopts is the one of flat sheet membrane, rolled film, hollow-fibre membrane, tubular membrane; The material of described ultra-filtration membrane is organic film material, stainless steel membrane material or ceramic membrane materials; Described organic film material comprises polysulfones, polyolefins, polyamide-based, polycarbonate-based, polyvinyl chloride.
The molecular weight cut-off of described ultra-filtration membrane is 1000 ~ 100000.
The molecular weight cut-off of described ultra-filtration membrane preferably 2000 ~ 10000.
The working pressure of described precise rectification tower is 0 ~ 500mmHg.
The working pressure of described precise rectification tower is preferably 5 ~ 100mmHg.
The working pressure of described precise rectification tower most preferably is 10 ~ 50mmHg.
Described precise rectification tower is packing tower, be filled with high efficiency separation filler in tower, described high efficiency separation filler is the one of metal sheet corrugated regular filler, wire cloth structured packing, metal mesh opening ripple packing, grid packing, Impulse packing or efficient random packing.
Described vacuum precision rectifying is continuous rectification or batch fractionating.
Purity uses in fragrance component higher than the bata-phenethyl alcohol of 99.9%.
Compared with prior art, the inventive method comprises using and has bioactive macromole impurity in ultra-filtration technique removing bata-phenethyl alcohol thick product; The thick product of bata-phenethyl alcohol after uf processing removes impurity through vacuum precision distillation technology, obtain purity higher than 99.9% the bata-phenethyl alcohol product with the flavouring essence quality being similar to the bata-phenethyl alcohol extracted from Flos Rosae Rugosae quintessence oil, this product can be used for food service industry.
Accompanying drawing explanation
Fig. 1 is the process flow diagram of the embodiment of the present invention 1;
Fig. 2 is the gas chromatogram of the product that the embodiment of the present invention 1 gathers;
Fig. 3 is the process flow diagram of the embodiment of the present invention 2;
In figure: head tank 1, topping-up pump 2, hyperfiltration membrane assembly 3, rectifying tower a4, rectifying tower b8, storage tank a5, storage tank b51, storage tank c52, storage tank d9, connect vacuum system pipeline 6, material-handling pump 7.
Embodiment
Elaborate to embodiments of the invention below, the present embodiment is implemented under premised on technical solution of the present invention, give detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
Embodiment 1
As shown in Figure 1, what biological fermentation process prepared inserts in head tank 1 containing the thick product of 85wt% bata-phenethyl alcohol, be conducted through hyperfiltration membrane assembly 3 by topping-up pump 2 to filter, hyperfiltration membrane assembly 3 selects molecular weight cut-off to be the polysulfones film of 3KD, and liquor inlet pressure is 3 × 10
5pa, top hole pressure is 0.6 × 10
5pa, collects permeate.
Permeate joined in the tower reactor of rectifying tower a4, adopt batch fractionating mode, whole operating system connects vacuum system carry out vacuum precision distillation operation by connecing vacuum system pipeline 6.The structured packing of rectifying tower a4 in-built raising effect wire cloth, packed height 5m, rectifying tower a4 operates under absolute pressure 10mmHg.In rectifying, first be the lower-boiling impurities of 4: 1 collection tower tops with reflux ratio, then with the mode of varying reflux ratio gather purity higher than 99.9% bata-phenethyl alcohol product, the reflux ratio of adopting the product stage is transitioned into 5: 1 gradually by 1: 1, after product collection terminates, gather product and put into storage tank b51, c52, release high-boiling-point impurity from rectifying tower a4 tower reactor.As shown in Figure 2, the chromatographic peak that in figure, 5.484min is corresponding is product bata-phenethyl alcohol to the gas-chromatography spectrogram of the product gathered, and purity is 99.95%, and flavouring essence quality is similar to the flavouring essence quality of the bata-phenethyl alcohol extracted from Flos Rosae Rugosae quintessence oil.
Embodiment 2
As shown in Figure 3, what biological fermentation process prepared is placed in head tank 1 containing the thick product of 90wt% bata-phenethyl alcohol is unified, deliver into hyperfiltration membrane assembly 3 by topping-up pump 2 to filter, hyperfiltration membrane assembly 3 selects molecular weight cut-off to be the ceramic membrane of 10KD, and liquor inlet pressure is 3 × 10
5pa, top hole pressure is 0.3 × 10
5pa, collects permeate.
Permeate is joined the middle part of rectifying tower a4, whole operating system connects vacuum system carry out vacuum precision distillation operation by connecing vacuum system pipeline 6.The random packing of rectifying tower 4 in-built raising effect, packed height 2m, rectifying tower a4 operates under absolute pressure 5mmHg.In rectifying.Tower top with reflux ratio 2: 1 continuous acquisition lower-boiling impurity, the continuous extraction material of tower reactor.Storage tank a5 inserted by rectifying tower a4 overhead extraction material, the material of tower reactor extraction is transported to the middle part of rectifying tower b8 by material-handling pump 7, proceed vacuum precision distillation operation, filling random packing in rectifying tower b8 tower, packed height 3m, rectifying tower b8 tower top absolute pressure 5mmHg, tower top gather purity higher than 99.9% bata-phenethyl alcohol product, insert in storage tank d9, release high-boiling-point impurity from rectifying tower 8 tower reactor simultaneously.The purity of gas chromatographic analysis result display bata-phenethyl alcohol product is 99.97%, and flavouring essence quality is similar to the flavouring essence quality extracting the bata-phenethyl alcohol obtained from Flos Rosae Rugosae quintessence oil.
Embodiment 3
A purification process for bata-phenethyl alcohol prepared by biological fermentation process, comprises the following steps:
1) pre-treatment of the thick product of bata-phenethyl alcohol: the thick product of the bata-phenethyl alcohol prepared with biological fermentation process is raw material, by macromole impurity residual in ultra-filtration equipment removing bata-phenethyl alcohol, collects permeate; The ultra-filtration membrane that described ultra-filtration equipment adopts to be molecular weight cut-off be 1000 flat sheet membrane; The material of described ultra-filtration membrane is polysulfones organic film material.
2) vacuum precision rectification and purification: permeate joined in precise rectification tower, removes lower-boiling impurity, high-boiling-point impurity respectively through vacuum precision rectifying, finally obtain purity higher than 99.9% bata-phenethyl alcohol product.
The working pressure of described precise rectification tower is 0mmHg.Described precise rectification tower is packing tower, is filled with high efficiency separation filler in tower, and described high efficiency separation filler is metal sheet corrugated regular filler.Described vacuum precision rectifying is continuous rectification.
Purity uses in fragrance component higher than the bata-phenethyl alcohol of 99.9%.
Embodiment 4
A purification process for bata-phenethyl alcohol prepared by biological fermentation process, comprises the following steps:
1) pre-treatment of the thick product of bata-phenethyl alcohol: the thick product of the bata-phenethyl alcohol prepared with biological fermentation process is raw material, by macromole impurity residual in ultra-filtration equipment removing bata-phenethyl alcohol, collects permeate; The ultra-filtration membrane that described ultra-filtration equipment adopts to be molecular weight cut-off be 2000 hollow-fibre membrane; The material of described ultra-filtration membrane is polyolefins organic film material.
2) vacuum precision rectification and purification: permeate joined in precise rectification tower, removes lower-boiling impurity, high-boiling-point impurity respectively through vacuum precision rectifying, finally obtain purity higher than 99.9% bata-phenethyl alcohol product.The working pressure of described precise rectification tower is preferably 5mmHg.Described precise rectification tower is packing tower, is filled with high efficiency separation filler in tower, and described high efficiency separation filler is metal mesh opening ripple packing.Described vacuum precision rectifying is batch fractionating.
Purity uses in fragrance component higher than the bata-phenethyl alcohol of 99.9%.
Embodiment 5
A purification process for bata-phenethyl alcohol prepared by biological fermentation process, comprises the following steps:
1) pre-treatment of the thick product of bata-phenethyl alcohol: the thick product of the bata-phenethyl alcohol prepared with biological fermentation process is raw material, by macromole impurity residual in ultra-filtration equipment removing bata-phenethyl alcohol, collects permeate; The ultra-filtration membrane that described ultra-filtration equipment adopts to be molecular weight cut-off be 100000 rolled film; The material of described ultra-filtration membrane is pvc material.
2) vacuum precision rectification and purification: permeate joined in precise rectification tower, removes lower-boiling impurity, high-boiling-point impurity respectively through vacuum precision rectifying, finally obtain purity higher than 99.9% bata-phenethyl alcohol product.
The working pressure of described precise rectification tower is 500mmHg.Described precise rectification tower is packing tower, is filled with high efficiency separation filler in tower, and described high efficiency separation filler is metal sheet corrugated regular filler.Described vacuum precision rectifying is continuous rectification.
Purity uses in fragrance component higher than the bata-phenethyl alcohol of 99.9%.
Embodiment 6
A purification process for bata-phenethyl alcohol prepared by biological fermentation process, comprises the following steps:
1) pre-treatment of the thick product of bata-phenethyl alcohol: the thick product of the bata-phenethyl alcohol prepared with biological fermentation process is raw material, by macromole impurity residual in ultra-filtration equipment removing bata-phenethyl alcohol, collects permeate; The ultra-filtration membrane that described ultra-filtration equipment adopts to be molecular weight cut-off be 5000 tubular membrane; The material of described ultra-filtration membrane is polyamide-based organic film material.
2) vacuum precision rectification and purification: permeate joined in precise rectification tower, removes lower-boiling impurity, high-boiling-point impurity respectively through vacuum precision rectifying, finally obtain purity higher than 99.9% bata-phenethyl alcohol product.
The working pressure of described precise rectification tower is 10mmHg.Described precise rectification tower is packing tower, is filled with high efficiency separation filler in tower, and described high efficiency separation filler is Impulse packing.Purity uses in fragrance component higher than the bata-phenethyl alcohol of 99.9%.
Embodiment 7
A purification process for bata-phenethyl alcohol prepared by biological fermentation process, comprises the following steps:
1) pre-treatment of the thick product of bata-phenethyl alcohol: the thick product of the bata-phenethyl alcohol prepared with biological fermentation process is raw material, by macromole impurity residual in ultra-filtration equipment removing bata-phenethyl alcohol, collects permeate; The ultra-filtration membrane that described ultra-filtration equipment adopts to be molecular weight cut-off be 10000 hollow-fibre membrane; The material of described ultra-filtration membrane is polyolefins organic film material.
2) vacuum precision rectification and purification: permeate joined in precise rectification tower, removes lower-boiling impurity, high-boiling-point impurity respectively through vacuum precision rectifying, finally obtain purity higher than 99.9% bata-phenethyl alcohol product.
The working pressure of described precise rectification tower is preferably 100mmHg.Described precise rectification tower is packing tower, is filled with high efficiency separation filler in tower, and described high efficiency separation filler is metal mesh opening ripple packing.Described vacuum precision rectifying is batch fractionating.
Purity uses in fragrance component higher than the bata-phenethyl alcohol of 99.9%.
Claims (10)
1. the purification process of bata-phenethyl alcohol prepared of biological fermentation process, is characterized in that, comprise the following steps:
1) pre-treatment of the thick product of bata-phenethyl alcohol: the thick product of the bata-phenethyl alcohol prepared with biological fermentation process is raw material, by macromole impurity residual in ultra-filtration equipment removing bata-phenethyl alcohol, collects permeate;
2) vacuum precision rectification and purification: permeate joined in precise rectification tower, removes lower-boiling impurity, high-boiling-point impurity respectively through vacuum precision rectifying, finally obtain purity higher than 99.9% bata-phenethyl alcohol product.
2. the purification process of bata-phenethyl alcohol prepared of biological fermentation process according to claim 1, it is characterized in that, the ultra-filtration membrane that described ultra-filtration equipment adopts is the one of flat sheet membrane, rolled film, hollow-fibre membrane, tubular membrane; The material of described ultra-filtration membrane is organic film material, stainless steel membrane material or ceramic membrane materials; Described organic film material comprises polysulfones, polyolefins, polyamide-based, polycarbonate-based, polyvinyl chloride.
3. the purification process of bata-phenethyl alcohol prepared of biological fermentation process according to claim 2, it is characterized in that, the molecular weight cut-off of described ultra-filtration membrane is 1000 ~ 100000.
4. the purification process of bata-phenethyl alcohol prepared of biological fermentation process according to claim 3, is characterized in that, the molecular weight cut-off of described ultra-filtration membrane preferably 2000 ~ 10000.
5. the purification process of bata-phenethyl alcohol prepared of biological fermentation process according to claim 1, it is characterized in that, the working pressure of described precise rectification tower is 0 ~ 500mmHg.
6. the purification process of bata-phenethyl alcohol prepared of biological fermentation process according to claim 5, it is characterized in that, the working pressure of described precise rectification tower is preferably 5 ~ 100mmHg.
7. the purification process of bata-phenethyl alcohol prepared of biological fermentation process according to claim 6, it is characterized in that, the working pressure of described precise rectification tower most preferably is 10 ~ 50mmHg.
8. the purification process of bata-phenethyl alcohol prepared of biological fermentation process according to claim 1, it is characterized in that, described precise rectification tower is packing tower, be filled with high efficiency separation filler in tower, described high efficiency separation filler is the one of metal sheet corrugated regular filler, wire cloth structured packing, metal mesh opening ripple packing, grid packing, Impulse packing or efficient random packing.
9. the purification process of bata-phenethyl alcohol prepared of biological fermentation process according to claim 1, it is characterized in that, described vacuum precision rectifying is continuous rectification or batch fractionating.
10. the purification process of bata-phenethyl alcohol prepared of biological fermentation process according to claim 1, it is characterized in that, purity uses in fragrance component higher than the bata-phenethyl alcohol of 99.9%.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110028384A (en) * | 2019-03-15 | 2019-07-19 | 江西省科学院微生物研究所 | A method of molecular distillation separation prepares 2 phenylethyl alcohol from bioconversion broth |
| CN115974650A (en) * | 2022-12-15 | 2023-04-18 | 南京化学试剂股份有限公司 | Method for efficiently producing phenethyl alcohol |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101583584A (en) * | 2007-01-18 | 2009-11-18 | 住友化学株式会社 | Method for purification of ss-phenylethyl alcohol |
| CN101723805A (en) * | 2009-12-08 | 2010-06-09 | 浙江工业大学 | Separation method for preparing natural 2-phenylethyl alcohol by biotransformation method |
-
2014
- 2014-12-05 CN CN201410738051.4A patent/CN104529700A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101583584A (en) * | 2007-01-18 | 2009-11-18 | 住友化学株式会社 | Method for purification of ss-phenylethyl alcohol |
| CN101723805A (en) * | 2009-12-08 | 2010-06-09 | 浙江工业大学 | Separation method for preparing natural 2-phenylethyl alcohol by biotransformation method |
Non-Patent Citations (1)
| Title |
|---|
| 李会静等: "微生物转化生产2-苯乙醇的原位产物转移技术研究进展", 《化工进展》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110028384A (en) * | 2019-03-15 | 2019-07-19 | 江西省科学院微生物研究所 | A method of molecular distillation separation prepares 2 phenylethyl alcohol from bioconversion broth |
| CN110028384B (en) * | 2019-03-15 | 2020-06-26 | 江西省科学院微生物研究所 | Method for preparing 2-phenethyl alcohol from biotransformation liquid by molecular distillation and separation |
| CN115974650A (en) * | 2022-12-15 | 2023-04-18 | 南京化学试剂股份有限公司 | Method for efficiently producing phenethyl alcohol |
| CN115974650B (en) * | 2022-12-15 | 2023-11-24 | 南京化学试剂股份有限公司 | Method for efficiently producing phenethyl alcohol |
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Application publication date: 20150422 |