CN104513964A - Method for modification treatment of artificial joint through magnetron sputtering - Google Patents
Method for modification treatment of artificial joint through magnetron sputtering Download PDFInfo
- Publication number
- CN104513964A CN104513964A CN201310460063.0A CN201310460063A CN104513964A CN 104513964 A CN104513964 A CN 104513964A CN 201310460063 A CN201310460063 A CN 201310460063A CN 104513964 A CN104513964 A CN 104513964A
- Authority
- CN
- China
- Prior art keywords
- joint prosthesis
- titanium dioxide
- composite film
- dioxide composite
- artificial joint
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The present invention discloses an artificial joint being subjected to a surface modification treatment, wherein a rare earth element-doped titanium dioxide composite film is uniformly coated on the surface of the artificial joint, the thickness of the titanium dioxide composite film is 20-600 nm, preferably 60-300 nm, the molar content of the rare earth element in the titanium dioxide composite film is 0.1-20%, preferably 0.2-10%, and the titanium dioxide composite film being subjected to rare earth element doping can be deposited on the artificial joint substrate surface through the magnetron sputtering technology, such that the anticoagulant biological coating can be synthesized on the artificial joint surface with the complex shape. According to the present invention, the blood compatibility and the wear resistance of the artificial joint treated by the method of the present invention are comprehensively improved.
Description
Technical field
The invention belongs to magnetron sputtering technology field, particularly a kind of method of joint prosthesis modification.
Background technology
Along with the raising of people's living standard and the progress of medical skill, joint prosthesis has been widely used in clinical treatment.These implant great majority are made up of titanium alloy.Due to such Biocompatibility can shortcoming, will produce a series of biochemical reaction when them and blood or bioresorbable, cause platelet adhesion reaction formation thrombus, or the biological respinse such as initiation sensitization, toxicity, inflammation, produce some physiology negative interaction in vivo.Therefore, the synthesis of biocompatible materials and the surface modification of interplantation joint prosthesis are one of key areas of bio-medical material research, and the development of novel anticoagulation biological coating material is international study hotspot all the time.
In recent years, the blood compatibility that titanium dioxide is good causes the extensive concern of researcher.Although can realize plane, simple joint prosthesis plated film, but then cannot carry out comprehensive plated film to curved surface, complicated joint prosthesis (the lobe frame surface as heart valve prosthesis), performance and the security in the joint prosthesis joint therefore obtained by traditional method are difficult to be guaranteed.And existing joint prosthesis joint, its endurance quality is better improved, but anticoagulation function still needs further raising.
Therefore, be necessary the joint prosthesis that anticoagulation function is provided, to solve the urgent requirement on Present clinical.
Summary of the invention
The object of this invention is to provide a kind of joint prosthesis surface treatment method with excellent anticoagulation function.
For realizing above-mentioned aspect object, on the one hand, the invention provides a kind of joint prosthesis through surface modification treatment, the surface uniform of this joint prosthesis is coated with the titanium dioxide composite film through light rare earths doping, the thickness of this titanium dioxide composite film is 20-600 nanometer, is preferably 60-300 nanometer; Wherein, the molar content of rare earth element in titanium dioxide composite film is 0.1%-20%, is preferably 0.2% ~ 10%.
The titanium dioxide composite anticoagulation material that the present invention adopts light rare earths to adulterate, and make the coating using it as joint prosthesis, thus make the joint prosthesis through surface modification treatment like this have good anticoagulation function.Rare earth compound has multiple drug action, and such as it has more excellent anticoagulation function and anti-inflammatory, the effect such as antibacterial and antitumor.The toxicologic research of long-term rare earth shows that rare earth belongs to hypotoxicity material, and almost, appropriate absorption contributes to the immunological competence improving body for its toxicity and iron.Thus, the titanium dioxide composite film that the present invention adopts light rare earths to adulterate comes modifying artificial joint, have received beyond thought effect.
In joint prosthesis of the present invention, the thickness of titanium dioxide composite film should control in 20-600 nanometer range; Because when the thickness of this composite membrane is less than 20 nanometers, then be difficult to form even, continuous print anticoagulation film on the surface of joint prosthesis, and when the thickness of this composite membrane is greater than 600 nanometer, the combination of itself and joint prosthesis matrix is through more strict process, otherwise this composite membrane easily comes off from matrix.Preferably, the thickness of titanium dioxide composite film is 60-300 nanometer.
The matrix of joint prosthesis of the present invention can be titanium alloy or stainless steel, as long as it is applicable to sputtering.
Preferably, the molar content of rare earth element in titanium dioxide composite film is 0.50% ~ 5%.
In joint prosthesis of the present invention, the titanium dioxide composite film through light rare earths doping can be on the surface by magnetron sputtering technique deposition joint prosthesis matrix; The target that sputtering sedimentation adopts is preferably the nano TiO 2 powder of light rare earths doping.The advantage adopting nano-powder is the composite membrane that easy acquisition all hooks, and the thickness of this composite membrane preferably only has 60-300 nanometer.Adopt magnetron sputtering technique to carry out sputtering sedimentation and have many advantages, such as, can carry out uniform comprehensive overlay film to joint prosthesis that is complex-shaped, curved surface; When such as adopting again multi sphere Magnetic filter vacuum sputtering ion deposition technology, the neutral particle that magnetic filter can produce sputtering and macroparticle filter out, and will almost guide on matrix and form composite membrane by 100% Ionized ion, substantially improve the performance of composite membrane, as binding property, homogeneity etc.
Sputtering sedimentation of the present invention also can be the rf magnetron sputtering applying radio-frequency voltage on composition target, and wherein, radio frequency power controls at 200 ~ 500 watts, and radio-frequency voltage controls at 800 ~ 1000 volts, and operating air pressure controls 10
-2~ 10
1handkerchief.
The present invention compared with prior art, adopt the light rare earths titania-doped anticoagulation biological coating film synthesized by aforesaid method, its advantage is: synthesized light rare earths titania-doped anticoagulation biological coating film blood compatibility is fabulous, comprehensive modification can be realized to complex-shaped joint prosthesis, evenly reliable, can industrial applications be realized; The anticoagulation function of the surface reforming layer obtained by these doping oxides is significantly better than the internationally recognized Artificial heart valve mould material of current Clinical practice, and modified coating easy control of components, reproducible, reliability is high.In a word, the blood compatibility of the joint prosthesis adopting method process of the present invention to obtain, anticorrosive and wear resisting property is improved comprehensively.
Embodiment
The nano TiO 2 powder that light rare earths adulterates is pressed into target according to the specification requirement of magnetron sputtering equipment, is placed on the target platform of magnetron sputtering equipment, needs the joint prosthesis of modification to be placed in sample table, be evacuated to 1x10
-4handkerchief, the argon gas of logical people's certain pressure, open shielding power supply, owing to being added with radio-frequency voltage on platform, form argon plasma, the titania-doped compound handle of argon ion bombardment light rare earths, the titanium of generation, rare earth element, Sauerstoffatom are deposited on artificial organs surface, have synthesized the titanium deoxid film of light rare earths doping.The parameter controlling film performance in sputter procedure is: radio frequency power 200 ~ 500 watts, radio-frequency voltage 800 ~ 1000 volts, operating air pressure 10
-2~ 10
1handkerchief, sample heating temperature is room temperature ~ 500 DEG C, and sputtering time is 0.1 ~ 3 hour.The thickness of the titanium dioxide composite film coating obtained is between 20-600 nanometer.
Claims (6)
1. the joint prosthesis through surface modification treatment, it is characterized in that, the surface of this joint prosthesis all hooks the titanium dioxide composite film be coated with through light rare earths doping, the thickness of this titanium dioxide composite film is 20-600 nanometer, be preferably 60-300 nanometer, the molar content of rare earth element in titanium dioxide composite film is that 0.1%-20% is preferably 0.2% ~ 10%.
2. joint prosthesis according to claim 1, is characterized in that, the matrix of this joint prosthesis is titanium alloy or stainless steel.
3. joint prosthesis according to claim 1, is characterized in that, the molar content of described rare earth element in described titanium dioxide composite film is 0.5% ~ 5%.
4. the joint prosthesis that one of claim 1-3 is described, is characterized in that, the described titanium dioxide composite film through light rare earths doping is deposited by magnetron sputtering technique on the surface of described joint prosthesis matrix.
5. joint prosthesis according to claim 4, is characterized in that, the target that described sputtering sedimentation adopts is the nano TiO 2 powder of light rare earths doping.
6. joint prosthesis according to claim 4, is characterized in that, described sputtering sedimentation applies rf magnetron sputtering on described composition target, wherein, and radio frequency power 200 ~ 500W, radio-frequency voltage 800 ~ 1000 volts, operating air pressure 10
-2~ 10
1pa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310460063.0A CN104513964A (en) | 2013-09-29 | 2013-09-29 | Method for modification treatment of artificial joint through magnetron sputtering |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310460063.0A CN104513964A (en) | 2013-09-29 | 2013-09-29 | Method for modification treatment of artificial joint through magnetron sputtering |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104513964A true CN104513964A (en) | 2015-04-15 |
Family
ID=52789834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310460063.0A Pending CN104513964A (en) | 2013-09-29 | 2013-09-29 | Method for modification treatment of artificial joint through magnetron sputtering |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104513964A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107160773A (en) * | 2017-05-11 | 2017-09-15 | 上海洁晟环保科技有限公司 | A kind of composite membrane with infra-red radiation heat sinking function and its production and use |
| CN107335092A (en) * | 2017-07-14 | 2017-11-10 | 贵州大学 | It is a kind of to be used to prevent Ca P coatings of abrasive dust disease and preparation method thereof |
-
2013
- 2013-09-29 CN CN201310460063.0A patent/CN104513964A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107160773A (en) * | 2017-05-11 | 2017-09-15 | 上海洁晟环保科技有限公司 | A kind of composite membrane with infra-red radiation heat sinking function and its production and use |
| CN107335092A (en) * | 2017-07-14 | 2017-11-10 | 贵州大学 | It is a kind of to be used to prevent Ca P coatings of abrasive dust disease and preparation method thereof |
| CN107335092B (en) * | 2017-07-14 | 2020-08-07 | 贵州大学 | Ca-P coating for preventing abrasive dust disease and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Zhang et al. | Synthesis and characterization of a bi-functional hydroxyapatite/Cu-doped TiO2 composite coating | |
| Kim et al. | Anodically nanostructured titanium oxides for implant applications | |
| Liu et al. | UV-irradiation-induced bioactivity on TiO2 coatings with nanostructural surface | |
| Zhang et al. | In vitro degradation, photo-dynamic and thermal antibacterial activities of Cu-bearing chlorophyllin-induced Ca–P coating on magnesium alloy AZ31 | |
| CN106835011A (en) | A kind of structural member with Diamond-like Carbon array and preparation method thereof | |
| Sun et al. | Hydroxyapatite coatings prepared by micro-arc oxidation in Ca-and P-containing electrolyte | |
| Lee et al. | The biocompatibility of HA thin films deposition on anodized titanium alloys | |
| WO2001048262A1 (en) | Method for forming a tio2-x film on a material surface by using plasma immersion ion implantation and the use thereof | |
| CN102286767B (en) | Composite coating on surface of magnesium alloy biological implant material and preparation method thereof | |
| Lee et al. | Hydroxyapatite coating on micropore-formed titanium alloy utilizing electrochemical deposition | |
| CN103924202A (en) | Metal support surface modification method | |
| JP6154884B2 (en) | Strontium-containing coating for body implants | |
| CN104213091B (en) | Method for improving bonding property of magnetron sputtering TiN coating on biomedical magnesium alloy surface | |
| CN103882377B (en) | The preparation method of anti-microbial type diamond/alloy/hydroxylapatite gradient polynary nanometer coating | |
| Popa et al. | Submicrometer hollow bioglass cones deposited by radio frequency magnetron sputtering: Formation mechanism, properties, and prospective biomedical applications | |
| Abdel-Hamid et al. | Electrochemical hydroxyapatite-cobalt ferrite nanocomposite coatings as well hyperthermia treatment of cancer | |
| CN101555597A (en) | Preparation method for preparing titanium oxide bioactive coating on the surface of nitinol alloy | |
| Chi et al. | Biomimetic hydroxyapatite grown on biomedical polymer coated with titanium dioxide interlayer to assist osteocompatible performance | |
| Thanigaiarul et al. | Surface modification of nanocrystalline calcium phosphate bioceramic by low energy nitrogen ion implantation | |
| Yu et al. | Synthesis and biological properties of Zn-incorporated micro/nano-textured surface on Ti by high current anodization | |
| CN104513964A (en) | Method for modification treatment of artificial joint through magnetron sputtering | |
| Khokhlova et al. | Oxide thin films as bioactive coatings | |
| Wang et al. | Cytotoxicity and antibacterial efficacy of silver nanoparticles deposited onto dopamine-functionalised titanium | |
| Chu et al. | Micro-nano hierarchical porous titania modified with ZnO nanorods for biomedical applications | |
| Ren et al. | Enhanced self-lubricating and antibacterial activity by building hard-yet-tough Ta-Ag-N films on Ti-6Al-4V |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DD01 | Delivery of document by public notice |
Addressee: WUXI HUIMING ELECTRONIC TECHNOLOGY CO., LTD. Document name: Notification of Passing Preliminary Examination of the Application for Invention |
|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150415 |