CN104511031A - Cecropin antibacterial peptide fermentation sterilization equipment and sterilization method thereof - Google Patents
Cecropin antibacterial peptide fermentation sterilization equipment and sterilization method thereof Download PDFInfo
- Publication number
- CN104511031A CN104511031A CN201310450659.2A CN201310450659A CN104511031A CN 104511031 A CN104511031 A CN 104511031A CN 201310450659 A CN201310450659 A CN 201310450659A CN 104511031 A CN104511031 A CN 104511031A
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- steam
- air
- sterilization
- heated
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- 230000001954 sterilising effect Effects 0.000 title claims abstract description 82
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 57
- 238000000034 method Methods 0.000 title claims abstract description 22
- 108050004290 Cecropin Proteins 0.000 title claims abstract description 20
- 238000000855 fermentation Methods 0.000 title claims abstract description 20
- 230000004151 fermentation Effects 0.000 title claims abstract description 20
- 239000003910 polypeptide antibiotic agent Substances 0.000 title abstract description 5
- 239000007788 liquid Substances 0.000 claims abstract description 26
- 238000003756 stirring Methods 0.000 claims abstract description 22
- 238000009434 installation Methods 0.000 claims description 11
- 208000033999 Device damage Diseases 0.000 abstract 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000382353 Pupa Species 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
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- Apparatus For Disinfection Or Sterilisation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Fertilizers (AREA)
- Processing Of Solid Wastes (AREA)
Abstract
The invention provides cecropin antibacterial peptide fermentation sterilization equipment and a sterilization method thereof. The equipment includes a sterilization tank and a stirrer mounted in the sterilization tank, three steam pipelines are disposed at the bottom of the sterilization tank, and one of the steam pipelines is connected to an air pipeline. The invention also includes a sterilization method. According to the invention, one steam pipeline is provided with the air pipeline so that air can enter at the same time, steam and air are fed simultaneously, air makes the steam disperse rapidly, a feed liquid can be heated evenly, sound and vibration can be reduced to avoid device damage, and also influence to the work environment is reduced. According to the invention, when the feed liquid is heated to 110DEG C, stirring can be stopped, and electric energy is saved.
Description
Technical field
The present invention relates to biological fermentation field, be specifically related to a kind of cecropin antimicrobial peptides fermentation and sterilization equipment and sterilizing methods thereof.
Background technology
Cecropin antimicrobial peptides is first Antibacterial Peptide From Animals be found, and 1980, is separated obtains by Boman etc. from sky Pupa bombycis.This kind of active polypeptide majority has the features such as strong basicity, heat stability and broad-spectrum antiseptic, and antibacterial peptide has very strong lethal effect to antibacterial, and especially it more causes the attention of people to the killing action of some drug resistance pathogen.
During current antibacterial peptide fermenting and producing sterilizing, that directly inside sterilization tank, logical high-temperature steam carries out sterilizing, during owing to just starting, feed temperature is lower, and vapor (steam) temperature is high, and Temperature Difference Ratio is larger, some feed liquid quick heatings, some intensifications are slow, and feed liquid is heated uneven, can produce huge sound and vibrations, large to sterilizing installation damage comparison, also affect working environment.
Summary of the invention
Give birth to the problem of huge sound and vibrations when the present invention is directed to above-mentioned existing feed liquid sterilizing, a kind of cecropin antimicrobial peptides fermentation and sterilization equipment and sterilizing methods thereof are provided, strong sound and vibrations can not be produced during its sterilizing, proterctive equipment.
The technical scheme that the present invention takes is:
A kind of cecropin antimicrobial peptides fermentation and sterilization equipment, comprises sterilization tank and is arranged on the agitator in sterilization tank, be provided with three jet chimneys, one of them jet chimney is connected with air line bottom sterilization tank.
Described air line is provided with control valve.
Utilize above-mentioned sterilizing installation to carry out a method for cecropin antimicrobial peptides fermentation and sterilization, comprise the steps:
(1) air, steam sterilization: after feed liquid enters sterilization tank, the jet chimney being connected with air line enters steam and air simultaneously, steam input 550-650 m
3/ hour, air input is 150-250m
3/ hour; Another two jet chimney lists enter steam, steam input 750-850 m
3/ hour, vapor (steam) temperature is 135 DEG C-145 DEG C, stirs simultaneously;
(2) when feed temperature is heated to 85-95 DEG C, stop into air;
(3) when feed temperature is heated to 105-115 DEG C, stop stirring;
(4) feed liquid is heated to 115-125 DEG C, sterilization 25-35 minute.
Utilize above-mentioned sterilizing installation to carry out a method for cecropin antimicrobial peptides fermentation and sterilization, comprise the steps:
(1), air, steam sterilization: after feed liquid enters sterilization tank, the jet chimney being connected with air line enters steam and air simultaneously, steam input 600 m
3/ hour, air input is 200m
3/ hour; Another two jet chimney lists enter steam, steam input 800 m
3/ hour, vapor (steam) temperature is 135 DEG C-145 DEG C, stirs simultaneously;
(2), when feed temperature is heated to 90 DEG C, stop into air;
(3), when feed temperature is heated to 110 DEG C, stop stirring;
(4), by feed liquid be heated to 120 DEG C, sterilize 30 minutes.
The present invention is provided with air line on a jet chimney, air can be entered simultaneously, enter steam and air during sterilizing of the present invention, air makes steam disperse rapidly simultaneously, and feed liquid is heated evenly, reduce sound and vibrations, avoid damage equipment, decrease the impact on working environment, the present invention is heated to 110 DEG C at feed temperature, just can stop stirring, save electric energy.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Detailed description of the invention
As shown in Figure 1, a kind of cecropin antimicrobial peptides fermentation and sterilization equipment, the agitator 5 comprising sterilization tank 1 and be arranged in sterilization tank 1, is provided with three jet chimneys 2 bottom sterilization tank 1, one of them jet chimney is connected with air line 3, air line 3 is provided with control valve 4.
Sterilizing methods embodiment 1: a kind of method utilizing above-mentioned sterilizing installation to carry out cecropin antimicrobial peptides fermentation and sterilization, comprises the steps:
(1), air, steam sterilization: after feed liquid enters sterilization tank, air line is connected with air compressor, and the jet chimney being connected with air line enters steam and air simultaneously, steam input 600 m
3/ hour, air input is 200m
3/ hour; Another two jet chimney lists enter steam, steam input 800 m
3/ hour, vapor (steam) temperature is 135 DEG C-145 DEG C, can be 135 DEG C, 138 DEG C, 140 DEG C, 143 DEG C or 150 DEG C, and namely vapor (steam) temperature can be arbitrary value between 135 DEG C-145 DEG C, and turn on agitator stirs simultaneously;
(2), when feed temperature is heated to 90 DEG C, stop into air because after 90 DEG C, feed temperature and the steam temperature difference smaller, huge sound and vibrations can not be produced;
(3), when feed temperature is heated to 110 DEG C, stop stirring, save electric energy;
(4), by feed liquid be heated to 120 DEG C, sterilize 30 minutes.
Sterilizing methods embodiment 2: a kind of method utilizing above-mentioned sterilizing installation to carry out cecropin antimicrobial peptides fermentation and sterilization, comprises the steps:
(1) air, steam sterilization: after feed liquid enters sterilization tank, the jet chimney being connected with air line enters steam and air simultaneously, steam input 550m
3/ hour, air input is 150m
3/ hour; Another two jet chimney lists enter steam, steam input 750 m
3/ hour, vapor (steam) temperature is 135 DEG C, stirs simultaneously;
(2) when feed temperature is heated to 85 DEG C, stop into air;
(3) when feed temperature is heated to 105 DEG C, stop stirring;
(4) feed liquid is heated to 115 DEG C, sterilizes 25 minutes.
Sterilizing methods embodiment 3: the above-mentioned sterilizing installation of a kind of exploitation right carries out the method for cecropin antimicrobial peptides fermentation and sterilization, comprises the steps:
(1) air, steam sterilization: after feed liquid enters sterilization tank, the jet chimney being connected with air line enters steam and air simultaneously, steam input 650 m
3/ hour, air input is 250m
3/ hour; Another two jet chimney lists enter steam, steam input 850 m
3/ hour, vapor (steam) temperature is 145 DEG C, stirs simultaneously;
(2) when feed temperature is heated to 95 DEG C, stop into air;
(3) when feed temperature is heated to 115 DEG C, stop stirring;
(4) feed liquid is heated to 125 DEG C, sterilizes 35 minutes.
Sterilizing methods embodiment 4: a kind of method utilizing above-mentioned sterilizing installation to carry out cecropin antimicrobial peptides fermentation and sterilization, comprises the steps:
(1) air, steam sterilization: after feed liquid enters sterilization tank, the jet chimney being connected with air line enters steam and air simultaneously, steam input 580 m
3/ hour, air input is 180m
3/ hour; Another two jet chimney lists enter steam, steam input 790 m
3/ hour, vapor (steam) temperature is 139 DEG C, stirs simultaneously;
(2) when feed temperature is heated to 91 DEG C, stop into air;
(3) when feed temperature is heated to 108 DEG C, stop stirring;
(4) feed liquid is heated to 119 DEG C, sterilizes 29 minutes.
Sterilizing methods embodiment 5: a kind of method utilizing the above-mentioned sterilizing installation of right to carry out cecropin antimicrobial peptides fermentation and sterilization, comprises the steps:
(1) air, steam sterilization: after feed liquid enters sterilization tank, the jet chimney being connected with air line enters steam and air simultaneously, steam input 620 m
3/ hour, air input is 220m
3/ hour; Another two jet chimney lists enter steam, steam input 840 m
3/ hour, vapor (steam) temperature is 142 DEG C, stirs simultaneously;
(2) when feed temperature is heated to 92 DEG C, stop into air;
(3) when feed temperature is heated to 110 DEG C, stop stirring;
(4) feed liquid is heated to 111 DEG C, sterilizes 31 minutes.
Sterilizing methods embodiment 6: a kind of sterilizing installation utilizing right above-mentioned carries out the method for cecropin antimicrobial peptides fermentation and sterilization, comprises the steps:
(1) air, steam sterilization: after feed liquid enters sterilization tank, the jet chimney being connected with air line enters steam and air simultaneously, steam input 650 m
3/ hour, air input is 250m
3/ hour; Another two jet chimney lists enter steam, steam input 850 m
3/ hour, vapor (steam) temperature is 145 DEG C, stirs simultaneously;
(2) when feed temperature is heated to 95 DEG C, stop into air;
(3) when feed temperature is heated to 115 DEG C, stop stirring;
(4) feed liquid is heated to 125 DEG C, sterilizes 35 minutes.
Claims (4)
1. a cecropin antimicrobial peptides fermentation and sterilization equipment, comprise sterilization tank (1) and be arranged on the agitator (5) in sterilization tank (1), sterilization tank (1) bottom is provided with three jet chimneys (2), it is characterized in that: one of them jet chimney is connected with air line (3).
2. cecropin antimicrobial peptides fermentation and sterilization equipment according to claim 1, is characterized in that: described air line (3) is provided with control valve (4).
3. utilize the sterilizing installation described in claim 1 or 2 to carry out a method for cecropin antimicrobial peptides fermentation and sterilization, comprise the steps:
(1) air, steam sterilization: after feed liquid enters sterilization tank, the jet chimney being connected with air line enters steam and air simultaneously, steam input 550-650 m
3/ hour, air input is 150-250m
3/ hour; Another two jet chimney lists enter steam, steam input 750-850 m
3/ hour, vapor (steam) temperature is 135 DEG C-145 DEG C, stirs simultaneously;
(2) when feed temperature is heated to 85-95 DEG C, stop into air;
(3) when feed temperature is heated to 105-115 DEG C, stop stirring;
(4) feed liquid is heated to 115-125 DEG C, sterilization 25-35 minute.
4. utilize the sterilizing installation described in claim 3 to carry out a method for cecropin antimicrobial peptides fermentation and sterilization, comprise the steps:
(1) air, steam sterilization: after feed liquid enters sterilization tank, the jet chimney being connected with air line enters steam and air simultaneously, steam input 600 m
3/ hour, air input is 200m
3/ hour; Another two jet chimney lists enter steam, steam input 800 m
3/ hour, vapor (steam) temperature is 135 DEG C-145 DEG C, stirs simultaneously;
(2) when feed temperature is heated to 90 DEG C, stop into air;
(3) when feed temperature is heated to 110 DEG C, stop stirring;
(4) feed liquid is heated to 120 DEG C, sterilizes 30 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310450659.2A CN104511031B (en) | 2013-09-29 | 2013-09-29 | Cecropin antibacterial peptide fermentation sterilization equipment and sterilization method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310450659.2A CN104511031B (en) | 2013-09-29 | 2013-09-29 | Cecropin antibacterial peptide fermentation sterilization equipment and sterilization method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104511031A true CN104511031A (en) | 2015-04-15 |
| CN104511031B CN104511031B (en) | 2017-04-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310450659.2A Active CN104511031B (en) | 2013-09-29 | 2013-09-29 | Cecropin antibacterial peptide fermentation sterilization equipment and sterilization method thereof |
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| CN (1) | CN104511031B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3444321A4 (en) * | 2017-06-01 | 2020-01-15 | Takase Tech Co., Ltd. | Method for producing fuel and device for producing fuel |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008105696A1 (en) * | 2007-03-01 | 2008-09-04 | Getinge Sterilization Ab | Sterilization device, sterilization process, vaporizing system and use of such a vaporizing system |
| CN101974409A (en) * | 2010-11-27 | 2011-02-16 | 福州大北农生物技术有限公司 | Bacterial culture fermentation tank device and fermentation technology thereof |
-
2013
- 2013-09-29 CN CN201310450659.2A patent/CN104511031B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008105696A1 (en) * | 2007-03-01 | 2008-09-04 | Getinge Sterilization Ab | Sterilization device, sterilization process, vaporizing system and use of such a vaporizing system |
| CN101974409A (en) * | 2010-11-27 | 2011-02-16 | 福州大北农生物技术有限公司 | Bacterial culture fermentation tank device and fermentation technology thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3444321A4 (en) * | 2017-06-01 | 2020-01-15 | Takase Tech Co., Ltd. | Method for producing fuel and device for producing fuel |
| TWI782027B (en) * | 2017-06-01 | 2022-11-01 | 日商Ｔａｋａｓｅ Ｔｅｃｈ股份有限公司 | fuel manufacturing method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104511031B (en) | 2017-04-19 |
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Effective date of registration: 20160804 Address after: 456550, No. 8 Luban Road, Linzhou industrial agglomeration area, Anyang, Henan, Linzhou Applicant after: LINZHOU SINAGRI YINGTAI BIOLOGICAL PEPTIDES CO.,LTD. Address before: 456550 No. 8 Luban Road, Linzhou industrial agglomeration, Anyang, Henan Applicant before: SINAGRI YINTHAI LINZHOU BIOLOGICAL PARK CO.,LTD. |
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Denomination of invention: The invention relates to a fermentation and sterilization equipment for cecropin antibacterial peptide and a sterilization method thereof Effective date of registration: 20200812 Granted publication date: 20170419 Pledgee: Anyang Investment Group Co.,Ltd. Pledgor: LINZHOU SINAGRI YINGTAI BIOLOGICAL PEPTIDES Co.,Ltd. Registration number: Y2020980004904 |
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Effective date of registration: 20200903 Granted publication date: 20170419 |
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Date of cancellation: 20220718 Granted publication date: 20170419 Pledgee: Anyang Investment Group Co.,Ltd. Pledgor: LINZHOU SINAGRI YINGTAI BIOLOGICAL PEPTIDES CO.,LTD. Registration number: Y2020980004904 |
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Date of cancellation: 20220926 Granted publication date: 20170419 |
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Denomination of invention: A fermentation sterilization equipment and sterilization method for Tianchansu antibacterial peptide Effective date of registration: 20230414 Granted publication date: 20170419 Pledgee: Anyang Investment Group Co.,Ltd. Pledgor: LINZHOU SINAGRI YINGTAI BIOLOGICAL PEPTIDES CO.,LTD. Registration number: Y2023980038083 |