CN104491894A - Online sterilization device and online sterilization process - Google Patents
Online sterilization device and online sterilization process Download PDFInfo
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- CN104491894A CN104491894A CN201510007395.2A CN201510007395A CN104491894A CN 104491894 A CN104491894 A CN 104491894A CN 201510007395 A CN201510007395 A CN 201510007395A CN 104491894 A CN104491894 A CN 104491894A
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- filter
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- vacuum pump
- filter element
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Abstract
The invention relates to the field of fine chemistry and provides an online sterilization device with a simple structure and capable of performing online sterilization on a filter and an online sterilization process. The online sterilization device comprises a cylindrical filter, wherein a discharge cavity is formed inside a filter element of the cylindrical filter, and a feed cavity is formed outside the filter element and inside a filter shell. The online sterilization device also comprises a feed pipe communicated with the feed cavity, a discharge pipe communicated with the discharge cavity and a vacuum pump communicated with the feed cavity of the filter. The online sterilization process comprises the following steps: (a) completely removing the feed liquid and water in the filter and pipeline system; (b) introducing saturated steam into the filter through the feed pipe; (c) discharging part of the steam through the discharge pipe; (d) starting the vacuum pump for vacuumizing; and (e) repeating the steps from b to d.
Description
Technical field
This technology relates to field of fine chemical, provides a kind of online bactericidal unit and a kind of online sterilization process.
Background technology
Filter element of precision filter needs online sterilizing in process of production, and the temperature of online sterilizing is generally 121 DEG C, is equivalent to the saturated vapour pressure under 0.11MPa.When sterilizing, filter element is moistening, and the filter element after moistening can produce moisture film, and the pure steam under right 0.3MPa all cannot penetrate filter element.Therefore online sterilizing is not thorough.
Summary of the invention
The object of this technology be to provide a kind of structure simple, the online bactericidal unit of online sterilizing and a kind of method is simple, sterilization effect is good online sterilization process can be carried out to filter.
The online bactericidal unit of the one provided in this technology is achieved through the following technical solutions:
This online bactericidal unit, comprises cartridge filter, and cartridge filter filter element is interior is discharging chamber, and filter element is outer, filter housing is interior is feed cavity; Also comprise the feed pipe communicated with feed cavity, the discharge nozzle communicated with discharging chamber; Also comprise the vacuum pump communicated with filter feed cavity.
The beneficial effect of this online bactericidal unit is:
Start vacuum pump evacuation, the steam of filter element is first drawn out of, only remaining aqueous water.Along with the increase of vacuum, in filter housing, absolute pressure reduces, when the absolute pressure in filter housing is reduced to the saturation vapor pressure corresponding with ambient temperature, water remaining in filter housing is boiled into steam, extracted out by continuation, eliminate the moisture film produced in filter element, make steam can penetrate filter element to discharging chamber, to the online sterilizing of filter element.
As the improvement to this online bactericidal unit, vacuum meter is set before vacuum pump and communicates with vacuum pump.
The online sterilization process of the one provided in this technology is achieved through the following technical solutions:
This online sterilization process, comprises the following steps:
Feed liquid in a, emptying filter and pipe-line system and moisture;
B, in filter, be filled with saturated vapor by feed pipe;
C, some vapor are discharged by discharge nozzle;
D, startup vacuum pump evacuation;
E, repetition step b-d.
The beneficial effect of this online sterilization process is:
By the feed liquid in filter and pipe-line system and moisture emptying put clean, for online sterilizing provides good activity bases.
Open feed pipe discharge nozzle, in filter, be filled with saturated vapor by feed pipe, feed cavity is carried out to sterilizing, carried out short time sterilizing to filter element, and some vapor is discharged by discharge nozzle; Meanwhile, in filter element, part steam coagulation is aqueous water, in filter element, form moisture film, intercepts vapor transmission filter element and enters discharging chamber.
Close feed pipe, discharge nozzle, start vacuum pump evacuation, the steam of filter element is first drawn out of, only remaining aqueous water.Along with the increase of vacuum, in filter housing, absolute pressure reduces, when the absolute pressure in filter housing is reduced to the saturation vapor pressure corresponding with ambient temperature, water remaining in filter housing is boiled into steam, extracted out by continuation, eliminate the moisture film produced in filter element, make steam can penetrate filter element to discharging chamber, to the online sterilizing of filter element.
Through repeatedly repeating, to filter and pipe-line system thoroughly online sterilizing.
Accompanying drawing explanation
Fig. 1 is the structural representation of this online bactericidal unit.
Detailed description of the invention
Below in conjunction with accompanying drawing, this technology is described further:
This online bactericidal unit shown in Figure 1, comprises cartridge filter, is discharging chamber 5 in cartridge filter filter element 4, is feed cavity 3 outside filter element 4, in filter housing 8; Also comprise the feed pipe 1 communicated with feed cavity 3, the discharge nozzle 2 communicated with discharging chamber 5; Also comprise the vacuum pump 7 communicated with filter feed cavity 3.Before vacuum pump 7, arrange vacuum meter 6 communicate with vacuum pump 7.
Feed pipe 1 and discharge nozzle 2 are all in series with valve (not shown), immediately to open, to close feed pipe 1 and discharge nozzle 2 as required.
Vacuum pump 7 is arranged on above cartridge filter, is connected with filter with fast-assembling chuck.
The object arranging vacuum meter 6 observes filter housing 8 internal vacuum situation.The range of vacuum meter 6 is 0.1 ~ 0MPa, temperature :-40 DEG C ~ 70 DEG C.
The online sterilization process using above-mentioned online bactericidal unit to carry out online sterilizing comprises by following steps:
A. the feed liquid in emptying filter and pipe-line system and moisture.By the feed liquid in filter and pipe-line system and moisture emptying put clean, for online sterilizing provides good activity bases.
B. in filter, saturated vapor is filled with by feed pipe.Open feed pipe discharge nozzle, in filter, be filled with saturated vapor by feed pipe, feed cavity is carried out to sterilizing, carried out short time sterilizing to filter element, and some vapor is discharged by discharge nozzle; Meanwhile, in filter element, part steam coagulation is aqueous water, in filter element, form moisture film, intercepts vapor transmission filter element and enters discharging chamber.
C. some vapor is discharged by discharge nozzle.
D. vacuum pump evacuation is started.Close feed pipe, discharge nozzle, start vacuum pump evacuation, the steam of filter element is first drawn out of, only remaining aqueous water.Along with the increase of vacuum, in filter housing, absolute pressure reduces, when the absolute pressure in filter housing is reduced to the saturation vapor pressure corresponding with ambient temperature, water remaining in filter housing is boiled into steam, extracted out by continuation, eliminate the moisture film produced in filter element, make steam can penetrate filter element to discharging chamber, to the online sterilizing of filter element.
E. step b-d is repeated.Through repeatedly repeating, to filter and pipe-line system thoroughly online sterilizing.
The beneficial effect of this technology is:
Use above-mentioned online bactericidal unit, can realize preferably for filter and pipe-line system thoroughly online sterilizing.
Claims (3)
1. an online bactericidal unit, comprises cartridge filter, and cartridge filter filter element is interior is discharging chamber, and filter element is outer, filter housing is interior is feed cavity; Also comprise the feed pipe communicated with feed cavity, the discharge nozzle communicated with discharging chamber, is characterized in that, also comprises the vacuum pump communicated with filter feed cavity.
2. online bactericidal unit according to claim 1, is characterized in that, arranges vacuum meter and communicate with vacuum pump before vacuum pump.
3. an online sterilization process, is characterized in that, comprises the following steps:
A. the feed liquid in emptying filter and pipe-line system and moisture;
B. in filter, saturated vapor is filled with by feed pipe;
C. some vapor is discharged by discharge nozzle;
D. vacuum pump evacuation is started;
E. step b-d is repeated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510007395.2A CN104491894B (en) | 2015-01-08 | 2015-01-08 | A kind of online bactericidal unit and a kind of online sterilization process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510007395.2A CN104491894B (en) | 2015-01-08 | 2015-01-08 | A kind of online bactericidal unit and a kind of online sterilization process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104491894A true CN104491894A (en) | 2015-04-08 |
| CN104491894B CN104491894B (en) | 2017-11-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510007395.2A Active CN104491894B (en) | 2015-01-08 | 2015-01-08 | A kind of online bactericidal unit and a kind of online sterilization process |
Country Status (1)
| Country | Link |
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| CN (1) | CN104491894B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110507832A (en) * | 2019-07-31 | 2019-11-29 | 南京金日轻工科技发展有限公司 | A kind of sterile assisted sterilization device applied in pharmacy liquid mixing system |
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| KR100729631B1 (en) * | 2006-01-11 | 2007-06-18 | 오승현 | Spray method in a disinfectant |
| CN201101729Y (en) * | 2007-11-20 | 2008-08-20 | 山东新华医疗器械股份有限公司 | GMP sterilizer with lift door |
| CN201200631Y (en) * | 2008-05-29 | 2009-03-04 | 山东新华医疗器械股份有限公司 | Biosafety steam sterilizer |
| CN201921604U (en) * | 2010-11-19 | 2011-08-10 | 山东新华医疗器械股份有限公司 | High efficient applying device for steam sterilizer |
| CN203263846U (en) * | 2013-05-17 | 2013-11-06 | 山东新华医疗器械股份有限公司 | Double-filter online sterilization device |
| CN103784989A (en) * | 2014-01-27 | 2014-05-14 | 楚天科技股份有限公司 | On-line sterilization pipeline system of breathing filter for sterile container |
| CN204395046U (en) * | 2015-01-08 | 2015-06-17 | 南京金日轻工科技发展有限公司 | A kind of online bactericidal unit |
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2015
- 2015-01-08 CN CN201510007395.2A patent/CN104491894B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100729631B1 (en) * | 2006-01-11 | 2007-06-18 | 오승현 | Spray method in a disinfectant |
| CN201101729Y (en) * | 2007-11-20 | 2008-08-20 | 山东新华医疗器械股份有限公司 | GMP sterilizer with lift door |
| CN201200631Y (en) * | 2008-05-29 | 2009-03-04 | 山东新华医疗器械股份有限公司 | Biosafety steam sterilizer |
| CN201921604U (en) * | 2010-11-19 | 2011-08-10 | 山东新华医疗器械股份有限公司 | High efficient applying device for steam sterilizer |
| CN203263846U (en) * | 2013-05-17 | 2013-11-06 | 山东新华医疗器械股份有限公司 | Double-filter online sterilization device |
| CN103784989A (en) * | 2014-01-27 | 2014-05-14 | 楚天科技股份有限公司 | On-line sterilization pipeline system of breathing filter for sterile container |
| CN204395046U (en) * | 2015-01-08 | 2015-06-17 | 南京金日轻工科技发展有限公司 | A kind of online bactericidal unit |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110507832A (en) * | 2019-07-31 | 2019-11-29 | 南京金日轻工科技发展有限公司 | A kind of sterile assisted sterilization device applied in pharmacy liquid mixing system |
| CN110507832B (en) * | 2019-07-31 | 2021-04-20 | 南京金日轻工科技发展有限公司 | Be applied to aseptic supplementary sterilization apparatus in pharmacy liquid preparation system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104491894B (en) | 2017-11-21 |
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