CN104491663A - Traditional Chinese medicine preparation for treating liver-stagnation and spleen-deficiency type insomnia - Google Patents

Traditional Chinese medicine preparation for treating liver-stagnation and spleen-deficiency type insomnia Download PDF

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CN104491663A
CN104491663A CN201410729861.3A CN201410729861A CN104491663A CN 104491663 A CN104491663 A CN 104491663A CN 201410729861 A CN201410729861 A CN 201410729861A CN 104491663 A CN104491663 A CN 104491663A
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chinese medicine
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spleen
medicine preparation
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石娜
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/09Lichens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/14Cupressaceae (Cypress family), e.g. juniper or cypress
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • A61K36/8905Cyperus (flatsedge)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9064Amomum, e.g. round cardamom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

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Abstract

The invention discloses a traditional Chinese medicine preparation for treating liver-stagnation and spleen-deficiency type insomnia. According to the pathogenetic characteristics of insomnia in the current society that frequent thinking is prone to causing anger, the anger causes injuries to the liver, and the frequent thinking causes the injuries to the spleen, thereby causing liver-stagnation and spleen-deficiency type insomnia, the traditional Chinese medicine preparation disclosed by the invention is prepared by selecting the following traditional Chinese medicines: notholirion bulbuliferum, villous amomum flower and peduncle, citrus aurantium, pericarpium canavaliae, round cardamom fruit shell, nutgrass flatsedge, wild radix salviae miltiorrhizae, nardostachyos root and rhizome, pedunculate acronychia wood, quartz, cladonia fallax lichen and cypress fruits and performing decoction with water to form a decoction. According to clinical tests, the total effective rate achieves 90.0%, which is obviously better than 78.0% in a control group. The traditional Chinese medicine preparation has no obvious side effects.

Description

A kind of Chinese medicine preparation for the treatment of liver-depression and spleen-insufficiency type insomnia
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine preparation for the treatment of liver-depression and spleen-insufficiency type insomnia.
Background technology
Insomnia is often referred to difficulty falling asleep or maintains sleep disorder (easily wake up, early awakening and difficulty falling asleep again), causes reduce the length of one's sleep or Quality Down can not meet individual physiological need, obviously affects social function or quality of life in the daytime.
In recent years, to the basic research of insomnia progressively deeply, treatment at present adopts a cognitive behavior therapy and sedative hypnotic Benzodiazepines, Non-benzodiazepine and antidepressant drug to doctor trained in Western medicine.These drug effects are very fast, but insomniac's long-term taking, side effect is more, easily produces drug dependence.To the patient of some addiction, personality also can change gradually, occurs dyspathy, irascible, selfish, stubborn etc.These all make western medicine insomnia be restricted, and the compliance of patient is also poor.
Insomnia belongs to the category that Chinese medicine " is insomnia ", also has in a large number about the record of primary disease in ancient medical book.Traditional Chinese medicine in treating insomnia, panglossia disease combines with dialectical, is debating tranquilizing the mind on disease basis, on dialectical basis " tonifying for deficiency syndrome, reducing for the excess syndrome adjust its deficiency and excess, the eliminating the pathogen with Tong Qi road ".Applicant proves through clinical practice for many years, Chinese medicine improving symptom, heighten the effect of a treatment, improve the quality of living and avoid also to show unique advantage in untoward reaction etc.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of liver-depression and spleen-insufficiency type insomnia.Characteristics of incidence according to society insomnia: irritability of thinking much, anger is impairing the liver then, the impairment of the spleen of thinking much, and stagnation of liver-QI with deficiency of the spleen is then sent out as primary disease, controls suitable soothing liver and strengthening spleen, mind tranquilizing and the heart calming.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment liver-depression and spleen-insufficiency type insomnia is made up of the Chinese medicine of following weight portion: Bulbus Notholirionis hyacinthini 1-3 part, Flos Amomi villosi 1-2 part, Citrus aurantium L. var. amara Engl. 1-2 part, Pericarppium Canavaliae 9-12 part, Pericarpium Amomi 2-6 part, dried tuber 15-25 part, Radix Salviae simplicifoliae 6-9 part, Radix Et Rhizoma Nardostachyos 2-4 part, Lignum seu Radix Acronychiae 15-25 part, Quartz Album 10-12 part, Cladonia fallax Abbayes 8-10 part, Strobilus Cupressi 9-13 part.
Preferred: Bulbus Notholirionis hyacinthini 2 parts, Flos Amomi villosi 1.5 parts, Citrus aurantium L. var. amara Engl. 1.5 parts, Pericarppium Canavaliae 11 parts, Pericarpium Amomi 4 parts, dried tuber 20 parts, Radix Salviae simplicifoliae 7 parts, Radix Et Rhizoma Nardostachyos 3 parts, Lignum seu Radix Acronychiae 20 parts, Quartz Album 11 parts, Cladonia fallax Abbayes 9 parts, Strobilus Cupressi 11 parts.
Preparation method decocting makes decoction.
Fang Zhong: Bulbus Notholirionis hyacinthini the chest stuffiness relieving promoting the circulation of QI, analgesia cough-relieving, preventing or arresting vomiting, stomach invigorating; Flos Amomi villosi the chest stuffiness relieving is regulated the flow of vital energy, eliminates the phlegm, is relievingd asthma; Citrus aurantium L. var. amara Engl. depressed liver-energy dispersing and QI regulating stomach function regulating; The Pericarppium Canavaliae therapeutic method to keep the adverse QI flowing downwards and in, removing blood stasis and activating blood flow; Pericarpium Amomi the chest stuffiness relieving whets the appetite; Dried tuber activating QI to alleviate the depression, to dispel the wind; Radix Salviae simplicifoliae the chest stuffiness relieving, wind-damp dispelling, QI invigorating; Radix Et Rhizoma Nardostachyos regulating QI to relieve pain, activating spleen and strengthening stomach; Lignum seu Radix Acronychiae circulation of qi promoting, invigorate blood circulation, spleen invigorating, cough-relieving; Quartz Album tranquilizing mind, diuresis, warming the lung kidney; The calm antiinflammatory of Cladonia fallax Abbayes, pain relieving; Strobilus Cupressi is calmed the nerves, removing heat from blood, stop blooding, dispel the wind.
Clinical data
1. 100 routine cases are numbered by the sequencing of consultation time by physical data, are divided into test group and matched group with random digits table.Treatment group 50 example, male 17 example, women 33 example, the age be 19-68 year, average 40.23 ± 10.79 years old, the most elder of the course of disease 21 years, the shortest person 1 month, average out to 37.49 ± 7.36 months, mild insomnia 34 example, moderate insomniac 19 example, severe insomnia person 6 example; Matched group 50 example, male 19 example, women 31 example; Age be 20-69 year, average 39.92 ± 10.47 years old, the most elder of the course of disease 19 years, the shortest person 1 month, average out to 35.81 ± 9.92 months, mild insomnia 37 example, moderate insomniac 16 example, severe insomnia person 7 example.
2. diagnostic criteria is formulated with reference to the diagnostic criteria of insomnia in " Chinese Spirit Obstacles classification and diagnostic criteria " (the 3rd edition) of psychiatric department association of Chinese Medical Association formulation.(1) almost with insomnia for unique symptom, comprise have difficulty in going to sleep, insomnia-middle, dreaminess, early awakening, or not easily to sleep again after waking up, sense of discomfort after waking up, tired or daytime sleepiness etc.; (2) there is the dominant idea of insomnia and extreme concern insomnia result.(3) to sleep quantity, quality dissatisfied cause significantly worried or social function is impaired.(4) occur 3 times at least weekly, and 1 month at least.
Tcm diagnosis standard: with reference to " new Chinese medicine guideline of clinical investigations " (trying), the guideline of clinical investigations of syndrome of stagnation of liver qi and spleen deficiency.
Main symptom: gastral cavilty or distending pain over the hypochondrium, abdominal distention, lack of appetite is indigestion and loss of appetite, and loose stool is not well.
Secondary card: be in a very depressed state or being irritable and getting angry easily anger, sighing frequently, gas is vowed in borborygmus, and abdominal pain diarrhea, rushes down rear alleviation of pain, and tongue fur is white or greasy, stringy pulse or thin.Possess above primary symptom 3 (gastral cavilty or distending pain over the hypochondrium indispensability), or primary symptom 2 (gastral cavilty or distending pain over the hypochondrium indispensability), secondary disease 2 is namely diagnosable.
3. Therapeutic Method (1) treatment group: use Chinese medicine preparation of the present invention, take Bulbus Notholirionis hyacinthini 2g, Flos Amomi villosi 1.5g, Citrus aurantium L. var. amara Engl. 1.5g, Pericarppium Canavaliae 11g, Pericarpium Amomi 4g, dried tuber 20g, Radix Salviae simplicifoliae 7g, Radix Et Rhizoma Nardostachyos 3g, Lignum seu Radix Acronychiae 20g, Quartz Album 11g, Cladonia fallax Abbayes 9g, Strobilus Cupressi 11g, every day 1 dose, decocting 2 times, respectively at before the meal and front 2 clothes of sleeping early, each 100ml; Within 14 days, be 1 course for the treatment of, treated for 2 courses for the treatment of continuously.
(2) matched group: diazepam, each 5mg, 1 time every night, takes before sleeping, the same treatment group course for the treatment of (transference cure person withdraw).
4. criterion of therapeutical effect is with reference to the criterion of therapeutical effect of insomnia in " new Chinese medicine guideline of clinical investigations ".Clinical recovery: recover normal the length of one's sleep or increase to more than 6 hours every night, sleeping deep, energetic after waking up.Effective: to increase by more than 3 hours the length of one's sleep, Depth of sleep increases.Effective: increase the length of one's sleep less than 3 hours, symptom alleviates.Invalid: insomnia is not improved or increases the weight of.
5. therapeutic effect sees the following form
Two groups of curative effects are than turning
Number of cases Clinical recovery Effective Effectively Invalid Clinical recovery rate Total effective rate
Treatment group 50 15 22 8 5 30% 90%
Matched group 50 5 12 22 11 10% 78%
According to therapeutic outcome, treatment group clinical recovery rate and total effective rate are apparently higher than matched group, and without obvious adverse reaction in patient treatment procedure, blood, urine, stool routine examination, electrocardiogram and Liver and kidney function have no significant change, and treat the untoward reaction still not having medicine to cause in following up a case by regular visits to for latter 3 months.The untoward reaction such as drowsiness, dizzy, weak that matched group patient has 12 examples to occur in various degree over the course for the treatment of; In the return visit of 3 months subsequently, there is withdrawal symptoms after having 7 routine drug withdrawals, show as excitement or melancholy, psychotic exacerbation, even faint from fear.
Detailed description of the invention
Embodiment one: take Bulbus Notholirionis hyacinthini 2g, Flos Amomi villosi 1.5g, Citrus aurantium L. var. amara Engl. 1.5g, Pericarppium Canavaliae 11g, Pericarpium Amomi 4g, dried tuber 20g, Radix Salviae simplicifoliae 7g, Radix Et Rhizoma Nardostachyos 3g, Lignum seu Radix Acronychiae 20g, Quartz Album 11g, Cladonia fallax Abbayes 9g, Strobilus Cupressi 11g, decocting makes decoction.
Embodiment two: take Bulbus Notholirionis hyacinthini 3g, Flos Amomi villosi 1g, Citrus aurantium L. var. amara Engl. 2g, Pericarppium Canavaliae 9g, Pericarpium Amomi 6g, dried tuber 15g, Radix Salviae simplicifoliae 9g, Radix Et Rhizoma Nardostachyos 2g, Lignum seu Radix Acronychiae 25g, Quartz Album 10g, Cladonia fallax Abbayes 10g, Strobilus Cupressi 9g, decocting makes decoction.
Embodiment three: take Bulbus Notholirionis hyacinthini 1g, Flos Amomi villosi 2g, Citrus aurantium L. var. amara Engl. 1g, Pericarppium Canavaliae 12g, Pericarpium Amomi 2g, dried tuber 25g, Radix Salviae simplicifoliae 6g, Radix Et Rhizoma Nardostachyos 4g, Lignum seu Radix Acronychiae 15g, Quartz Album 12g, Cladonia fallax Abbayes 8g, Strobilus Cupressi 13g, decocting makes decoction.

Claims (2)

1. treat a liver-depression and spleen-insufficiency type insomnia's Chinese medicine preparation, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Bulbus Notholirionis hyacinthini 1-3 part, Flos Amomi villosi 1-2 part, Citrus aurantium L. var. amara Engl. 1-2 part, Pericarppium Canavaliae 9-12 part, Pericarpium Amomi 2-6 part, dried tuber 15-25 part, Radix Salviae simplicifoliae 6-9 part, Radix Et Rhizoma Nardostachyos 2-4 part, Lignum seu Radix Acronychiae 15-25 part, Quartz Album 10-12 part, Cladonia fallax Abbayes 8-10 part, Strobilus Cupressi 9-13 part.
2. a kind of Chinese medicine preparation for the treatment of liver-depression and spleen-insufficiency type insomnia according to claim 1, is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Bulbus Notholirionis hyacinthini 2 parts, Flos Amomi villosi 1.5 parts, Citrus aurantium L. var. amara Engl. 1.5 parts, Pericarppium Canavaliae 11 parts, Pericarpium Amomi 4 parts, dried tuber 20 parts, Radix Salviae simplicifoliae 7 parts, Radix Et Rhizoma Nardostachyos 3 parts, Lignum seu Radix Acronychiae 20 parts, Quartz Album 11 parts, Cladonia fallax Abbayes 9 parts, Strobilus Cupressi 11 parts.
CN201410729861.3A 2014-11-27 2014-11-27 Traditional Chinese medicine preparation for treating liver-stagnation and spleen-deficiency type insomnia Pending CN104491663A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009033105A1 (en) * 2007-09-07 2009-03-12 Bionovo, Inc. Estrogenic extracts of rheum palmatum l of the polygonaceae family and uses thereof
CN103919986A (en) * 2014-04-01 2014-07-16 杜秀兰 Traditional Chinese medicine for treating insomnia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009033105A1 (en) * 2007-09-07 2009-03-12 Bionovo, Inc. Estrogenic extracts of rheum palmatum l of the polygonaceae family and uses thereof
CN103919986A (en) * 2014-04-01 2014-07-16 杜秀兰 Traditional Chinese medicine for treating insomnia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
唐启善: "舒肝安寐汤治疗失眠症42例", 《四川中医》 *

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